Patents by Inventor Charles T. Goodhue
Charles T. Goodhue has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6025335Abstract: The invention relates to nucleoside dimers containing an L-sugar in at least one of the nucleosides and their pharmaceutical compositions.Type: GrantFiled: September 21, 1995Date of Patent: February 15, 2000Assignee: Lipitek International, Inc.Inventors: Alexander L. Weis, Charles T. Goodhue, Kirupathevy Pulenthiran
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Patent number: 5885972Abstract: This invention relates to .alpha. and .beta.-L-pyranosyl nucleosides of Formula (I), wherein the nucleoside substitution on the pyranosyl carbohydrate molecule comprises a substituted or unsubstituted purine (adenine or guanine) or pyrimidine (cytosine, uracil, thymine and hypoxanthine) base. Also provided are methods to make the .alpha. and .beta.-L-pyranosyl nucleosides and methods of using such to treat cancer in a mammal.Type: GrantFiled: October 2, 1996Date of Patent: March 23, 1999Assignee: Genencor International, Inc.Inventors: Alexander L. Weis, Charles T. Goodhue
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Patent number: 5672594Abstract: This invention relates to .alpha. and .beta.-L-erythrosyl nucleosides of the formula (I), wherein the nucleoside substitution on the erythrosyl carbohydrate molecule comprises a substituted or unsubstituted purine (adenine or guanine) or pyrimidine (cytosine, uracil, thymine and hypoxanthine) base. Also provided are methods to make the .alpha. and .beta.-L-erythrosyl nucleosides and methods of using such to treat cancer in a mammal.Type: GrantFiled: October 24, 1994Date of Patent: September 30, 1997Assignee: Genencor International, Inc.Inventors: Alexander L. Weis, Tamas Bakos, Charles T. Goodhue
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Patent number: 5559101Abstract: This invention relates to .alpha. and .beta. L-ribofuranosyl nucleosides, processes for their preparation, pharmaceutical compositions containing them, and methods of using them to treat various diseases in mammals.Type: GrantFiled: October 24, 1994Date of Patent: September 24, 1996Assignees: Genencor International, Inc., Lipitek, Inc.Inventors: Alexander L. Weis, Kirupathevy Shanmuganathan, Charles T. Goodhue
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Patent number: 5476965Abstract: Provided are enzymatic methods for the selective hydrolytic resolution of certain enantiomers of a pharmaceutical compound, the pharmaceutical compound comprising a (.+-.) mixture of a .alpha.-substituted 2-methyl proprionic acid derivative. Specifically provided is the selective enzymatic resolution of either the R(+) or S(-) enantiomer of (.+-.)-ethyl ciprofibrate. Also provided are substantially pure enantiomers of R(+) and S(-) ciprofibrate.Type: GrantFiled: February 18, 1994Date of Patent: December 19, 1995Assignee: Genencor International, Inc.Inventors: Matthew W. Chase, Charles T. Goodhue, Robert Seemayer, Gregory M. Whited
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Patent number: 5418151Abstract: There is provided a regio-selective method for the resolution of carbohydrate monoester mixtures, by treating such mixtures with one or more selective enzymes. The resolution of such mixtures results in monoesters comprising significantly purer isolates of one desired isomer.Type: GrantFiled: August 7, 1992Date of Patent: May 23, 1995Assignee: Genencor International, Inc.Inventors: Charles T. Goodhue, Theresa C. Paulson, Robert Seemayer
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Patent number: 5114850Abstract: Acetate esters of diols and polyols can be prepared in aqueous systems using a biocatalyst derived from Corynebacterium oxydans. The method involves the step of reacting a diol or polyol with an acetate ester in a substantially aqueous environment in the presence of said biocatalyst.Type: GrantFiled: June 22, 1990Date of Patent: May 19, 1992Assignee: Eastman Kodak CompanyInventors: Frank A. Pettrone, Gregory M. Whited, Charles T. Goodhue
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Patent number: 4588683Abstract: Disclosed herein is a method for preparing 11.beta., 17.alpha., 20, 21-tetrahydroxy steroids of the pregnane class. This method comprises incubating the corresponding 17.alpha., 20.alpha. or .beta., 21-trihydroxy steroid in the presence of a culture medium capable of effecting the 11.beta.-hydroxylation, such medium comprising a fungal culture of the genus Curvularia. Also disclosed herein is a method for preparing 11.beta., 17.alpha., 21-trihydroxy-20-oxo steroids of the pregnane class. This method comprises the hydroxylation method described hereinabove followed by conversion of the resulting 11.beta., 17.alpha., 20.alpha. or .beta., 21-tetrahydroxy steroid into the corresponding 11.beta., 17.alpha., 21-trihydroxy-20-oxo steroid.Type: GrantFiled: February 6, 1984Date of Patent: May 13, 1986Assignee: Eastman Kodak CompanyInventors: Charles T. Goodhue, Gwendolyn C. Kydd, Charles H. Foster, Charles A. McCombs
