Patents by Inventor Chien Hsing Chang

Chien Hsing Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12097025
    Abstract: The present invention provides a measuring method for prolonging a usage lifetime of a biosensor to measure a physiological signal representative of a physiological parameter associated with an analyte in a biofluid. The biosensor includes two working electrodes at least partially covered by a chemical reagent and two counter electrodes having silver and a silver halide, and each silver halide has an initial amount.
    Type: Grant
    Filed: July 31, 2020
    Date of Patent: September 24, 2024
    Assignee: BIONIME CORPORATION
    Inventors: Chun-Mu Huang, Chieh-Hsing Chen, Heng-Chia Chang, Chi-Hao Chen, Chien-Chung Chen
  • Patent number: 11982828
    Abstract: A display device includes a light guide plate, a cover lens, a first optical layer, a second optical layer and a display. The light guide plate has a first surface and a second surface opposite to the first surface. The cover lens is disposed on the first surface of the light guide plate. The first optical layer is disposed between the first surface and the cover lens. The second optical layer is disposed between the first surface and the first optical layer. For visible light, a light absorption rate of the first optical layer is larger than or equal to a light absorption rate of the second optical layer. The display is disposed on the second surface of the light guide plate.
    Type: Grant
    Filed: February 17, 2023
    Date of Patent: May 14, 2024
    Assignee: E Ink Holdings Inc.
    Inventor: Chien-Hsing Chang
  • Patent number: 11921395
    Abstract: A reflective active device array substrate includes a substrate, a plurality of active devices, a protective layer, and a plurality of metal oxide conductor layers. The active devices are dispersedly disposed on the substrate. The protective layer is disposed on the substrate and covers the active devices. The protective layer has a plurality of openings, and each of the openings exposes a source or a drain of the corresponding active device, respectively. The metal oxide conductor layers are disposed on the substrate and cover the protective layer. Each of the metal oxide conductor layers is electrically connected to the source or the drain of the corresponding active device through the corresponding opening.
    Type: Grant
    Filed: April 10, 2020
    Date of Patent: March 5, 2024
    Assignee: E Ink Holdings Inc.
    Inventor: Chien-Hsing Chang
  • Publication number: 20230350288
    Abstract: An anti-glare layer and a manufacturing method thereof are provided. The manufacturing method of the anti-glare layer includes providing a substrate, coating an anti-glare material layer on the substrate, and performing a photolithography process on the anti-glare material layer through a gray-scale mask to form the anti-glare layer. The anti-glare layer includes multiple protrusion portions with different heights.
    Type: Application
    Filed: February 17, 2023
    Publication date: November 2, 2023
    Applicant: E Ink Holdings Inc.
    Inventor: Chien-Hsing Chang
  • Publication number: 20230324594
    Abstract: A display device includes a light guide plate, a cover lens, a first optical layer, a second optical layer and a display. The light guide plate has a first surface and a second surface opposite to the first surface. The cover lens is disposed on the first surface of the light guide plate. The first optical layer is disposed between the first surface and the cover lens. The second optical layer is disposed between the first surface and the first optical layer. For visible light, a light absorption rate of the first optical layer is larger than or equal to a light absorption rate of the second optical layer. The display is disposed on the second surface of the light guide plate.
    Type: Application
    Filed: February 17, 2023
    Publication date: October 12, 2023
    Applicant: E Ink Holdings Inc.
    Inventor: Chien-Hsing Chang
  • Publication number: 20230297184
    Abstract: Provided is an inspection tool for a touch panel, including a substrate adapted to be placed on the touch panel and multiple protrusions disposed on the substrate in correspondence to multiple touch inspection points and arranged along an inspection trajectory. An inspection method for a touch panel is also provided.
    Type: Application
    Filed: January 12, 2023
    Publication date: September 21, 2023
    Applicant: E Ink Holdings Inc.
    Inventors: Chien-Hsing Chang, Ying-Ta Chen, Yun-Nan Hsieh
  • Patent number: 11605329
    Abstract: A display apparatus, including a display panel and a first driver, is provided. The display panel includes multiple pixel circuits and multiple first wires. The first wires are configured to transmit multiple first driving signals. Each of the first wires includes a first portion and a second portion. The first driving signal is transmitted in the first portion and the second portion in different directions. The first driver is coupled to the display panel. The first driver is configured to output the driving signals to drive the display panel.
    Type: Grant
    Filed: July 8, 2021
    Date of Patent: March 14, 2023
    Assignee: E Ink Holdings Inc.
    Inventor: Chien-Hsing Chang
  • Patent number: 11575072
    Abstract: A display device includes a pixel array, at least one flexible substrate, and at least one optical blocking layer. The flexible substrate is located below the pixel array. The optical blocking layer is located between the flexible substrate and the pixel array. The optical blocking layer includes a first sub-layer and a second sub-layer. The first sub-layer is located between the second sub-layer and the flexible substrate, and a refractive index of the first sub-layer is different from a refractive index of the second sub-layer.
