Abstract: A package structure including a semiconductor die, a redistribution circuit structure and an electronic device is provided. The semiconductor die is laterally encapsulated by an insulating encapsulation. The redistribution circuit structure is disposed on the semiconductor die and the insulating encapsulation. The redistribution circuit structure includes a colored dielectric layer, inter-dielectric layers and redistribution conductive layers embedded in the inter-dielectric layers. The electronic device is disposed over the colored dielectric layer and electrically connected to the redistribution circuit structure.

Abstract: An optical fiber transmission device includes a substrate, a photonic integrated circuit, and an optical fiber assembly. The photonic integrated circuit is disposed on an area of the substrate. The substrate has a protruding structure at an interface with an edge of the photonic integrated circuit. The optical fiber assembly includes an optical fiber and a ferrule that sleeves the optical fiber. The protruding structure of the substrate is configured to abut against the ferrule to limit the position of the optical fiber assembly in a vertical direction of the substrate, such that the protruding structure is a stopper for the optical fiber assembly in the vertical direction.

Abstract: An optical fiber network device includes a fiber and a photonic integrated circuit. Fiber receives a first optical signal and transmits a second optical signal. A first wavelength of first optical signal is different from a second wavelength of second optical signal. Photonic integrated circuit includes a laser chip, a photodetector, a wavelength division multiplexing coupler, a first optical modulation element and a second optical modulation element. Laser chip is disposed on photonic integrated circuit, and is configured to generate first optical signal. Photodetector detects second optical signal. Wavelength division multiplexing coupler is configured to couple first optical signal to fiber, and receives second optical signal. First optical modulation element is coupled to wavelength division multiplexing coupler and laser chip, and is configured to modulate first optical signal.

Abstract: An isolated bispecific antibody or antigen-binding portion thereof includes a first chain which specifically binds to human PD-1(hPD-1) and blocks the interaction between hPD-1 and PD-L1, and a second chain which specifically binds to human CD47 and inhibits its interaction with SIRP-alpha, where the first chain and the second chain are coupled in a knob-in-hole format through their respective CH3 domain.

Abstract: An acoustic wave element includes: a substrate; a bonding structure on the substrate; a support layer on the bonding structure; a first electrode including a lower surface on the support layer; a cavity positioned between the support layer and the first electrode and exposing a lower surface of the first electrode; a piezoelectric layer on the first electrode; and a second electrode on the piezoelectric layer, wherein at least one of the first electrode and the second electrode includes a first layer and a second layer that the first layer has a first acoustic impedance and a first electrical impedance, the second layer has a second acoustic impedance and a second electrical impedance, wherein the first acoustic impedance is higher than the second acoustic impedance, and the second electrical impedance is lower than the first electrical impedance.

Abstract: Methods for increasing immune therapy response and predicting likelihood of cancer metastasis by analyzing the expression of genes associated with replication stress response. In some aspects, cancers are treated with immune checkpoint inhibitors and/or MEK inhibitors. Methods for selecting patients by analyzing the expression of genes associated with a defect in replication stress response are also provided.

Abstract: The present disclosure provides a spraying system and a using method thereof. The spraying system includes a lifting apparatus and a spraying apparatus. The spraying apparatus connects to the lifting apparatus and includes a stage, a multi-axis transfer mechanism, a spraying component, a driving component, a surface profile detector, and a controlling component. The multi-axis transfer mechanism is disposed on the stage. The spraying component is disposed on the multi-axis transfer mechanism and the stage. The driving component is disposed on the stage and connects to the lifting apparatus. The surface profile detector is disposed on the stage and scans an area to be sprayed to obtain scanning data. The controlling component is disposed on the stage and controls the lifting apparatus, the spraying component, and the driving component according to the scanning data and pre-stored initial data.

Abstract: The present disclosure provides isolated monoclonal antibodies or antigen-binding portions thereof that specifically bind to CD47 preferably human CD47 with high affinity, and can enhance tumor-targeting immune response by therapeutically boosting the phagocytic function of macrophage for cancer treatment. The disclosure also provides antibodies that are chimeric, humanized, bispecific, derivatized, single chain antibodies or portions of fusion proteins. Nucleic acid molecules encoding the antibodies of the disclosed invention and hybridoma are also provided. Pharmaceutical compositions comprising the antibodies of the disclosed invention are also provided. This disclosure also provides methods for regulating innate immune responses, as well as methods for treating cancer using an anti-CD47 antagonist antibody of the disclosed invention.

Abstract: An electrowetting on dielectric (EWOD) device able to self-detect an open-circuit or closed-circuit condition includes a detection chip, a power input module, a switch module, a detection module, and a determination module. The detection chip includes a channel, several driving electrodes, and a detection electrode. Each driving electrode can couple with the detection electrode to form the driving loop. The switch unit selects one of the driving electrodes to be electrically connected to the power input module for receiving a power voltage from the power input module. The detection module receives a detection voltage outputted by the detection electrode and accumulates the detection voltage to obtain an accumulated voltage. The determination module compares the accumulated voltage with a specified voltage for determining whether the driving loop is open-circuit or closed-circuit. A method for a self-detection circuit in EWOD device is also disclosed.

