Abstract: The present invention relates to anti-VEGF-A/anti-ANG2 antibodies, e.g. in the form of a bispecific Fab fragment, and methods of using the same.

Abstract: The present invention relates to the treatment of cancer, in particular breast cancer, particularly triple-negative breast cancer. More particularly, the invention concerns methods and means for cancer treatment involving a specific set of tumor antigens.

Abstract: The present teachings relate to a method for controlling a production process, for manufacturing a chemical product, comprising: providing an upstream object identifier comprising input material data and at least one desired performance parameter related to the chemical product; determining a set of process and/or operation parameters based on the upstream object identifier and the at least one desired performance parameter; determining zone-specific control settings for each of the equipment zones based on the determined set of process and/or operation parameters and historical data; providing the zone-specific control settings for controlling the production of the chemical product related to the upstream object identifier. The present teachings also relate to a system for controlling a production process, a use of the control settings, and a software product for implementing the method steps disclosed herein.

Abstract: The present teachings relate to a method for digitally tracking a chemical product manufactured at an industrial plant comprising at least one equipment; and, the product being manufactured by processing, via the equipment, at least one input material using a production process, which method comprises: providing, via an interface, an object identifier comprising input material data; wherein the input material data is indicative of one or more property of the input material, receiving, via the interface, process data from the equipment; the process data being indicative of the process parameters and/or equipment operating conditions that the input material is processed under, appending, to the object identifier, at least a part of the process data. The present teachings also relate to a system for digitally tracking a chemical product and a software product.

Abstract: A method of diagnosing a valve is described, which has an electrodynamic actuator, which includes a magnet arrangement for generating a magnetic field and a control element which is movable relative to the magnet arrangement and is coupled to a movably arranged coil. At least one electrical variable of the electrodynamic actuator is measured over a measurement period to detect a time course of the electrical variable. The time course of the electrical variable is evaluated over an evaluation period to determine at least one induction-dependent valve variable which is assigned to the motion profile of the electrodynamic actuator. A diagnosis module and a valve are furthermore described.

Abstract: A method provides a circuit carrier arrangement that includes: a cooling plate (1) which has spacer and fastening elements (3) for connection to a printed circuit board (2) in a spaced-apart manner; a printed circuit board (2) which has bores (4) for receiving spring element sleeves (9); at least one power semiconductor component (10) which is connected by a soldered connection to the printed circuit board (2) and fastening elements (3) in the state in which it is fitted with the cooling plate (1) by means of plug-in connections (11) of spring-action configuration; and at least one spring element (5) having at least two spring element sleeves (9) between which a web (6) that is connected to the spring element sleeves (9) extends, and supporting elements (7) arranged on either side of said web and at least one spring plate (8) being arranged on said web.

Abstract: The present invention relates to an arrangement for detecting a torque on a machine element (01). The arrangement comprises a sleeve (03) arranged on the machine element (01), wherein the sleeve (03) has a magnetized region (07). The arrangement furthermore comprises a magnetic field sensor, which is arranged opposite the sleeve (03), and an intermediate sleeve (02). The intermediate sleeve (02) is arranged between the machine element (01) and the sleeve (03) and has an elevation (04) at each of the two end regions thereof. The elevations (04) come to abut the machine element (01). The sleeve (03) and the intermediate sleeve (02) are connected to one another for conjoint rotation. The invention furthermore relates to a vehicle having an arrangement for detecting a torque on a machine element (01).

Abstract: The present teachings relate to a method for controlling a downstream production process for manufacturing a chemical product using at least one precursor material, the method comprising: providing a set of downstream control settings for controlling the production of the chemical product, wherein the downstream control settings are determined based on: a downstream object identifier; the downstream object identifier comprising precursor data; at least one desired downstream performance parameter related to the chemical product; downstream historical data; and wherein the set of downstream control settings is usable for manufacturing the chemical product at the downstream industrial plant. The present teachings also relate to a system, a use and a software product.

Abstract: The invention relates to a biofilter for biologically cleaning a waste gas stream containing contaminants, having at least one filter module through which the waste gas stream is to flow. The filter module has at least one filter layer containing an organic filter material, and the at least one filter layer being supported by at least one grating structure which is in particular oriented at least substantially horizontally. According to the invention, so that the biofilter can be operated cost-effectively, with low effort and with a high filtering efficiency over the longest possible period, the at least one grating structure formed by elongate grating elements which are arranged at least substantially crosswise and are in particular oriented at least substantially horizontally.

Abstract: A torque sensor for measuring a torque on a shaft using the measuring principle of inverse magnetostriction, on which a magnetised sleeve is fastened as the primary sensor. The sleeve is provided with at least two circumferential portions which are arranged at an axial distance from one another and magnetised in opposing directions and interact in a contactless manner with respective measuring coils arranged fixedly opposite hereto for acquiring measured values. The magnetised sleeve consists of a non-magnetic carrier sleeve part, on the outer lateral surface of which the magnetized circumferential portions are attached by deposition welding of a ferromagnetic material.

Abstract: The present invention relates to anti-VEGF-A/anti-ANG2 antibodies, e.g. in the form of a bispecific Fab fragment, and methods of using the same.

