Abstract: The present invention provides SOCE inhibitors that are useful as therapeutic agents in a variety of applications. The present invention also relates to pharmaceutical compositions, products and kits comprising such SOCE inhibitors, and methods of using the SOCE inhibitors in the treatment of a variety of diseases.

Abstract: A process for shaping, by compaction, a fibrous structure obtained by three-dimensional or multilayer weaving between a plurality of layers of warp yarns and a plurality of layers of weft yarns. The yarns of each plurality of layers of warp yarns and layers of weft yarns are coated with a sizing composition. The shaping includes a pre-compaction stage followed by a stage of final compaction of the fibrous structure. During pre-compaction and final compaction, the fibrous structure is at a temperature greater than or equal to the softening temperature of the sizing composition. The process further includes the cooling of the fibrous preform obtained after final compaction of the fibrous structure.

Abstract: Methods and systems for optimizing the flight of an aircraft are disclosed. The trajectory is divided into segments, each of the segments being governed by distinct sets of equations, depending on engine thrust mode and on vertical guidance (climb, cruise or descent). By assuming two, aerodynamic and engine-speed, models, data from flight recordings are received and a number of parameters from a parameter-optimization engine is iteratively determined by applying a least-squares calculation until a predefined minimality criterion is satisfied. The parameter optimization engine is next used to predict the trajectory point following a given point. Software aspects and system (e.g. FMS and/or EFB) aspects are described.

Abstract: A method of making a medical implant is provided by electrospinning a polymer solution to form a preform around a mandrel. The formed preform distinguishes an inner surface and an outer surface. The formed preform is removed from the mandrel and flipped inside-out resulting in the inner surface of the formed preform becoming the outer surface of the inside-out flipped preform, and the outer surface of the formed preform becoming the inner surface of the inside-out flipped preform. At least part of the inside-out flipped preform forms the medical implant such as e.g. an artificial heart valve, an artificial leaflet, an artificial graft, or an artificial vessel. The products made according to the method of this invention greatly improve the performance and durability of the medical implant.

Abstract: Methods are provided for supervising a motor control unit with at least two separate channels, each of the two channels including at least: means for executing a given application task AS, the application task AS including a plurality of successively executed computations between which latency periods elapse; a first component capable of performing the computations; a second component capable of storing data; the application tasks AS of the channels being capable of communicating. The method comprising includes the following steps: a) detecting a latency period; b) performing, during this latency period, an operating state test of at least one of the components; and c) determining a state of the component corresponding to a failure state or a healthy state.

Abstract: A method for determining a trajectory of an aircraft intended to fly over a field of operation with a view to performing an action on a target at a given time is provided. The method comprises a step of computing a set of sections between a starting point, intermediate points and the target. A first type of section has a rectilinear overall shape so as to limit the time spent by the aircraft in non-secure areas. A second type of section has a sinusoidal shape so as to allow a time reserve to adjust a position of the aircraft over the target at said given time with a view to performing the action.

Abstract: Devices and computer-implemented methods for analyzing aircraft trajectories, the method includes the steps of receiving data associated with a plurality of aircraft trajectories; breaking the trajectories down into a plurality of vectors, a vector comprising one or more sequences of enumerators; aligning multiple vectorized trajectories by shifting sequences of enumerators by one or more positions; and detecting one or more anomalies in one or more trajectories by unsupervised classification (e.g. DBSCAN). Developments describe the supervised determination of trajectory anomaly detection models, the use of density-based algorithms, the use of one or more neural networks and/or decision trees, one or more display steps, notably displaying root causes (explainable or understandable artificial intelligence), the processing of avionics data flows, etc. System (e.g. computing) and software aspects are described.

Abstract: A process for chiral separation of ethyl 3-amino-1-[(3R,4S)-4-cyanotetrahydropyran-3-yl]pyrazole-4-carboxylate (VI) from the racemic mixture of ethyl 3-amino-1-[(3R,4S)-4-cyanotetrahydropyran-3-yl]pyrazole-4-carboxylate and ethyl 3-amino-1-[(3S,4R)-4-cyanotetrahydropyran-3-yl]pyrazole-4-carboxylate (V).

Abstract: The invention relates to an engine control device comprising a first control channel (V1) and a second control channel (V2), each control channel comprising a first sensor (CAV1, CAV2) and a second sensor (CBV2, CBV2), each configured to provide, respectively, a first measurement (A) and a second measurement (B) to each channel, each of the channels having an active or passive state defining an active channel (V1) or a passive channel (V2), the active channel (V1) being designed to control at least one actuator (ACT) of the engine while the passive channel (V2) is designed to take over for the active channel if the latter fails.

