Patents by Inventor Christian Lutz

Christian Lutz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220296278
    Abstract: Embodiments of a universal clamp apparatus for an orthopedic exterior fixator are disclosed. The universal clamp apparatus can be operated without the need for tools, with extraordinary tightening precision, and with low risk of losing stability. The universal clamp apparatus has at least one pin/rod clamp, but preferably two pin/rod clamps. Each clamp has seating grooves for snapping in and attaching to at least one of the following: a frame rod associated with a frame of the fixator and/or a bone pin for implantation in a bone fragment. A screw mechanism, such as a clamp screw, extends through and connects the first and second pin/rod clamps. An ergonomically designed knob having at least one collapsible or non-collapsible turn lever acts as a torque amplifier when rotated to tighten and untighten the pin/rod clamps to the frame rod and/or bone pin by movement along the clamp screw.
    Type: Application
    Filed: November 11, 2021
    Publication date: September 22, 2022
    Inventors: Bruce H. Ziran, Patrick Kelly Capeheart, Christian Lutz, Ole Prien, Roman Rau
  • Patent number: 11446388
    Abstract: The invention relates to a conjugate comprising (a) an amatoxin comprising (i) an amino acid 4 with a 6?-deoxy position; and (ii) an amino acid 8 with an S-deoxy position; (b) a BCMA-binding moiety comprising (i) the variable domains of humanized antibody J22.9-ISY, and (ii) a heavy chain constant region comprising a D265C mutation; and (c) a protease-cleavable linker linking said amatoxin and said target-binding moiety. The invention furthermore relates to a pharmaceutical composition comprising such conjugate, particularly for use in the treatment of multiple myeloma.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: September 20, 2022
    Assignee: HEIDELBERG PHARMA RESEARCH GMBH
    Inventors: Torsten Hechler, Michael Kulke, Christian Lutz, Andreas Pahl, Christoph Müller, Werner Simon, Anikó Pálfi
  • Publication number: 20220274995
    Abstract: The invention relates to novel methods for synthesizing amanitin derivatives having an amino group attached to position 6? of the central tryptophan moiety. The invention furthermore relates to a novel amanitin derivative having an amino group attached to position 6? of the central tryptophan moiety, novel conjugates of such amanitin derivative, and pharmaceutical compositions comprising such conjugates.
    Type: Application
    Filed: May 11, 2022
    Publication date: September 1, 2022
    Applicant: Heidelberg Pharma Research GmbH
    Inventors: Werner Simon, Susanne Werner-Simon, Christian Lutz, Christoph Müller, Torsten Hechler, Michael Kulke
  • Patent number: 11420971
    Abstract: The invention relates to novel methods for synthesizing amanitin derivatives having an amino group attached to position 6? of the central tryptophan moiety. The invention furthermore relates to a novel amanitin derivative having an amino group attached to position 6? of the central tryptophan moiety, novel conjugates of such amanitin derivative, and pharmaceutical compositions comprising such conjugates.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: August 23, 2022
    Assignee: Heidelberg Pharma Research GmbH
    Inventors: Werner Simon, Susanne Werner-Simon, Christian Lutz, Christoph Müller, Torsten Hechler, Michael Kulke
  • Patent number: 11413074
    Abstract: An assembly for assisting with positioning of an intervertebral implant, including an implant holder having an elongate body extending along a longitudinal axis between first and second ends, the first end being adapted to be attached to the stabilising wedge of an intervertebral implant, the first end of the implant holder having a deflection device including an opening having a central axis substantially perpendicular to the longitudinal axis of the implant holder but not converging with the longitudinal axis, the opening allowing the braid of an implant to pass therethrough in such a way that, when in use, the braid may have a first portion extending substantially perpendicularly to the longitudinal axis from the implant to the opening, and a second portion extending from the opening to the free end in a plane substantially parallel to the longitudinal axis of the implant holder to allow the tensioning of the braid.
    Type: Grant
    Filed: August 16, 2018
    Date of Patent: August 16, 2022
    Inventor: Christian Lutz
  • Publication number: 20220168034
    Abstract: The disclosure relates to medical devices and methods of manufacturing medical devices. An orthopedic screw includes an inner core member having a head having a first outer diameter, a tip having a second outer diameter, and a body extending between the head and the tip and having a third outer diameter that is less than the first outer diameter and the second outer diameter. An outer body member is disposed circumferentially around the body of the inner core member and defines an outer body member external thread. The tip of the inner core member can define an inner core member external thread that forms an interrupted thread with the outer body member external thread.
    Type: Application
    Filed: February 18, 2022
    Publication date: June 2, 2022
    Applicant: GLW, Inc.
    Inventors: Thomas Hoon Lee, Axel Cremer, Klaus Dorawa, Christian Lutz, Stefan Völzow, Lowell Weil, JR.
