Abstract: The present invention relates to extracted microbial lipids, microbial cells comprising the lipid, and extracts thereof. The present invention also relates to use of these lipids, cells and extracts in foods, feedstuffs and beverages.

Abstract: An applicator for applying a friction modifying material to the surface of a rail is provided. The applicator comprises a resilient body for applying a composition to a surface of a rail. The resilient body comprises an outer impervious surface and defines a sealed passageway that extends through the resilient body for the composition to flow through; and an applicator support, wherein the resilient body is secured to the applicator support. A rail applicator assembly and methods for using the applicator are also provided.

Abstract: An applicator for applying a friction modifying material to the surface of a rail is provided. The applicator comprises a resilient body for applying a composition to a surface of a rail. The resilient body comprises an outer impervious surface and defines a sealed passageway that extends through the resilient body for the composition to flow through; and an applicator support, wherein the resilient body is secured to the applicator support. A rail applicator assembly and methods for using the applicator are also provided.

Abstract: An applicator for applying a friction modifying material to the surface of a rail is provided. The applicator comprises a resilient body for applying a composition to a surface of a rail. The resilient body comprises an outer impervious surface and defines a sealed passageway that extends through the resilient body for the composition to flow through; and an applicator support, wherein the resilient body is secured to the applicator support. A rail applicator assembly and methods for using the applicator are also provided.

Abstract: A rail gauge face applicator is provided. The gauge face applicator comprises a resilient pad comprising one or more than one channel extending from one or more than one inlet to one or more than one outlet. The one or more than one channel is operable from a closed position when the pressure within the channel is low to an open position when the pressure within the channel is raised. Thus, when the pressure of the friction modifying material is raised the one or more than one channel opens and material can be delivered from the one or more than one outlet. The applicator further comprises a rail engagement element which allows the gauge face applicator to be positioned appropriately to engage a rail. The applicator may be less prone to clogging and may be more efficient at delivering friction modifying material efficiently than prior art applicators.

Abstract: A trough for use on wiping bar assembly of a rail lubrication system, wherein the wiping bar assembly includes a Manifold body and a flow passageway having an exit end at least partially defined in the manifold body. The trough includes a body having a first section and a second section extending away from the first section, wherein the first section of the body is positioned adjacent the exit end, and wherein a mat is provided within the trough.

Abstract: A clamp device for mounting a rail device onto a railroad rail includes a clamp body having an upper section and a lower section. The clamp body defines a recess portion between the upper and lower sections and a bore extending through the lower section of the clamp body. A bolt having a first end and a second end extends through the bore of the clamp body. The clamp device also includes a quick release mechanism having a lever arm and a cam member pivotally connected to the second end of the bolt. The lever arm is connected to the cam member and has a clamped position and a released position whereby pivoting the lever arm from the released position to the clamped position draws the first end of the bolt and the clamp body together.

Abstract: An applicator for applying a friction modifying material to the surface of a rail is provided. The applicator comprises a resilient body for applying a composition to a surface of a rail. The resilient body comprises an outer impervious surface and defines a sealed passageway that extends through the resilient body for the composition to flow through; and an applicator support, wherein the resilient body is secured to the applicator support. A rail applicator assembly and methods for using the applicator are also provided.

Abstract: A rail gauge face applicator is provided. The gauge face applicator comprises a resilient pad comprising one or more than one channel extending from one or more than one inlet to one or more than one outlet. The one or more than one channel is operable from a closed position when the pressure within the channel is low to an open position when the pressure within the channel is raised. Thus, when the pressure of the friction modifying material is raised the one or more than one channel opens and material can be delivered from the one or more than one outlet. The applicator further comprises a rail engagement element which allows the gauge face applicator to be positioned appropriately to engage a rail. The applicator may be less prone to clogging and may be more efficient at delivering friction modifying material efficiently than prior art applicators.

Abstract: A clamp device for mounting a rail device onto a railroad rail includes a clamp body having an upper section and a lower section. The clamp body defines a recess portion between the upper and lower sections and a bore extending through the lower section of the clamp body. A bolt having a first end and a second end extends through the bore of the clamp body. The clamp device also includes a quick release mechanism having a lever arm and a cam member pivotally connected to the second end of the bolt. The lever arm is connected to the cam member and has a clamped position and a released position whereby pivoting the lever arm from the released position to the clamped position draws the first end of the bolt and the clamp body together.

Abstract: A trough for use on wiping bar assembly of a rail lubrication system, wherein the wiping bar assembly includes a manifold body and a flow passageway having an exit end at least partially defined in the manifold body. The trough includes a body having a first section and a second section extending away from the first section, wherein the first section of the body is positioned adjacent the exit end, and wherein a mat is provided within the trough.

Abstract: The present invention provides methods and kits for treating depression, perimenopausal depression, schizophrenia, anxiety, panic attacks, binge eating, social phobia, or preventing deterioration of cognitive function by administering to a patient in need thereof a therapeutically effect amount of an estrogen agonist/antagonist of formula I

Abstract: Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or “linker” defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 Å, are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.

Abstract: Angiotensin-converting enzyme is a zinc metallopeptidase that plays roles in blood pressure regulation and fertility. The catalytic activities of angiotensin converting enzymes include the production of the potent vasopressor angiotensin II from angiotensin I, and the inactivation of the vasodilatory peptide bradykinin. Zace2 is a new form of human zinc metallopeptidase, characterized as an angiotensin converting enzyme paralog that is expressed primarily in tissues of the digestive system. Two murine orthologs are also described.

Abstract: Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or “linker” defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 Å, are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.

Abstract: Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or “linker” defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 Å, are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.

Abstract: Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or “linker” defined as including a covalent bond per se so 29 as to space the aromatic systems at a distance 1.5-15Å, are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.

Abstract: Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or "linker" defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 .ANG., are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.

Abstract: Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or "linker" defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 .ANG., are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.

Abstract: Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or "linker" defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 .ANG., are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.