Patents by Inventor Christopher J. Chang

Christopher J. Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210238212
    Abstract: The electrochemical carbon dioxide reduction reaction (CO2RR) provides opportunities to synthesize value-added products from this greenhouse gas in a sustainable manner. Efficient catalysts for this reaction are provided that selectively drive CO2 reduction over the thermodynamic and kinetically competitive hydrogen evolution reaction (HER) in organic or aqueous electrolytes. The catalysts are metal-polypyridyl coordination complexes of a redox non-innocent terpyridine-based pentapyridine ligand and a first-row transition metal. The metal-ligand cooperativity in [Fe(tpyPY2Me)]2+ drives the electrochemical reduction of CO2 to CO at low overpotentials with high selectivity for CO2RR (>90%).
    Type: Application
    Filed: February 1, 2021
    Publication date: August 5, 2021
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jeffrey S. Derrick, Matthias Loipersberger, Jeffrey R. Long, Martin Head-Gordon, Christopher J. Chang
  • Patent number: 11078582
    Abstract: The present invention provides for a composition comprising a heterostructure capable of electrochemical CO reduction to a carbon-carbon product, comprising an inorganic material and a porous molecule.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: August 3, 2021
    Assignee: The Regents of the University of California
    Inventors: Christopher J Chang, Ming Gong, Zhi Cao, Wei Liu
  • Publication number: 20210230215
    Abstract: Proteins are labeled by contacting the protein with a thiophosphorodichloridate reagent under conditions to effect chemoselective histidine conjugation.
    Type: Application
    Filed: March 20, 2021
    Publication date: July 29, 2021
    Applicant: The Regents of the University of California
    Inventors: Christopher J. Chang, Shang Jia
  • Publication number: 20210155600
    Abstract: Chemoselective conjugation is achieved through redox reactivity by reacting an N-transfer oxidant with a thioether substrate in a redox reaction in an aqueous environment to form a conjugation product. In embodiments, Redox-Activated Chemical Tagging (ReACT) strategies for methionine-based protein functionalization. Oxaziridine (Ox) compounds serve as oxidant-mediated reagents for direct functionalization by converting methionine to the corresponding sulfimide conjugation product.
    Type: Application
    Filed: February 1, 2021
    Publication date: May 27, 2021
    Applicant: The Regents of the University of California
    Inventors: Christopher J. Chang, F. Dean Toste, Alec H. Christian, Patti Zhang
  • Publication number: 20210061842
    Abstract: The present disclosure provides puromycin-based probes, as well as compositions and kits comprising the probes. The present disclosure provides methods of detecting an analyte, and imaging methods, using the probes.
    Type: Application
    Filed: March 20, 2019
    Publication date: March 4, 2021
    Inventors: Christopher J. Chang, Yik Sham Clive Chung
  • Patent number: 10730892
    Abstract: Probes for formaldehyde (FA) including a homoallylamine trigger group attached to a detectable moiety are provided. Aspects of the probes include luminogenic or fluorogenic probes, such as a probe including a quencher in energy-receiving proximity to a fluorophore. Also provided are methods of using the probes for sensitive and bio orthogonal detection of FA in a sample. Aspects of the methods include selectively reacting the probe with the formaldehyde in the sample to a release (e.g., via a 2-aza-Cope rearrangement) a reporter group comprising a detectable moiety. Aspects of the methods detecting formaldehyde in a cell, tissue, organ or fluid in a subject. Also provided are compositions and kits including the subject probes that find use in practicing various embodiments of the subject methods.
    Type: Grant
    Filed: August 18, 2016
    Date of Patent: August 4, 2020
    Assignee: The Regents of the University of California
    Inventors: Christopher J. Chang, Thomas Francis Brewer, Jefferson Chan
  • Publication number: 20200113937
    Abstract: The present disclosure provides ionophore compounds, which are useful for facilitating delivery of a metal ion to a cell, tissue or organ of interest. The present disclosure provides compositions comprising the subject ionophore compounds. The present disclosure provides methods of delivering a metal ion intracellularly to a target cell. The present disclosure also provides methods of treating a condition associated with a metal deficiency in an individual.
