Abstract: The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the co-stimulatory pathway without binding to the natural ligand. The cytoplasmic domain of the receptor contains a portion of the 4-1BB signaling domain. Embodiments of the invention relate to polynucleotides that encode the receptor, vectors and host cells encoding a chimeric receptor, particularly including T cells and natural killer (NK) cells and methods of use.

Abstract: The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the co-stimulatory pathway without binding to the natural ligand. The cytoplasmic domain of the receptor contains a portion of the 4-1BB signaling domain. Embodiments of the invention relate to polynucleotides that encode the receptor, vectors and host cells encoding a chimeric receptor, particularly including T cells and natural killer (NK) cells and methods of use.

Abstract: The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the co-stimulatory pathway without binding to the natural ligand. The cytoplasmic domain of the receptor contains a portion of the 4-1BB signaling domain. Embodiments of the invention relate to polynucleotides that encode the receptor, vectors and host cells encoding a chimeric receptor, particularly including T cells and natural killer (NK) cells and methods of use.

Abstract: The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the co-stimulatory pathway without binding to the natural ligand. The cytoplasmic domain of the receptor contains a portion of the 4-1BB signaling domain. Embodiments of the invention relate to polynucleotides that encode the receptor, vectors and host cells encoding a chimeric receptor, particularly including T cells and natural killer (NK) cells and methods of use.

Abstract: The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the co-stimulatory pathway without binding to the natural ligand. The cytoplasmic domain of the receptor contains a portion of the 4-1BB signaling domain. Embodiments of the invention relate to polynucleotides that encode the receptor, vectors and host cells encoding a chimeric receptor, particularly including T cells and natural killer (NK) cells and methods of use.

Abstract: A touch-sensitive vehicle display device is disclosed. The touch-sensitive vehicle display device comprises a body having a display including a touch panel on a surface thereof, whereby a screen operation is performed on the surface of the display by a touch-screen operation; an operation plate provided along the surface of the display; and a controller controlling information to be indicated on the display. The operation plate includes an opening section to indicate a switch provided to face the touch panel, and a plurality of touch-sensitive switch-confirmation portions provided on an end portion of the opening section for switch indication, and the controller controls a switch-indication portion to be inside the opening section to indicate switching in the display, and controls a plurality of selection-switches to be in the switch-indication portion to correspond to the plurality of switch-confirmation portions.

Abstract: Provided is an in-car operation display device which improves the operability of a display unit. The display unit is used for indications and operations for car-installed functions such as settings and instructions of the car-installed functions. An operating means (first switch plate SpL, second switch plate SpR) includes an operating-plate portion (6L, 6R) configured to be operated to move along a display screen 5a of a display unit 5. The operating-plate portion (6L, 6R) includes a protruding switch portion (touch-sensor protrusion 10-15).

Abstract: The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the co-stimulatory pathway without binding to the natural ligand. The cytoplasmic domain of the receptor contains a portion of the 4-1BB signaling domain. Embodiments of the invention relate to polynucleotides that encode the receptor, vectors and host cells encoding a chimeric receptor, particularly including T cells and natural killer (NK) cells and methods of use.

Abstract: A touch-sensitive vehicle display device is disclosed. The touch-sensitive vehicle display device comprises a body having a display including a touch panel on a surface thereof, whereby a screen operation is performed on the surface of the display by a touch-screen operation; an operation plate provided along the surface of the display; and a controller controlling information to be indicated on the display. The operation plate includes an opening section to indicate a switch provided to face the touch panel, and a plurality of touch-sensitive switch-confirmation portions provided on an end portion of the opening section for switch indication, and the controller controls a switch-indication portion to be inside the opening section to indicate switching in the display, and controls a plurality of selection-switches to be in the switch-indication portion to correspond to the plurality of switch-confirmation portions.

Abstract: The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the co-stimulatory pathway without binding to the natural ligand. The cytoplasmic domain of the receptor contains a portion of the 4-1BB signaling domain. Embodiments of the invention relate to polynucleotides that encode the receptor, vectors and host cells encoding a chimeric receptor, particularly including T cells and natural killer (NK) cells and methods of use.