  • Patent number: 11253304
    Abstract: The disclosure relates to medical devices and methods of manufacturing medical devices. An orthopedic screw includes an inner core member having a head having a first outer diameter, a tip having a second outer diameter, and a body extending between the head and the tip and having a third outer diameter that is less than the first outer diameter and the second outer diameter. An outer body member is disposed circumferentially around the body of the inner core member and defines an outer body member external thread. The tip of the inner core member can define an inner core member external thread that forms an interrupted thread with the outer body member external thread.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: February 22, 2022
    Assignee: GLW, Inc.
    Inventors: Thomas Hoon Lee, Axel Cremer, Klaus Dorawa, Christian Lutz, Stefan Völzow, Lowell Weil, Jr.
  • Publication number: 20210317752
    Abstract: A device cleans a core engine of a jet engine. The device has: a nozzle installation which is configured for introducing a cleaning medium into the core engine; a connector configured to connect the device in a rotationally fixed manner to a shaft of a fan of the jet engine; and a line connection configured to supply the cleaning medium, which is connected to the nozzle installation by a rotary coupling. The nozzle installation comprises nozzles, comprising at least one flat jet nozzle, and at least one full cone nozzle or hollow cone nozzle.
    Type: Application
    Filed: August 1, 2019
    Publication date: October 14, 2021
    Inventors: Dirk Deja, Christian Lutz, Sina Glasse
  • Patent number: 11067152
    Abstract: A drive device includes a drive machine, such as an electric motor, gear reduction planetary gear sets, and a differential. One of the gear reduction planetary gear sets utilizes multi-step planetary gears. The differential is a spur gear differential. To reduce axial length, one of the gearwheels of each multi-step planetary gears axially overlaps with planetary gears of the spur gear differential.
    Type: Grant
    Filed: April 9, 2018
    Date of Patent: July 20, 2021
    Assignee: Schaeffler Technologies AG & Co. KG
    Inventors: Thorsten Biermann, Christian Lutz, Daniel Burghardt
  • Patent number: 11065956
    Abstract: A drive device for a motor vehicle includes a drive machine and a transmission device having a triple planetary great set and having a first and second clutch, wherein the triple planetary gear set has a plurality of triple planet gears, wherein each triple planet gear includes a first gear, a second gear, and a third gear. The three gears of each triple planet gear are connected to each other for conjoint rotation and are jointly rotatably accommodated on a planet carrier, and the drive machine is connected to the triple planetary gear set by the first clutch and a first sun gear or by the second clutch and a second sun gear.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: July 20, 2021
    Assignee: SCHAEFFLER TECHNOLOGIES AG & CO. KG
    Inventors: Christian Lutz, Philip Wurzberger
  • Publication number: 20210164360
    Abstract: A device cleans a core engine of a jet engine. The device has: a nozzle installation configured to introduce a cleaning medium into the core engine; a connector configured to connect the device in a rotationally fixed manner to a shaft of a fan of the jet engine; and a line connection configured to supply the cleaning medium, the line connection being connected to the nozzle installation by a rotary coupling. The nozzle installation has first contact faces configured to bear axially on fan blades of the fan, the first contact faces being configured for defined positioning of the nozzle installation relative to the jet engine.
    Type: Application
    Filed: August 1, 2019
    Publication date: June 3, 2021
    Inventors: Dirk Deja, Christian Lutz, Marc Hacker
  • Publication number: 20210138081
    Abstract: The invention relates to a conjugate comprising (a) an amatoxin comprising (i) an amino acid 4 with a 6?-deoxy position; and (ii) an amino acid 8 with an S-deoxy position; (b) a target-binding moiety; and (c) optionally a linker linking said amatoxin and said target-binding moiety. The invention furthermore relates to a pharmaceutical composition comprising such conjugate.
    Type: Application
    Filed: March 2, 2017
    Publication date: May 13, 2021
    Inventors: Christian Lutz, Jan Anderl, Christoph Müller, Werner Simon, Susanne Werner-Simon, Torsten Hechler, Michael Kulke
  • Publication number: 20210130412
    Abstract: The invention relates to novel methods for synthesizing amanitin derivatives having a hydroxy group attached to the central tryptophan moiety. The invention furthermore relates to novel amanitin derivatives having a hydroxy group attached to position 4?, 5? or 7? of the central tryptophan moiety, novel conjugates of such amanitin derivatives, and pharmaceutical compositions comprising such conjugates.
