Patents by Inventor Christoph Huwe

Christoph Huwe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Progesterone receptor antagonists
    Patent number: 9109004
    Abstract: The invention relates to 17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-dien-11-aryl derivatives of formula I with progesterone-antagonizing action and methods of production thereof, use thereof for the treatment and/or prevention of diseases and use thereof for producing medicinal products for the treatment and/or prevention of diseases, in particular uterine fibroids (myomata, uterine leiomyomata), endometriosis, heavy menstrual bleeding, meningiomata, hormone-dependent breast cancers and menopause-associated complaints or for fertility control and emergency contraception.
    Type: Grant
    Filed: February 8, 2011
    Date of Patent: August 18, 2015
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Wolfgang Schwede, Ulrich Klar, Carsten Möller, Andrea Rotgeri, Wilhelm Bone, Christoph Huwe
  • Progesterone receptor antagonists
    Patent number: 9085603
    Abstract: The invention relates to 17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-dien-11-aryl derivatives of the formula I with a progesterone antagonizing effect and processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and also their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular of uterus fibroids (myomas, uterine leiomyomas), endometriosis, heavy menstrual bleeding, meningiomas, hormone-dependent breast cancers and troubles associated with the menopause or for monitoring fertility and emergency contraception.
    Type: Grant
    Filed: February 8, 2011
    Date of Patent: July 21, 2015
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Wolfgang Schwede, Ulrich Klar, Carsten Möller, Andrea Rotgeri, Wilhelm Bone, Christoph Huwe
  • Progesterone receptor antagonists
    Patent number: 8969328
    Abstract: The invention relates to 17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-dien-11-aryl derivatives of formula I with progesterone-antagonizing action and methods of production thereof, use thereof for the treatment and/or prevention of diseases and use thereof for producing medicinal products for the treatment and/or prevention of diseases, in particular uterine fibroids (myomata, uterine leiomyomata), endometriosis, heavy menstrual bleeding, meningiomata, hormone-dependent breast cancers and menopause-associated complaints or for fertility control and emergency contraception.
    Type: Grant
    Filed: February 8, 2011
    Date of Patent: March 3, 2015
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Wolfgang Schwede, Ulrich Klar, Carsten Möller, Andrea Rotgeri, Wilhelm Bone, Christoph Huwe
  • PROGESTERONE RECEPTOR ANTAGONISTS
    Publication number: 20130072464
    Abstract: The invention relates to 17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-dien-11-aryl derivatives of formula I with progesterone-antagonizing action and methods of production thereof, use thereof for the treatment and/or prevention of diseases and use thereof for producing medicinal products for the treatment and/or prevention of diseases, in particular uterine fibroids (myomata, uterine leiomyomata), endometriosis, heavy menstrual bleeding, meningiomata, hormone-dependent breast cancers and menopause-associated complaints or for fertility control and emergency contraception.
    Type: Application
    Filed: February 8, 2011
    Publication date: March 21, 2013
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Wolfgang Schwede, Ulrich Klar, Carsten Möller, Andrea Rotgeri, Wilhelm Bone, Christoph Huwe
  • Progesterone Receptor Antagonists
    Publication number: 20130005697
    Abstract: The invention relates to 17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-dien-11-aryl derivatives of the formula I with a progesterone antagonising effect and processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and also their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular of uterus fibroids (myomas, uterine leiomyomas), endometriosis, heavy menstrual bleeding, meningiomas, hormone-dependent breast cancers and troubles associated with the menopause or for monitoring fertility and emergency contraception.
    Type: Application
    Filed: February 8, 2011
    Publication date: January 3, 2013
    Applicant: Bayer Intellectual Property GmbH
    Inventors: Wolfgang Schwede, Ulrich Klar, Carsten Möller, Andrea Rotgeri, Wilhelm Bone, Christoph Huwe
  • Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments
    Patent number: 7750000
    Abstract: The invention relates to novel inhibitors of kinases, and pharmaceutical compositions comprising them. The inhibitors are substituted imidazo[1,2b]pyridazines.
    Type: Grant
    Filed: September 1, 2006
    Date of Patent: July 6, 2010
    Assignee: Bayer Schering Pharma AG
    Inventors: Olaf Prien, Stuart James Ince, Knut Eis, Christoph Huwe, Ulrich Lücking, Rolf Jautelat, Ulrich Zügel, Judith Günther, Benjamin Bader, Manfred Husemann, Karina Schuck
  • CDK-inhibitory pyrimidines, their production and use as pharmaceutical agents
    Patent number: 7598260
    Abstract: This invention relates to pyrimidine derivatives of general formula I in which R1, R2, X, A and B have the meanings that are contained in the description, as inhibitors of the cyclin-dependent kinases, their production as well as their use as medications for treating various diseases.
