Patents by Inventor Christoph Schachtele

Christoph Schachtele has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9925193
    Abstract: The present invention relates to thioether derivatives (1) as protein kinase inhibitors, which are useful for the treatment, relieve and/or prevention of diseases associated with abnormal and hyperproliferation of cells in a mammal, especially humans, and which are particularly useful for the treatment of all forms of cancer.
    Type: Grant
    Filed: November 11, 2013
    Date of Patent: March 27, 2018
    Assignee: ProQinase GmbH
    Inventors: Michael Kubbutat, Christoph Schachtele, Jan Ehlert, Frank Totzke, Conrad Kunick, Sebastian Wolfel, Holger Weber
  • Publication number: 20150328219
    Abstract: The present invention relates to thioether derivatives (1) as protein kinase inhibitors, which are useful for the treatment, relieve and/or prevention of diseases associated with abnormal and hyperproliferation of cells in a mammal, especially humans, and which are particularly useful for the treatment of all forms of cancer.
    Type: Application
    Filed: November 11, 2013
    Publication date: November 19, 2015
    Inventors: Michael KUBBUTAT, Christoph SCHÄCHTELE, Jan EHLERT, Frank TOTZKE, Conrad KUNICK, Sebastian WÖLFEL, Holger WEBER
  • Publication number: 20070149523
    Abstract: Compounds of formula (I) and salts and physiologically functional derivatives thereof, wherein R2 is attached at the 4- or 5-position of the thiazole ring and is hydrogen, alkyl, halogen, cyano, alkoxy, haloalkoxy, or alkylamino; X independently represents a divalent linkage group selected from S, O, NR4, SO, or SO2; R4 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, or heterocyclyl; R1 is attached at the 4- or 5-position of the thiazole ring and independently represents a group of formula (II): ?wherein the dotted line represents a single or double bond; * indicates the point of attachment to the thiazole ring; and n is 1, 2, or 3. Also disclosed are pharmaceutical compositions comprising the above compounds and method of treatments for cancer and other diseases.
    Type: Application
    Filed: November 14, 2006
    Publication date: June 28, 2007
    Inventors: Jan Ehlert, Thomas Herz, Rolf Krauss, Micheal Kubbutat, Martin Lang, Stefano Pegoraro, Christoph Schachtele, Frank Totzke, Ute Zirrgiebel
  • Publication number: 20050143382
    Abstract: The present invention relates to furazanopyrazine derivatives of the general formula (I): wherein: R? represents —NR1R2 or —OR9 R? represents —NR5—NR3R4, —NR5—ORb, —O—NR3R4; wherein R1 to R9 in formula (I) represent independently of each other a variety of different substituents comprising alkyl, aryl, aralkyl, alkylaryl, heteroaryl groups and monofunctional moieties.
    Type: Application
    Filed: November 2, 2004
    Publication date: June 30, 2005
    Applicant: 4SC AG
    Inventors: Katharina Aulinger-Fuchs, Thomas Herz, Rolf Krauss, Michael Kubbatat, Martin Lang, Christoph Schachtele, Frank Totzke
  • Patent number: 6444662
    Abstract: Described are salts of hyperforin and adhyperforin of formula I [A−]m[B]p+  (I) wherein m is an integer from 1 to 3, p is equal to m and gives the total number of positive charges of the residue [B], [A−] is an anion of formula II with n=0 or 1 and [B]p+ is an ion of an alkali metal or an ammonium ion of a salt-forming nitrogen base of formula III wherein R1 through R4 have a variety of meanings including hydrogen, alkyl, cycloalkyl and similar groups which in turn may be substituted with one or more substituents. The salts serve inter alia for enriching or purifying hyperforin and adhyperforin from St. John's Wort extracts. Pharmaceutical preparations containing the salts are used for treating Alzheimer's Disease.
    Type: Grant
    Filed: August 11, 2000
    Date of Patent: September 3, 2002
    Assignee: Willmar Schwabe GmbH & Co.
    Inventors: Shyam Sunder Chatterjee, Clemens Erdelmeier, Klaus Klessing, Dieter Marme, Christoph Schächtele
  • Patent number: 5945440
    Abstract: The present invention is concerned with the use of indolocarbazole imides of the general formula (I): ##STR1## for the preparation of pharmaceutical compositions for the treatment and/or prevention of cancer, virus diseases (for example HIV infections), heart and blood vessel diseases (for example high blood pressure, thromboses, heart rhythm disturbances and atheroscleroses), bronchopulmonary diseases, degenerative diseases of the central nervous system (for example Alzheimer's disease), inflammatoryl diseases (for example rheumatism and arthritis), diseases of the immune system (for example allergies), as well as psoriasis and for use as immune suppressives; as well as new compounds of general formula (I).
