Patents by Inventor Christoph Spiess

Christoph Spiess has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190040142
    Abstract: The presently disclosed subject matter relates to multispecific antibodies, e.g., bispecific antibodies and biepitopic antibodies, and methods for screening for such antibodies, and a novel antibody structure that can be used to screen for such bispecific antibodies and biepitopic antibodies.
    Type: Application
    Filed: May 8, 2018
    Publication date: February 7, 2019
    Applicant: GENENTECH, INC.
    Inventors: Diana Ronai Dunshee, Joanne Hongo, Hok Seon Kim, Junichiro Sonoda, Christoph Spiess, Angie Grace Yee
  • Publication number: 20180305462
    Abstract: The instant disclosure provides antibody fragments (e.g., Fab and F(ab?)2) having reduced or no reactivity towards pre-existing anti-hinge antibodies (AHA) and compositions comprising such antibody fragments, as well as methods of making and using such antibody fragments and compositions.
    Type: Application
    Filed: April 30, 2018
    Publication date: October 25, 2018
    Applicant: GENENTECH, INC.
    Inventors: Yu-Ju G. Meng, Hok Seon Kim, Ingrid Kim, Christoph Spiess
  • Publication number: 20180282431
    Abstract: Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.
    Type: Application
    Filed: October 27, 2017
    Publication date: October 4, 2018
    Inventors: Justin SCHEER, Christoph SPIESS, Daniel G. YANSURA
  • Publication number: 20180177873
    Abstract: Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains and/or CH1/CL domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.
    Type: Application
    Filed: October 20, 2017
    Publication date: June 28, 2018
    Applicant: Genentech, Inc.
    Inventors: PAUL CARTER, CHRISTOPH SPIESS, YIYUAN YIN, JIANHUI ZHOU, WENDY SANDOVAL, JACOB CORN, MICHAEL DILLON
  • Publication number: 20180105605
    Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
    Type: Application
    Filed: December 11, 2017
    Publication date: April 19, 2018
    Inventors: Yongmei Chen, James Ernst, Hok Seon Kim, Junichiro Sonoda, Christoph Spiess, Scott Stawicki, Yan Wu
  • Patent number: 9884919
    Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
    Type: Grant
    Filed: July 19, 2016
    Date of Patent: February 6, 2018
    Assignee: GENENTECH, INC.
    Inventors: Yongmei Chen, James Ernst, Hok Seon Kim, Junichiro Sonoda, Christoph Spiess, Scott Stawicki, Yan Wu
  • Publication number: 20180030434
    Abstract: The invention provides methods of identifying bacteria comprising binding polypeptides. The invention also provides methods of identifying bacteria with improved expression of binding polypeptides. The invention also provides methods of identifying binding polypeptides with improved expression. The invention also provides engineered bacteria suitable for use in the methods of the invention. The invention also provides compositions that can be obtained using the methods, for example, anti-interleukin-13 (IL-13) antibodies with improved expression and/or stability. The invention also provides libraries comprising binding polypeptide (e.g., antibody) variants.
    Type: Application
    Filed: October 12, 2017
    Publication date: February 1, 2018
    Inventors: Twyla Noelle LOMBANA, Rebekah MCKENNA, Christoph SPIESS, Karthik VEERAVALLI, Michael DILLON
  • Patent number: 9873748
    Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: January 23, 2018
    Assignee: GENENTECH, INC.
    Inventors: Yongmei Chen, James Ernst, Hok Seon Kim, Junichiro Sonoda, Christoph Spiess, Scott Stawicki, Yan Wu
  • Publication number: 20170334985
    Abstract: The invention provides anti-IL-13/IL-17 bispecific antibodies, in particular, anti-IL13/IL17 AA, AF and FF antibodies and methods of using the same, including without limitation, methods of using the anti-IL-13/IL-17 bispecific antibodies for treating moderate to severe asthma and/or eosinophilic asthma.
    Type: Application
    Filed: February 23, 2017
    Publication date: November 23, 2017
    Applicant: Genentech, Inc.
    Inventors: LAWREN WU, JOSEPH R. ARRON, MICHAEL DILLON, DAVID F. CHOY, SUE SOHN, CHRISTOPH SPIESS, WHITNEY SHATZ
  • Patent number: 9637557
    Abstract: Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.
    Type: Grant
    Filed: April 22, 2011
    Date of Patent: May 2, 2017
    Assignee: Genentech, Inc.
    Inventors: Justin Scheer, Christoph Spiess, Daniel G. Yansura
  • Publication number: 20160368985
    Abstract: The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.
    Type: Application
    Filed: June 16, 2016
    Publication date: December 22, 2016
    Inventors: Isidro HOTZEL, Teemu T. JUNTTILA, Ji LI, Justin SCHEER, Danielle DICARA, Diego ELLERMAN, Christoph SPIESS, Paul J. CARTER
  • Publication number: 20160319038
    Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
    Type: Application
    Filed: July 19, 2016
    Publication date: November 3, 2016
    Applicant: GENENTECH, INC.
    Inventors: YONGMEI CHEN, James Ernst, Hok Seon Kim, Junichiro Sonoda, Christoph Spiess, Scott Stawicki, Yan Wu
  • Publication number: 20160207995
    Abstract: The invention provides anti-IL-4 antibodies and bispecific antibodies and methods of using the same.
    Type: Application
    Filed: September 18, 2015
    Publication date: July 21, 2016
    Applicant: GENENTECH, INC.
    Inventors: Daniel G. Yansura, Nancy Y. Chiang, Mark S. Dennis, Michael Dillon, Germaine G. Fuh, Gerald R. Nakamura, Christoph Spiess, Lawren C. Wu, Yin Zhang
  • Publication number: 20150218276
    Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
    Type: Application
    Filed: December 23, 2014
    Publication date: August 6, 2015
    Applicant: GENENTECH, INC.
    Inventors: Yongmei Chen, James Ernst, Hok Seon Kim, Junichiro Sonoda, Christoph Spiess, Scott Stawicki, Yan Wu
  • Publication number: 20110287009
    Abstract: Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.
    Type: Application
    Filed: April 22, 2011
    Publication date: November 24, 2011
    Applicant: Genentech, Inc.
    Inventors: Justin Scheer, Christoph Spiess, Daniel G. Yansura