Abstract: The invention provides compounds that degrade the epidermal growth factor receptor (EGFR) including mutant forms via the ubiquitination of the EGFR protein and subsequent proteasomal degradation. The compounds are useful for the treatment of various cancers.

Abstract: This disclosure relates to various systems and methods related to preventative laser-based treatment of a dental tissue; for example, to prevent a patient from forming cavities. In some instances, a laser-based treatment system can generate a laser beam pulse with a fluence profile at a treatment site that results in either an increase in acid resistance of the tissue or removal of carbonate from the tissue, without melting or ablating the tissue. In some instances, the laser-based treatment system can direct the laser beam to various locations within a treatment site according to a temporal and/or spatial pattern, that results in either an increase in acid resistance of the tissue or removal of carbonate from the tissue, without melting or ablating the tissue. Many other systems and techniques for preventative and other laser-based treatment are also described.

Abstract: This disclosure relates to various systems and methods related to preventative laser-based treatment of a dental tissue; for example, to prevent a patient from forming cavities. In some instances, a laser-based treatment system can generate a laser beam pulse with a fluence profile at a treatment site that results in either an increase in acid resistance of the tissue or removal of carbonate from the tissue, without melting or ablating the tissue. In some instances, the laser-based treatment system can direct the laser beam to various locations within a treatment site according to a temporal and/or spatial pattern, that results in either an increase in acid resistance of the tissue or removal of carbonate from the tissue, without melting or ablating the tissue. Many other systems and techniques for preventative and other laser-based treatment are also described.

Abstract: A scalable software application or platform for interfacing an organization or partner comprising multiple entities or business units to a job screening system for generating a grade or score for a candidate or job applicant for one or more of the entities. According to an embodiment, the software application comprises an Application Programming Interface (API) configured to interface an organization or a partner, for instance, a whitelist customer, comprising a plurality of entities or business units to a job screening system. According to an embodiment, the Application Programming Interface comprises a companies API endpoint, a jobs API endpoint, an applications API endpoint and an authentication API endpoint. The API is configured to provide an organization or partner level integration level with the job screening system for the companies or entities associated with the organization or partner.

Abstract: A computer system, computer program product and computer-implemented method for generating job recommendations for one or more candidates or applicants. The system is configured to generate a candidate, e.g. prospective candidate, vector comprising embedded data or information associated with the candidate. The prospective candidate vector is compared to vectors with embedded data for other applicants to match the prospective candidate with past applicants or candidates and generate a list of past applicants and/or the jobs applied for by the past applicants, and to generate a job title vector comprising the job titles. According to an exemplary implementation, the system is configured to generate a baseline recommendation utilizing the job title vector and comprising a plurality of open jobs with a ranking or score for the prospective candidate. According to another aspect, the system is configured to re-rank the open jobs and the recommendation based on additional data and/or weighting factors.

Abstract: Methods and systems for a heads-up configurable vehicle dash display are provided. Specifically, a configurable dash may comprise one or more displays that are capable of receiving input from a user. At least one of these displays may be configured to present a plurality of custom applications that, when manipulated by at least one user, are adapted to control and/or monitor functions associated with a vehicle and/or associated peripheral devices. It is anticipated that the function and appearance of the plurality of custom applications may be altered via user and/or processor input.

Abstract: A system for an improved control of data stream management in a vehicle, said system comprising: a media controller; a processor; a storage element coupled to the processor; encoded instructions; wherein the system is configured to: select at least a first input/output system to receive a packet payload by the media controller; determine an applicable rule set governing a destination input/output system and payload type; determine a current input/output system configuration; determine whether the payload can be provided to each of the destination input/output systems; detect a stimulus indicating that caching of media is to be performed; selectively cache the payload from the destination input/output system for future playback for an operator at the first destination input/output system or at another operator-specific input/output system by the media controller; and wherein the selective caching for future playback on operator-specific input/output system results in improved vehicular data stream management.

Abstract: This disclosure relates to various systems and methods related to preventative laser-based treatment of a dental tissue; for example, to prevent a patient from forming cavities. In some instances, a laser-based treatment system can generate a laser beam pulse with a fluence profile at a treatment site that results in either an increase in acid resistance of the tissue or removal of carbonate from the tissue, without melting or ablating the tissue. In some instances, the laser-based treatment system can direct the laser beam to various locations within a treatment site according to a temporal and/or spatial pattern, that results in either an increase in acid resistance of the tissue or removal of carbonate from the tissue, without melting or ablating the tissue. Many other systems and techniques for preventative and other laser-based treatment are also described.

Abstract: A computer system and computer-implemented method for screening potential candidates for an employment position or other role or function based in-part on historical data or information associated with the hiring and/or dismissal of one or more candidates.

Abstract: A computer system and computer-implemented method for screening potential candidates for an employment position or other role or function wherein the employment position is categorized according to one or more pre-determined job buckets.

