Patents by Inventor Christopher Bruce Howard

Christopher Bruce Howard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9234019
    Abstract: The present invention relates to isolated Cpn10 polypeptides possessing an increased affinity for a PRR ligand compared to Ala Cpn10 polypeptide. In a further embodiment, the present invention also relates to modified chaperonin 10 polypeptides, and to nucleic acids encoding the same and to compositions comprising such polypeptides and uses thereof.
    Type: Grant
    Filed: April 9, 2009
    Date of Patent: January 12, 2016
    Assignee: CBio Limited
    Inventors: Dean Jason Naylor, Richard James Brown, Christopher Bruce Howard, Christopher John De Bakker, Linda Alisson Ward, Jeanette Elizabeth Stok, Andrew Leigh James, Daniel Scott Lambert, Kylie Jane Ralston, Walter Rene Antonius Van Heumen
  • Publication number: 20150274794
    Abstract: The invention relates generally to chaperonin 10 N-terminal variants. More specifically, the invention relates to chaperonin 10 N-terminal variants with enhanced immunomodulatory capacity and/or enhanced binding affinity for pathogen-associated molecular patterns (PAMPs) and/or damage-associated molecular patterns (PAMPs).
    Type: Application
    Filed: January 13, 2015
    Publication date: October 1, 2015
    Inventors: Dean Jason NAYLOR, Richard James BROWN, Christopher Bruce HOWARD, Christopher John DE BAKKER, Jeanette Elizabeth STOK, Andrew Leigh JAMES, Daniel Scott LAMBERT, Kylie Jane RALSTON, Walter Rene Antonius VAN HEUMEN, Linda Allison WARD
  • Patent number: 9079967
    Abstract: The present invention relates to isolated Chaperonin 10 polypeptides possessing immunomodulatory activity, but lacking, or substantially lacking, protein folding activity.
    Type: Grant
    Filed: August 19, 2013
    Date of Patent: July 14, 2015
    Assignee: Invion Limited
    Inventors: Dean Jason Taylor, Barbara Jane Johnson, Caroline Amanda Dobbin, Christopher Bruce Howard, Linda Allison Ward
  • Patent number: 8933033
    Abstract: The invention relates generally to chaperonin 10 N-terminal variants. More specifically, the invention relates to chaperonin 10 N-terminal variants with enhanced immunomodulatory capacity and/or enhanced binding affinity for pathogen-associated molecular patterns (PAMPs) and/or damage-associated molecular patterns (DAMPs).
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: January 13, 2015
    Assignee: CBio Limited
    Inventors: Dean Jason Naylor, Richard James Brown, Christopher Bruce Howard, Christopher John De Bakker, Jeanette Elizabeth Stok, Andrew Leigh James, Daniel Scott Lambert, Kylie Jane Ralston, Walter Rene Antonius Van Heumen, Linda Allison Ward
  • Publication number: 20140093524
    Abstract: The present invention relates to isolated Chaperonin 10 polypeptides possessing immunomodulatory activity, but lacking, or substantially lacking, protein folding activity.
    Type: Application
    Filed: August 19, 2013
    Publication date: April 3, 2014
    Applicant: INVION Limited
    Inventors: Dean Jason TAYLOR, Barbara Jane JOHNSON, Caroline Amanda Dobbin, Christopher Bruce HOWARD, Linda Allison WARD
  • Patent number: 8513201
    Abstract: The present invention relates to isolated Chaperonin 10 polypeptides possessing immunomodulatory activity, but lacking, or substantially lacking, protein folding activity.
    Type: Grant
    Filed: June 7, 2011
    Date of Patent: August 20, 2013
    Assignee: Invion Limited
    Inventors: Dean Jason Naylor, Barbara Jane Johnson, Caroline Amanda Dobbin, Christopher Bruce Howard, Linda Allison Ward
  • Publication number: 20120328635
    Abstract: The invention relates generally to chaperonin 10 N-terminal variants. More specifically, the invention relates to chaperonin 10 N-terminal variants with enhanced immunomodulatory capacity and/or enhanced binding affinity for pathogen-associated molecular patterns (PAMPs) and/or damage-associated molecular patterns (DAMPs).
    Type: Application
    Filed: October 8, 2010
    Publication date: December 27, 2012
    Applicant: CBio Limited
    Inventors: Dean Jason Naylor, Richard James Brown, Christopher Bruce Howard, Christopher John De Bakker, Jeanette Elizabeth Stok, Andrew Leigh James, Daniel Scott Lambert, Kylie Jane Ralston, Walter Rene Antonius Van Heumen, Linda Allison Ward
  • Publication number: 20120014998
    Abstract: The present invention relates to isolated Chaperonin 10 polypeptides possessing immunomodulatory activity, but lacking, or substantially lacking, protein folding activity.