    Type: Application
    Filed: January 13, 2021
    Publication date: May 6, 2021
    Applicant: Heidelberg Pharma Research GmbH
    Inventors: Christian Lutz, Werner Simon, Susanne Werner-Simon, Christoph Müller, Torsten Hechler, Michael Kulke
  • Patent number: 10961277
    Abstract: The invention relates to novel methods for synthesizing amanitin derivatives having a hydroxy group attached to the central tryptophan moiety. The invention furthermore relates to novel amanitin derivatives having a hydroxy group attached to position 4?, 5? or 7? of the central tryptophan moiety, novel conjugates of such amanitin derivatives, and pharmaceutical compositions comprising such conjugates.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: March 30, 2021
    Assignee: Heidelberg Pharma Research GmbH
    Inventors: Christian Lutz, Werner Simon, Susanne Werner-Simon, Christoph Müller, Torsten Hechler, Michael Kulke
  • Publication number: 20210077571
    Abstract: The present invention relates to an amatoxin-linker construct comprising an amatoxin according to formula (I) wherein: R1 and R2 are each —OH, R3 is NH2, or a linker which carries a reactive group Y for linking said amatoxin to a target-binding moiety, R4 is H or a linker which carries a reactive group Y for linking said amatoxin to a target-binding moiety, R5 is absent or ?O, wherein R3 and R4 cannot be the same, for use in the manufacture of a binding moiety-toxin conjugate for the treatment of a solid tumor, and a respective binding moiety-toxin conjugate for the treatment of a solid tumor.
    Type: Application
    Filed: April 12, 2019
    Publication date: March 18, 2021
    Applicant: Heidelberg Pharma Research GmbH
    Inventors: Christoph Müller, Werner Simon, Christian Lutz, Susanne Werner-Simon, Torsten Hechler, Michael Kulke, Andreas Pahl
  • Publication number: 20210061805
    Abstract: The invention relates to novel methods for synthesizing amanitin derivatives having an amino group attached to position 6? of the central tryptophan moiety. The invention furthermore relates to a novel amanitin derivative having an amino group attached to position 6? of the central tryptophan moiety, novel conjugates of such amanitin derivative, and pharmaceutical compositions comprising such conjugates.
    Type: Application
    Filed: August 6, 2018
    Publication date: March 4, 2021
    Applicant: Heidelberg Pharma Research GmbH
    Inventors: Werner Simon, Susanne Werner-Simon, Christian Lutz, Christoph Müller, Torsten Hechler, Michael Kulke
  • Publication number: 20200407440
    Abstract: Amatoxins, as well as antibody-drug conjugates (ADCs) comprising an amatoxin are provided, as well as compositions and methods of using the same. The compositions and methods provided herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy and to improve the engraftment of hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant procedure. Methods and compositions for the treatment of various hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, as well as prevention of graft-versus-host-disease (GVHD), are provided.
    Type: Application
    Filed: April 24, 2020
    Publication date: December 31, 2020
    Inventors: Charlotte Fenton McDonagh, Rajiv Panwar, Ganapathy N. Sarma, Torsten Hechler, Michael Kulke, Andreas Pahl, Christoph Mueller, Werner Simon, Christian Lutz, Francesca Gallo
  • Publication number: 20200345807
    Abstract: The invention relates to a PSMA-targeting conjugate comprising (a) an amatoxin; (b) a small molecule PSMA-targeting moiety; and (c) optionally a linker linking said amatoxin and said small molecule PSMA-targeting moiety. The invention furthermore relates to a pharmaceutical composition comprising such conjugate.
    Type: Application
    Filed: September 24, 2018
    Publication date: November 5, 2020
    Applicant: Heidelberg Pharma Research GmbH
    Inventors: Francesca Gallo, Barbara Korsak, Christoph Mueller, Torsten Hechler, Andreas Pahl, Michael Kulke, Werner Simon, Christian Lutz
  • Patent number: 10779871
    Abstract: A flexible surgical screw driver comprises a rotatable handle member, a shaft member and a flexible member. The handle member is configured with a first coupling means and the shaft member with a second coupling means. These first and second coupling means are configured to cooperate such that the handle member and the shaft member are angularly displaceable relative to each other and such that said handle member and said shaft member are non-rotatably coupled to each other for driving a screw with rotation transmitted from the handle member. The flexible member is configured to connect the handle member and the shaft member to each other and hold said handle member and said shaft member together such that the longitudinal axes thereof are substantially aligned and such that angular displacement of the handle member and the shaft member relative to each other such that the longitudinal axes thereof are misaligned, can be performed against the action of said flexible member.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: September 22, 2020
    Assignee: SWEMAC INNOVATION AB
    Inventors: Christian Lutz, Klaus Dorawa
  • Patent number: 10731039
    Abstract: The invention relates to a powder paint comprising at least one base powder paint and at least one effect powder paint having effect pigments, said effect pigments being dispersed in a melt made from transparent effect powder paint. The invention also relates to a method for producing said type of powder paint and to an effect powder coating containing said type of powder paint.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: August 4, 2020
    Assignee: TIGER COATINGS GMBH & CO. KG
    Inventors: Christian Lutz, Carsten Herzhoff