Patents by Inventor Christopher J. Myatt
Christopher J. Myatt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9658222Abstract: A cartridge for processing a sample includes (a) a planar waveguide with upper and lower planar surfaces defining an optical axis therebetween, wherein the upper planar surface has a plurality of capture molecules bound thereto, (b) a lens portion, coupled to the planar waveguide, for focusing and refracting a light beam propagating parallel to, but offset from, the optical axis such that the light beam couples into the planar waveguide and propagates therein along the optical axis at a non-zero, internal propagation angle ? relative to the upper planar surface, and (c) a sample chamber for positioning the sample in contact with the plurality of capture molecules such that a target analyte of the sample is detectable through (i) an assay involving the target analyte and the capture molecules and (ii) evanescent illumination of the assay using the light beam within the planar waveguide.Type: GrantFiled: December 14, 2015Date of Patent: May 23, 2017Assignee: Mbio Diagnostics, Inc.Inventors: Kevin D. Moll, Kurt R. Vogel, Marie J. Delaney, Michael J. Lochhead, Christopher J. Myatt
-
Publication number: 20160187333Abstract: A cartridge for processing a sample includes (a) a planar waveguide with upper and lower planar surfaces defining an optical axis therebetween, wherein the upper planar surface has a plurality of capture molecules bound thereto, (b) a lens portion, coupled to the planar waveguide, for focusing and refracting a light beam propagating parallel to, but offset from, the optical axis such that the light beam couples into the planar waveguide and propagates therein along the optical axis at a non-zero, internal propagation angle ? relative to the upper planar surface, and (c) a sample chamber for positioning the sample in contact with the plurality of capture molecules such that a target analyte of the sample is detectable through (i) an assay involving the target analyte and the capture molecules and (ii) evanescent illumination of the assay using the light beam within the planar waveguide.Type: ApplicationFiled: December 14, 2015Publication date: June 30, 2016Inventors: Kevin D. Moll, Kurt R. Vogel, Marie J. Delaney, Michael J. Lochhead, Christopher J. Myatt
-
Patent number: 9212995Abstract: A rapid diagnostic system that delivers a panel of serologic assay results using a small amount of blood, serum, or plasma is described. The system includes a disposable cartridge, including an integral lens portion coupled to a planar waveguide, and a reader instrument, based on planar waveguide imaging technology. The cartridge incorporates a microarray of recombinant antigens and antibody controls in a fluidic channel, providing multiple parallel fluorescence assay results for a single sample.Type: GrantFiled: March 15, 2013Date of Patent: December 15, 2015Assignee: MBio Diagnostics, Inc.Inventors: Kevin D. Moll, Kurt R. Vogel, Marie J. Delaney, Michael J. Lochhead, Christopher J. Myatt, Keagan B. Rowley
-
Publication number: 20150355178Abstract: The present disclosure pertains to detection of biomarkers in a sample. More particularly, the disclosure relates to methods for treating the sample to liberate certain analytes prior to the assay. Composition for disrupting the HIV virus and antibody-antigen complex to release p24 antigen is also disclosed. The disclosed methods and compositions are compatible with existing HIV antigen/antibody combination assays and improve the sensitivity of such assays.Type: ApplicationFiled: September 4, 2013Publication date: December 10, 2015Inventors: Christopher J. Myatt, Daniel T. Nieuwlandt, Gregory McLintock Husar, Charles H. Greef
-
Patent number: 8697435Abstract: A system for sample preparation and analyte detection includes a cartridge, with a fluidic channel, a waveguide, and a capture spot. The system further includes a force field generator, an imaging system, and a fluid, which includes a sample potentially containing a target analyte, first type particles, which include binding moieties specific for the target analyte and are responsive to a force field, and second type particles, which include binding moieties specific for the target analyte and are capable of generating a signal. When the sample contains the target analyte, specific binding interactions between the target analyte and binding moieties link first and second type particles via the target analyte to form multiple-particle complex capturable at a capture spot. The force field allows manipulation of the particles and multiple-particle complex such that the detected signal from the second type particles is indicative of the target analyte within the sample.Type: GrantFiled: August 30, 2010Date of Patent: April 15, 2014Assignee: MBio Diagnostics, Inc.Inventors: James R. Heil, Michael J. Lochhead, Kevin D. Moll, Christopher J. Myatt
-
