Patents by Inventor Christopher Bruce Howard
Christopher Bruce Howard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9234019Abstract: The present invention relates to isolated Cpn10 polypeptides possessing an increased affinity for a PRR ligand compared to Ala Cpn10 polypeptide. In a further embodiment, the present invention also relates to modified chaperonin 10 polypeptides, and to nucleic acids encoding the same and to compositions comprising such polypeptides and uses thereof.Type: GrantFiled: April 9, 2009Date of Patent: January 12, 2016Assignee: CBio LimitedInventors: Dean Jason Naylor, Richard James Brown, Christopher Bruce Howard, Christopher John De Bakker, Linda Alisson Ward, Jeanette Elizabeth Stok, Andrew Leigh James, Daniel Scott Lambert, Kylie Jane Ralston, Walter Rene Antonius Van Heumen
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Publication number: 20150274794Abstract: The invention relates generally to chaperonin 10 N-terminal variants. More specifically, the invention relates to chaperonin 10 N-terminal variants with enhanced immunomodulatory capacity and/or enhanced binding affinity for pathogen-associated molecular patterns (PAMPs) and/or damage-associated molecular patterns (PAMPs).Type: ApplicationFiled: January 13, 2015Publication date: October 1, 2015Inventors: Dean Jason NAYLOR, Richard James BROWN, Christopher Bruce HOWARD, Christopher John DE BAKKER, Jeanette Elizabeth STOK, Andrew Leigh JAMES, Daniel Scott LAMBERT, Kylie Jane RALSTON, Walter Rene Antonius VAN HEUMEN, Linda Allison WARD
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Patent number: 9079967Abstract: The present invention relates to isolated Chaperonin 10 polypeptides possessing immunomodulatory activity, but lacking, or substantially lacking, protein folding activity.Type: GrantFiled: August 19, 2013Date of Patent: July 14, 2015Assignee: Invion LimitedInventors: Dean Jason Taylor, Barbara Jane Johnson, Caroline Amanda Dobbin, Christopher Bruce Howard, Linda Allison Ward
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Patent number: 8933033Abstract: The invention relates generally to chaperonin 10 N-terminal variants. More specifically, the invention relates to chaperonin 10 N-terminal variants with enhanced immunomodulatory capacity and/or enhanced binding affinity for pathogen-associated molecular patterns (PAMPs) and/or damage-associated molecular patterns (DAMPs).Type: GrantFiled: October 8, 2010Date of Patent: January 13, 2015Assignee: CBio LimitedInventors: Dean Jason Naylor, Richard James Brown, Christopher Bruce Howard, Christopher John De Bakker, Jeanette Elizabeth Stok, Andrew Leigh James, Daniel Scott Lambert, Kylie Jane Ralston, Walter Rene Antonius Van Heumen, Linda Allison Ward
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Publication number: 20140093524Abstract: The present invention relates to isolated Chaperonin 10 polypeptides possessing immunomodulatory activity, but lacking, or substantially lacking, protein folding activity.Type: ApplicationFiled: August 19, 2013Publication date: April 3, 2014Applicant: INVION LimitedInventors: Dean Jason TAYLOR, Barbara Jane JOHNSON, Caroline Amanda Dobbin, Christopher Bruce HOWARD, Linda Allison WARD
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Patent number: 8513201Abstract: The present invention relates to isolated Chaperonin 10 polypeptides possessing immunomodulatory activity, but lacking, or substantially lacking, protein folding activity.Type: GrantFiled: June 7, 2011Date of Patent: August 20, 2013Assignee: Invion LimitedInventors: Dean Jason Naylor, Barbara Jane Johnson, Caroline Amanda Dobbin, Christopher Bruce Howard, Linda Allison Ward
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Publication number: 20120328635Abstract: The invention relates generally to chaperonin 10 N-terminal variants. More specifically, the invention relates to chaperonin 10 N-terminal variants with enhanced immunomodulatory capacity and/or enhanced binding affinity for pathogen-associated molecular patterns (PAMPs) and/or damage-associated molecular patterns (DAMPs).Type: ApplicationFiled: October 8, 2010Publication date: December 27, 2012Applicant: CBio LimitedInventors: Dean Jason Naylor, Richard James Brown, Christopher Bruce Howard, Christopher John De Bakker, Jeanette Elizabeth Stok, Andrew Leigh James, Daniel Scott Lambert, Kylie Jane Ralston, Walter Rene Antonius Van Heumen, Linda Allison Ward
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Publication number: 20120014998Abstract: The present invention relates to isolated Chaperonin 10 polypeptides possessing immunomodulatory activity, but lacking, or substantially lacking, protein folding activity.Type: ApplicationFiled: June 7, 2011Publication date: January 19, 2012Applicant: CBIO LIMITEDInventors: DEAN JASON NAYLOR, BARBARA JANE JOHNSON, CAROLINE AMANDA DOBBIN, CHRISTOPHER BRUCE HOWARD, LINDA ALLISON WARD