    Type: Grant
    Filed: May 7, 1998
    Date of Patent: August 31, 1999
    Assignee: Goedecke Aktiengesellschaft
    Inventors: Jurgen Kleinschroth, Christoph Schachtele, Johannes Hartenstein, Claus Rudolph, Hubert Barth, Julian Aranda, Hans Jurgen Betche
  • Patent number: 5883114
    Abstract: The present invention is concerned with the use of indolocarbazole imides of the general formula (I): ##STR1## for the preparation of pharmaceutical compositions for the treatment and/or prevention of cancer, virus diseases (for example HIV infections), heart and blood vessel diseases (for example high blood pressure, thromboses, heart rhythm disturbances and atheroscleroses), bronchopulmonary diseases, degenerative diseases of the central nervous system (for example Alzheimer's disease), inflammatory diseases (for example rheumatism and arthritis), diseases of the immune system (for example allergies), as well as psoriasis and for use as immune suppressives; as well as new compounds of general formula (I).
    Type: Grant
    Filed: February 15, 1995
    Date of Patent: March 16, 1999
    Assignee: Goedecke Aktiengesellschaft
    Inventors: Jurgen Kleinschroth, Christoph Schachtele, Johannes Hartenstein, Claus Rudolph, Hubert Barth, Julian Aranda, Hans Jurgen Betche
  • Patent number: 5750555
    Abstract: The instant invention is a compound of formulaA--X--Y--E.sub.n --R.sup.5in which A is a bis-indolylmaleinimide or indolopyrrolocarbazole useful in the treatment and/or prevention of cancer, viral diseases, thrombosis, heart rhythm disturbances, atherosclerosis, bronchopulmonary diseases, degenerative diseases of the central nervous system, inflammatory diseases, diseases of the immune system, psoriasis, and immune suppression. A pharmaceutical composition and methods of preparing the compounds are also included.
    Type: Grant
    Filed: November 15, 1996
    Date of Patent: May 12, 1998
    Assignee: Goedecke Aktiengesellschaft
    Inventors: Uwe Trostmann, Christoph Schachtele, Johannes Hartenstein, Claus Rudolph, Hubert Barth, Reinhard Reck, Walter Kolch
  • Patent number: 5516915
    Abstract: The present invention provides bis-(1H-indol-3-yl)maleinimide derivatives and the pharmacologically acceptable salts thereof, processes for the preparation of these compounds, and pharmaceutical compositions containing them for the treatment of heart and blood vessel diseases, such as thromboses, arteriosclerosis, hypertension, of inflammatory processes, allergies, cancer, and certain degenerative damages of the central nervous system, as well as of diseases of the immune system and viral diseases.
    Type: Grant
    Filed: September 12, 1994
    Date of Patent: May 14, 1996
    Assignee: Goedecke Aktiengesellschaft
    Inventors: Hubert Barth, Johannes Hartenstein, Claus Rudolph, Christoph Schachtele, Hans-Jurgen Betche, Reinhard Reck, Hartmut Osswald
  • Patent number: 5489608
    Abstract: The present invention provides indolocarbazole derivatives of the formula ##STR1## as well as the regioisomeric mixtures thereof, pharmacologically acceptable salts thereof, processes for the preparation thereof, and pharmaceutical compositions containing them for the treatment and/or prophylaxis of heart and blood vessel diseases, such as thromboses, arterioscleroses, hypertonias, of bronchopulmonary diseases, inflammatory processes, allergies, cancers and degenerative damage of the central nervous system, and for the treatment of viral diseases.
    Type: Grant
    Filed: February 2, 1995
    Date of Patent: February 6, 1996
    Assignee: Goedecke Aktiengesellschaft
    Inventors: Jurgen Kleinschroth, Johannes Hartenstein, Christoph Schachtele, Claus Rudolph
  • Patent number: 5438050
    Abstract: New indolocarbazoles of formula: ##STR1## or a pharmaceutically acceptable salt thereof, processes for their preparation, compositions containing, and methods for using the composition for the inhibition of protein kinases, such as protein kinase C, for the prevention and/or treatment of heart and blood vessel diseases such as thromboses, arterioscleroses, hypertension, or for inflammatory processes, allergies, cancers, viral diseases, and certain degenerative damages of the central nervous system are disclosed.
