Patents by Inventor Chengzao Sun

Chengzao Sun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11845808
    Abstract: The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel diseases.
    Type: Grant
    Filed: January 14, 2021
    Date of Patent: December 19, 2023
    Assignees: Janssen Biotech, Inc., Protagonist Therapeutics, Inc.
    Inventors: Chengzao Sun, Brian Troy Frederick, Sandeep Somani, Gregory Thomas Bourne, Raymond Patch, Ashok Bhandari
  • Publication number: 20220402983
    Abstract: The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel diseases.
    Type: Application
    Filed: January 14, 2021
    Publication date: December 22, 2022
    Inventors: Chengzao Sun, Brian Troy Frederick, Sandeep Somani, Ashok Bhandari, Raymond Patch, Stephanie Barros, Raffaele Ingenito, Roberto Costante, Danila Branca, Elisabetta Bianchi
  • Publication number: 20210261622
    Abstract: The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel diseases.
    Type: Application
    Filed: January 14, 2021
    Publication date: August 26, 2021
    Inventors: Chengzao Sun, Brian Troy Frederick, Sandeep Somani, Gregory Thomas Bourne, Raymond Patch, Ashok Bhandari, Raffaele Ingenito, Roberto Costante, Danila Branca, Elisabetta Bianchi
  • Publication number: 20170114114
    Abstract: Compounds are provided having inter alia good duration of action, high potency and/or convenient dosing regimens including oral administration. The compounds are engineered polypeptides which incorporate an albumin binding domain in combination with one or more biologically active polypeptides. Also provided are pharmaceutical compositions and methods of treatment for diseases and disorders including obesity and overweight, diabetes, dyslipidemia, hyperlipidemia, Alzheimer's disease, fatty liver disease, short bowel syndrome, Parkinson's disease, cardiovascular disease, and other and disorders of the central nervous system.
    Type: Application
    Filed: January 4, 2017
    Publication date: April 27, 2017
    Inventors: Mary Erickson, David C. Litzinger, Soumitra S. Ghosh, Zijian Guo, Swetha Neravetla, Chengzao Sun, Manoj P. Samant, Odile E. Levy, Abhinandini Sharma, Lala Mamedova, Christopher Soares
  • Patent number: 9593154
    Abstract: Compounds are provided having inter alia good duration of action, high potency and/or convenient dosing regimens including oral administration. The compounds are engineered polypeptides which incorporate an albumin binding domain in combination with one or more biologically active polypeptides. Also provided are pharmaceutical compositions and methods of treatment for diseases and disorders including obesity and overweight, diabetes, dyslipidemia, hyperlipidemia, Alzheimer's disease, fatty liver disease, short bowel syndrome, Parkinson's disease, cardiovascular disease, and other and disorders of the central nervous system.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: March 14, 2017
    Assignees: AstraZeneca Pharmaceuticals LP, Amylin Pharmaceuticals, LLC
    Inventors: Mary Erickson, David C. Litzinger, Soumitra S. Ghosh, Zijian Guo, Swetha Neravetla, Chengzao Sun, Manoj P. Samant, Odile E. Levy, Abhinandini Sharma, Lala Mamedova, Christopher J. Soares
  • Patent number: 9249181
    Abstract: There are provided compounds and methods for amidating the C-terminus of a polypeptide. The methods include reacting a polypeptide which includes a C-terminal thioester or C-terminal selenoester with any one of a defined set of auxiliary molecules under conditions suitable to produce a polypeptide adduct which includes the auxiliary molecule chemically bound at the C-terminal of the polypeptide. The auxiliary molecule can be a substituted or unsubstituted 2-phenyl-2-amino ethanethiol, a substituted or unsubstituted 2-phenyl-2-amino ethaneselenol, or a substituted xanthene. In the subsequent step, a portion of the auxiliary molecule is removed from the C-terminal of the polypeptide adduct and leaving the amide nitrogen under conditions suitable to form a C-terminal free amide polypeptide.
    Type: Grant
    Filed: September 8, 2011
    Date of Patent: February 2, 2016
    Assignees: Amylin Pharmaceuticals, LLC, AstraZeneca Pharmaceuticals LP
    Inventors: Chengzao Sun, Behrouz Bruce Forood, Gary Luo, Soumitra S. Ghosh
  • Publication number: 20140221282
    Abstract: There are provided compounds having two peptide hormones bound to a central water-soluble polymeric spacer and methods of use thereof.
    Type: Application
    Filed: May 24, 2012
    Publication date: August 7, 2014
    Inventors: Chengzao Sun, Behrouz Bruce Forood
  • Publication number: 20140221287
    Abstract: There are provided polypeptide conjugates having enhanced duration of biological activity, and methods of use thereof. The polypeptide conjugates include duration enhancing moieties, including water soluble polymers, bound to the polypeptide components of defined sequence. Methods of use are provided for treatment of metabolic disorders. Methods of use are provided for treatment of an eating disorder, insulin resistance, obesity, overweight, abnormal postprandial hyperglycemia, Type I diabetes, Type II diabetes, gestational diabetes, metabolic syndrome, dumping syndrome, hypertension, dyslipidemia, cardiovascular disease, hyper lipidemia, sleep apnea, cancer, pulmonary hypertension, cholescystitis, osteoarthritis, or short bowel syndrome.