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Patent number: 7977458Abstract: A novel granule dispersion composition which comprises water and, dispersed therein, a finely pulverized, sparingly water-soluble substance. The granule dispersion composition is prepared by dispersing in water a granular material which comprises a specific substance sparingly soluble in water, a polymer, and an oil and has an average particle diameter of 1 ?m or smaller and in which the ratio of the total weight of the polymer and oil to the weight of the specific substance is 1.5 or higher.Type: GrantFiled: August 31, 2006Date of Patent: July 12, 2011Assignee: CBIO LimitedInventors: Dean Jason Naylor, Barbara Jane Johnson, Caroline Amanda Dobbin, Christopher Bruce Howard, Linda Allison Ward
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Patent number: 7951613Abstract: Methods of use of Chaperonin 10 (Cpn10) are provided for regulating Toll-like receptor signaling and/or Toll-like receptor inducible immunomodulator secretion. Cpn10 negatively regulates Toll-like receptor agonist-induced pro-inflammatory cytokine and chemokine secretion, examples being IL-6 and RANTES, respectively. Cpn10 positively regulates Toll-like receptor agonist-induced anti-inflammatory cytokine and chemokine secretion, an example being IL-10. These immunoregulatory activities of Cpn10 may be useful in the treatment of diseases, disorders and conditions resulting from excessive pro-inflammatory cytokine and chemokine secretion. This invention also relates to producing, designing and/or screening Cpn10 agonists and antagonists according to their ability to regulate Toll-like receptor signaling and/or Toll-like receptor inducible immunomodulator secretion.Type: GrantFiled: September 3, 2009Date of Patent: May 31, 2011Assignee: CBIO LimitedInventors: Barbara Jane Johnson, Andreas Suhrbier, Dean Jason Naylor, Caroline Amanda Dobbin, Christopher Bruce Howard
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Publication number: 20110082073Abstract: The present invention relates to isolated Cpn10 polypeptides possessing an increased affinity for a PRR ligand compared to Ala Cpn10 polypeptide. In a further embodiment, the present invention also relates to modified chaperonin 10 polypeptides, and to nucleic acids encoding the same and to compositions comprising such polypeptides and uses thereof.Type: ApplicationFiled: April 9, 2009Publication date: April 7, 2011Applicant: CBIO LIMITEDInventors: Dean Jason Naylor, Richard James Brown, Christopher Bruce Howard, Christopher John De Bakker, Linda Alisson Ward, Jeanette Elizabeth Stok, Andrew Leigh James, Daniel Scott Lambert, Kylie Jane Ralston, Walter Rene Antonius Van Heumen
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Publication number: 20090325882Abstract: Methods of use of Chaperonin 10 (Cpn10) are provided for regulating Toll-like receptor signaling and/or Toll-like receptor inducible immunomodulator secretion. Cpn10 negatively regulates Toll-like receptor agonist-induced pro-inflammatory cytokine and chemokine secretion, examples being IL-6 and RANTES, respectively. Cpn10 positively regulates Toll-like receptor agonist-induced anti-inflammatory cytokine and chemokine secretion, an example being IL-10. These immunoregulatory activities of Cpn10 may be useful in the treatment of diseases, disorders and conditions resulting from excessive pro-inflammatory cytokine and chemokine secretion. This invention also relates to producing, designing and/or screening Cpn10 agonists and antagonists according to their ability to regulate Toll-like receptor signaling and/or Toll-like receptor inducible immunomodulator secretion.Type: ApplicationFiled: September 3, 2009Publication date: December 31, 2009Applicant: CBIO LIMITEDInventors: BARBARA JANE JOHNSON, ANDREAS SUHRBIER, DEAN JASON NAYLOR, CAROLINE AMANDA DOBBIN, CHRISTOPHER BRUCE HOWARD
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Publication number: 20090305400Abstract: A novel granule dispersion composition which comprises water and, dispersed therein, a finely pulverized, sparingly water-soluble substance. The granule dispersion composition is prepared by dispersing in water a granular material which comprises a specific substance sparingly soluble in water, a polymer, and an oil and has an average particle diameter of 1 ?m or smaller and in which the ratio of the total weight of the polymer and oil to the weight of the specific substance is 1.5 or higher.Type: ApplicationFiled: August 31, 2006Publication date: December 10, 2009Inventors: Dean Jason Naylor, Barbara Jane Johnson, Caroline Amanda Dobbin, Christopher Bruce Howard, Linda Allison Ward