Patents by Inventor Christopher T. Culbertson
Christopher T. Culbertson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11965881Abstract: Methods and devices for microfluidic detection of a biological maker in a biospecimen collected from a subject are disclosed. The microfluidic devices include nanoparticle-based nanosensors comprising supramolecular recognition sequences, protease consensus sequences, post-translationally modifiable sequences, or sterically hindered benzylether bonds for specific interaction with a biological marker. Also disclosed are particular nanosensors for detecting cytokines, and other proteins based upon supramolecular recognition without chemical modification or enzymatic cleavage.Type: GrantFiled: March 24, 2017Date of Patent: April 23, 2024Assignees: Kansas State University Research Foundation, Board of Regents of The University of Texas SystemInventors: Massoud Motamedi, Allan R. Brasier, Stefan H. Bossmann, Christopher T. Culbertson, Deryl Troyer
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Patent number: 11923062Abstract: Various aspects described herein relate to presenting drug dispensing information. Data related to a plurality of dispensing events initiated by one or more employees, of an electronic drug dispensing system can be received. A set of dispensing events of the plurality of dispensing events can be determined as constituting possible misappropriation of drugs by the one or more employees. An alert related to the set of dispensing events can be provided based on determining that the set of dispensing events constitute possible misappropriation of drugs.Type: GrantFiled: February 22, 2023Date of Patent: March 5, 2024Assignee: Protenus, Inc.Inventors: Nicholas T. Culbertson, Robert K. Lord, Christopher David Jeschke, Cosme Adrover
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Patent number: 11318470Abstract: Microfluidic devices and nanobiosensors comprising a magnetic nanoparticle attached to a reporter molecule via a release unit for microfluidic-based detection of a target analyte in a biological sample. The nanobiosensors can be magnetically manipulated or guided through the microfluidics channels for incubation with the biological sample, concentration of the nanobiosensors, and detection of target analytes, without having to pump the entire initial sample through a microfluidic channel of the microfluidic device. The magnetic nanoparticles are separated from the reporter molecules before detection and can be re-used.Type: GrantFiled: November 17, 2017Date of Patent: May 3, 2022Assignee: Kansas State University Research FoundationInventors: Christopher T. Culbertson, Stefan H. Bossmann
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Publication number: 20200300849Abstract: Methods and devices for microfluidic detection of a biological maker in a biospecimen collected from a subject are disclosed. The microfluidic devices include nanoparticle-based nanosensors comprising supramolecular recognition sequences, protease consensus sequences, post-translationally modifiable sequences, or sterically hindered benzylether bonds for specific interaction with a biological marker. Also disclosed are particular nanosensors for detecting cytokines, and other proteins based upon supramolecular recognition without chemical modification or enzymatic cleavage.Type: ApplicationFiled: March 24, 2017Publication date: September 24, 2020Inventors: Massoud Motamedi, Allan R. Brasier, Stefan H. Bossmann, Christopher T. Culbertson, Deryl Troyer
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Publication number: 20190351416Abstract: Microfluidic devices and nanobiosensors comprising a magnetic nanoparticle attached to a reporter molecule via a release unit for microfluidic-based detection of a target analyte in a biological sample. The nanobiosensor can be magnetically manipulated or guided through the microfluidics channels for incubation with the biological sample, concentration of the nanobiosensors, and detection of target analytes, without having to pump the entire initial sample through the microfluidic channel. The magnetic nanoparticles are separated from the reporter molecules before detection and can be re-used.Type: ApplicationFiled: November 17, 2017Publication date: November 21, 2019Inventors: Christopher T. Culbertson, Stefan H. Bossmann
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Publication number: 20120273702Abstract: Disclosed are electroactive polymer actuators and their use on microfluidic devices. Such actuators can comprise an electrode, an electroactive polymer, and a fluid-conducting channel. The electroactive polymer can be at least partially disposed between the electrode and the fluid-conducting channel. Furthermore, methods for creating a hydrodynamic force in a microfluidic device are disclosed by creating a potential difference across an electroactive polymer disposed on the microfluidic device.Type: ApplicationFiled: April 19, 2010Publication date: November 1, 2012Applicant: KANSAS STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Christopher T. Culbertson, Alexander K. Price
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Patent number: 8083915Abstract: A microfabricated device employing a bridging membrane and methods for electrokinetic transport of a liquid phase biological or chemical material using the same are described. The bridging membrane is deployed in or adjacent to a microchannel and permits either ionic current flow or the transport of gas species, while inhibiting the bulk flow of material. The use of bridging membranes in accordance with this invention is applicable to a variety of processes, including electrokinetically induced pressure flow in a region of a microchannel that is not influenced by an electric field, sample concentration enhancement and injection, as well as improving the analysis of materials where it is desired to eliminate electrophoretic bias. Other applications of the bridging membranes according to this invention include the separation of species from a sample material, valving of fluids in a microchannel network, mixing of different materials in a microchannel, and the pumping of fluids.Type: GrantFiled: October 19, 2007Date of Patent: December 27, 2011Assignee: UT-Battelle, LLCInventors: Stephen C. Jacobson, J. Michael Ramsey, Christopher T. Culbertson, William B. Whitten, Robert S. Foote
