Patents by Inventor Chunhui Xie
Chunhui Xie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12173324Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.Type: GrantFiled: November 16, 2022Date of Patent: December 24, 2024Assignee: Vertex Pharmaceuticals IncorporatedInventors: George Harb, Chunhui Xie
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Publication number: 20240382532Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic islet cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.Type: ApplicationFiled: April 26, 2024Publication date: November 21, 2024Applicant: Vertex Pharmaceuticals IncorporatedInventors: George Harb, Chunhui Xie, Bryce W. Carey, Aleksander Szymaniak, Christopher Thanos, Evrett Thompson, Rebecca Chinn, Suyash Raj
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Publication number: 20240358767Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro in the presence of one or more chemical compounds that inhibit PI3K/Akt/mTOR signaling. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of making use thereof.Type: ApplicationFiled: November 7, 2022Publication date: October 31, 2024Applicant: VERTEX PHARMACEUTICALS INCORPORATEDInventors: Chunhui XIE, George HARB, Elizabeth RYU, Nicholas TECENO, Christopher FARRAR
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Publication number: 20240271100Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.Type: ApplicationFiled: July 30, 2021Publication date: August 15, 2024Applicant: VERTEX PHARMACEUTICALS INCORPORATEDInventors: George HARB, Chunhui XIE
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Patent number: 12049645Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.Type: GrantFiled: July 30, 2021Date of Patent: July 30, 2024Inventors: George Harb, Chunhui Xie
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Patent number: 11992506Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic islet cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.Type: GrantFiled: November 1, 2022Date of Patent: May 28, 2024Assignee: VERTEX PHARMACEUTICALS INCORPORATEDInventors: George Harb, Chunhui Xie, Bryce W. Carey, Aleksander Szymaniak, Christopher Thanos, Evrett Thompson, Rebecca Chinn, Suyash Raj
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Publication number: 20230395250Abstract: Systems for customizing and troubleshooting the display of surgical data and wireless pairing techniques for surgical instruments are disclosed.Type: ApplicationFiled: May 16, 2023Publication date: December 7, 2023Inventors: Christopher A. Denzinger, Monica L. Z. Rivard, Matthew D. Cowperthwait, Felix J. Bork, Risto Kojcev, Leonardo N. Rossoni, Chunhui Xie
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Publication number: 20230381361Abstract: A biological indicator analyzer includes a plurality of wells, a plurality of organism detector features, and a user input feature such as a touch screen. Each well is configured to receive a respective biological indicator. Each organism detector feature is configured to detect whether a biological indicator disposed in a corresponding well of the plurality of wells contains a living organism. The touch screen is configured to receive user input and provide information to the user indicating a status of biological indicator analysis. The biological indicator analyzer may be used to analyze a biological indicator that was positioned in a sterilization chamber of a sterilizing cabinet along with at least one medical device that is to be sterilized. The analysis may indicate whether the sterilization cycle in the sterilization chamber as successful.Type: ApplicationFiled: August 14, 2023Publication date: November 30, 2023Applicant: ASP Global Manufacturing GMBHInventors: Brian J. Thompson, Jacob S. Childs, Chunhui Xie, Marco A. Mangiaterra, Darius D. Eghbal, Margaret D. Shaffer, Jeremy M. Yarwood, Benjamin M. Fryer, Howell B. Schwartz, Philippe Kanh Dang, Yaeer Lev, Venkata Danam
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Publication number: 20230364291Abstract: A sterilizing cabinet performs a method of processing a medical device, such as a used medical device or an otherwise non-sterile medical device. The method includes receiving input from a user selecting a sterilization cycle from a plurality of available sterilization cycles. The sterilizing cabinet identifies a biological indicator associated with the selected sterilization cycle. The sterilizing cabinet prompts the user via a touch screen display to place the medical device and the biological indicator into a sterilization chamber of a sterilizing cabinet. The sterilizing cabinet performs load conditioning on the medical device in the sterilization chamber. The sterilizing cabinet then performs the selected sterilization cycle on the medical device in the sterilization chamber after completing the act of load conditioning.Type: ApplicationFiled: May 12, 2023Publication date: November 16, 2023Applicant: ASP Global Manufacturing GMBHInventors: Brian J. Thompson, Jacob S. Childs, Chunhui Xie, Marco A. Mangiaterra, Darius D. Eghbal, Margaret D. Shaffer, Jeremy M. Yarwood, Benjamin M. Fryer
