Abstract: The invention provides novel substituted heterocyclic rings represented by Formula I, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of RIPK1 and the therapeutic methods.

Abstract: The polyethylene according to the present disclosure has a short relaxation time and a uniform particle size, thereby preparing a chlorinated polyethylene excellent in chlorination productivity and glass transition temperature by reacting with chlorine. And, a PVC composition with improved impact strength may also be prepared by including the same.

Abstract: The polyethylene according to the present disclosure reacts with chlorine to prepare a chlorinated polyethylene having excellent processability during extrusion with a high tensile strength by implementing a molecular structure having a high content of medium molecular weight, and may also prepare a CPE compound including the chlorinated polyethylene.

Abstract: The polyethylene according to the present disclosure has a molecular structure having a narrow particle distribution and a low content of ultra-high molecular weight, so that a chlorinated polyethylene having excellent chlorination productivity and thermal stability may be prepared by reacting the polyethylene with chlorine. And, a PVC composition including the same with improved impact strength may also be prepared.

Abstract: A supported metallocene catalyst can include a silica-based carrier and an aluminum alkyl halide, a cocatalyst compound, and a metallocene compound supported in the silica-based carrier. The aluminum alkyl halide is supported at higher rate on the surface of the silica-based carrier than inside the pores, and the cocatalyst compound is supported at higher rate inside the pores of the silica-based carrier than on the surface of the silica-based carrier. Such a supported metallocene catalyst can be prepared by: (i) supporting an aluminum alkyl halide in a silica-based carrier; (ii) supporting a cocatalyst compound in the silica-based carrier in which the aluminum alkyl halide is supported; and (iii) supporting a metallocene compound in the carrier in which the aluminum alkyl halide and the cocatalyst compound are supported. Such a supported metallocene catalyst can be used to polymerize polyolefins with excellent activity and polyolefin with a uniform powder morphology.

Abstract: There is provided a method for preparing a metallocene-supported catalyst that exhibits catalytic activity, and yet, can decrease fine generation, and thus, can minimize fouling and chunk generation, and can stably prepare polyethylene having excellent properties.

Abstract: The present disclosure relates to a polyethylene, which is reacted with chlorine to prepare a chlorinated polyethylene having excellent processability and size stability during high-speed extrusion by optimizing a high-crystalline region in a molecular structure, and a CPE compound including the same.

Abstract: The present disclosure relates to a polyethylene, which is reacted with chlorine to prepare a chlorinated polyethylene having excellent chlorination productivity and thermal stability by enabling an increase in chlorination temperature, and facilitating deoxidation, dehydration and drying processes during chlorination processing, by implementing an enlarged area of the middle and high molecular weight regions in the molecular structure of the polyethylene.

Abstract: Provided are a hybrid supported catalyst which includes two or more kinds of transition metal compounds having the following Chemical Formulas 1 and 2, thereby preparing a polyolefin, particularly, a high-density polyethylene having a molecular structure which is optimized to improve tensile strength of a chlorinated polyolefin compound, and a method of preparing a polyolefin using the same: wherein all the variables are described herein.

Abstract: There are provided a polyethylene capable of improving tensile strength while maintaining excellent processability and Mooney viscosity characteristics when preparing a chlorinated polyethylene compound by implementing a molecular structure having a low content of low molecular weight and a high content of high molecular weight, and a chlorinated polyethylene prepared using the same.

Abstract: The polyethylene according to the present disclosure has a short relaxation time and a uniform particle size, thereby preparing a chlorinated polyethylene excellent in chlorination productivity and glass transition temperature by reacting with chlorine. And, a PVC composition with improved impact strength may also be prepared by including the same.

Abstract: The polyethylene according to the present disclosure reacts with chlorine to prepare a chlorinated polyethylene having excellent processability during extrusion with a high tensile strength by implementing a molecular structure having a high content of medium molecular weight, and may also prepare a CPE compound including the chlorinated polyethylene.

Abstract: The polyethylene according to the present disclosure has a molecular structure having a narrow particle distribution and a low content of ultra-high molecular weight, so that a chlorinated polyethylene having excellent chlorination productivity and thermal stability may be prepared by reacting the polyethylene with chlorine. And, a PVC composition including the same with improved impact strength may also be prepared.

Abstract: A polyethylene according to the present disclosure maintains a stable crystal structure at a high temperature and ensures excellent uniformity in chlorine distribution, thereby preparing a chlorinated polyethylene having excellent chlorination productivity and thermal stability by reacting with chlorine, and may also prepare a PVC compound with improved impact strength by including the chlorinated polyethylene.