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Patent number: 7931790Abstract: A microfabricated device employing a bridging membrane and methods for electrokinetic transport of a liquid phase biological or chemical material using the same are described. The bridging membrane is deployed in or adjacent to a microchannel and permits either ionic current flow or the transport of gas species, while inhibiting the bulk flow of material. The use of bridging membranes in accordance with this invention is applicable to a variety of processes, including electrokinetically induced pressure flow in a region of a microehannel that is not influenced by an electric field, sample concentration enhancement and injection, as well as improving the analysis of materials where it is desired to eliminate electrophoretic bias. Other applications of the bridging membranes according to this invention include the separation of species from a sample material, valving of fluids in a microchannel network, mixing of different materials in a microchannel, and the pumping of fluids.Type: GrantFiled: October 19, 2007Date of Patent: April 26, 2011Assignee: UT-Battelle, LLCInventors: Stephen C. Jacobson, J. Michael Ramsey, Christopher T. Culbertson, William B. Whitten, Robert S. Foote
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Patent number: 7909973Abstract: A microfabricated device employing a bridging membrane and methods for electrokinetic transport of a liquid phase biological or chemical material using the same are described. The bridging membrane is deployed in or adjacent to a microchannel and permits either ionic current flow or the transport of gas species, while inhibiting the bulk flow of material. The use of bridging membranes in accordance with this invention is applicable to a variety of processes, including electrokinetically induced pressure flow in a region of a microchannel that is not influenced by an electric field, sample concentration enhancement and injection, as well as improving the analysis of materials where it is desired to eliminate electrophoretic bias. Other applications of the bridging membranes according to this invention include the separation of species from a sample material, valving of fluids in a microchannel network, mixing of different materials in a microchannel, and the pumping of fluids.Type: GrantFiled: October 19, 2007Date of Patent: March 22, 2011Assignee: UT-Battelle, LLCInventors: Stephen C. Jacobson, J. Michael Ramsey, Christopher T. Culbertson, William B. Whitten, Robert S. Foote
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Publication number: 20090032399Abstract: A microfabricated device employing a bridging membrane and methods for electrokinetic transport of a liquid phase biological or chemical material using the same are described. The bridging membrane is deployed in or adjacent to a microchannel and permits either ionic current flow or the transport of gas species, while inhibiting the bulk flow of material. The use of bridging membranes in accordance with this invention is applicable to a variety of processes, including electrokinetically induced pressure flow in a region of a microchannel that is not influenced by an electric field, sample concentration enhancement and injection, as well as improving the analysis of materials where it is desired to eliminate electrophoretic bias. Other applications of the bridging membranes according to this invention include the separation of species from a sample material, valving of fluids in a microchannel network, mixing of different materials in a microchannel, and the pumping of fluids.Type: ApplicationFiled: October 19, 2007Publication date: February 5, 2009Inventors: Stephen C. Jacobson, J. Michael Ramsey, Christopher T. Culbertson, William B. Whitten, Robert S. Foote
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Publication number: 20080272000Abstract: A microfabricated device employing a bridging membrane and methods for electrokinetic transport of a liquid phase biological or chemical material using the same are described. The bridging membrane is deployed in or adjacent to a microchannel and permits either ionic current flow or the transport of gas species, while inhibiting the bulk flow of material. The use of bridging membranes in accordance with this invention is applicable to a variety of processes, including electrokinetically induced pressure flow in a region of a microchannel that is not influenced by an electric field, sample concentration enhancement and injection, as well as improving the analysis of materials where it is desired to eliminate electrophoretic bias. Other applications of the bridging membranes according to this invention include the separation of species from a sample material, valving of fluids in a microchannel network, mixing of different materials in a microchannel, and the pumping of fluids.Type: ApplicationFiled: October 19, 2007Publication date: November 6, 2008Inventors: Stephen C. Jacobson, J. Michael Ramsey, Christopher T. Culbertson, William B. Whitten, Robert S. Foote