    Type: Application
    Filed: October 7, 2019
    Publication date: April 16, 2020
    Inventors: Christopher J. Chang, Timothy Su, Marie Heffern
  • Patent number: 10605799
    Abstract: A method of selective detection of a concentration of a metal ion species in a subject is provided in which a biofluid sample is obtained from the subject. The biofluid sample is exposed to a functionalized porous aromatic polymer. The polymer selectively captures and concentrates the metal ion species from the biofluid. Subsequently, the biofluid is washed from the polymer. The polymer is then exposed to a solution comprising a colorimetric indicator that extracts the metal ion species from the washed polymer thereby changing a color of the solution as a function of an amount of the metal ion species in the polymer. The concentration of the metal ion species in the subject is then spectroscopically determined from the color of the solution.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: March 31, 2020
    Assignee: The Regents of The University of California
    Inventors: Christopher J. Chang, Jeffrey R. Long, Sumin Lee, Gokhan Barin
  • Publication number: 20190290784
    Abstract: The present disclosure features a condensation reaction and a luciferin-unmasking reaction that can be carried out under physiological conditions. In general, the condensation reaction involves reacting a bicyclic reactant with an aminothiol derivative, generating a luciferin or luciferin derivative. A luciferin can provide detectable luminescence. A luciferin derivative can be unmasked to provide detectable luminescence in a luciferin-unmasking reaction. The present disclosure provides bicyclic reactants and aminothiol derivatives suitable for use in the condensation reaction. The condensation and luciferin-unmasking reactions find use in a variety of applications, which are also provided.
    Type: Application
    Filed: June 13, 2019
    Publication date: September 26, 2019
    Inventors: Christopher J. Chang, Carolyn R. Bertozzi, Genevieve C. van de Bittner, Elena A. Dubikovskaya
  • Publication number: 20190257838
    Abstract: Chemoselective conjugation is achieved through redox reactivity by reacting an N-transfer oxidant with a thioether substrate in a redox reaction in an aqueous environment to form a conjugation product. In embodiments, Redox-Activated Chemical Tagging (ReACT) strategies for methionine-based protein functionalization. Oxaziridine (Ox) compounds serve as oxidant-mediated reagents for direct functionalization by converting methionine to the corresponding sulfimide conjugation product.
    Type: Application
    Filed: May 2, 2019
    Publication date: August 22, 2019
    Applicant: The Regents of the University of California
    Inventors: ShiXian Lin, XiaoYu Yang, F. Dean Toste, Christopher J. Chang
  • Patent number: 10328161
    Abstract: The present disclosure features a condensation reaction and a luciferin-unmasking reaction that can be carried out under physiological conditions. In general, the condensation reaction involves reacting a bicyclic reactant with an aminothiol derivative, generating a luciferin or luciferin derivative. A luciferin can provide detectable luminescence. A luciferin derivative can be unmasked to provide detectable luminescence in a luciferin-unmasking reaction. The present disclosure provides bicyclic reactants and aminothiol derivatives suitable for use in the condensation reaction. The condensation and luciferin-unmasking reactions find use in a variety of applications, which are also provided.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: June 25, 2019
    Assignee: The Regents of the University of California
    Inventors: Christopher J. Chang, Carolyn R. Bertozzi, Genevieve C. van de Bittner, Elena A. Dubikovskaya
  • Patent number: 10245330
    Abstract: The present disclosure provides compositions for in vivo imaging of hydrogen peroxide; and methods for detecting hydrogen peroxide in vivo. The compositions and methods find use in various diagnostic applications, which are also provided.
    Type: Grant
    Filed: July 5, 2017
    Date of Patent: April 2, 2019
    Assignee: The Regents of the University of California
    Inventors: Christopher J. Chang, Alexander R. Lippert
  • Publication number: 20190062936
    Abstract: The present invention provides for a composition comprising a heterostructure capable of electrochemical CO reduction to a carbon-carbon product, comprising an inorganic material and a porous molecule.
    Type: Application
    Filed: August 29, 2018
    Publication date: February 28, 2019
    Applicant: The Regents of the University of California
    Inventors: Christopher J. CHANG, Ming GONG, Zhi CAO, Wei LIU
  • Patent number: 10160980
    Abstract: This disclosure provides systems, methods, and apparatus related to artificial photosynthesis. In one aspect a system includes a photoanode chamber including a photoanode assembly, a photocathode chamber including a photocathode assembly, an electrical connection electrically connecting the photoanode assembly and the photocathode assembly, a membrane separating the photoanode chamber and the photocathode chamber, and a microorganism disposed in the photocathode chamber. The photoanode assembly is operable to oxidize water to generate oxygen, protons, and electrons. The membrane is permeable to the protons and operable to allow the protons to travel to the photocathode chamber. The electrical connection provides electrons to the photocathode assembly. The microorganism comprises a metabolic pathway to reduce carbon dioxide and to generate a carbon-based compound using the electrons or hydrogen formed by two protons.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: December 25, 2018
    Assignee: The Regents of the University of California
    Inventors: Peidong Yang, Michelle C. Y. Chang, Christopher J. Chang, Chong Liu, Joseph J. Gallagher, Eva M. Nichols
  • Publication number: 20180215773
    Abstract: Probes for formaldehyde (FA) including a homoallylamine trigger group attached to a detectable moiety are provided. Aspects of the probes include luminogenic or fluorogenic probes, such as a probe including a quencher in energy-receiving proximity to a fluroophore. Also provided are methods of using the probes for sensitive and bio orthogonal detection of FA in a sample. Aspects of the methods include selectively reacting the probe with the formaldehyde in the sample to a release (e.g., via a 2-aza-Cope rearrangement) a reporter group comprising a detectable moiety. Aspects of the methods detecting formaldehyde in a cell, tissue, organ or fluid in a subject. Also provided are compositions and kits including the subject probes that find use in practicing various embodiments of the subject methods.
