Patents by Inventor Christoph Winfried Johannes Steiger
Christoph Winfried Johannes Steiger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240108241Abstract: Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).Type: ApplicationFiled: December 15, 2023Publication date: April 4, 2024Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., The General Hospital CorporationInventors: Robert S. Langer, Carlo Giovanni Traverso, Malvika Verma, Feyisope Eweje, Christoph Winfried Johannes Steiger, Junwei Li, Nhi Phan, Hen-Wei Huang, Jacqueline Chu, John Ashraf Fou Salama
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Patent number: 11850034Abstract: Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).Type: GrantFiled: May 12, 2021Date of Patent: December 26, 2023Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Robert S. Langer, Carlo Giovanni Traverso, Malvika Verma, Feyisope Eweje, Christoph Winfried Johannes Steiger, Junwei Li, Nhi Phan, Hen-Wei Huang, Jacqueline Chu, John Ashraf Fou Salama
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Publication number: 20220378363Abstract: Transient molecules in the gastrointestinal (GI) tract, such as nitric oxide and hydrogen sulfide, are important signals and mediators of inflammatory bowel disease (IBD). Because these molecules may be short-lived in the body, they are difficult to detect. To track these reactive molecules in the GI tract, a miniaturized device has been developed that integrates genetically engineered probiotic biosensors with a custom-designed photodetector and readout chip. Leveraging the molecular specificity of living sensors, bacteria were genetically encoded to respond to IBD-associated molecules by luminescing. Low-power electronic readout circuits (e.g., using nanowatt power) integrated into the device convert the light from just 1 ?L of bacterial culture into a wireless signal. Biosensor monitoring was demonstrated in the GI tract of small and large animal models and integration of all components into a sub-1.4 cm3 ingestible form factor capable of supporting wireless communication.Type: ApplicationFiled: April 26, 2022Publication date: December 1, 2022Applicants: Massachusetts Institute of Technology, Trustees of Boston University, The Brigham and Women's Hospital, Inc.Inventors: Timothy Kuan-Ta Lu, Rabia Tugce Yazicigil Kirby, Carlo Giovanni Traverso, Jenna Ahn, Maria Eugenia Inda, Miguel Jimenez, Qijun Liu, Phillip Nadeau, Christoph Winfried Johannes Steiger, Adam Wentworth
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Publication number: 20220202721Abstract: Articles and methods for delivering a therapeutic agent to a subject are described. These articles and methods may be useful, in some cases, for the delivery of therapeutic agents to the colon of a subject. In some embodiments, an article is configured to release a secretion inducing agent e.g., to stimulate the release of intestinal fluids. The article, in some embodiments, comprises a therapeutic agent such that the stimulated release of intestinal fluid increases the amount of therapeutic agent available for absorption by the colon. For example, in some embodiments, the articles and methods described herein advantageously promote increased absorption of therapeutic agents in subjects as compared to traditionally administered therapeutic agents without additional components such as a secretion inducing agent. In some embodiments, articles and methods described herein may increase the motility of the colon of a subject.Type: ApplicationFiled: January 6, 2022Publication date: June 30, 2022Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Carlo Giovanni Traverso, Joshua Korzenik, Robert S. Langer, Christoph Winfried Johannes Steiger
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Patent number: 11318293Abstract: A platform technology has been designed to provide a means for controlled delivery of single or multiple doses of therapeutic, prophylactic, diagnostic or identifying agents to livestock. The delivery system is based on a livestock ear tag that releases therapeutic and/or prophylactic agent when applied to the ear or other desired anatomical target of the animal. The agent to be delivered is encapsulated in or on microneedles and or microparticles and or nanoparticles or combination thereof on a surface thereon of the male or female part of the tag, which is pressed into the skin so that the microneedles penetrate into the epidermis and dermis layers of the skin. The agent is then released into the animal from the microneedles and or microparticles and or nanoparticles or combination thereof at the site of contact into the epidermis and dermis layers of the skin.Type: GrantFiled: November 26, 2019Date of Patent: May 3, 2022Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Michael S. Williams, Jason Siu Wei Li, Jacob Coffey, Christoph Winfried Johannes Steiger, Miguel Jimenez, Robert S. Langer, Ester Caffarel Salvador, Alex Abramson, Carlo Giovanni Traverso