    Type: Grant
    Filed: January 15, 2021
    Date of Patent: February 7, 2023
    Assignee: E Ink Holdings Inc.
    Inventor: Chien-Hsing Chang
  • Publication number: 20220122508
    Abstract: A display apparatus, including a display panel and a first driver, is provided. The display panel includes multiple pixel circuits and multiple first wires. The first wires are configured to transmit multiple first driving signals. Each of the first wires includes a first portion and a second portion. The first driving signal is transmitted in the first portion and the second portion in different directions. The first driver is coupled to the display panel. The first driver is configured to output the driving signals to drive the display panel.
    Type: Application
    Filed: July 8, 2021
    Publication date: April 21, 2022
    Applicant: E Ink Holdings Inc.
    Inventor: Chien-Hsing Chang
  • Patent number: 11269434
    Abstract: A touch structure including an insulating substrate, an electromagnetic shielding structure layer, a sensing circuit structure layer, a first insulating layer, and a second insulating layer is provided. The electromagnetic shielding structure layer is disposed on the insulating substrate, and located between the insulating substrate and the sensing circuit structure layer. The sensing circuit structure layer is disposed on the insulating substrate, and includes a first sensing circuit layer and a second sensing circuit layer. The first insulating layer is disposed between the electromagnetic shielding structure layer and the first sensing circuit layer. The second insulating layer is disposed between the first sensing circuit layer and the second sensing circuit layer.
    Type: Grant
    Filed: May 22, 2020
    Date of Patent: March 8, 2022
    Assignee: E Ink Holdings Inc.
    Inventor: Chien-Hsing Chang
  • Publication number: 20210305462
    Abstract: A display device includes a pixel array, at least one flexible substrate, and at least one optical blocking layer. The flexible substrate is located below the pixel array. The optical blocking layer is located between the flexible substrate and the pixel array. The optical blocking layer includes a first sub-layer and a second sub-layer. The first sub-layer is located between the second sub-layer and the flexible substrate, and a refractive index of the first sub-layer is different from a refractive index of the second sub-layer.
    Type: Application
    Filed: January 15, 2021
    Publication date: September 30, 2021
    Inventor: Chien-Hsing CHANG
  • Patent number: 10954305
    Abstract: The present invention relates to therapeutic ADCs comprising a drug attached to an anti-cancer antibody or antigen-binding antibody fragment. Preferably the drug is SN-38. More preferably the antibody or fragment thereof binds to Trop-2 and the therapy is used to treat a Trop-2 positive cancer. Most preferably the antibody is hRS7. The ADC is administered to a subject with a cancer in combination with an ABCG2 inhibitor. The combination therapy is effective to treat cancers that are resistant to drug alone and/or to ADC alone.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: March 23, 2021
    Assignee: Immunomedics, Inc.
    Inventors: Chien-Hsing Chang, David M. Goldenberg
  • Publication number: 20200371628
    Abstract: A touch structure including an insulating substrate, an electromagnetic shielding structure layer, a sensing circuit structure layer, a first insulating layer, and a second insulating layer is provided. The electromagnetic shielding structure layer is disposed on the insulating substrate, and located between the insulating substrate and the sensing circuit structure layer. The sensing circuit structure layer is disposed on the insulating substrate, and includes a first sensing circuit layer and a second sensing circuit layer. The first insulating layer is disposed between the electromagnetic shielding structure layer and the first sensing circuit layer. The second insulating layer is disposed between the first sensing circuit layer and the second sensing circuit layer.
    Type: Application
    Filed: May 22, 2020
    Publication date: November 26, 2020
    Applicant: E Ink Holdings Inc.
    Inventor: Chien-Hsing Chang
  • Publication number: 20200341344
    Abstract: A reflective active device array substrate includes a substrate, a plurality of active devices, a protective layer, and a plurality of metal oxide conductor layers. The active devices are dispersedly disposed on the substrate. The protective layer is disposed on the substrate and covers the active devices. The protective layer has a plurality of openings, and each of the openings exposes a source or a drain of the corresponding active device, respectively. The metal oxide conductor layers are disposed on the substrate and cover the protective layer. Each of the metal oxide conductor layers is electrically connected to the source or the drain of the corresponding active device through the corresponding opening.
    Type: Application
    Filed: April 10, 2020
    Publication date: October 29, 2020
    Applicant: E Ink Holdings Inc.