Abstract: A touch-sensitive vehicle display device is disclosed. The touch-sensitive vehicle display device comprises a body having a display including a touch panel on a surface thereof, whereby a screen operation is performed on the surface of the display by a touch-screen operation; an operation plate provided along the surface of the display; and a controller controlling information to be indicated on the display. The operation plate includes an opening section to indicate a switch provided to face the touch panel, and a plurality of touch-sensitive switch-confirmation portions provided on an end portion of the opening section for switch indication, and the controller controls a switch-indication portion to be inside the opening section to indicate switching in the display, and controls a plurality of selection-switches to be in the switch-indication portion to correspond to the plurality of switch-confirmation portions.

Abstract: Provided is an in-car operation display device which improves the operability of a display unit. The display unit is used for indications and operations for car-installed functions such as settings and instructions of the car-installed functions. An operating means (first switch plate SpL, second switch plate SpR) includes an operating-plate portion (6L, 6R) configured to be operated to move along a display screen 5a of a display unit 5. The operating-plate portion (6L, 6R) includes a protruding switch portion (touch-sensor protrusion 10-15).

Abstract: A touch-sensitive vehicle display device is disclosed. The touch-sensitive vehicle display device comprises a body having a display including a touch panel on a surface thereof, whereby a screen operation is performed on the surface of the display by a touch-screen operation; an operation plate provided along the surface of the display; and a controller controlling information to be indicated on the display. The operation plate includes an opening section to indicate a switch provided to face the touch panel, and a plurality of touch-sensitive switch-confirmation portions provided on an end portion of the opening section for switch indication, and the controller controls a switch-indication portion to be inside the opening section to indicate switching in the display, and controls a plurality of selection-switches to be in the switch-indication portion to correspond to the plurality of switch-confirmation portions.

Abstract: The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the co-stimulatory pathway without binding to the natural ligand. The cytoplasmic domain of the receptor contains a portion of the 4-1BB signaling domain. Embodiments of the invention relate to polynucleotides that encode the receptor, vectors and host cells encoding a chimeric receptor, particularly including T cells and natural killer (NK) cells and methods of use.

Abstract: The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the co-stimulatory pathway without binding to the natural ligand. The cytoplasmic domain of the receptor contains a portion of the 4-1BB signaling domain. Embodiments of the invention relate to polynucleotides that encode the receptor, vectors and host cells encoding a chimeric receptor, particularly including T cells and natural killer (NK) cells and methods of use.

Abstract: The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the co-stimulatory pathway without binding to the natural ligand. The cytoplasmic domain of the receptor contains a portion of the 4-1BB signaling domain. Embodiments of the invention relate to polynucleotides that encode the receptor, vectors and host cells encoding a chimeric receptor, particularly including T cells and natural killer (NK) cells and methods of use.

Abstract: The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the co-stimulatory pathway without binding to the natural ligand. The cytoplasmic domain of the receptor contains a portion of the 4-1BB signaling domain. Embodiments of the invention relate to polynucleotides that encode the receptor, vectors and host cells encoding a chimeric receptor, particularly including T cells and natural killer (NK) cells and methods of use.

Abstract: The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the co-stimulatory pathway without binding to the natural ligand. The cytoplasmic domain of the receptor contains a portion of the 4-1BB signaling domain. Embodiments of the invention relate to polynucleotides that encode the receptor, vectors and host cells encoding a chimeric receptor, particularly including T cells and natural killer (NK) cells and methods of use.

Abstract: The present invention relates to novel methods for preferentially activating and expanding NK cells. The methods utilize the stimulatory effects of IL-15 and CD137 ligand to preferentially expand and activate NK cells in a mixed cell culture comprising NK cells.

Abstract: The present invention relates to novel methods for preferentially activating and expanding NK cells. The methods utilize the stimulatory effects of IL-15 and CD137 ligand to preferentially expand and activate NK cells in a mixed cell culture comprising NK cells.