Abstract: A circuit carrier arrangement includes: a cooling plate (1) which has spacer and fastening elements (3) for connection to a printed circuit board (2) in a spaced-apart manner; a printed circuit board (2) which has bores (4) for receiving spring element sleeves (9); at least one power semiconductor component (10) which is connected by a soldered connection to the printed circuit board (2) and fastening elements (3) in the state in which it is fitted with the cooling plate (1) by means of plug-in connections (11) of spring-action configuration; and at least one spring element (5) having at least two spring element sleeves (9) between which a web (6) that is connected to the spring element sleeves (9) extends, and supporting elements (7) arranged on either side of said web and at least one spring plate (8) being arranged on said web.

Abstract: A gangway bellow includes an outer bellow presenting corrugations forming a plurality of valleys presenting each a valley top portion facing upwardly and connected at each end to a valley top corner forming a junction between the valley top portion and a respective bellow side. The gangway bellow further includes at least one drainage channel so that liquid accumulating into at least one of the valley top portions flows through the at least one drainage channel along the respective bellow side.

Abstract: The invention relates to a friction surface clutch (10) for use in motor vehicles, in particular for switching an air compressor or the like, wherein the friction surface clutch comprises a first tapered element (11) having a first friction surface (12) and a second tapered element (13) having a second friction surface (14), wherein the friction surface clutch has an actuating device (15) having an actuating element (16) for force-locked connection and disconnection of the tapered elements, wherein the tapered elements are in force-locked connection in an unactuated operating state of the friction surface clutch, wherein the actuating device comprises a pressure element (21) coupled to the actuating element and a lever device (22) interacting with the first tapered element, wherein the pressure element can be engaged with the lever device in an actuated operating state of the friction surface clutch so that the force-locked connection can be disconnected, wherein the first tapered element has a guide part, in

Abstract: A valve having a valve body to which an actuator can be fastened is specified, the valve body including at least a first and a second housing part made of plastic, a first fluid duct being formed in the first housing part and a second fluid duct being formed in the second housing part, and at least one of the two fluid ducts opening out at a valve seat, and at least one elongated, rectilinear stiffening element being inserted in sections both into the first housing part and into the second housing part, and the at least one stiffening element being at least approximately perpendicular to a plane in which the at least one valve seat extends.

Abstract: A valve with an electrodynamic actuator includes a magnet device that generates a magnetic field and a drive element that is movable relative to the magnet device. The drive element is pivotally mounted and comprises a current-carrying air coil that is arranged in the magnetic field and is fixedly coupled to a coil carrier made of a non-magnetic material. Sealing surfaces for sealing valve seats are arranged on two opposite sides of the drive element, such that the sealing surfaces face in opposite directions. A housing is comprised of a plurality of plastic housing parts and a metallic encasement. The metallic encasement surrounds an upper area of the housing in which the electrodynamic actuator is arranged and at least partially surrounds a lower area of the housing in which fluid channels are arranged.

Abstract: A valve having a valve body to which an actuator can be fastened is specified, the valve body including at least a first and a second housing part made of plastic, a first fluid duct being formed in the first housing part and a second fluid duct being formed in the second housing part, and at least one of the two fluid ducts opening out at a valve seat, and at least one elongated, rectilinear stiffening element being inserted in sections both into the first housing part and into the second housing part, and the at least one stiffening element being at least approximately perpendicular to a plane in which the at least one valve seat extends.

Abstract: A method of diagnosing a valve is described, which has an electrodynamic actuator, which includes a magnet arrangement for generating a magnetic field and a control element which is movable relative to the magnet arrangement and is coupled to a movably arranged coil. At least one electrical variable of the electrodynamic actuator is measured over a measurement period to detect a time course of the electrical variable. The time course of the electrical variable is evaluated over an evaluation period to determine at least one induction-dependent valve variable which is assigned to the motion profile of the electrodynamic actuator. A diagnosis module and a valve are furthermore described.

Abstract: A roller leveler and related method for leveling stock which includes an upper roller frame with an upper leveling unit, and a lower roller frame which has a machine bed with a lower leveling unit. The upper roller frame can be moved upward and downward relative to the lower roller frame by hydraulic drives. The upper leveling unit includes a plurality of upper leveling rollers and the lower leveling unit has a plurality of lower leveling rollers. The upper leveling rollers are supported with upper bearing plates and the lower leveling rollers are supported with lower bearing plates. At least several of the upper and lower leveling rollers are connected at one end to drive shafts of a drive device. A frame is moveable into and out of the roller leveler.

Abstract: The device described herein and the associated method relate, in particular, to a holding device for a wind tunnel test stand 1, in particular for a wind tunnel balance. The device may comprise a holding base 5a, 6a, which may be arranged outside of a conveyor belt 3 of the wind tunnel test stand 1, and a support element 7 having at least two ends 7a, 7b. Via a connection element 13, one end of the support element 7 may be connected to a wheel 22 of a test object 4. Furthermore, a support device 8 may be provided, which may be connected to the support element 7 in such a way that a change in a rotational orientation of the support element 7 can cause a lifting or lowering movement of the support device 8.