    Type: Application
    Filed: August 18, 2016
    Publication date: August 2, 2018
    Inventors: Christopher J. Chang, Thomas Francis Brewer, Jefferson Chan
  • Publication number: 20180024112
    Abstract: A method of selective detection of a concentration of a metal ion species in a subject is provided in which a biofluid sample is obtained from the subject. The biofluid sample is exposed to a functionalized porous aromatic polymer. The polymer selectively captures and concentrates the metal ion species from the biofluid. Subsequently, the biofluid is washed from the polymer. The polymer is then exposed to a solution comprising a colorimetric indicator that extracts the metal ion species from the washed polymer thereby changing a color of the solution as a function of an amount of the metal ion species in the polymer. The concentration of the metal ion species in the subject is then spectroscopically determined from the color of the solution.
    Type: Application
    Filed: May 11, 2017
    Publication date: January 25, 2018
    Inventors: Christopher J. Chang, Jeffrey R. Long, Sumin Lee, Gokhan Barin
  • Publication number: 20170296681
    Abstract: The present disclosure provides compositions for in vivo imaging of hydrogen peroxide; and methods for detecting hydrogen peroxide in vivo. The compositions and methods find use in various diagnostic applications, which are also provided.
    Type: Application
    Filed: July 5, 2017
    Publication date: October 19, 2017
    Inventors: Christopher J. Chang, Alexander R. Lippert
  • Patent number: 9499916
    Abstract: New metal persulfido compositions of matter are described. In one embodiment the metal is molybdenum and the metal persulfido complex mimics the structure and function of the triangular active edge site fragments of MoS2, a material that is the current industry standard for petroleum hydro desulfurization, as well as a promising low-cost alternative to platinum for electrocatalytic hydrogen production. This molecular [(PY5W2)MoS2]x+ containing catalyst is capable of generating hydrogen from acidic-buffered water or even seawater at very low overpotentials at a turnover frequency rate in excess of 500 moles H2 per mole catalyst per second, with a turnover number (over a 20 hour period) of at least 19,000,000 moles H2 per mole of catalyst.
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: November 22, 2016
    Assignee: The Regents of the University of California
    Inventors: Jeffrey R. Long, Christopher J. Chang, Hemamala I. Karunadasa, Marcin Majda
  • Publication number: 20160264920
    Abstract: This disclosure provides systems, methods, and apparatus related to artificial photosynthesis. In one aspect a system includes a photoanode chamber including a photoanode assembly, a photocathode chamber including a photocathode assembly, an electrical connection electrically connecting the photoanode assembly and the photocathode assembly, a membrane separating the photoanode chamber and the photocathode chamber, and a microorganism disposed in the photocathode chamber. The photoanode assembly is operable to oxidize water to generate oxygen, protons, and electrons. The membrane is permeable to the protons and operable to allow the protons to travel to the photocathode chamber. The electrical connection provides electrons to the photocathode assembly. The microorganism comprises a metabolic pathway to reduce carbon dioxide and to generate a carbon-based compound using the electrons or hydrogen formed by two protons.
    Type: Application
    Filed: March 4, 2016
    Publication date: September 15, 2016
    Inventors: Peidong Yang, Michelle C.Y. Chang, Christopher J. Chang, Chong Liu, Joseph J. Gallagher, Eva M. Nichols
  • Patent number: 9329191
    Abstract: Carbon monoxide (CO) is a member of the gasotransmitter family that includes NO and H2S and is implicated in a variety of pathological and physiological conditions. Whereas exogenous therapeutic additions of CO to tissues and whole animals have been well studied, the real-time spatial and temporal tracking of CO at the cellular level remains an open challenge. We now report a new type of turn-on fluorescent probe for selective CO detection by exploiting palladium-mediated carbonylation reactivity. The compounds of the invention are capable of detecting CO both in aqueous buffer and in live cells with high selectivity over a range of biologically relevant reactive small molecules, providing a potentially powerful approach for interrogating its chemistry in biological systems.
    Type: Grant
    Filed: August 26, 2013
    Date of Patent: May 3, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Christopher J. Chang, Brian William Michel