Abstract: A computer-implemented method for optimizing a mission of an aircraft, the aircraft having a predefined flight plan between a starting point and an arrival point, the flight plan comprising a set of waypoints.

Abstract: The present application relates to crystalline forms of 1-[(3R,4S)-4-cyanotetrahydropyran-3-yl]-3-[(2-fluoro-6-methoxy-4-pyridyl) amino]pyrazole-4-carboxamide and processes for the preparation thereof. The compound is useful for the treatment of JAK-mediated diseases or conditions such as atopic dermatitis.

Abstract: The application relates to processes for the preparation of 1-[(3R,4S)-4-cyanotetrahydropyran-3-yl]-3-[(2-fluoro-6-methoxy-4-pyridyl) amino]pyrazole-4-carboxamide (I) which include (i) a synthesis for bromo and iodo pyridine intermediates, (ii) a synthesis of a pyrazole ester intermediate which can be obtained in enantiopure form and (iii) the combination of these intermediates into compound (I).

Abstract: The present disclosure encompasses crystalline forms of N1-(1-cyanocyclopropyl)-N2-((1S)-1-{4?-[(1R-2,2-difluoro-1-hydroxyethyl]biphenyl-4-yl}-2,2,2-trifluoroethyl)-4-fluoro-L-leucinamide and processes for the preparation thereof.

Abstract: A method of preparing a compound of Formula (I) comprising reacting the compound of Formula (A) with a base and a compound of Formula (B) to yield a compound of Formula (C).

Abstract: A method of making a medical implant is provided by electrospinning a polymer solution to form a preform around a mandrel. The formed preform distinguishes an inner surface and an outer surface. The formed preform is removed from the mandrel and flipped inside-out resulting in the inner surface of the formed preform becoming the outer surface of the inside-out flipped preform, and the outer surface of the formed preform becoming the inner surface of the inside-out flipped preform. At least part of the inside-out flipped preform forms the medical implant such as e.g. an artificial heart valve, an artificial leaflet, an artificial graft, or an artificial vessel. The products made according to the method of this invention greatly improve the performance and durability of the medical implant.

Abstract: Endoluminal and other as implantable prostheses are fabricated in electrospinning apparatus including a target and an applicator. A solution comprising a polymer and a solvent is directed to the target with a first electrical potential between the target and the applicator to produce a first set of fibers. The same or another solution is continued to be delivered through the applicator onto the target while applying a second electrical potential to produce a second set of fibers having a second solvent fraction, and the same or different solution may be delivered while applying a third potential difference to produce a laminated structure having at least three layers. By properly controlling the electrical potentials and solvent fractions, an adhesive layer can be formed to serve a glue or adhesive between the inner and outer layers, and a stent or other scaffold may be positioned between the inner and outer layers to form a covered stent or graft.

Abstract: A method is provided for calculating the prediction of required navigation performance for a trajectory associated with a list of segments of a flight plan. A method is also provided for displaying the navigation performance as a corridor trajectory and adapted to guarantee compliance with the navigation performance requirements while offering immediate viewing of the navigation latitude in a corridor.

Abstract: An improved process for producing a compound of Formula (I).

Abstract: A volumetric pump comprising a product metering chamber, a metering piston mounted inside the chamber so as to slide between top dead center and bottom dead center, a sleeve at least partially delimiting an intake chamber and an exhaust chamber for the product, and a product dispenser that is mounted so as to be able to move with respect to the sleeve and is able to place the metering chamber alternately into communication with the intake chamber and the exhaust chamber is provided. The pump also comprises a pressure sensor that is able to measure the pressure of the product inside the metering chamber, and a control unit that is connected to the pressure sensor and is able to verify the presence of pressure peaks exhibiting a value greater than or equal to a predetermined pressure threshold.

Abstract: Drone for dispersing capsules containing biological active agents for combatting pests, including propulsion means ensuring movement of the aircraft in a horizontal direction parallel with the ground and a capsule distributing and jettisoning system with a vertical ejector, for in-flight ejection of the capsules toward the ground in a direction perpendicular to the horizontal direction of movement of the drone. Taking into account the movement direction of the drone, the vertical ejector is positioned in front of the propulsion means, and the capsule distribution and jettisoning system includes a capsule reservoir which is connected to an element for guiding the capsules toward a capsule counting and metering system including a plate for selecting and separating the capsules, the plate having holes calibrated for the passage of a single capsule toward the vertical jettisoning ejector and being mounted for rotation relative to the vertical ejector via a thrust generating motor.