Patents by Inventor Chee Kiong Lim
Chee Kiong Lim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11339425Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lends can be a bi-convex lens.Type: GrantFiled: April 12, 2019Date of Patent: May 24, 2022Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Jacob K. Freudenthal, Geoffrey Dahlhoff, Kevin Maher, Ming Song Chen, Gary Lim, Ronald Danehy, David Fortescue, Ming Shen, Woon Liang Soh, Francis T. Cheng, Ruoyun Wu, Thiam Chye Lee, Gary A. Chappell, Chee Kiong Lim, Jeff Dere, Ted Straub, Jorge Fonseca, Kuan Moon Boo, Soo Yong Lau
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Patent number: 10835901Abstract: A thermal block assembly including a sample block and two or more thermoelectric devices, is disclosed. The sample block has a top surface configured to receive a plurality of reaction vessels and an opposing bottom surface. The thermoelectric devices are operably coupled to the sample block, wherein each thermoelectric device includes a housing for a thermal sensor and a thermal control interface with a controller. Each thermoelectric device is further configured to operate independently from each other to provide a substantially uniform temperature profile throughout the sample block.Type: GrantFiled: June 30, 2017Date of Patent: November 17, 2020Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Hon Siu Shin, Chin Yong Koo, Way Xuang Lee, Chee Kiong Lim, Chee Wee Ching, Niroshan Ramachandran
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Publication number: 20200101461Abstract: In one aspect, a thermal cycler system including a sample block and a thermoelectric device is disclosed. In various embodiments, the sample block has a first surface configured to receive a plurality of reaction vessels and an opposing second surface. In various embodiments the thermoelectric device is operably coupled to the second surface of the sample block. In various embodiments a thermal control unit is provided. In various embodiments the thermal control unit includes a computer processing unit. In various embodiments the thermal control unit includes an electrical current source. In various embodiments the thermal control unit also includes an electrical interface portion configured to connect the thermoelectric device with the electrical current source by way of an electrical cable. In various embodiments the thermal control unit is oriented in a different plane than the sample block and thermoelectric cooler.Type: ApplicationFiled: September 26, 2019Publication date: April 2, 2020Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Chee Kiong LIM, Way Xuang LEE, Wuh Ken LOH, Chee Wee CHING, Chin Yong KOO, Siew Ying KOH, Tiong Han TOH, Kuan Moon BOO, Soo Yong LAU
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Patent number: 10493419Abstract: Aspects of the present teachings describe a method and apparatus for automatically controlling a block temperature to reduce undershooting and overshooting of the temperatures of a sample contained in the block and participating in a polymerase chain reaction (PCR). The adaptive thermal block temperature control begins when a sample temperature enters a sample window region between a preliminary setpoint temperature and a target setpoint temperature for the sample. Based on thermodynamic behavior of the sample and the predetermined phase of PCR, predicting a time period measured subsequent to the preliminary setpoint temperature when the sample will reach the target setpoint suitable for the predetermined phase of PCR. During this time period, varying the block temperature ramp rate with a series of cooling and heating changes to ensure the block temperature reaches the target setpoint temperature at approximately the same time as the sample reaches the same.Type: GrantFiled: May 16, 2016Date of Patent: December 3, 2019Assignee: Applied Biosystems, LLCInventors: Chee Kiong Lim, Chee Wee Ching
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Patent number: 10471431Abstract: In one aspect, a thermal cycler system including a sample block and a thermoelectric device is disclosed. In various embodiments, the sample block has a first surface configured to receive a plurality of reaction vessels and an opposing second surface. In various embodiments the thermoelectric device is operably coupled to the second surface of the sample block. In various embodiments a thermal control unit is provided. In various embodiments the thermal control unit includes a computer processing unit. In various embodiments the thermal control unit includes an electrical current source. In various embodiments the thermal control unit also includes an electrical interface portion configured to connect the thermoelectric device with the electrical current source by way of an electrical cable. In various embodiments the thermal control unit is oriented in a different plane than the sample block and thermoelectric cooler.Type: GrantFiled: February 4, 2015Date of Patent: November 12, 2019Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Chee Kiong Lim, Way Xuang Lee, Wuh Ken Loh, Chee Wee Ching, Chin Yong Koo, Siew Ying Koh, Tiong Han Toh, Kuan Moon Boo, Soo Yong Lau
