Patents by Inventor Che-Hung Robert Lee
Che-Hung Robert Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210369833Abstract: Immunogenic compositions that include a bacterial capsular polysaccharide conjugated to a carrier protein are described. In some embodiments, the bacterial capsular polysaccharide is a Neisseria meningitidis capsular polysaccharide. The carrier protein includes an N. meningitidis factor H binding protein (fHbp) linked to cholera toxin subunit B (CTB). Administration of the immunogenic compositions elicits an immune response that includes production of meningococcal polysaccharide-specific and fHbP-specific antibodies. Use of the immunogenic compositions as meningococcal vaccines is also described.Type: ApplicationFiled: August 11, 2021Publication date: December 2, 2021Applicant: THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human ServicInventors: Gregory A. Price, Che-Hung Robert Lee, Margaret Bash
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Patent number: 11116830Abstract: Immunogenic compositions that include a bacterial capsular polysaccharide conjugated to a carrier protein are described. In some embodiments, the bacterial capsular polysaccharide is a Neisseria meningitidis capsular polysaccharide. The carrier protein includes an N. meningitidis factor H binding protein (fHbp) linked to cholera toxin subunit B (CTB). Administration of the immunogenic compositions elicits an immune response that includes production of meningococcal polysaccharide-specific and fHbp-specific antibodies. Use of the immunogenic compositions as meningococcal vaccines is also described.Type: GrantFiled: December 18, 2018Date of Patent: September 14, 2021Assignee: THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human ServicesInventors: Gregory A. Price, Che-Hung Robert Lee, Margaret C. Bash
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Publication number: 20210154288Abstract: Immunogenic compositions that include a bacterial capsular polysaccharide conjugated to a carrier protein are described. In some embodiments, the bacterial capsular polysaccharide is a Neisseria meningitidis capsular polysaccharide. The carrier protein includes an N. meningitidis factor H binding protein (fHbp) linked to cholera toxin subunit B (CTB). Administration of the immunogenic compositions elicits an immune response that includes production of meningococcal polysaccharide-specific and fHbp-specific antibodies. Use of the immunogenic compositions as meningococcal vaccines is also described.Type: ApplicationFiled: December 18, 2018Publication date: May 27, 2021Applicant: THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human ServicInventors: Gregory A. Price, Che-Hung Robert Lee, Margaret Bash
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Patent number: 9956278Abstract: Disclosed herein are meningococcal immunogenic conjugates which can elicit immune responses against meningococcal polysaccharides (PS) from groups A, C, W-135, and Y and group B factor H binding protein (fHbp). The disclosed conjugates also exhibit bactericidal activity against meningococcal A, C, W-135, Y, B, and X serogroups. Also disclosed are improved methods for preparing conjugates, such as immunogenic conjugates, including activation of a polysaccharide with a cyanylation agent at about 4° C.Type: GrantFiled: August 1, 2016Date of Patent: May 1, 2018Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventor: Che-Hung Robert Lee
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Publication number: 20160331824Abstract: Disclosed herein are meningococcal immunogenic conjugates which can elicit immune responses against meningococcal polysaccharides (PS) from groups A, C, W-135, and Y and group B factor H binding protein (fHbp). The disclosed conjugates also exhibit bactericidal activity against meningococcal A, C, W-135, Y, B, and X serogroups. Also disclosed are improved methods for preparing conjugates, such as immunogenic conjugates, including activation of a polysaccharide with a cyanylation agent at about 4° C.Type: ApplicationFiled: August 1, 2016Publication date: November 17, 2016Applicant: The United States of America, as represented by the Secretary, Dept. of Health and Human ServicesInventor: Che-Hung Robert Lee
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Patent number: 9474795Abstract: Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.Type: GrantFiled: November 2, 2015Date of Patent: October 25, 2016Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Che-Hung Robert Lee, Carl E. Frasch
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Patent number: 9427476Abstract: Disclosed herein are meningococcal immunogenic conjugates which can elicit immune responses against meningococcal polysaccharides (PS) from groups A, C, W-135, and Y and group B factor H binding protein (fHbp). The disclosed conjugates also exhibit bactericidal activity against meningococcal A, C, W-135, Y, B, and X serogroups. Also disclosed are improved methods for preparing conjugates, such as immunogenic conjugates, including activation of a polysaccharide with a cyanylation agent at about 4° C.Type: GrantFiled: May 23, 2013Date of Patent: August 30, 2016Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, The United States of America, as Represented by the Secretary of the ArmyInventors: Che-Hung Robert Lee, Valerian B. Pinto
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Publication number: 20160136256Abstract: Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.Type: ApplicationFiled: November 2, 2015Publication date: May 19, 2016Applicant: The United States of America, as represented by the Secretary, Department of Health and Human ServInventors: Che-Hung Robert Lee, Carl E. Frasch
