Patents by Inventor Charles Rauch
Charles Rauch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10099283Abstract: A method of forming a component having an internal passage defined therein includes positioning a jacketed core with respect to a mold. The jacketed core includes a hollow structure formed from at least a first material and a second material, and an inner core disposed within the hollow structure. The method also includes introducing a component material in a molten state into a cavity of the mold, and cooling the component material in the cavity to form the component. The inner core defines the internal passage within the component.Type: GrantFiled: December 17, 2015Date of Patent: October 16, 2018Assignee: General Electric CompanyInventors: Stanley Frank Simpson, Stephen Francis Rutkowski, Canan Uslu Hardwicke, Joseph Leonard Moroso, Steven Charles Rauch
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Publication number: 20180238175Abstract: A method and device for retaining position of a consumable core during composite article manufacturing is taught herein by inserting a consumable core having a consumable core body and a plurality of retention artifacts into a composite precursor hollow feature of a composite precursor structure. Then positioning the consumable core such that the plurality of retention artifacts projecting from the consumable core exterior surface at least partially engage with a substantially spatially replicate surface geometry in the composite precursor hollow feature. The consumable core is then consumed as a soluble infiltrant to form a composite article.Type: ApplicationFiled: February 21, 2017Publication date: August 23, 2018Inventors: Marc Lionel Benjamin, Steven Charles Rauch
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Publication number: 20170173683Abstract: A method of forming a component having an internal passage defined therein includes positioning a jacketed core with respect to a mold. The jacketed core includes a hollow structure formed from at least a first material and a second material, and an inner core disposed within the hollow structure. The method also includes introducing a component material in a molten state into a cavity of the mold, and cooling the component material in the cavity to form the component. The inner core defines the internal passage within the component.Type: ApplicationFiled: December 17, 2015Publication date: June 22, 2017Inventors: Stanley Frank Simpson, Stephen Francis Rutkowski, Canan Uslu Hardwicke, Joseph Leonard Moroso, Steven Charles Rauch
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Publication number: 20130020843Abstract: A disposable and portable seating apparatus made from a single sheet of recyclable material, such as corrugated cardboard. The apparatus is intended to be used as temporary seating for events, festivals, gatherings, or similar situations where seating is not readily available, or practical. The structural component of the seating apparatus is designed to interlock providing optimal strength to support the weight of an average adult. The design and material allow the seating apparatus to be assembled and disassembled relatively easily, without the use of any tools or additional bonding agents, such as glue, staples, or other adhesives. After use, the seat can be turned upside down and serve as a recycling container, or trash receptacle for discarded materials, such as; cans, bottles, etc. The exterior of the assembled may act as a medium for advertising purposes, used by companies promoting products, events, contests, teams, or organizations.Type: ApplicationFiled: January 25, 2012Publication date: January 24, 2013Inventors: Dustin Charles Rauch, Gabriela Moraes Rauch
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Patent number: 7695948Abstract: A metalloprotease that converts TNF-? from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.Type: GrantFiled: February 21, 2007Date of Patent: April 13, 2010Assignee: Immunex CorporationInventors: Roy A. Black, Charles Rauch, Carl J. March, Douglas P. Cerretti
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Publication number: 20100015137Abstract: A protein designated TRAIL receptor binds the protein known as TNF-Related Apoptosis-Inducing Ligand (TRAIL). The TRAIL receptor finds use in purifying TRAIL or inhibiting activities thereof. Isolated DNA sequences encoding TRAIL-R polypeptides are provided, along with expression vectors containing the DNA sequences, and host cells transformed with such recombinant expression vectors. Antibodies that are immunoreactive with TRAIL-R are also provided.Type: ApplicationFiled: December 23, 2008Publication date: January 21, 2010Inventors: Charles Rauch, Henning Walczak
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Patent number: 7625553Abstract: Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.Type: GrantFiled: February 9, 2007Date of Patent: December 1, 2009Assignee: Immunex CorporationInventors: Kenneth H. Grabstein, Dirk M. Anderson, June R. Eisenman, Victor Fung, Charles Rauch
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Patent number: 7528239Abstract: A protein designated TRAIL receptor binds the protein known as TNF-Related Apoptosis-Inducing Ligand (TRAIL). The TRAIL receptor finds use in purifying TRAIL or inhibiting activities thereof. Isolated DNA sequences encoding TRAIL-R polypeptides are provided, along with expression vectors containing the DNA sequences, and host cells transformed with such recombinant expression vectors. Antibodies that are immunoreactive with TRAIL-R are also provided.Type: GrantFiled: August 20, 1999Date of Patent: May 5, 2009Assignee: Immunex CorporationInventors: Charles Rauch, Henning Walczak