    Inventor: Chien-Hsing Chang
  • Patent number: 10669338
    Abstract: The present invention concerns compositions and methods of use of anti-PD-1 antibodies comprising CDR sequences corresponding to SEQ ID NO:1 to SEQ ID NO:6. Preferably the antibody is a humanized antibody comprising the variable region amino acid sequences of SEQ ID NO: 9 and SEQ ID NO:10. The antibodies are of use to treat cancer and may be administered alone or with another standard anti-cancer therapy. The methods may comprise administering the anti-PD-1 antibody or antigen-binding fragment thereof in combination with one or more therapeutic agents such as antibody-drug conjugates, interferons (preferably interferon-?), and/or other checkpoint inhibitor antibodies.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: June 2, 2020
    Assignee: Immunomedics, Inc.
    Inventors: Chien-Hsing Chang, David M. Goldenberg
  • Patent number: 10662252
    Abstract: The present invention concerns compositions and methods of use of bispecific antibodies comprising at least one binding site for Trop-2 (EGP-1) and at least one binding site for CD3. The bispecific antibodies are of use for inducing an immune response against a Trop-2 expressing tumor, such as carcinoma of the esophagus, pancreas, lung, stomach, colon, rectum, urinary bladder, breast, ovary, uterus, kidney or prostate. The methods may comprising administering the bispecific antibody alone, or with one or more therapeutic agents such as antibody-drug conjugates, interferons (preferably interferon-?), and/or checkpoint inhibitor antibodies. The bispecific antibody is capable of targeting effector T cells, NK cells, monocytes or neutrophils to induce leukocyte-mediated cytotoxicity of Trop-2+ cancer cells. The cytotoxic immune response is enhanced by co-administration of interferon, checkpoint inhibitor antibody and/or ADC.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: May 26, 2020
    Assignee: IBC Pharmaceuticals, Inc.
    Inventors: Chien-Hsing Chang, David M. Goldenberg, Edmund A. Rossi, Diane Rossi
  • Publication number: 20190369103
    Abstract: Described herein are compositions and methods of use of anti-Trop-2 antibodies or antigen-binding fragment thereof to isolate, enrich, detect, diagnose and/or characterize circulating tumor cells (CTCs) from patients with a Trop-2 positive cancer. Preferably, the antibody is an RS7, 162-46.2 or MAB650 antibody. The compositions and methods are of use to detect, diagnose and/or treat metastatic Trop-2+ cancers, such as breast, ovarian, cervical, endometrial, lung, prostate, colon, rectum, stomach, esophageal, bladder, renal, pancreatic, thyroid, epithelial or head-and-neck cancer.
    Type: Application
    Filed: August 22, 2019
    Publication date: December 5, 2019
    Inventors: David M. Goldenberg, Hans J. Hansen, Chien-Hsing Chang
  • Patent number: 10436788
    Abstract: Described herein are compositions and methods of use of anti-Trop-2 antibodies or antigen-binding fragment thereof to isolate, enrich, detect, diagnose and/or characterize circulating tumor cells (CTCs) from patients with a Trop-2 positive cancer. Preferably, the antibody is an RS7, 162-46.2 or MAB650 antibody. The compositions and methods are of use to detect, diagnose and/or treat metastatic Trop-2+ cancers, such as breast, ovarian, cervical, endometrial, lung, prostate, colon, rectum, stomach, esophageal, bladder, renal, pancreatic, thyroid, epithelial or head-and-neck cancer.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: October 8, 2019
    Assignee: Immunomedics, Inc.
    Inventors: David M. Goldenberg, Hans J. Hansen, Chien-Hsing Chang
  • Patent number: 10385139
    Abstract: The present invention concerns compositions and methods of use of bispecific antibodies comprising at least one anti-TNF-? antibody or antigen-binding fragment thereof and at least one anti-IL-6 antibody or antigen-binding fragment thereof. Preferably, the bispecific antibody is in the form of a DNLĀ® complex. The anti-TNF-? or anti-IL-6 antibodies may comprise specific CDR sequences disclosed herein. The compositions and methods are of use to treat autoimmune disease, immune system dysfunction or inflammatory disease, as disclosed herein.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: August 20, 2019
    Assignee: IBC Pharmaceuticals, Inc.
    Inventors: David M. Goldenberg, Rongxiu Li, Chien-Hsing Chang
  • Publication number: 20190248917
    Abstract: The present invention relates to therapeutic ADCs comprising a drug attached to an anti-cancer antibody or antigen-binding antibody fragment. Preferably the drug is SN-38. More preferably the antibody or fragment thereof binds to Trop-2 and the therapy is used to treat a Trop-2 positive cancer. Most preferably the antibody is hRS7. The ADC is administered to a subject with a cancer in combination with an ABCG2 inhibitor. The combination therapy is effective to treat cancers that are resistant to drug alone and/or to ADC alone.
    Type: Application
    Filed: April 24, 2019
    Publication date: August 15, 2019
    Inventors: Chien-Hsing Chang, David M. Goldenberg