Abstract: A multi-function opto-electronic detection apparatus for detecting molecular characteristics of a test sample. The appratuses comprises functional mode subsystems including a detecting light source subsystem for generating sampling beams for illuminating the test sample; a manipulation optics subsystem for aligning the sampling beam onto the test sample; a target signal processing subsystem for analyzing target beams emerging from the test sample resulting from the illuminating of the sampling beam; and a sample fixation subsystem for holding the test sample. The detecting light source subsystem, manipulation optics subsystem and target signal processing subsystem are assembled into one of several possible optical sampling setups for the detection characteristics of the test sample. The functional mode setups include at least ellispometer, confocal image scanner, photon tunneling scanning microscope and interferometer.

Abstract: A microarray biochip includes a transparent substrate and a plurality of indented reaction zones formed on the substrate. Each reaction zone has a plurality of adhesive units of a preset height formed thereon in an array fashion, and a top surface to form a first adhesive surface and lateral side surfaces to form second adhesive surfaces. The invention can effectively hold sample solution and retain end label products after calorimetric or fluorometric reaction, and increases reaction area and be adopted for use in optical or reflective detection devices.

Abstract: A mixing apparatus for biochips consists of a oscillation unit with controllable vibration frequency, a transmission section driven by the oscillation unit for transferring vibration of the oscillation unit, and a mixing unit connecting to and driven by the transmission section and locating at a selected distance above the biochip surface. The oscillation unit may generate vibration of a specific frequency and the vibration frequency, amplitude and duration may be controlled for effectively mixing and separating sample solution rapidly, simply and more economically.

Abstract: A microarray biochip workstation allowing positioning of chips, immobilization of molecules, mixing of sample solution, molecular interactions and washing and processing qualitative and quantitative analyses consists of a positioning device for holding a biochip, a mixing device for acting on the sample solution applied on the biochip, a pumping device for removing the sample solution from the biochip surface that does not react, and a reading device for detecting reaction results of the biochip. The workstation thus constructed provides an integrated and effective work interface.

Abstract: A spirometric system can be used to determine static and dynamic lung function for diagnosis, therapy and evaluation. In recent years, air pollution and deteriorating environment cause respiratory diseases increasing rapidly. A portable spirometric system, which for home care and possible screening test in the hospital is the answer to this needs. Recently, the established technologies of microelectromechanical system (MEMS) have enabled the possible minimization of spirometer with microsensor. It includes the modular design for low power consumptions, precision volume productions, competitive price for disposable sensors. In this invention, the focus is to improve sensor's performance by using MEMS technologies and material selection. Fabricating microsensor uses semiconductor processes, which aims to increases sensor's performance and lower cost by future mass production.

Abstract: A multi-functional opto-electronic system is mainly applied to the real-time metrologies of biomedical or biochemical reactions as well as the in-situ manufacturing measurements of biochips. The configuration of this system is built up by integration of at least four different near-field optical metrological principles, which share a part of common optical path design and allow to turn on several functions such as ellipsometer, Laser Doppler vibrometer or interferometer (LDV/I), surface plasmon resonance (SPR) for amplitude and phase detection, phase shifting interference microscope, photon tunneling microscope, optical coherence tomography (OCT) and imaging microscope by switching few components in the system. With the creation of a novel opto-mechanical design and its associated signal processing methodologies, both the signal detection of the biomedical reactions and biomedical imaging concerned for the future trend in the modern biomedical sciences are achieved with high resolutions.