Abstract: A system or method for reconfiguring (dynamically) a vehicle display may comprise: a Graphical User Interface (“GUI”) including a first display area; an input gesture area of the first display area; a HUD unit; a non-transitory computer readable medium having instructions stored thereon that, when executed by a processor, configure the system to: (1) display, at a first time, a configuration area to a portion of the GUI, wherein the configuration area includes at least one of a vehicle dash information, readouts, instruments, indicators, or controls arranged as a visual representation of a virtual dash display for the HUD unit; (2) receive a gesture input at the GUI, wherein the gesture input corresponds to an instruction to reconfigure at least one of a layout, size, position, features, instruments, indicators, color schemes, or controls for display on at least one of an above a vehicle dash by the HUD unit, a reconfigurable dash display, a reconfigurable console display, or a reconfigurable user device disp

Abstract: Methods and systems are presented for accepting inputs into a vehicle or other conveyance to control functions of the conveyance. A vehicle control system can receive gestures and other inputs. The vehicle control system can also obtain information about the user of the vehicle control system and information about the environment in which the conveyance is operating. Based on the input and the other information, the vehicle control system can modify or improve the performance or execution of user interface and functions of the conveyance. The changes make the user interfaces and/or functions user-friendly and intuitive.

Abstract: A method and system of providing zone-specific control of one or more of features of at least one communication device by a vehicle, the system comprising: a microprocessor executable feature control module connected with at least communication device (connected device), wherein the feature control module is configured to receive input from at least one of a sensor of the communication device or specific zone/s to locate the at least one communication device with respect to the zone/s; at least one of the feature control module or device location module determining for the at least one connected device, the specific zone associated with the at least one connected device, wherein the specific zone is labeled with a rule or condition for degree of restriction of one or more features of the at least one connected device; and the feature control module limiting access or control of one or more features of the at least one connected device based on the rules or conditions assigned to the determined zone, wherein t

Abstract: A method and system for diagnosing and communicating events associated with one or more components of vehicle is described. In general, a vehicle may provide information regarding its recorded and/or monitored system and component states via a self-diagnostic and/or reporting capability.

Abstract: A system for an improved control of data stream management in a vehicle, said system comprising: a media controller; a processor; a storage element coupled to the processor; encoded instructions; wherein the system is configured to: select at least a first input/output system to receive a packet payload by the media controller; determine an applicable rule set governing a destination input/output system and payload type; determine a current input/output system configuration; determine whether the payload can be provided to each of the destination input/output systems; detect a stimulus indicating that caching of media is to be performed; selectively cache the payload from the destination input/output system for future playback for an operator at the first destination input/output system or at another operator-specific input/output system by the media controller; and wherein the selective caching for future playback on operator-specific input/output system results in improved vehicular data stream management.

Abstract: A method for map updating in a conveyance, said method comprising the steps of: collecting information as it relates to at least one of a road and traffic condition, road position, lane number, or time stamp at a marker from at least one of fixed roadside signal or a data collection module; aggregating with with at least one of a vehicle reading collected for at least one of a first vehicle as it relates to at least one of mapped location, route information, vehicle operator information, vehicle performance, time of operation, route information, duration of route; generating a roadway map comprises information regarding a traffic level along a selected roadway and wherein the map updating module uses the deviations to identify an alternative travel route between the first and second locations (updated roadway map); and delivering at least one of an updated report or updated roadway map to at least the first vehicle.

Abstract: The vehicle control system/method for adapting a control function based on a user profile may comprise: a gesture recognition module; a user profile module; a function control module; a processor; a non-transitory storage element coupled to the processor; encoded instructions stored in the non-transitory storage element, wherein the encoded instructions when implemented by the processor, configure the system to: identify a user; retrieve a user profile for the identified user; receive at a gesture recognition module, an input indicating a gesture from the user; identify a control function request corresponding to the gesture input; send a verification of the control function request; and receive at a function control module characteristics parsed from the user profile that effect the control function request by the user profile module to adapt a control function command for an adapted control function output by the function control module.

Abstract: A system/method adapted to aggregate vehicle or operator data for reconstructing a road event for authority purposes, said system comprising: a storage device with stored data (information) collected from an aggregating device (controller) in communication with at least one of various sensors, data capturing means, image capturing means, or metrics; a reporting module that evaluates collected information stored in the storage device to determine a driving behavior of a driver associated with the vehicle, and determine whether the driving behavior includes one or more triggering events that are one or more of operator-defined or authority-defined for communication to at least one of an authority source; a communication module enabling querying for at least one of said information by at least one of an authority source for reconstructing the road event of interest upon a threshold-grade road event triggered and relaying the reconstructed road event to at least one of an authority source for at least one of the

Abstract: Methods and systems for a heads-up configurable vehicle dash display are provided. Specifically, a configurable dash may comprise one or more displays that are capable of receiving input from a user. At least one of these displays may be configured to present a plurality of custom applications that, when manipulated by at least one user, are adapted to control and/or monitor functions associated with a vehicle and/or associated peripheral devices. It is anticipated that the function and appearance of the plurality of custom applications may be altered via user and/or processor input.

Abstract: In one configuration, a method includes a a method for dynamic or predictive fleet-wide operations, said method comprising the steps of: receiving vehicle state data from each operative and occupied vehicle in a fleet of vehicles, the vehicle state data comprising a plurality of parameters; receiving calendar event data and a supplemental factor data from a user device paired to a vehicle control center of said each operative and occupied vehicle in said fleet of vehicles; aggregating the vehicle state data, calendar event data, and the supplemental factor data associated with said each operative and occupied vehicle in said fleet of vehicles to produce aggregate operational and occupant data; and determining a trend in said aggregate operational and occupant data between data associated with one and data associated with another operative and occupied vehicle in said fleet of vehicles; and wherein the trend informs an action that relates to at least one of dynamic or predictive fleet-wide operation, including