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Patent number: 7419575Abstract: Microfluidic systems and methods are disclosed which are adapted to transport and lyse cellular components of a test sample for analysis. The disclosed microfluidic systems and methods, which employ an electric field to rupture the cell membrane, cause unusually rapid lysis, thereby minimizing continued cellular activity and resulting in greater accuracy of analysis of cell processes.Type: GrantFiled: June 1, 2004Date of Patent: September 2, 2008Assignee: UT-Battelle, LLCInventors: Christopher T. Culbertson, Stephen C. Jacobson, Maxine A. McClain, J. Michael Ramsey
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Publication number: 20080128279Abstract: A microfabricated device employing a bridging membrane and methods for electrokinetic transport of a liquid phase biological or chemical material using the same are described. The bridging membrane is deployed in or adjacent to a microchannel and permits either ionic current flow or the transport of gas species, while inhibiting the bulk flow of material. The use of bridging membranes in accordance with this invention is applicable to a variety of processes, including electrokinetically induced pressure flow in a region of a microehannel that is not influenced by an electric field, sample concentration enhancement and injection, as well as improving the analysis of materials where it is desired to eliminate electrophoretic bias. Other applications of the bridging membranes according to this invention include the separation of species from a sample material, valving of fluids in a microchannel network, mixing of different materials in a microchannel, and the pumping of fluids.Type: ApplicationFiled: October 19, 2007Publication date: June 5, 2008Inventors: Stephen C. Jacobson, J. Michael Ramsey, Christopher T. Culbertson, William B. Whitten, Robert S. Foote
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Publication number: 20040224397Abstract: Microfluidic systems and methods are disclosed which are adapted to transport and lyse cellular components of a test sample for analysis. The disclosed microfluidic systems and methods, which employ an electric field to rupture the cell membrane, cause unusually rapid lysis, thereby minimizing continued cellular activity and resulting in greater accuracy of analysis of cell processes.Type: ApplicationFiled: June 1, 2004Publication date: November 11, 2004Inventors: Christopher T. Culbertson, Stephen C. Jacobson, Maxine A. McClain, J. Michael Ramsey
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Patent number: 6783647Abstract: Microfluidic systems and methods are disclosed which are adapted to transport and lyse cellular components of a test sample for analysis. The disclosed microfluidic systems and methods, which employ an electric field to rupture the cell membrane, cause unusually rapid lysis, thereby minimizing continued cellular activity and resulting in greater accuracy of analysis of cell processes.Type: GrantFiled: October 19, 2001Date of Patent: August 31, 2004Assignee: UT-Battelle, LLCInventors: Christopher T. Culbertson, Stephen C. Jacobson, Maxine A. McClain, J. Michael Ramsey
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Patent number: 6685809Abstract: A microfabricated device employing a bridging membrane and methods for electrokinetic transport of a liquid phase biological or chemical material using the same are described. The bridging membrane is deployed in or adjacent to a microchannel and permits either ionic current flow or the transport of gas species, while inhibiting the bulk flow of material. The use of bridging membranes in accordance with this invention is applicable to a variety of processes, including electrokinetically induced pressure flow in a region of a microchannel that is not influenced by an electric field, sample concentration enhancement and injection, as well as improving the analysis of materials where it is desired to eliminate electrophoretic bias. Other applications of the bridging membranes according to this invention include the separation of species from a sample material, valving of fluids in a microchannel network, mixing of different materials in a microchannel, and the pumping of fluids.Type: GrantFiled: February 4, 1999Date of Patent: February 3, 2004Assignee: UT-Battelle, LLCInventors: Stephen C. Jacobson, J. Michael Ramsey, Christopher T. Culbertson, William B. Whitten, Robert S. Foote
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Publication number: 20030086333Abstract: A device for electrohydrodynamically (EHD) mixing fluids includes a mixing channel, the mixing channel having at least one supply channel fluidicly connected thereto for transport of fluid into the mixing channel. At least two electrodes are provided, at least one of the electrodes for charging at least a portion of the fluid in the mixing channel. The electrodes impose an electric field in the mixing channel to induce EHD mixing of the fluid in the mixing channel. A method for EHD mixing of fluids applies an electric field to a mixing channel to induce EHD mixing.Type: ApplicationFiled: November 5, 2001Publication date: May 8, 2003Inventors: Constantinos Tsouris, David W. DePaoli, Christopher T. Culbertson, Stephen C. Jacobson, J. Michael Ramsey
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Publication number: 20030075446Abstract: Microfluidic systems and methods are disclosed which are adapted to transport and lyse cellular components of a test sample for analysis. The disclosed microfluidic systems and methods, which employ an electric field to rupture the cell membrane, cause unusually rapid lysis, thereby minimizing continued cellular activity and resulting in greater accuracy of analysis of cell processes.Type: ApplicationFiled: October 19, 2001Publication date: April 24, 2003Inventors: Christopher T. Culbertson, Stephen C. Jacobson, Maxine A. McClain, J. Michael Ramsey