Patents by Inventor Chris Vezina

Chris Vezina has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic human anti-IL-1R1 monoclonal antibody
    Patent number: 9534053
    Abstract: Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: January 3, 2017
    Assignees: Amgen Inc., E.R. Squibb & Sons, L.L.C.
    Inventors: Brian Varnum, Chris Vezina, Alison Witte, Xueming Qian, Francis Hall Martin, Haichun Huang, Gary Elliott
  • THERAPEUTIC HUMAN ANTI-IL-1R1 MONOCLONAL ANTIBODY
    Publication number: 20140335099
    Abstract: Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
    Type: Application
    Filed: March 5, 2014
    Publication date: November 13, 2014
    Applicants: Amgen Inc., Medarex, L.L.C.
    Inventors: Brian Varnum, Chris Vezina, Alison Witte, Xueming Qian, Francis Hall Martin, Haichun Huang, Gary Elliott
  • Therapeutic human anti-IL-1R1 monoclonal antibody
    Patent number: 8710203
    Abstract: Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
    Type: Grant
    Filed: August 7, 2013
    Date of Patent: April 29, 2014
    Assignees: Amgen Inc., Medarex, L.L.C.
    Inventors: Brian Varnum, Chris Vezina, Alison Witte, Xueming Qian, Francis Hall Martin, Haichun Huang, Gary Elliot
  • THERAPEUTIC HUMAN ANTI-IL-1R1 MONOCLONAL ANTIBODY
    Publication number: 20140039164
    Abstract: Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
    Type: Application
    Filed: August 7, 2013
    Publication date: February 6, 2014
    Applicants: Medarex, Inc., Amgen Inc.
    Inventors: Brian Varnum, Chris Vezina, Alison Witte, Xueming Qian, Francis Hall Martin, Haichun Huang, Gary Elliott
  • Therapeutic human anti-IL-1R1 monoclonal antibody
    Patent number: 8518407
    Abstract: Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
    Type: Grant
    Filed: April 18, 2012
    Date of Patent: August 27, 2013
    Assignees: Amgen Inc., Medarex, Inc.
    Inventors: Brian Varnum, Chris Vezina, Alison Witte, Xueming Qian, Francis Hall Martin, Haichun Huang, Gary Elliott
  • THERAPEUTIC HUMAN ANTI-IL-1R1 MONOCLONAL ANTIBODY
    Publication number: 20120269824
    Abstract: Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
    Type: Application
    Filed: April 18, 2012
    Publication date: October 25, 2012
    Applicants: Medarex, Inc., Amgen Inc.
    Inventors: Brian Varnum, Chris Vezina, Alison Witte, Xueming Qian, Francis Hall Martin, Haichun Huang, Gary Elliott
  • Therapeutic human anti-IL-1R1 monoclonal antibody
    Patent number: 8236559
    Abstract: Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
    Type: Grant
    Filed: September 15, 2008
    Date of Patent: August 7, 2012
    Assignees: Medarex, Inc., Amgen Inc.
    Inventors: Brian Varnum, Chris Vezina, Alison Witte, Xueming Qian, Francis Hall Martin, Haichun Huang, Gary Elliott
  • Homogeneous Antibody Populations
    Publication number: 20100226925
    Abstract: The present invention is generally directed to methods of producing an increase in the enrichment and/or recovery of preferred forms of monoclonal antibodies. More particularly, the invention relates to methods for eliminating disulfide heterogeneity in the hinge region of recombinant IgG2 antibody proteins.
    Type: Application
    Filed: September 11, 2008
    Publication date: September 9, 2010
    Applicant: AMGEN INC.
    Inventors: Thomas M. Dillon, Pavel Bondarenko, Jette Wypych, Martin J. Allen, Alain Balland, Margaret Speed Ricci, Amy Guo, Wenyan Shen, Jeonghoon Sun, Chris Vezina
  • Therapeutic Human Anti-IL-1R1 Monoclonal Antibody
    Publication number: 20090214559
    Abstract: Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
    Type: Application
    Filed: September 15, 2008
    Publication date: August 27, 2009
    Applicants: AMGEN, INC., MEDAREX INC.
    Inventors: Brian Varnum, Chris Vezina, Alison Witte, Xueming Qian, Francis Hall Martin, Haichun Huang, Gary Elliott
  • Therapeutic human anti-IL1-R1 monoclonal antibody
    Patent number: 7438910
    Abstract: Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
    Type: Grant
    Filed: September 5, 2003
    Date of Patent: October 21, 2008
    Assignees: Amgen Inc., Medarex, Inc.
    Inventors: Brian Varnum, Chris Vezina, Alison Witte, Xueming Qian, Francis Hall Martin, Haichun Huang, Gary Elliott
  • Screening method for antibodies and other selective IL-1 binding agents that allow binding to IL-1 receptor but not activation thereof
    Publication number: 20050084493
    Abstract: The invention concerns methods of treating IL-1-mediated disease by administering a selective IL-1 binding agents that form an antagonist complex with the IL-1 ligand. The antagonist complex can bind to the IL-1 receptor without activating the receptor. The selective binding agents contemplated by this invention thus have the properties of free ligand absorption (through binding of the selective binding agent to free IL-1? or ?) and receptor activation inhibition (through binding of the antagonist complex to the receptor and preventing its activation).
    Type: Application
    Filed: November 9, 2004
    Publication date: April 21, 2005
    Inventors: Alison Witte, Brian Varnum, Xueming Qian, Chris Vezina
  • Therapeutic human anti-IL1-R1 monoclonal antibody
    Publication number: 20040097712
    Abstract: Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
    Type: Application
    Filed: September 5, 2003
    Publication date: May 20, 2004
    Applicant: Amgen, Inc. A Corporation of the State of Delaware
    Inventors: Brian Varnum, Chris Vezina, Alison Witte, Xueming Qian, Francis Hall Martin, Haichun Huang, Gary Elliott
  • Antibodies and other selective IL-1 binding agents that allow binding to IL-1 receptor but not activation thereof
    Publication number: 20030026806
    Abstract: The invention concerns methods of treating IL-1-mediated disease by administering a selective IL-1 binding agents that form an antagonist complex with the IL-1 ligand. The antagonist complex can bind to the IL-1 receptor without activating the receptor. The selective binding agents contemplated by this invention thus have the properties of free ligand absorption (through binding of the selective binding agent to free IL-1&agr; or &bgr;) and receptor activation inhibition (through binding of the antagonist complex to the receptor and preventing its activation).
    Type: Application
    Filed: October 29, 2001
    Publication date: February 6, 2003
    Applicant: Amgen Inc.
    Inventors: Alison Witte, Brian C. Varnum, Xueming Qian, Chris Vezina