Abstract: Antibodies which bind human CEACAM5 protein, as well as isolated nucleic acids and host cells containing a sequence encoding said antibodies are disclosed. Immunoconjugates containing said antibodies linked to a growth-inhibitory agent, and pharmaceutical compositions containing antibodies or said immunoconjugates are also disclosed. A use of the antibodies, immunoconjugates, and pharmaceutical compositions disclosed herein is provided for the treatment of cancer or for diagnostic purposes.

Abstract: A computed tomography device includes a holding frame and a ring mount, being movably mounted to the holding frame. The ring mount includes an x-ray detector, with a semiconductor material, operable in an equilibrium of statistical states of occupation. In an embodiment, the computed tomography device includes a first power supply, set up to supply power, in an operating state of the computed tomography device, to a first lot of components of the computed tomography device, the first lot of components being arranged on the ring mount for an image generation process; and a second power supply, separable from the first power supply in terms of circuitry, to supply power to a second lot of components of the computed tomography device in a resting state of the computed tomography device, the components of the second lot being set up to hold the semiconductor material in the equilibrium.

Abstract: The invention relates to a disc brake, comprising a brake carrier, a brake caliper, brake shoes, and an actuating piston. The brake carrier has at least one mounting point for mounting on a vehicle. The actuating piston is displaceably accommodated on the brake caliper and is actuatable for carrying out a service brake function of the disc brake. At least one further actuating piston is provided, which in the direction of its longitudinal axis is displaceably accommodated on the brake caliper. For carrying out the service brake function, the at least two actuating pistons are actuatable, and for carrying out a parking brake function, one of the actuating pistons is actuatable. The invention further relates to a disc brake system and a parking brake system.

Abstract: A brake caliper arrangement includes a housing, a restoring device, a first brake lining arrangement and a second brake lining arrangement. The first brake lining arrangement and the second brake lining arrangement can be moved relative to one another from a respective starting position with a reduction of an initial spacing which exists between them. The restoring device includes first and second restoring elements. The first restoring element may prestress the first brake lining arrangement into its starting position, while the second restoring element may prestress the second brake lining arrangement into its starting position. The first and/or second restoring elements may be supported, on both sides of a central region of the brake lining arrangement, on the associated brake lining arrangement. The first and/or second restoring elements may be twisted elastically at least in sections in order to generate the prestress.

Abstract: A computed tomography device includes a holding frame and a ring mount, being movably mounted to the holding frame. The ring mount includes an x-ray detector, with a semiconductor material, operable in an equilibrium of statistical states of occupation. In an embodiment, the computed tomography device includes a first power supply, set up to supply power, in an operating state of the computed tomography device, to a first lot of components of the computed tomography device, the first lot of components being arranged on the ring mount for an image generation process; and a second power supply, separable from the first power supply in terms of circuitry, to supply power to a second lot of components of the computed tomography device in a resting state of the computed tomography device, the components of the second lot being set up to hold the semiconductor material in the equilibrium.

Abstract: A counting x-ray detector includes a converter element, a rewiring unit and an evaluation unit including pixel electrodes. In an embodiment, the converter element includes a first electrode on a surface facing away from the evaluation unit and a pixelated second electrode having a plurality of electrode elements on a surface facing toward the evaluation unit. The rewiring unit is on a surface of the converter element facing toward the evaluation unit. First contacts of electrically conductive connections between the electrode elements and the pixel electrodes are provided on a surface of the rewiring unit and include a first areal distribution; and second such contacts are provided on a surface of the rewiring unit, including a relatively smaller second areal distribution. An areal extent of the evaluation unit is relatively smaller than an areal extent of the converter element.

Abstract: A brake caliper arrangement includes a housing, a restoring device, a first brake lining arrangement and a second brake lining arrangement. The first brake lining arrangement and the second brake lining arrangement can be moved relative to one another from a respective starting position with a reduction of an initial spacing which exists between them. The restoring device includes first and second restoring elements. The first restoring element may prestress the first brake lining arrangement into its starting position, while the second restoring element may prestress the second brake lining arrangement into its starting position. The first and/or second restoring elements may be supported, on both sides of a central region of the brake lining arrangement, on the associated brake lining arrangement. The first and/or second restoring elements may be twisted elastically at least in sections in order to generate the prestress.

Abstract: The invention relates to a disc brake, comprising a brake carrier, a brake caliper, brake shoes, and an actuating piston. The brake carrier has at least one mounting point for mounting on a vehicle. The actuating piston is displaceably accommodated on the brake caliper and is actuatable for carrying out a service brake function of the disc brake. At least one further actuating piston is provided, which in the direction of its longitudinal axis is displaceably accommodated on the brake caliper. For carrying out the service brake function, the at least two actuating pistons are actuatable, and for carrying out a parking brake function, one of the actuating pistons is actuatable. The invention further relates to a disc brake system and a parking brake system.

Abstract: A detector is disclosed for detecting X-ray and/or gamma radiation, including a scintillator element for converting the X-ray and/or gamma radiation into light. The scintillator element has at least one side surface, an upper side and a lower side, a first photodiode on the lower side of the scintillator element. The detector further includes an electronic evaluation device, a light source designed to illuminate the scintillator element, and a light-impermeable housing which surrounds the scintillator element, the first photodiode, the electronic evaluation device and the light source.