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Publication number: 20210361919Abstract: Articles for rapid release of components including, for example, quick release capsules, are generally provided. Advantageously, in some embodiments, the articles described herein may be configured to prevent fluid from contacting a component h contained therein (e.g., tissue interfacing component) or payload contained therein until a desired time, e.g., the time at which the component is configured to release from the article to a location internal to a subject (e.g., localize to a tissue wall in the subject). In some embodiments, the article comprises a first compartment and a second compartment not in fluid communication with the first compartment. In some embodiments, the first compartment and second compartment are fluidically isolated. For example, in some cases, the first compartment comprises a mechanism for releasing a component contained within the article and the second compartment comprises the component.Type: ApplicationFiled: May 17, 2019Publication date: November 25, 2021Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., Novo Nordisk A/SInventors: Robert S. Langer, Carlo Giovanni Traverso, Alex G. Abramson, David Dellal, Christoph Winfried Johannes Steiger, Niclas Roxhed, Ester Caffarel Salvador, Vance Soares, Daniel Minahan, Morten Revsgaard Frederiksen
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Publication number: 20210353174Abstract: Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).Type: ApplicationFiled: May 12, 2021Publication date: November 18, 2021Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., The General Hospital CorporationInventors: Robert S. Langer, Carlo Giovanni Traverso, Malvika Verma, Feyisope Eweje, Christoph Winfried Johannes Steiger, Junwei Li, Nhi Phan, Hen-Wei Huang, Jacqueline Chu, John Ashraf Fou Salama
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Publication number: 20210046011Abstract: Articles and methods for delivering a therapeutic agent to a subject are described. These articles and methods may be useful, in some cases, for the delivery of therapeutic agents to the colon of a subject. In some embodiments, an article is configured to release a secretion inducing agent e.g., to stimulate the release of intestinal fluids. The article, in some embodiments, comprises a therapeutic agent such that the stimulated release of intestinal fluid increases the amount of therapeutic agent available for absorption by the colon. For example, in some embodiments, the articles and methods described herein advantageously promote increased absorption of therapeutic agents in subjects as compared to traditionally administered therapeutic agents without additional components such as a secretion inducing agent. In some embodiments, articles and methods described herein may increase the motility of the colon of a subject.Type: ApplicationFiled: August 12, 2020Publication date: February 18, 2021Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Carlo Giovanni Traverso, Joshua Korzenik, Robert S. Langer, Christoph Winfried Johannes Steiger
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Publication number: 20200164193Abstract: A platform technology has been designed to provide a means for controlled delivery of single or multiple doses of therapeutic, prophylactic, diagnostic or identifying agents to livestock. The delivery system is based on a livestock ear tag that releases therapeutic and/or prophylactic agent when applied to the ear or other desired anatomical target of the animal. The agent to be delivered is encapsulated in or on microneedles and or microparticles and or nanoparticles or combination thereof on a surface thereon of the male or female part of the tag, which is pressed into the skin so that the microneedles penetrate into the epidermis and dermis layers of the skin. The agent is then released into the animal from the microneedles and or microparticles and or nanoparticles or combination thereof at the site of contact into the epidermis and dermis layers of the skin.Type: ApplicationFiled: November 26, 2019Publication date: May 28, 2020Inventors: Michael S. Williams, Jason Siu Wei Li, Jacob Coffey, Christoph Winfried Johannes Steiger, Miguel Jimenez, Robert S. Langer, Ester Caffarel Salvador, Alex Abramson
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Publication number: 20190365645Abstract: Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the article includes dimensions configured for transesophageal retrieval. In some cases, the articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).Type: ApplicationFiled: May 31, 2019Publication date: December 5, 2019Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Carlo Giovanni Traverso, Robert S. Langer, Michael J. Cima, Malvika Verma, Niclas Roxhed, Christoph Winfried Johannes Steiger, Karan Vishwanath