Patent number: 8586347Abstract: A rapid diagnostic system that delivers a panel of serologic assay results using a small amount of blood, serum, or plasma is described. The system includes a disposable cartridge and a reader instrument, based on planar waveguide imaging technology. The cartridge incorporates a microarray of recombinant antigens and antibody controls in a fluidic channel, providing multiple parallel fluorescence assay results for a single sample.Type: GrantFiled: September 15, 2011Date of Patent: November 19, 2013Assignee: MBio Diagnostics, Inc.Inventors: Michael J. Lochhead, Jeffrey Ives, Kathryn Todorof, Charles Greef, Marie J. Delaney, Kevin D. Moll, Kurt R. Vogel, Keagan B. Rowley, Evelyn S. Woodruff, John S. Dunn, Christopher J. Myatt, Daniel T. Nieuwlandt
-
Patent number: 8300993Abstract: A sample can be illuminated for analysis using apparatus including a light source, a planar waveguide, and a refractive volume. The light source provides light along a propagation vector. The planar waveguide is oriented such that the propagation vector is perpendicular to the normal vector of the planar waveguide and offset from the planar waveguide in a direction parallel to the normal vector of the planar waveguide. The refractive volume is positioned proximate to the planar waveguide and can optically coupling light provided by the light source to the planar waveguide.Type: GrantFiled: November 12, 2009Date of Patent: October 30, 2012Assignee: MBio Diagnostics, Inc.Inventors: Kevin D. Moll, Kurt R. Vogel, Marie J. Delaney, Michael J. Lochhead, Christopher J. Myatt
-
Publication number: 20120088230Abstract: A system for enumeration of objects such as cells in a sample is disclosed. The system uses a low-cost cartridge and a reader instrument, based on planar waveguide imaging technology. Cells of a blood sample may be stained with fluorescence-tagged antibodies and are loaded onto the cartridge where the differentially labeled cells may be distinguished and quantified.Type: ApplicationFiled: October 11, 2011Publication date: April 12, 2012Inventors: Monique Givens, Jeffrey Ives, Michael J. Lochhead, Marie J. Delaney, Kevin D. Moll, Keagan B. Rowley, Kurt R. Vogel, Christopher J. Myatt
-
Publication number: 20120071342Abstract: A rapid diagnostic system that delivers a panel of serologic assay results using a small amount of blood, serum, or plasma is described. The system includes a disposable cartridge and a reader instrument, based on planar waveguide imaging technology. The cartridge incorporates a microarray of recombinant antigens and antibody controls in a fluidic channel, providing multiple parallel fluorescence assay results for a single sample.Type: ApplicationFiled: September 15, 2011Publication date: March 22, 2012Applicant: MBIO DIAGNOSTICS, INC.Inventors: Michael J. Lochhead, Jeffrey Ives, Kathryn Todorof, Charles Greef, Marie J. Delaney, Kevin D. Moll, Kurt R. Vogel, Keagan B. Rowley, Evelyn S. Woodruff, John S. Dunn, Christopher J. Myatt, Daniel T. Nieuwlandt
-
Publication number: 20110065209Abstract: A system for sample preparation and analyte detection includes a cartridge, with a fluidic channel, a waveguide, and a capture spot. The system further includes a force field generator, an imaging system, and a fluid, which includes a sample potentially containing a target analyte, first type particles, which include binding moieties specific for the target analyte and are responsive to a force field, and second type particles, which include binding moieties specific for the target analyte and are capable of generating a signal. When the sample contains the target analyte, specific binding interactions between the target analyte and binding moieties link first and second type particles via the target analyte to form multiple-particle complex capturable at a capture spot. The force field allows manipulation of the particles and multiple-particle complex such that the detected signal from the second type particles is indicative of the target analyte within the sample.Type: ApplicationFiled: August 30, 2010Publication date: March 17, 2011Applicant: mBio Diagnostics, Inc.Inventors: James R. Heil, Michael J. Lochhead, Kevin D. Moll, Christopher J. Myatt
-
Publication number: 20110012026Abstract: An apparatus for illuminating a sample includes a planar waveguide. The planar waveguide includes a first substrate, including a first outer surface and a first inner surface, and a second substrate, including a second outer surface and a second inner surface. The first and second inner surfaces of the first and second substrates, respectively, are spaced apart from each other and partly define a volume for confining the sample therein. The apparatus also includes a light source for providing light directed toward the planar waveguide, such that the light is optically coupled to and contained within the planar waveguide between the outer surfaces of the first and second substrates, while illuminating at least a portion of the sample confined within the volume.Type: ApplicationFiled: September 16, 2010Publication date: January 20, 2011Applicant: MBIO DIAGNOSTICS, INC.Inventors: Kevin D. Moll, Kurt R. Vogel, Marie J. Delaney, Michael J. Lochhead, Christopher J. Myatt
-