Abstract: The present disclosure provides a spraying system and a using method thereof. The spraying system includes a lifting apparatus and a spraying apparatus. The spraying apparatus connects to the lifting apparatus and includes a stage, a multi-axis transfer mechanism, a spraying component, a driving component, a surface profile detector, and a controlling component. The multi-axis transfer mechanism is disposed on the stage. The spraying component is disposed on the multi-axis transfer mechanism and the stage. The driving component is disposed on the stage and connects to the lifting apparatus. The surface profile detector is disposed on the stage and scans an area to be sprayed to obtain scanning data. The controlling component is disposed on the stage and controls the lifting apparatus, the spraying component, and the driving component according to the scanning data and pre-stored initial data.

Abstract: Methods for increasing immune therapy response and predicting likelihood of cancer metastasis by analyzing the expression of genes associated with replication stress response. In some aspects, cancers are treated with immune checkpoint inhibitors and/or MEK inhibitors. Methods for selecting patients by analyzing the expression of genes associated with a defect in replication stress response are also provided.

Abstract: Methods for identifying and treating cancers that are homologous recombination (HR)-repair defective. In some aspects, HR defective cancers are treated with a PARP inhibitor therapy. Methods for sensitizing cancers to a PARP inhibitor therapy are also provided.

Abstract: A measuring apparatus includes a first angle measuring member, a second angle measuring member, and a display module. The first angle measuring member includes a first connecting shaft, a first needle rotatably connected to the first connecting shaft, and a first angle measuring instrument. The second angle measuring member includes a second connecting shaft, a second needle rotatably connected to the second connecting shaft, and a second angle measuring instrument. The first angle measuring instrument is configured to measure a first angle between the first needle and the first connecting shaft, and the second angle measuring instrument is configured to measure a second angle between the second needle and the second connecting shaft. The display module is configured to calculate a size of the object based on the first angle, the second angle, and lengths of the first connecting shaft and the second connecting shaft.

Abstract: An electronic device includes a host module and a first expansion module. The first expansion module has a first wall and a second wall substantially parallel to the first wall. A host connector is located on the second wall. The first expansion module includes a first coupling wall and a first expansion wall substantially parallel to the first coupling wall. A first coupler is located on the first coupling wall. The first expansion module can be stacked on the host module where the first coupling wall contacts the second wall. The first coupler is electrically and detachably coupled to the host connector.

Abstract: A temperature sensing apparatus configured to measure a temperature distribution of a surface to be measured is provided. The temperature sensing apparatus includes a lens set, a filtering module, a plurality of sensor arrays, and a processing unit. The lens set is configured to receive radiation from the surface to be measured. The filtering module is configured to filter the radiation from the lens set into a plurality of radiation portions respectively having different wavelengths. The sensor arrays are configured to respectively sense the radiation portions. The processing unit is configured to calculate an intensity ratio distribution of the radiation between the different wavelengths according to the radiation portions respectively sensed by the sensor arrays and determine the temperature distribution according to the intensity ratio distribution. A laser processing system and a temperature measuring method are also provided.

Abstract: A measuring apparatus includes a first angle measuring member, a second angle measuring member, and a display module. The first angle measuring member includes a first connecting shaft, a first needle rotatably connected to the first connecting shaft, and a first angle measuring instrument. The second angle measuring member includes a second connecting shaft, a second needle rotatably connected to the second connecting shaft, and a second angle measuring instrument. The first angle measuring instrument is configured to measure a first angle between the first needle and the first connecting shaft, and the second angle measuring instrument is configured to measure a second angle between the second needle and the second connecting shaft. The display module is configured to calculate a size of the object based on the first angle, the second angle, and lengths of the first connecting shaft and the second connecting shaft.

Abstract: An enclosure for a handheld electronic device includes a base defining a recess, a rectangular, hollow frame, a rectangular, hollow double-sided adhesive tape, a rectangular, hollow silicone rubber layer and a transparent plate. The recess receives therein a main body and a display panel of the electronic device. The frame, the double-sided adhesive tape and the silicone rubber layer are sequentially received in the recess along a direction from an inside toward an opening of the recess of the enclosure and surround the display panel. The transparent plate is secured to fronts of the silicone rubber layer and the display panel and adhered by the silicon rubber layer to cover the opening of the recess.

Abstract: An electronic device includes a host module and a first expansion module. The first expansion module has a first wall and a second wall substantially parallel to the first wall. A host connector is located on the second wall. The first expansion module includes a first coupling wall and a first expansion wall substantially parallel to the first coupling wall. A first coupler is located on the first coupling wall. The first expansion module can be stacked on the host module where the first coupling wall contacts the second wall. The first coupler is electrically and detachably coupled to the host connector.

Abstract: A temperature sensing apparatus configured to measure a temperature distribution of a surface to be measured is provided. The temperature sensing apparatus includes a lens set, a filtering module, a plurality of sensor arrays, and a processing unit. The lens set is configured to receive radiation from the surface to be measured. The filtering module is configured to filter the radiation from the lens set into a plurality of radiation portions respectively having different wavelengths. The sensor arrays are configured to respectively sense the radiation portions. The processing unit is configured to calculate an intensity ratio distribution of the radiation between the different wavelengths according to the radiation portions respectively sensed by the sensor arrays and determine the temperature distribution according to the intensity ratio distribution. A laser processing system and a temperature measuring method are also provided.

Abstract: Methods for identifying and treating cancers that are homologous recombination (HR)-repair defective. In some aspects, HR defective cancers are treated with a PARP inhibitor therapy. Methods for sensitizing cancers to a PARP inhibitor therapy are also provided.