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Publication number: 20190300936Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lends can be a bi-convex lens.Type: ApplicationFiled: April 12, 2019Publication date: October 3, 2019Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Jacob K. FREUDENTHAL, Geoffrey DAHLHOFF, Kevin MAHER, Ming Song CHEN, Gary LIM, Ronald DANEHY, David FORTESCUE, Ming SHEN, Woon Liang Soh, Francis T. CHENG, Ruoyun WU, Thiam Chye LEE, Gary A. CHAPPELL, Chee Kiong LIM, Jeff DERE, Ted E. STRAUB, Jorge FONSECA, Kuan Moon BOO, Soo Yong LAU
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Patent number: 10137452Abstract: A method for performing polymerase chain reactions (PCR) for improving thermal non-uniformity is provided. The method includes measuring a first temperature, by a first sensor, of a first sample block sector of a sample block and measuring a second temperature, by a second sensor, of a second sample block sector of the sample block that is adjacent to the first sample block sector. The method further includes calculating, by a thermoelectric controller, a difference in temperature between the first temperature and the second temperature and adjusting, by the thermoelectric controller, the first temperature of the first sample block sector based on the difference in temperature by using one or more thermoelectric coolers. The one or more thermoelectric coolers is configured to heat or cool the first sample block sector by adjusting power output from the thermoelectric controller.Type: GrantFiled: January 19, 2017Date of Patent: November 27, 2018Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Thomas Conner, Chee Kiong Lim, Michael Pallas, Chee Wee Ching
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Publication number: 20180311672Abstract: An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling.Type: ApplicationFiled: June 27, 2018Publication date: November 1, 2018Inventors: Hon Siu Shin, Jew Kwee Ngui, Chee Kiong Lim, Ching Ong Lau, Lim Hi Tan, Yang Hooi Kee
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Patent number: 10010887Abstract: An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling.Type: GrantFiled: October 10, 2014Date of Patent: July 3, 2018Assignee: Applied Biosystems, LLCInventors: Hon Siu Shin, Jew Kwee Ngui, Chee Kiong Lim, Ching Ong Lau, Lim Hi Tan, Yang Hooi Kee
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Publication number: 20180056296Abstract: A thermal block assembly including a sample block and two or more thermoelectric devices, is disclosed. The sample block has a top surface configured to receive a plurality of reaction vessels and an opposing bottom surface. The thermoelectric devices are operably coupled to the sample block, wherein each thermoelectric device includes a housing for a thermal sensor and a thermal control interface with a controller. Each thermoelectric device is further configured to operate independently from each other to provide a substantially uniform temperature profile throughout the sample block.Type: ApplicationFiled: June 30, 2017Publication date: March 1, 2018Inventors: Hon Siu SHIN, Chin Yong KOO, Way Xuang LEE, Chee Kiong LIM, Chee Wee CHING, Niroshan RAMACHANDRAN
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Publication number: 20170225169Abstract: A method for performing polymerase chain reactions (PCR) for improving thermal non-uniformity is provided. The method includes measuring a first temperature, by a first sensor, of a first sample block sector of a sample block and measuring a second temperature, by a second sensor, of a second sample block sector of the sample block that is adjacent to the first sample block sector. The method further includes calculating, by a thermoelectric controller, a difference in temperature between the first temperature and the second temperature and adjusting, by the thermoelectric controller, the first temperature of the first sample block sector based on the difference in temperature by using one or more thermoelectric coolers. The one or more thermoelectric coolers is configured to heat or cool the first sample block sector by adjusting power output from the thermoelectric controller.Type: ApplicationFiled: January 19, 2017Publication date: August 10, 2017Inventors: Thomas Conner, Chee Kiong Lim, Michael Pallas, Chee Wee Ching
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Patent number: 9566583Abstract: A method for performing polymerase chain reactions (PCR) for improving thermal non-uniformity is provided. The method includes measuring a first temperature, by a first sensor, of a first sample block sector of a sample block and measuring a second temperature, by a second sensor, of a second sample block sector of the sample block that is adjacent to the first sample block sector. The method further includes calculating, by a thermoelectric controller, a difference in temperature between the first temperature and the second temperature and adjusting, by the thermoelectric controller, the first temperature of the first sample block sector based on the difference in temperature by using one or more thermoelectric coolers. The one or more thermoelectric coolers is configured to heat or cool the first sample block sector by adjusting power output from the thermoelectric controller.Type: GrantFiled: April 8, 2011Date of Patent: February 14, 2017Assignee: Life Technologies CorporationInventors: Thomas Conner, Chee Kiong Lim, Michael Pallas, Chee Wee Ching