Abstract: An X-ray detector includes a stack arrangement with a scattered radiation grid and a planar converter element including a first surface and a second surface. The converter element includes a first electrode embodied on the first surface and a pixelated second electrode with two adjacent first electrode elements. The two adjacent first electrode elements include a first width and a first length and the two adjacent first electrode elements are embodied the second surface opposite the first surface. The scattered radiation grid includes a grid wall with a thickness along the boundary between the two adjacent first electrode elements. The grid wall is arranged to be substantially perpendicular on the first surface and, in a projection, substantially parallel to the direction of incidence of the radiation and to the surface normal of the first surface. The grid wall at least partially overlaps the two adjacent first electrode elements.

Abstract: A method is described for determining the polarization state of a sensor of an X-ray detector. In the method, the X-ray detector is illuminated with a sequence of light pulses wherein the individual pulses of the light pulse sequence have a different intensity. It is further determined at what intensity of the light pulses, charge pulses generated by the sensor of the X-ray detector exceed a threshold voltage of a signal detection circuit. Also described is a method for obtaining and/or setting functional data of a sensor of an X-ray detector and/or of a sensor illumination unit. Furthermore, an X-ray detector is described.

Abstract: The invention relates to anti-TNF? antibodies which are engineered to exhibit a pH-sensitive antigen binding. The invention is preferably directed to anti-TNF? antibody adalimumab (Humira®) or biologically active variants and fragments thereof, wherein the original adalimumab antibody or variant or fragment thereof is engineered by modifications of amino acid sequence within the variable regions. Specifically, the invention relates to adalimumab or biologically active variants or fragments thereof, wherein the CDR domains are modified by replacing one or more amino acid residues by histidine residues.

Abstract: A counting x-ray detector includes a converter element, a rewiring unit and an evaluation unit including pixel electrodes. In an embodiment, the converter element includes a first electrode on a surface facing away from the evaluation unit and a pixelated second electrode having a plurality of electrode elements on a surface facing toward the evaluation unit. The rewiring unit is on a surface of the converter element facing toward the evaluation unit. First contacts of electrically conductive connections between the electrode elements and the pixel electrodes are provided on a surface of the rewiring unit and include a first areal distribution; and second such contacts are provided on a surface of the rewiring unit, including a relatively smaller second areal distribution. An areal extent of the evaluation unit is relatively smaller than an areal extent of the converter element.

Abstract: A method is disclosed for detecting incident X-ray radiation by way of a direct-converting X-ray radiation detector. A semi-conductor material used for detection purposes is irradiated with additional radiation with an energy level of at least 1.6 eV in order to produce additional charge carriers. A direct-converting X-ray radiation detector is disclosed for detecting X-ray radiation, at least including a semi-conductor material used for X-ray detection and at least one radiation source which irradiates the semi-conductor material with additional radiation, the radiation having an energy level of at least 1.6 eV. A CT system including an X-ray radiation detector is also disclosed.

Abstract: A method is for the production of a scintillator fiber. In an embodiment, the method includes provisioning a suspension of a binder dissolved in a solvent and a scintillator material; and pressing the suspension into a precipitation bath in which the binder is insoluble.

Abstract: A method is disclosed for detecting x-rays using an x-ray detector which includes a direct-conversion semiconductor detector element. Additional radiation is supplied to the semiconductor detector element using a radiation source, and the supply of the additional radiation is controlled and/or regulated on the basis of a specified target value. In at least one embodiment, the target value can be specified in a variable manner over time as a sequence of target values. An x-ray detector system is further disclosed, with which the method can be carried out.

Abstract: A method is for the production of a scintillator fiber. In an embodiment, the method includes provisioning a suspension of a binder dissolved in a solvent and a scintillator material; and pressing the suspension into a precipitation bath in which the binder is insoluble.

Abstract: An X-ray detector is disclosed, in particular for a computed tomography system. In an embodiment, the X-ray detector includes a regular arrangement of measuring pixels for covering a measuring surface. A plurality of the measuring pixels of the regular arrangement are constructed as direct converting measuring pixels, and remaining ones of the measuring pixels are constructed as indirect converting measuring pixels.

Abstract: A direct conversion X-ray detector for the detection of X-rays includes at least a semiconductor used for detecting X-rays, which has areas that are shaded against X-rays and unshaded areas, a pixelated electrode attached to the semiconductor and an all-over electrode attached to the semiconductor opposite the pixelated electrode, and at least one light source to illuminate the all-over electrode with additional light radiation for the purpose of generating additional charge carriers. In an embodiment, the at least one light source is designed such that the shaded areas are irradiated with a different intensity of the additional light radiation than are the unshaded areas. A CT system including the direct conversion X-ray detector is also disclosed, together with a method for the detection of incident X-rays via direct conversion X-ray detector, wherein the shaded areas are irradiated with a different intensity of the additional light radiation than the unshaded areas.

Abstract: The invention relates to anti-TNFa antibodies which are engineered to exhibit a pH-sensitive antigen binding. The invention is preferably directed to anti-TNFa antibody adalimumab (Humira®) or biologically active variants and fragments thereof, wherein the original adalimumab antibody or variant or fragment thereof is engineered by modifications of amino acid sequence within the variable regions. Specifically, the invention relates to adalimumab or biologically active variants or fragments thereof, wherein the CDR domains are modified by replacing one or more amino acid residues by histidine residues.