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Patent number: 4499184Abstract: Methods, compositions and elements for the analysis of total cholesterol in aqueous fluids containing cholesterol and cholesterol esters are disclosed. Cholesterol esters in the fluid samples are first converted to cholesterol by:(a) contacting a sample of the fluid with sufficient amounts of lysolecithin and an enzyme exhibiting lecithin:cholesterol acyl transferase (LCAT) activity to convert substantially all the cholesterol esters to cholesterol in the sample, and(b) removing cholesterol from the aqueous fluid other than by conversion to cholesterol esters.The total cholesterol is quantitatively determined by measuring the amount of the removed cholesterol. For example, the amount is measured gravimetrically or by converting the cholesterol to a detectable product.Type: GrantFiled: June 1, 1982Date of Patent: February 12, 1985Assignee: Eastman Kodak CompanyInventor: Charles T. Goodhue
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Patent number: 4444886Abstract: An enzyme which catalyzes the hydrolysis of glycerol esters is disclosed. The enzyme is specific for alkyl esters wherein the alkyl group has from 1 to 4 carbon atoms inclusive. The enzyme is particularly useful in hydrolyzing a diacetyl glycerol ester. The enzyme is from the microorganism Bacillus subtilis ATCC No. 31954.Type: GrantFiled: August 11, 1982Date of Patent: April 24, 1984Assignee: Eastman Kodak CompanyInventors: Theodore W. Esders, Charles T. Goodhue, Ohannes K. Esmerian
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Patent number: 4374930Abstract: A method for the purification and recovery of cholesterol oxidase is disclosed. Cholesterol oxidase is purified by a method including the steps of:(a) contacting a solution of the cholesterol oxidase to be purified with a chromatography composition comprising an unbound water-insoluble steroid which is a nonsubstrate for cholesterol oxidase so as to adsorb the cholesterol oxidase on the steroid;(b) separating the solution from the steroid; and(c) contacting the steroid with an eluting solution containing a surfactant at a concentration between 0.001 percent and 10 percent so as to recover the adsorbed cholesterol oxidase.In a preferred embodiment, the solution containing the cholesterol oxidase to be purified is a microorganism growth medium having cholesterol oxidase activity and, prior to the step of contacting the solution with a steroid, the solution is contacted with an ion-exchange chromatography material.Type: GrantFiled: October 19, 1981Date of Patent: February 22, 1983Assignee: Eastman Kodak CompanyInventors: Roy E. Snoke, Charles T. Goodhue
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Patent number: 4276377Abstract: A urease-free creatinine iminohydrolase enzyme preparation obtained from an aerobic soil microorganism. The enzyme of the preparation preferably has a molecular weight of from about 250,000 to 300,000; a maximum activity at a pH between 7 and 8 as measured at 37.degree. C.; a K.sub.m of about 3 to 5 mM for creatinine as measured at 37.degree. C., pH 7.5; and a specific activity for creatinine of at least about 1.0 unit per milligram of protein in the preparation as measured at 37.degree. C., pH 7.5. The preferred enzyme preparation is derived from the aerobic soil microorganism ATCC 31,546. Assay methods, compositions, and elements containing the aforementioned urease-free creatinine iminohydrolase for the determination of creatinine in an aqueous liquid are also disclosed.Type: GrantFiled: November 5, 1979Date of Patent: June 30, 1981Assignee: Eastman Kodak CompanyInventors: Charles T. Goodhue, Theodore W. Esders, Prakash S. Masurekar
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Patent number: 4275152Abstract: A novel process is described for hydrolyzing protein-bound cholesterol esters such as are found in blood serum. The method comprises contacting sample containing protein-bound cholesterol esters with a compatible mixture of an enzyme preparation which demonstrates cholesterol ester hydrolase activity and, as an effector, a surfactant which is an alkyl phenoxy polyethoxy ethanol comprising a polyoxyethylene chain of less than about 20 oxyethylene units.Hydrolysis compositions comprising compatible mixtures of an enzyme preparation which demonstrates cholesterol ester hydrolase activity and an effector which is a surfactant as described are also disclosed, as are analytical elements comprising at least one layer which includes such a hydrolysis composition.Type: GrantFiled: July 30, 1979Date of Patent: June 23, 1981Assignee: Eastman Kodak CompanyInventors: Theodore W. Esders, Charles T. Goodhue, Christine A. Michrina
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Patent number: 4275151Abstract: A novel process is described for hydrolyzing protein-bound cholesterol esters such as are found in blood serum. The method comprises contacting sample containing protein-bound cholesterol esters with a compatible mixture of an enzyme preparation which demonstrates cholesterol ester hydrolase activity and, as an effector, a surfactant which is an alkyl phenoxy polyethoxy ethanol comprising a polyoxyethylene chain of less than about 20 oxyethylene units.Hydrolysis compositions comprising compatible mixtures of an enzyme preparation which demonstrates cholesterol ester hydrolase activity and an effector which is a surfactant as described are also disclosed, as are analytical elements comprising at least one layer which includes such a hydrolysis composition.Type: GrantFiled: December 18, 1978Date of Patent: June 23, 1981Assignee: Eastman Kodak CompanyInventors: Theodore W. Esders, Charles T. Goodhue, Christine A. Michrina