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Publication number: 20080160571Abstract: A metalloprotease that converts TNF-? from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.Type: ApplicationFiled: February 21, 2007Publication date: July 3, 2008Applicant: Immunex CorporationInventors: Roy A. Black, Charles Rauch, Carl J. March, Douglas P. Cerretti
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Publication number: 20080090762Abstract: Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.Type: ApplicationFiled: February 9, 2007Publication date: April 17, 2008Inventors: Kenneth Grabstein, Dirk Anderson, June Eisenman, Victor Fung, Charles Rauch
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Patent number: 7199224Abstract: A metalloprotease that converts TNF-? from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.Type: GrantFiled: April 25, 2003Date of Patent: April 3, 2007Assignee: Immunex CorporationInventors: Roy A Black, Charles Rauch, Carl J March, Douglas P Cerretti
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Publication number: 20070063787Abstract: The present antenna system includes a balun for coupling an antenna to a feed line. The balun has at least two transmission line transformers, such that the transmission line transformers are coupled in parallel at their inputs with the feedline, and coupled in series at their outputs with the antenna. At least one of the transmission line transformers maintained by the balun is fabricated so that it has reduced power dissipation properties, and reduced electromagnetic stress handling properties with respect to the other transmission line transformers. Such considerations reduce fabrication time, waste of material, and the cost of the balun.Type: ApplicationFiled: September 19, 2006Publication date: March 22, 2007Inventor: Charles Rauch
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Patent number: 7192935Abstract: Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.Type: GrantFiled: November 28, 2000Date of Patent: March 20, 2007Assignee: Amgen Inc.Inventors: Kenneth H. Grabstein, Dirk M. Anderson, June R. Eisenman, Victor Fung, Charles Rauch
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Patent number: 6642358Abstract: A protein designated TRAIL receptor binds the protein known as TNF-Related Apoptosis-Inducing Ligand (TRAIL). The TRAIL receptor finds use in purifying TRAIL or inhibiting activities thereof. Isolated DNA sequences encoding TRAIL-R polypeptides are provided, along with expression vectors containing the DNA sequences, and host cells transformed with such recombinant expression vectors. Antibodies that are immunoreactive with TRAIL-R are also provided.Type: GrantFiled: May 25, 2000Date of Patent: November 4, 2003Assignee: Immunex CorporationInventors: Charles Rauch, Henning Walczak
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Publication number: 20030175816Abstract: A metalloprotease that converts TNF-&agr; from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.Type: ApplicationFiled: April 25, 2003Publication date: September 18, 2003Applicant: Immunex CorporationInventors: Roy A. Black, Charles Rauch, Carl J. March, Douglas P. Cerretti
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Patent number: 6569642Abstract: A protein designated TRAIL receptor binds the protein known as TNF-Related Apoptosis-Inducing Ligand (TRAIL). The TRAIL receptor finds use in purifying TRAIL or inhibiting activities thereof. Isolated DNA sequences encoding TRAIL-R polypeptides are provided, along with expression vectors containing the DNA sequences, and host cells transformed with such recombinant expression vectors. Antibodies that are immunoreactive with TRAIL-R are also provided.Type: GrantFiled: March 27, 2000Date of Patent: May 27, 2003Assignee: Immunex CorporationInventors: Charles Rauch, Henning Walczak
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Patent number: 6555354Abstract: A metalloprotease that converts TNF-&agr; from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.Type: GrantFiled: November 29, 2000Date of Patent: April 29, 2003Assignee: Immunex CorporationInventors: Roy A. Black, Charles Rauch, Carl J. March, Douglas P. Cerretti
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Publication number: 20020115175Abstract: A metalloprotease that converts TNF-&agr; from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.Type: ApplicationFiled: November 29, 2000Publication date: August 22, 2002Inventors: Roy A. Black, Charles Rauch, Carl J. March, Douglas P. Cerretti
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Patent number: 6406901Abstract: A metalloprotease that converts TNF-&agr; from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.Type: GrantFiled: May 26, 2000Date of Patent: June 18, 2002Assignee: Immunex CorporationInventors: Roy A. Black, Charles Rauch, Carl J. March, Douglas P. Cerretti
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Patent number: 6406877Abstract: A metalloprotease that converts TNF-&agr; from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.Type: GrantFiled: November 29, 2000Date of Patent: June 18, 2002Assignee: Immunex CorporationInventors: Roy A. Black, Charles Rauch, Carl J. March, Douglas P. Cerretti