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Publication number: 20160256845Abstract: Aspects of the present teachings describe a method and apparatus for automatically controlling a block temperature to reduce undershooting and overshooting of the temperatures of a sample contained in the block and participating in a polymerase chain reaction (PCR). The adaptive thermal block temperature control begins when a sample temperature enters a sample window region between a preliminary setpoint temperature and a target setpoint temperature for the sample. Based on thermodynamic behavior of the sample and the predetermined phase of PCR, predicting a time period measured subsequent to the preliminary setpoint temperature when the sample will reach the target setpoint suitable for the predetermined phase of PCR. During this time period, varying the block temperature ramp rate with a series of cooling and heating changes to ensure the block temperature reaches the target setpoint temperature at approximately the same time as the sample reaches the same.Type: ApplicationFiled: May 16, 2016Publication date: September 8, 2016Inventors: Chee Kiong Lim, Chee Wee Ching
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Publication number: 20160214110Abstract: A thermal block assembly including a sample block and two or more thermoelectric devices, is disclosed. The sample block has a top surface configured to receive a plurality of reaction vessels and an opposing bottom surface. The thermoelectric devices are operably coupled to the sample block, wherein each thermoelectric device includes a housing for a thermal sensor and a thermal control interface with a controller. Each thermoelectric device is further configured to operate independently from each other to provide a substantially uniform temperature profile throughout the sample block.Type: ApplicationFiled: September 15, 2014Publication date: July 28, 2016Inventors: Hon Siu SHIN, Chin Yong KOO, Way Xuang LEE, Chee Kiong LIM, Chee Wee CHING, Niroshan RAMACHANDRAN
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Publication number: 20150231636Abstract: In one aspect, a thermal cycler system including a sample block and a thermoelectric device is disclosed. In various embodiments, the sample block has a first surface configured to receive a plurality of reaction vessels and an opposing second surface. In various embodiments the thermoelectric device is operably coupled to the second surface of the sample block. In various embodiments a thermal control unit is provided. In various embodiments the thermal control unit includes a computer processing unit. In various embodiments the thermal control unit includes an electrical current source. In various embodiments the thermal control unit also includes an electrical interface portion configured to connect the thermoelectric device with the electrical current source by way of an electrical cable. In various embodiments the thermal control unit is oriented in a different plane than the sample block and thermoelectric cooler.Type: ApplicationFiled: February 4, 2015Publication date: August 20, 2015Inventors: Chee Kiong Lim, Way Xuang LEE, Wuh Ken LOH, Chee Wee CHING, Chin Yong KOO, Siew Ying KOH, Tiong Han TOH, Kuan Moon BOO, Soo Yong LAU
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Patent number: D740838Type: GrantFiled: April 8, 2014Date of Patent: October 13, 2015Assignee: Life Technologies CorporationInventors: Chee Kiong Lim, Kok Siong Teo, Gary A. Chappell
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Patent number: D785008Type: GrantFiled: September 22, 2015Date of Patent: April 25, 2017Assignee: Life Technologies CorporationInventors: Chee Kiong Lim, Kok Siong Teo, Gary Chappell
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Patent number: D785009Type: GrantFiled: September 22, 2015Date of Patent: April 25, 2017Assignee: Life Technologies CorporationInventors: Chee Kiong Lim, Kok Siong Teo, Gary Chappell
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Patent number: D823869Type: GrantFiled: October 14, 2016Date of Patent: July 24, 2018Assignees: LIFE TECHNOLOGIES CORPORATION, PIERCE BIOTECHNOLOGY, INC., LIFE TECHNOLOGIES HOLDINGS PTE LIMITEDInventors: Sean Zimmerman, Chee Kiong Lim, Scott Rickes, Gregory Kilmer, John Langan, Kok Siong Teo
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Patent number: D942479Type: GrantFiled: June 22, 2018Date of Patent: February 1, 2022Assignees: Life Technologies Corporation, Pierce Biotechnology, Inc.Inventors: Sean Zimmerman, Chee Kiong Lim, Scott Rickes, Gregory Kilmer, John Langan, Kok Siong Teo