    Type: Grant
    Filed: June 26, 2007
    Date of Patent: October 6, 2009
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Thomas Brumby, Rolf Jautelat, Olaf Prien, Martina Schäfer, Gerhard Siemeister, Ulrich Lücking, Christoph Huwe
  • Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents
    Patent number: 7504410
    Abstract: This invention relates to pyrimidine derivatives of general formula (I) as inhibitors of kinases, their production as well as their use as medications for treating various diseases.
    Type: Grant
    Filed: November 28, 2003
    Date of Patent: March 17, 2009
    Assignee: Schering Aktiengesellschaft
    Inventors: Judi Bryant, Monica J. Kochanny, Shendong Yuan, Seock-Kyu Khim, Brad O. Buckman, Damian O. Arnaiz, Ulf Bomer, Hans Briem, Peter Esperling, Christoph Huwe, Joachim Kuhnke, Martina Schafer, Lars Wortmann, Dirk Kosemund, Emil Eckle, Richard I. Feldman, Gary B. Phillips
  • 1-(Het)aryl-3-[hetaryl-piperidin-4-yl]-thioureas as modulators of the EP2 receptor
    Publication number: 20080125435
    Abstract: The present invention relates to aryl-3-[(het)aryl-piperidin-4-yl]-thioureas, processes for the production thereof and the use thereof for the production of pharmaceutical agents for the treatment of diseases and indications which are connected with the EP2 receptor.
    Type: Application
    Filed: September 6, 2007
    Publication date: May 29, 2008
    Inventors: Nico Brauer, Bernd Buchmann, Christoph Huwe, Marcus Koppitz, Antonius Ter Laak, Gernot Langer, Bernhard Lindenthal, Olaf Peters, Tim Wintermantel
  • Quinoline derivatives, their preparation, their use, and medicaments comprising them
    Publication number: 20080056987
    Abstract: The present invention relates to a quinoline derivative having the general formula (A) in which R1, R2, W, X, Y and Z are indicated in the description and the claims, the use of the compounds of the general formula (A) for the treatment of various disorders, and the preparation of compounds of the general formula (A).
    Type: Application
    Filed: June 20, 2007
    Publication date: March 6, 2008
    Inventors: Olaf Prien, Knut Eis, Duy Nguyen, Christoph Huwe, Wolfgang Schwede, Judith Guenther, Dieter Zopf
  • CDK-Inhibitory pyrimidines, their production and use as pharmaceutical agents
    Publication number: 20080039447
    Abstract: This invention relates to pyrimidine derivatives of general formula I in which R1, R2, X, A and B have the meanings that are contained in the description, as inhibitors of the cyclin-dependent kinases, their production as well as their use as medications for treating various diseases.
    Type: Application
    Filed: June 26, 2007
    Publication date: February 14, 2008
    Inventors: Thomas Brumby, Rolf Jautelat, Olaf Prien, Martina Schafer, Gerhard Siemeister, Ulrich Lucking, Christoph Huwe
  • SUBSTITUTED ISOXAZOLINES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, METHODS OF PREPARING SAME, AND USES OF SAME
    Publication number: 20080027059
    Abstract: The invention relates to substituted isoxazolines according to the general formula (I): in which A, R1, R2, R3, R4, Z, X, m, n, and p, are given in the claims, and salts thereof, to pharmaceutical compositions comprising said substituted isoxazolines, to methods of preparing said substituted isoxazolines as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases known to be at least in part mediated by HDAC activity or whose symptoms are known to be alleviated by HDAC inhibitors.
    Type: Application
    Filed: July 11, 2007
    Publication date: January 31, 2008
    Inventors: Dominic Brittain, Benjamin Bader, Philip Lienau, Gerhard Siemeister, Takayuki Tatamiya, Hilmar Weinmann, Christoph Huwe
  • CDK-inhibitory pyrimidines, their production and use as pharmaceutical agents
    Patent number: 7291624
    Abstract: This invention relates to pyrimidine derivatives of general formula I in which R1, R2, X, A and B have the meanings that are contained in the description, as inhibitors of the cyclin-dependent kinases, their production as well as their use as medications for treating various diseases.