    Type: Application
    Filed: June 7, 2011
    Publication date: January 19, 2012
    Applicant: CBIO LIMITED
    Inventors: DEAN JASON NAYLOR, BARBARA JANE JOHNSON, CAROLINE AMANDA DOBBIN, CHRISTOPHER BRUCE HOWARD, LINDA ALLISON WARD
  • Patent number: 7977458
    Abstract: A novel granule dispersion composition which comprises water and, dispersed therein, a finely pulverized, sparingly water-soluble substance. The granule dispersion composition is prepared by dispersing in water a granular material which comprises a specific substance sparingly soluble in water, a polymer, and an oil and has an average particle diameter of 1 ?m or smaller and in which the ratio of the total weight of the polymer and oil to the weight of the specific substance is 1.5 or higher.
    Type: Grant
    Filed: August 31, 2006
    Date of Patent: July 12, 2011
    Assignee: CBIO Limited
    Inventors: Dean Jason Naylor, Barbara Jane Johnson, Caroline Amanda Dobbin, Christopher Bruce Howard, Linda Allison Ward
  • Patent number: 7951613
    Abstract: Methods of use of Chaperonin 10 (Cpn10) are provided for regulating Toll-like receptor signaling and/or Toll-like receptor inducible immunomodulator secretion. Cpn10 negatively regulates Toll-like receptor agonist-induced pro-inflammatory cytokine and chemokine secretion, examples being IL-6 and RANTES, respectively. Cpn10 positively regulates Toll-like receptor agonist-induced anti-inflammatory cytokine and chemokine secretion, an example being IL-10. These immunoregulatory activities of Cpn10 may be useful in the treatment of diseases, disorders and conditions resulting from excessive pro-inflammatory cytokine and chemokine secretion. This invention also relates to producing, designing and/or screening Cpn10 agonists and antagonists according to their ability to regulate Toll-like receptor signaling and/or Toll-like receptor inducible immunomodulator secretion.
    Type: Grant
    Filed: September 3, 2009
    Date of Patent: May 31, 2011
    Assignee: CBIO Limited
    Inventors: Barbara Jane Johnson, Andreas Suhrbier, Dean Jason Naylor, Caroline Amanda Dobbin, Christopher Bruce Howard
  • Publication number: 20110082073
    Abstract: The present invention relates to isolated Cpn10 polypeptides possessing an increased affinity for a PRR ligand compared to Ala Cpn10 polypeptide. In a further embodiment, the present invention also relates to modified chaperonin 10 polypeptides, and to nucleic acids encoding the same and to compositions comprising such polypeptides and uses thereof.
    Type: Application
    Filed: April 9, 2009
    Publication date: April 7, 2011
    Applicant: CBIO LIMITED
    Inventors: Dean Jason Naylor, Richard James Brown, Christopher Bruce Howard, Christopher John De Bakker, Linda Alisson Ward, Jeanette Elizabeth Stok, Andrew Leigh James, Daniel Scott Lambert, Kylie Jane Ralston, Walter Rene Antonius Van Heumen
  • Publication number: 20090325882
    Abstract: Methods of use of Chaperonin 10 (Cpn10) are provided for regulating Toll-like receptor signaling and/or Toll-like receptor inducible immunomodulator secretion. Cpn10 negatively regulates Toll-like receptor agonist-induced pro-inflammatory cytokine and chemokine secretion, examples being IL-6 and RANTES, respectively. Cpn10 positively regulates Toll-like receptor agonist-induced anti-inflammatory cytokine and chemokine secretion, an example being IL-10. These immunoregulatory activities of Cpn10 may be useful in the treatment of diseases, disorders and conditions resulting from excessive pro-inflammatory cytokine and chemokine secretion. This invention also relates to producing, designing and/or screening Cpn10 agonists and antagonists according to their ability to regulate Toll-like receptor signaling and/or Toll-like receptor inducible immunomodulator secretion.
    Type: Application
    Filed: September 3, 2009
    Publication date: December 31, 2009
    Applicant: CBIO LIMITED
    Inventors: BARBARA JANE JOHNSON, ANDREAS SUHRBIER, DEAN JASON NAYLOR, CAROLINE AMANDA DOBBIN, CHRISTOPHER BRUCE HOWARD
  • Publication number: 20090305400
    Abstract: A novel granule dispersion composition which comprises water and, dispersed therein, a finely pulverized, sparingly water-soluble substance. The granule dispersion composition is prepared by dispersing in water a granular material which comprises a specific substance sparingly soluble in water, a polymer, and an oil and has an average particle diameter of 1 ?m or smaller and in which the ratio of the total weight of the polymer and oil to the weight of the specific substance is 1.5 or higher.
    Type: Application
    Filed: August 31, 2006
    Publication date: December 10, 2009
    Inventors: Dean Jason Naylor, Barbara Jane Johnson, Caroline Amanda Dobbin, Christopher Bruce Howard, Linda Allison Ward