Patents by Inventor Chung Hang J. Choi

Chung Hang J. Choi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
    Patent number: 11213593
    Abstract: Spherical nucleic acids (SNAs), consisting of densely packed, highly oriented polynucleotide strands attached to the surface of nanoparticles, are able to overcome the typical challenges of nucleic acid delivery. The present disclosure demonstrates that G-rich SNAs exhibit several-fold higher uptake into cells relative to SNAs rich in other nucleotides. This disclosure provides an effective strategy to maximize the intracellular delivery of SNAs, which is applicable to other nanoparticle systems, thus establishing an important design consideration for nanoparticle-based intracellular delivery of therapeutics.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: January 4, 2022
    Assignee: Northwestern University
    Inventors: Chad A. Mirkin, Chung Hang J. Choi, Suguna P. Narayan, Liangliang Hao, Evelyn Auyeung
  • THE SEQUENCE-SPECIFIC CELLULAR UPTAKE OF SPHERICAL NUCLEIC ACID NANOPARTICLE
    Publication number: 20180344873
    Abstract: Spherical nucleic acids (SNAs), consisting of densely packed, highly oriented polynucleotide strands attached to the surface of nanoparticles, are able to overcome the typical challenges of nucleic acid delivery. The present disclosure demonstrates that G-rich SNAs exhibit several-fold higher uptake into cells relative to SNAs rich in other nucleotides. This disclosure provides an effective strategy to maximize the intracellular delivery of SNAs, which is applicable to other nanoparticle systems, thus establishing an important design consideration for nanoparticle-based intracellular delivery of therapeutics.
    Type: Application
    Filed: November 20, 2015
    Publication date: December 6, 2018
    Inventors: Chad A. Mirkin, Chung Hang J. Choi, Sunguna P. Narayan, Liangliang Hao, Evelyn Auyeung
  • Targeting Kidney Mesangium With Nanoparticles of Defined Diameter
    Publication number: 20120148489
    Abstract: Described herein are methods of treating a disorder affecting the mesangial cells in a subject by administering an engineered nanoparticle (ENP) capable of delivering a therapeutic agent to the subject. Also provided are diagnostic methods for administering to a subject an ENP, analyzing a mesangial cell of the subject and determining whether the engineered nanoparticle is present in a mesangial cell of the subject.
    Type: Application
    Filed: December 9, 2011
    Publication date: June 14, 2012
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Mark E. Davis, Chung Hang J. Choi, Jonathan Zuckerman
  • Targeting Kidney Mesangium With Nanoparticles of Defined Diameter
    Publication number: 20120148488
    Abstract: Described herein are methods of treating a disorder affecting the mesangial cells in a subject by administering an engineered nanoparticle (ENP) capable of delivering a therapeutic agent to the subject. Also provided are diagnostic methods for administering to a subject an ENP, analyzing a mesangial cell of the subject and determining whether the engineered nanoparticle is present in a mesangial cell of the subject.
    Type: Application
    Filed: December 9, 2011
    Publication date: June 14, 2012
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Mark E. Davis, Chung Hang J. Choi, Jonathan Zuckerman