Patents by Inventor Christene A. Huang

Christene A. Huang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230073248
    Abstract: Embodiments disclosed herein relate to compositions and methods for inducing transplantation tolerance using immunomodulation agents. In certain embodiments compositions and methods disclosed herein, concern administering a composition including, but not limited to, anti-CD3 immunotoxin and administering a composition including, but not limited to, peripheral blood cells obtained from a donor of an organ, tissue or cells to be transplanted. In some embodiments, compositions and methods disclosed here can be used for modulating B- and/or T-cell-mediated immunity and/or rejection by reducing or eliminating anti-donor antibody production. Other embodiments concern modulating T-cell production in a subject preparing for, undergoing organ, tissue or cellular transplantation; or having or expected of developing GvHD for reducing the risk of, preventing or treating rejection or GvHD. In certain embodiments, combination compositions of anti-CD3 immunotoxin and peripheral blood cells from a donor are contemplated.
    Type: Application
    Filed: August 18, 2022
    Publication date: March 9, 2023
    Inventors: Christene A. Huang, David M. Neville, JR., Elizabeth Anne Pomfret, Raimon Duran-Struuck, Zhirui Wang
  • Publication number: 20220127368
    Abstract: IL2-CCR4 bispecific immunotoxin, CCR4-IL2 bispecific immunotoxin, and methods of use thereof for treatment of refractory and recurrent human CD25+ and/or CCR4+ cutaneous T cell lymphoma, and other human CD25+ or CCR4+ tumors. The bispecific immunotoxin can be also used for broad cancer treatment via depleting CD25+ or CCR4+ Tregs.
    Type: Application
    Filed: February 19, 2020
    Publication date: April 28, 2022
    Inventors: Zhirui Wang, Christene Huang, David Mathes, Elizabeth Pomfret
  • Patent number: 9944689
    Abstract: Mutant forms of human CTLA4, and their use, e.g., in xenotransplantation.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: April 17, 2018
    Assignee: The General Hospital Corporation
    Inventors: Zhirui Wang, Christene A. Huang, David H. Sachs
  • Patent number: 9764006
    Abstract: IL-2 fusion toxins, e.g., bivalent-IL2 fusion toxins, and methods of use thereof.
    Type: Grant
    Filed: December 9, 2013
    Date of Patent: September 19, 2017
    Assignee: The General Hospital Corporation
    Inventors: Zhirui Wang, Christene A. Huang, David H. Sachs
  • Patent number: 9758566
    Abstract: This invention relates to recombinant CTLA-4 proteins, e.g., soluble CTLA-4 or CTLA-4 fusion toxins, and methods for making and using them.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: September 12, 2017
    Assignee: The General Hospital Corporation
    Inventors: Zhirui Wang, David H. Sachs, Christene A. Huang
  • Publication number: 20170121419
    Abstract: Anti-human chemokine (C—C motif) Receptor 4 immunotoxins and methods of use thereof, e.g., for depleting Tregs as an immunotherapy for the treatment of cancer; for the treatment of cancers associated with CCR4+ tumor cells such as skin homing cutaneous T cell lymphoma, adult T cell leukemia/lymphoma, and acute T-cell lymphoblastic leukemia; and for the depletion of CCCR4+ Th2 cells for the treatment of allergy-related conditions such as asthma.
    Type: Application
    Filed: June 12, 2015
    Publication date: May 4, 2017
    Inventors: Zhirui Wang, David H. Sachs, Christene A. Huang, Joren Christian Madsen
  • Publication number: 20160030526
    Abstract: IL-2 fusion toxins, e.g., bivalent-IL2 fusion toxins, and methods of use thereof.
    Type: Application
    Filed: December 9, 2013
    Publication date: February 4, 2016
    Inventors: Zhirui Wang, Christene A. Huang, David H. Sachs
  • Publication number: 20160017018
    Abstract: Mutant forms of human CTLA4, and their use, e.g., in xenotransplantation.
    Type: Application
    Filed: March 5, 2014
    Publication date: January 21, 2016
    Inventors: Zhirui Wang, Christene A. Huang, David H. Sachs
  • Publication number: 20150118260
    Abstract: This invention relates to recombinant CTLA-4 proteins, e.g., soluble CTLA-4 or CTLA-4 fusion toxins, and methods for making and using them.
    Type: Application
    Filed: February 28, 2013
    Publication date: April 30, 2015
    Inventors: Zhirui Wang, David H. Sachs, Christene A. Huang
  • Publication number: 20090220995
    Abstract: A method to determine the optimal administration protocol of allogeneic donor tissue to treat a disease in a human, using an animal model of human disease.
    Type: Application
    Filed: February 28, 2008
    Publication date: September 3, 2009
    Inventors: David H. Sachs, Christene Huang, Patricia S. Cho, Sicco Pompa