Abstract: A method of forming a heat exchanger tube, particularly suited for condensing applications, contemplates cold-rolling a metallic strip to emboss a hydrophobic surface texture, to thereby form an embossed surface on the metallic strip. The method includes roll forming the metallic strip to a tubular shape, with the embossed surface on the exterior of the tubular shape, and welding the edges of the roll-formed strip to form a heat exchanger tube.

Abstract: Provided herein multispecific (e.g., bispecific) binding molecules comprising a first binding domain that binds an extracellular portion of dystroglycan and a second binding domain that binds laminin-2. Further provided herein are methods for making such binding molecules and uses of such binding molecules for treating and/or preventing alpha-dystroglycanopathies.

Abstract: A vehicle steering wheel is provided that includes a rotatable rim comprising a core structure, a steering angle sensor sensing an angle of rotation of the rim, and a plurality of proximity sensors located on the rim and spaced apart from one another along an arc length. The vehicle steering wheel also includes a controller processing sensed outputs generated by each of the plurality of proximity sensors and determining operator input commands based on the sensed outputs. The controller assigns a function to each of the proximity sensors that changes as the rim is rotated at an angle such that a given function associated with a proximity sensor remains at the same position in space.

Abstract: Provided herein are FGFR1/KLB targeting agonistic antigen-binding proteins, or fragments thereof, having improved physico-chemical properties. Also provided herein are conjugates comprising an FGFR1/KLB targeting agonistic antigen-binding protein, or a fragment thereof, and at least one GLP-1R agonistic peptide. Further provided are pharmaceutical compositions comprising the antibody (or fragment thereof), or the conjugate provided herein, and the use of the antibody (or fragment thereof, or the use of the conjugate in medicine.

Abstract: The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.

Abstract: An impact protection reinforcement of a vehicle construction, which is supportively fastenable in the vehicle construction against the action of external mechanical extraordinary load conditions and comprises the following features: an elongated profile element with a longitudinal center line and a transversal center line arranged transversely to the longitudinal center line, which has in the longitudinal direction at each end side a fastening end and a central part therebetween, wherein the central part consists of a circumferentially closed hollow profile with a base layer and a top layer arranged opposite to the base layer, which are connected to each other via lateral faces, and the fastening ends each have a flat shape with at least two fastening points which are spaced apart differently from the transversal center line and the longitudinal center line and are provided as welding connection points to the vehicle construction.

Abstract: A vehicle floor assembly includes a floor structure and a capacitive proximity sensor assembly configured to detect a user touch command and a user pressure command. The floor assembly further includes a controller for receiving the user touch command and pressure command and controlling a vehicle related operation based on the detected user input commands.

Abstract: Provided herein are bivalent, bispecific binding proteins that specifically bind to two different HIV-1 Env protein epitopes.

Abstract: The present invention concerns antibody-like binding protein specifically binding to CD3 and binding specifically to at least one further antigen, for example CD123. The present invention also concerns antibody-like binding protein specifically binding to CD123 and binding specifically to at least one further antigen. The invention further concerns anti-CD3 antibodies and anti-CD123 antibodies. The invention also relates to pharmaceutical compositions comprising the antibody-like binding protein, anti-CD3 antibodies or anti-CD123 antibodies of the invention, and their use to treat cancer. The invention further relates to isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibody-like binding protein, anti-CD3 or anti-CD123 antibody and the use of said anti-CD123 antibody as a diagnostic tool.

Abstract: The invention provides antibody-like binding proteins comprising four polypeptide chains that form four antigen binding sites, wherein each pair of polypeptides forming an antibody-like binding protein possesses dual variable domains having a cross-over orientation. The invention also provides methods for making such antigen-like binding proteins.

Abstract: A vehicle floor assembly includes a floor structure and a capacitive proximity sensor assembly configured to detect a user touch command and a user pressure command. The floor assembly further includes a controller for receiving the user touch command and pressure command and controlling a vehicle related operation based on the detected user input commands.

Abstract: Systems, methods, and devices for remotely controlling functionalities of vehicles are disclosed herein. Example systems, methods and devices may include determining that a remote control device is located at a position associated with a functionality, establishing a communication connection between the remote control device and the functionality based on a machine readable medium associated with the position, and causing a user interface on the remote control device to present one or more settings associated with the functionality.

Abstract: Systems, methods, and devices for remotely controlling functionalities of vehicles are disclosed herein. Example systems, methods and devices may include determining that a remote control device is located at a position associated with a functionality, establishing a communication connection between the remote control device and the functionality based on a machine readable medium associated with the position, and causing a user interface on the remote control device to present one or more settings associated with the functionality.

Abstract: The present invention relates to fusion molecules that have binding specificity for pyoverdine type I, II and III and pyochelin and can be used in various applications, including diagnostic and/or therapeutic applications, for example, to inhibit or reduce growth of P. aeruginosa and/or to prevent or treat P. aeruginosa biofilm infection as well as diseases or disorders associated with P. aeruginosa biofilm infection. The present invention also concerns methods of producing the fusion molecules described herein as well as compositions and kits comprising such fusion molecules. The present invention further relates to nucleic acid molecules encoding the fusion molecules described herein.

Abstract: The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.

Abstract: The present invention concerns antibody-like binding protein specifically binding to CD3 and binding specifically to at least one further antigen, for example CD123. The present invention also concerns antibody-like binding protein specifically binding to CD123 and binding specifically to at least one further antigen. The invention further concerns anti-CD3 antibodies and anti-CD123 antibodies. The invention also relates to pharmaceutical compositions comprising the antibody-like binding protein, anti-CD3 antibodies or anti-CD123 antibodies of the invention, and their use to treat cancer. The invention further relates to isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibody-like binding protein, anti-CD3 or anti-CD123 antibody and the use of said anti-CD123 antibody as a diagnostic tool.

Abstract: The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.

Abstract: Provided herein multispecific (e.g., bispecific) binding molecules comprising a first binding domain that binds an extracellular portion of dystroglycan and a second binding domain that binds laminin-2. Further provided herein are methods for making such binding molecules and uses of such binding molecules for treating and/or preventing alpha-dystroglycanopathies.

Abstract: An impact protection reinforcement of a vehicle construction, which is supportively fastenable in the vehicle construction against the action of external mechanical extraordinary load conditions and comprises the following features: an elongated profile element with a longitudinal center line and a transversal center line arranged transversely to the longitudinal center line, which has in the longitudinal direction at each end side a fastening end and a central part therebetween, wherein the central part consists of a circumferentially closed hollow profile with a base layer and a top layer arranged opposite to the base layer, which are connected to each other via lateral faces, and the fastening ends each have a flat shape with at least two fastening points which are spaced apart differently from the transversal center line and the longitudinal center line and are provided as welding connection points to the vehicle construction.