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Patent number: 4241178Abstract: A method is described for the assay of glycerol (as either free glycerol or a fatty acid ester of glycerol) in aqueous liquids such as blood serum. The method comprises the steps ofI: contacting in the presence of an electron acceptor (a) a sample to be assayed and (b) a novel reagent composition comprising1. optionally, a lipase which hydrolyzes triglycerides to glycerol;2. glycerol kinase;3. adenosine triphosphate;4. .alpha.-glycerophosphate oxidase to produce a detectable change in the presence of triglyceride or a general positive sample; andII: detecting the occurrence of said detectable change.The lipase is included when fatty acid esters of glycerol (i.e., triglycerides) are to be detected. Free glycerol from whatever source can be detected with a composition comprising 2-4 above. According to a preferred embodiment, the electron acceptor is oxygen and the reagent composition also includes a hydrogen peroxide indicator composition, i.e.Type: GrantFiled: January 6, 1978Date of Patent: December 23, 1980Assignee: Eastman Kodak CompanyInventors: Theodore W. Esders, Charles T. Goodhue
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Patent number: 4179334Abstract: A novel process is described for hydrolyzing protein-bound triglycerides such as blood serum triglycerides comprising contacting sample containing protein-bound triglycerides with a compatible mixture of an enzyme preparation which demonstrates triglyceride hydrolase activity and, as an effector, a surfactant.Hydrolysis compositions comprising compatible mixtures of an enzyme preparation which demonstrates triglyceride hydrolase activity and an effector which is a surfactant are also described, as are analytical elements comprising at least one layer which includes a hydrolysis composition which comprises such a compatible mixture of an enzyme preparation which demonstrates triglyceride hydrolase activity and a surfactant.Type: GrantFiled: August 19, 1976Date of Patent: December 18, 1979Assignee: Eastman Kodak CompanyInventors: Theodore W. Esders, Charles T. Goodhue, Christine A. Michrina
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Patent number: 4166763Abstract: Compositons and multilayer analytical elements comprising lactate oxidase which is substantially free of catalase and preferably produced by Streptococcus faecalis ATCC 12755 are provided for the quantitative analysis of lactic acid or lactate, especially in serum. The lactate oxidase catalyzes the reduction of lactic acid or lactate to pyruvate and hydrogen peroxide and the quantity of lactic acid or lactate is determined by detecting the amount of hydrogen peroxide produced. Preferably, the hydrogen peroxide is detected colorimetrically using a peroxidase-catalyzed detection system.Type: GrantFiled: December 10, 1976Date of Patent: September 4, 1979Assignee: Eastman Kodak CompanyInventors: Theordore W. Esders, Charles T. Goodhue, Richard M. Schubert
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Patent number: 4166005Abstract: An improved process for producing .alpha.-glycerophosphate oxidase provides yields of more than 1500 U per liter. The enzyme is produced by growing a member of the family Lactobacillaceae in a medium comprising pyruvate and an inducer for .alpha.-glycerophosphate oxidase. In the preferred embodiment, a medium comprising a mixture of glucose and pyruvate as carbon sources provides a synergistic effect on the production of .alpha.-glycerophosphate oxidase.Type: GrantFiled: January 3, 1978Date of Patent: August 28, 1979Assignee: Eastman Kodak CompanyInventors: Prakash S. Masurekar, Charles T. Goodhue
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Patent number: 4093517Abstract: An improved fermentation method comprises growing a cholesterol oxidase-producing microorganism in a medium comprising a carbon source, such as glycerol, yeast extract, a nonionic surfactant, an auxiliary carbon source which is also an inducer of cholesterol oxidase, and trace salts. Yields of cholesterol oxidase up to about 900 U. (international units) per liter have been obtained using the improved method of the present invention.Type: GrantFiled: November 15, 1976Date of Patent: June 6, 1978Assignee: Eastman Kodak CompanyInventors: Prakash S. Masurekar, Charles T. Goodhue
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Patent number: RE32016Abstract: Compositions and multilayer analytical elements comprising lactate oxidase which is substantially free of catalase and preferably produced by Streptococcus faecalis ATCC 12755 are provided for the quantitative analysis of lactic acid or lactate, especially in serum. The lactate oxidase catalyzes the reduction of lactic acid or lactate to pyruvate and hydrogen peroxide and the quantity of lactic acid or lactate is determined by detecting the amount of hydrogen peroxide produced. Preferably, the hydrogen peroxide is detected colorimetrically using a peroxidase-catalyzed detection system.Type: GrantFiled: August 31, 1981Date of Patent: October 29, 1985Assignee: Eastman Kodak CompanyInventors: Theodore W. Esders, Charles T. Goodhue, Richard M. Schubert