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Patent number: 9198976Abstract: Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.Type: GrantFiled: May 5, 2014Date of Patent: December 1, 2015Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Che-Hung Robert Lee, Carl E. Frasch
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Patent number: 9175033Abstract: Methods for preparing complex multivalent immunogenic conjugates that include simultaneously reacting a plurality or immunogenic-distinct polysaccharides with at least one protein to make the complex multivalent immunogenic conjugates. The simultaneous reaction involves reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant.Type: GrantFiled: August 6, 2013Date of Patent: November 3, 2015Assignee: The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventor: Che-Hung Robert Lee
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Patent number: 9173931Abstract: Methods for the manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency. Simplified purification processes can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.Type: GrantFiled: August 6, 2004Date of Patent: November 3, 2015Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, FiocruzInventors: Ellen Jessouroun, Ivna Alana Freitas Brasileiro Da Silveira, Renata Chagas Bastos, Carl E. Frasch, Che-Hung Robert Lee
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Publication number: 20150182613Abstract: This disclosure relates to vaccine formulations comprising an immunogenic composition for inducing antibodies to both S. pneumoniae and N. meningitides in a subject. In a preferred aspect, the immunogenic composition comprises covalently conjugated recombinant PsaA (“rPsaA”) from S. pneumoniae and capsular polysaccharide from N. meningitidis serogroup C. This disclosure further relates to methods for producing the immunogenic composition as well as methods for their use.Type: ApplicationFiled: November 20, 2014Publication date: July 2, 2015Inventors: Stanley Shih-Peng Tai, Che-Hung Robert Lee
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Publication number: 20150110829Abstract: Disclosed herein are meningococcal immunogenic conjugates which can elicit immune responses against meningococcal polysaccharides (PS) from groups A, C, W-135, and Y and group B factor H binding protein (fHbp). The disclosed conjugates also exhibit bactericidal activity against meningococcal A, C, W-135, Y, B, and X serogroups. Also disclosed are improved methods for preparing conjugates, such as immunogenic conjugates, including activation of a polysaccharide with a cyanylation agent at about 4° C.Type: ApplicationFiled: May 23, 2013Publication date: April 23, 2015Inventors: Che-Hung Robert Lee, Valerian B. Pinto
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Publication number: 20140322258Abstract: Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.Type: ApplicationFiled: May 5, 2014Publication date: October 30, 2014Applicant: The Government of the United States of America, as represented by the Secretary of the Department ofInventors: Che-Hung Robert Lee, Carl E. Frasch
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Patent number: 8753649Abstract: Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.Type: GrantFiled: May 10, 2013Date of Patent: June 17, 2014Assignee: The United States of America, as Represented by the Secretary, Department of Health and Human ServicesInventors: Che-Hung Robert Lee, Carl E. Frasch
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Publication number: 20140044748Abstract: Methods for preparing complex multivalent immunogenic conjugates that include simultaneously reacting a plurality or immunogenic-distinct polysaccharides with at least one protein to make the complex multivalent immunogenic conjugates. The simultaneous reaction involves reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant.Type: ApplicationFiled: August 6, 2013Publication date: February 13, 2014Applicant: The Gov't of the U.S.A. as represented by the Secretary of the Dept. of Health & Human ServicesInventor: Che-Hung Robert Lee
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Publication number: 20130337004Abstract: Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.Type: ApplicationFiled: May 10, 2013Publication date: December 19, 2013Applicant: The Government of the United States of America, as represented by the Secretary of the Department ofInventors: Che-Hung Robert Lee, Carl E. Frasch
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Patent number: 8557250Abstract: Methods for preparing complex multivalent immunogenic conjugates that include simultaneously reacting a plurality or immunogenic-distinct polysaccharides with at least one protein to make the complex multivalent immunogenic conjugates. The simultaneous reaction involves reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant.Type: GrantFiled: April 5, 2012Date of Patent: October 15, 2013Assignee: The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventor: Che-Hung Robert Lee
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Patent number: 8465749Abstract: Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.Type: GrantFiled: September 23, 2011Date of Patent: June 18, 2013Assignee: The United States of America, as represented by the Secretary of the Department of Health and Human ServicesInventors: Che-Hung Robert Lee, Carl E. Frasch
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Publication number: 20120195922Abstract: Methods for preparing complex multivalent immunogenic conjugates that include simultaneously reacting a plurality or immunogenic-distinct polysaccharides with at least one protein to make the complex multivalent immunogenic conjugates. The simultaneous reaction involves reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant.Type: ApplicationFiled: April 5, 2012Publication date: August 2, 2012Inventor: Che-Hung Robert Lee