    Type: Grant
    Filed: January 21, 1994
    Date of Patent: August 1, 1995
    Assignee: Godecke Aktiengesellschaft
    Inventors: Jurgen Kleinschroth, Johannes Hartenstein, Hubert Barth, Christoph Schachtele, Claus Rudolph, Gunter Weinheimer, Hartmut Osswald
  • Patent number: 5401875
    Abstract: The invention concerns 2-aminocarboxylic acids and derivatives of formula ##STR1## processes for their preparation, as well as medicaments containing them for the inhibition of protein kinase C and thus for the prevention and/or treatment of heart and blood vessel diseases, such as thromboses, arterioscleroses, hypertension, of inflammatory processes, allergies, cancers, and certain degenerative damages of the central nervous system.
    Type: Grant
    Filed: April 22, 1991
    Date of Patent: March 28, 1995
    Assignee: Godecke Aktiengesellschaft
    Inventors: Uwe Trostmann, Johannes Hartenstein, Claus Rudolph, Christoph Schachtele, Hartmut Osswald, Gunter Weinheimer
  • Patent number: 5380746
    Abstract: The present invention provides bis-(1H-indol-3-yl)maleinimide derivatives and the pharmacologically acceptable salts thereof, processes for the preparation of these compounds, and pharmaceutical compositions containing them for the treatment of heart and blood vessel diseases, such as thromboses, arteriosclerosis, hypertension, of inflammatory processes, allergies, cancer, and certain degenerative damages of the central nervous system, as well as of diseases of the immune system and viral diseases.
    Type: Grant
    Filed: March 9, 1993
    Date of Patent: January 10, 1995
    Assignee: Goedecke Aktiengesellschaft
    Inventors: Hubert Barth, Johannes Hartenstein, Claus Rudolph, Christoph Schachtele, Hans-Jurgen Betche, Reinhard Reck, Hartmut Osswald
  • Patent number: 5322844
    Abstract: The invention concerns new derivatives of certain alkoxy-4(1H)-pyridones, processes for preparing them, and pharmaceutical compositions containing them. The compounds of the invention are useful in the prevention and/or treatment of heart and blood vessel diseases such as thromboses, arteriosclerosis and hypertension, and of inflammatory processes, allergies, cancers, and certain degenerative damage of the central nervous system.
    Type: Grant
    Filed: October 7, 1992
    Date of Patent: June 21, 1994
    Assignee: Godecke Aktiengesellschaft
    Inventors: Julian Aranda, Johannes Hartenstein, Reinhard Reck, Christoph Schachtele, Claus Rudolph, Hartmut Osswald, Gunter Weinheimer
  • Patent number: 5043335
    Abstract: The present invention provides 9,10,11,12-tetrahydro-9,12-epoxy-1H-diindolo [1,2,3-fg: 3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione and 9,10,11,12-tetrahydro-2-(tetrahydro-5-methoxy-2-furanyl) -9,12-epoxy-1H-diindolo[1,2,3-fg: 3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione process for the preparation thereof, pharmaceutical compositions containing the compounds, and use of the compounds in heart and blood vessel diseases such as thromboses, arterioscleroses, hypertension and inflammatory diseases, allergies, cancer and certain degenerative damage of the central nervous system, as well as diseases of the immune system.
    Type: Grant
    Filed: July 23, 1990
    Date of Patent: August 27, 1991
    Assignee: Godecke Aktiengesellschaft
    Inventors: Jurgen Kleinschroth, Johannes Hartenstein, Christoph Schachtele, Claus Rudolph
  • Patent number: 4912107
    Abstract: The invention concerns new pyrrolocarbazole derivatives of formula ##STR1## processes for their preparation, as well as medicaments containing these for the inhibition of protein kinases, such as protein kinase C, and thus for the prevention and/or treatment of heart and blood vessel diseases, such as thromboses, arterioscleroses, hypertension, of inflammatory processes, allergies, cancers, and certain degenerative damages of the central nervous system as well as for the treatment of viral diseases.
    Type: Grant
    Filed: September 26, 1989
    Date of Patent: March 27, 1990
    Assignee: Goedecke Aktiengesellschaft
    Inventors: Jurgen Kleinschroth, Johannes Hartenstein, Christoph Schachtele, Claus Rudolph, David J. Dooley, Gunther Weinheimer
  • Patent number: 4855489
    Abstract: The present invention covers a novel series of 2-acyloxypropylamine derivatives, processes for preparing them, compositions containing them, and methods for using them. The compounds are active in the inhibition of protein kinase C and thrombocyto aggregation stimulated by diacylglycerols.
    Type: Grant
    Filed: July 15, 1987
    Date of Patent: August 8, 1989
    Assignee: Goedecke Aktiengesellschaft
    Inventors: Uwe Trostmann, Christoph Schachtele, Karl Mannhardt, Claus Rudolph, Dieter Marme