    Type: Grant
    Filed: May 11, 2004
    Date of Patent: November 6, 2007
    Assignee: Bayer Schering Pharma AG
    Inventors: Thomas Brumby, Rolf Jautelat, Olaf Prien, Martina Schäfer, Gerhard Siemeister, Ulrich Lücking, Christoph Huwe
  • Fluorenes and carbazoles as ligands of the EP2 receptor
    Publication number: 20070197524
    Abstract: The present invention relates to carbazoles/fluorenes, to processes for their preparation and to their use for preparing pharmaceutical agents for the treatment of disorders connected to the EP2 receptor.
    Type: Application
    Filed: December 21, 2006
    Publication date: August 23, 2007
    Inventors: Nico Brauer, Bernd Buchmann, Christoph Huwe, Bernhard Lindenthal, Gernot Langer, Olaf Peters, Gerd Schubert, Ulrich Bothe, Luisella Toschi, Michaele Peters-Kottig
  • Compound and a composition including such a compound
    Patent number: 7235561
    Abstract: This invention relates to pyrimidine derivatives of general formula I in which R1, R2, X, A and B have the meanings that are contained in the description, as inhibitors of the cyclin-dependent kinases, their production as well as their use as medications for treating various diseases.
    Type: Grant
    Filed: May 29, 2002
    Date of Patent: June 26, 2007
    Assignee: Schering AG
    Inventors: Thomas Brumby, Rolf Jautelat, Olaf Prien, Martina Schäfer, Gerhard Siemeister, Ulrich Lücking, Christoph Huwe
  • Tetrahydronaphthalene derivatives, processes for their preparation and their use as antiinflammatory agents
    Publication number: 20070129359
    Abstract: The invention relates to multiply substituted tetrahydronaphthalene derivatives of the formula (I) processes for their preparation and their use as anti-inflammatory agents.
    Type: Application
    Filed: May 1, 2006
    Publication date: June 7, 2007
    Inventors: Christoph Huwe, Werner Skuballa, Duy Nguyen, Heike Schaecke, Wheeseong Lee
  • Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments
    Publication number: 20070093490
    Abstract: The invention relates to novel inhibitors of kinases, methods for preparing such inhibitors, intermediates for the preparation of such inhibitors and uses of such inhibitors.
    Type: Application
    Filed: September 1, 2006
    Publication date: April 26, 2007
    Inventors: Olaf Prien, Stuart Ince, Knut Eis, Christoph Huwe, Ulrich Lucking, Rolf Jautelat, Ulrich Zugel, Judith Gunther, Benjamin Bader, Manfred Husemann, Karina Schuck
  • Piperazine derivatives that destabilize androgen receptors
    Patent number: 6861432
    Abstract: This invention relates to new piperazine derivatives of general formula I, in which V, W, n, R, R?, i, j, Y and Z have the meaning that is indicated in the description. The compounds according to the invention are distinguished by a diazacycloalkane substituent. They have at their disposal a special action with respect to the action that destabilizes the androgen receptor and can be used, for example, for treating prostrate cancer.
    Type: Grant
    Filed: November 22, 2002
    Date of Patent: March 1, 2005
    Assignee: Schering Aktiengesellschaft
    Inventors: Arwed Cleve, Christoph Huwe, Volker Schulze, Helmut Morack, Dieter Zopf, Jens Hoffmann, Andreas Reichel
  • CDK-inhibitory pyrimidines, their production and use as pharmaceutical agents
    Publication number: 20040224966
    Abstract: This invention relates to pyrimidine derivatives of general formula I 1
    Type: Application
    Filed: May 11, 2004
    Publication date: November 11, 2004
    Inventors: Thomas Brumby, Rolf Jautelat, Olaf Prien, Martina Schafer, Gerhard Siemeister, Ulrich Lucking, Christoph Huwe
  • Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents
    Publication number: 20040186118
    Abstract: This invention relates to pyrimidine derivatives of general formula (I) as inhibitors of kinases, their production as well as their use as medications for treating various diseases
    Type: Application
    Filed: November 28, 2003
    Publication date: September 23, 2004
    Inventors: Judi Bryant, Monica J. Kochanny, Shendong Yuan, Seock-Kyu Khim, Brad O. Buckman, Damian O. Arnaiz, Ulf Bomer, Hans Briem, Peter Esperling, Christoph Huwe, Joachim Kuhnke, Martina Schafer, Lars Wortmann, Dirk Kosemund, Emil Eckle, Richard J. Feldman, Gary B. Phillips