Publication number: 20100284430Abstract: Systems, methods, circuits and/or devices for generating high repetition rate ultra-short pulses are described. As one of many examples, an optical pulse generating laser system is described that produces mode-locked optical pulses. The laser system incorporates an optical pulse generation device that includes two optical loops coupled via a beam splitter. In addition, the optical pulse generation device includes an optical gain medium that is associated with the first optical loop, and a saturable element that is disposed in either the first optical loop or the second optical loop. The saturable element is operable to modulate a group of optical pulses propagating in at least one of the first optical loop and the second optical loop to create a group of substantially regular modulated pulses.Type: ApplicationFiled: February 8, 2008Publication date: November 11, 2010Applicant: Precision Photonics CorporationInventors: Jacob Lasri, Kurt R. Vogel, Neil R. Claussen, Christopher J. Myatt
-
Publication number: 20090294051Abstract: A method of assembling precision optical or optomechanical components of otherwise incompatible chemistry that provides first and second components having respective first and second polished contacting surfaces to be bonded; deposits a thin film dielectric coating at the surface of the first and or second polished surface, and contacts the coated portion of the first or second components with the respective contacting surfaces to be bonded, while maintaining alignment of the two components, to form a single structure.Type: ApplicationFiled: April 29, 2009Publication date: December 3, 2009Applicant: Precision Photonics CorporationInventors: Nick Traggis, Neil R. Claussen, Ove Lyngnes, Christopher J. Myatt
-
Publication number: 20090294017Abstract: A method of assembling precision optical or optomechanical components of otherwise incompatible chemistry that provides first and second components having respective first and second polished contacting surfaces to be bonded; deposits a thin film dielectric coating at the surface of the first and or second polished surface, and contacts the coated portion of the first or second components with the respective contacting surfaces to be bonded, while maintaining alignment of the two components, to form a single structure.Type: ApplicationFiled: November 3, 2008Publication date: December 3, 2009Applicant: Precision Photonics CorporationInventors: Nick Traggis, Neil R. Claussen, Ove Lyngnes, Christopher J. Myatt
-
Publication number: 20090294050Abstract: This invention is a method of assembling precision optical or optomechanical components that provides first and second components having respective first and second polished contacting surfaces to be bonded; generates a hydrophilic surface on at least a portion of at least one of the first or second surfaces; rinses the hydrophilic portion with water or another suitable solvent; and contacts the hydrophilic portion of the first or second components with the respective contacting surfaces to be bonded, while maintaining alignment of the two components, to form a single structureType: ApplicationFiled: September 19, 2008Publication date: December 3, 2009Applicant: PRECISION PHOTONICS CORPORATIONInventors: Nick Traggis, Christopher J. Myatt
-
Patent number: 6870629Abstract: The invention allows for the accurate, real-time readout of the optical frequency of a swept-wavelength laser device by counting the number of fringes of a calibrated etalon that occur as the laser is swept. The distinguishing feature of the present invention is that the etalon fringe signal is phase-locked to a slave signal of a higher multiple frequency. The higher frequency of the slave signal divides the frequency interval of the etalon fringe spacing by the additional frequency multiple. The slave signal therefore generates a scale for optical frequency that is of higher resolution than possible with the etalon alone. The phase-lock also insures that the slave signal tracks monotonic scans of the optical frequency regardless of scan profile. The invention also allows for the precise, real-time control of the optical frequency of a laser during the sweep of the laser.Type: GrantFiled: October 29, 2002Date of Patent: March 22, 2005Assignee: Precision Photonics CorporationInventors: Kurt R. Vogel, Timothy P. Dinneen, Michael E. Deeds, Jason R. Ensher, Christopher J. Myatt
-
Publication number: 20030035120Abstract: The invention describes devices and methods for determining the wavelength of coherent optical radiation such as is emitted from a laser source. The apparatus is monolithic with no moving parts and consists of optical components that generate signal periodic in the optical frequency of the coherent radiation detected by the component. Each optical component generates a signal with a different period. Differences between the periods of the signals generated by the optical frequency-dependent optical components provides a means of measuring optical wavelengths over a range far exceeding the free spectral range limitations of conventional interferometers. The method of the present invention allows for measurement of optical frequency with an uncertainty of much less than the period of the optical frequency-dependent optical components forming the apparatus.Type: ApplicationFiled: April 10, 2002Publication date: February 20, 2003Inventors: Christopher J. Myatt, Kurt R. Vogel, Tim Dinneen, Jason R. Ensher