    Type: Application
    Filed: May 24, 2012
    Publication date: August 7, 2014
    Applicants: ASTRAZENECA PHARMACEUTICALS LP, AMYLIN PHARMACEUTICALS, LLC
    Inventors: Chengzao Sun, Manoj P. Samant, Swetha Neravetla
  • Publication number: 20140066370
    Abstract: The disclosure provides Polypeptide Conjugates with multiple improved pharmacological and pharmacokinetic properties and their use in treating various diseases and conditions, such as diabetes and/or obesity.
    Type: Application
    Filed: November 23, 2010
    Publication date: March 6, 2014
    Applicant: Amylin Pharmaceuticals, LLC
    Inventors: Behrouz Bruce Forood, Soumitra S. Ghosh, James L. Trevaskis, Chengzao Sun, Odile Esther Levy, Lawrence J. D'Souza, Christopher J. Soares
  • Publication number: 20140058070
    Abstract: There are provided compounds and methods for amidating the C-terminus of a polypeptide. The method include reacting a polypeptide which includes a C-terminal thioester or C-terminal selenoester with any one of a defined set of auxiliary molecules under conditions suitable to produce a polypeptide adduct which includes the auxiliary molecule chemically bound at the C-terminal of the polypeptide. In the subsequent step, the auxiliary molecule is removed from the C-terminal of the polypeptide adduct under conditions suitable to produce an amidated polypeptide.
    Type: Application
    Filed: September 8, 2011
    Publication date: February 27, 2014
    Applicant: AstraZeneca Pharmaceuticala LP
    Inventors: Chengzao Sun, Behrouz Bruce Forood, Gary Luo, Soumitra S. Ghosh
  • Patent number: 8138361
    Abstract: Provided herein are C-10 taxane carbamates and pharmaceutically acceptable derivatives thereof. In certain embodiments, provided herein are compounds, compositions and methods for treating cancer and taupathy.
    Type: Grant
    Filed: December 27, 2006
    Date of Patent: March 20, 2012
    Assignees: The Trustees Of The University Of Pennsylvania, Acidophil, LLC
    Inventors: Carlo Ballatore, Angelo J Castellino, Amos B Smith, III, Joel Desharnais, Chengzao Sun, Simon E Aspland
  • Publication number: 20090306014
    Abstract: Provided herein are C-10 taxane carbamates and pharmaceutically acceptable derivatives thereof. In certain embodiments, provided herein are compounds, compositions and methods for treating cancer and taupathy.
    Type: Application
    Filed: December 27, 2006
    Publication date: December 10, 2009
    Applicants: Acidophil llc, The Trustees of the University of Pennsylvania
    Inventors: Carlo Ballatore, Angelo J. Castellino, Amos B. Smith, III, Joel Desharnais, Chengzao Sun, Simon E. Aspland
  • Publication number: 20060234909
    Abstract: In one embodiment, provided herein are compositions and methods for increasing drug efficiency. In certain embodiments, the compositions contain conjugates having the formula: D-L-S wherein D is a drug moiety; L, which may or may not be present, is a non-releasing linker moiety; and S is a substrate for a protein or lipid kinase that is overexpressed, overactive or exhibits undesired activity in a target system.
    Type: Application
    Filed: March 14, 2006
    Publication date: October 19, 2006
    Inventors: Michael Newman, Angelo Castellino, Joel Desharnais, Zijian Guo, Qing Li, Carlo Ballatore, Chengzao Sun
  • Publication number: 20050187147
    Abstract: In one embodiment, provided herein are compositions and methods for increasing drug efficiency. In certain embodiments, the compositions contain conjugates having the formula: D-L-S wherein D is a drug moiety; L, which may or may not be present, is a non-releasing linker moiety; and S is a substrate for a protein or lipid kinase that is overexpressed, overactive or exhibits undesired activity in a target system.
    Type: Application
    Filed: September 22, 2004
    Publication date: August 25, 2005
    Inventors: Michael Newman, Angelo Castellino, Joel Desharnais, Zijian Guo, Qing Li, Carlo Ballatore, Chengzao Sun
  • Publication number: 20050148534
    Abstract: In certain embodiments, provided herein are compositions and methods for increasing drug efficiency. The conjugates provided are in certain embodiments, for compositions and methods in treatment of variety of diseases and have the formula 1: D-L-S??(1) or formula 2: D-L-S???(2) wherein D is a drug moiety; L, which may or may not be present, is a non-releasing linker moiety; S is a substrate for a kinase, other than a hexokinase, a protein kinase or a lipid kinase; and S? is a substrate for a phosphotransferase, other than a hexokinase, a protein kinase or a lipid kinase.
    Type: Application
    Filed: September 22, 2004
    Publication date: July 7, 2005
    Inventors: Angelo Castellino, Carlo Ballatore, Simon Aspland, Joel Desharnais, Michael Newman, Chengzao Sun, Peter Wirsching