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Publication number: 20230358630Abstract: A boundary adaptive structural fatigue damage detection method driven by time-domain information entropy comprises a sensor sequence composed of several sensors arranged on the structure, which is used to apply excitation to the structure, collect the displacement time-history response curves at different positions on the structure, and establish a database of time-history data. According to the data set in the database, the information entropy of the time-history response at different positions on the acquisition structure is obtained based on the information entropy to measure the disorder degree of the time-domain response signal. According to the location of several sensors, the information entropy values of the time-history response are connected in turn to obtain the time-history information entropy curve of the whole structure. Analyze of time-history information entropy curve, and the information entropy curve will show jump phenomena to determine the location of the crack.Type: ApplicationFiled: April 13, 2023Publication date: November 9, 2023Applicants: Jiangxi University of Science and Technology, Hohai University, JSTI GroupInventors: Maosen CAO, Tongfa DENG, Ruke TAN, Chunhui XIE, Yufeng ZHANG, Zha NI, Zeyu WANG
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Patent number: 11766495Abstract: A biological indicator analyzer includes a plurality of wells, a plurality of organism detector features, and a user input feature such as a touch screen. Each well is configured to receive a respective biological indicator. Each organism detector feature is configured to detect whether a biological indicator disposed in a corresponding well of the plurality of wells contains a living organism. The touch screen is configured to receive user input and provide information to the user indicating a status of biological indicator analysis. The biological indicator analyzer may be used to analyze a biological indicator that was positioned in a sterilization chamber of a sterilizing cabinet along with at least one medical device that is to be sterilized. The analysis may indicate whether the sterilization cycle in the sterilization chamber as successful.Type: GrantFiled: February 10, 2020Date of Patent: September 26, 2023Inventors: Brian J. Thompson, Jacob S. Childs, Chunhui Xie, Marco A. Mangiaterra, Darius D. Eghbal, Margaret D. Shaffer, Jeremy M. Yarwood, Benjamin M. Fryer, Howell B. Schwartz, Philippe Kanh Dang, Yaeer Lev, Venkata Danam
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Publication number: 20230218676Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic islet cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.Type: ApplicationFiled: November 1, 2022Publication date: July 13, 2023Applicant: Vertex Pharmaceuticals IncorporatedInventors: George Harb, Chunhui Xie, Bryce W. Carey, Aleksander Szymaniak, Christopher Thanos, Evrett Thompson, Rebecca Chinn, Suyash Raj
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Patent number: 11660365Abstract: A sterilizing cabinet performs a method of processing a medical device, such as a used medical device or an otherwise non-sterile medical device. The method includes receiving input from a user selecting a sterilization cycle from a plurality of available sterilization cycles. The sterilizing cabinet identifies a biological indicator associated with the selected sterilization cycle. The sterilizing cabinet prompts the user via a touch screen display to place the medical device and the biological indicator into a sterilization chamber of a sterilizing cabinet. The sterilizing cabinet performs load conditioning on the medical device in the sterilization chamber. The sterilizing cabinet then performs the selected sterilization cycle on the medical device in the sterilization chamber after completing the act of load conditioning.Type: GrantFiled: May 7, 2020Date of Patent: May 30, 2023Assignee: ASP Global Manufacturing GmbHInventors: Brian J. Thompson, Jacob S. Childs, Chunhui Xie, Marco A. Mangiaterra, Darius D. Eghbal, Margaret D. Shaffer, Jeremy M. Yarwood, Benjamin M. Fryer
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Publication number: 20230092449Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.Type: ApplicationFiled: November 16, 2022Publication date: March 23, 2023Applicant: Vertex Pharmaceuticals IncorporatedInventors: George Harb, Chunhui Xie
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Publication number: 20220090020Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.Type: ApplicationFiled: July 30, 2021Publication date: March 24, 2022Applicant: Vertex Pharmaceuticals IncorporatedInventors: George Harb, Chunhui Xie
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Publication number: 20200330636Abstract: A sterilizing cabinet performs a method of processing a medical device, such as a used medical device or an otherwise non-sterile medical device. The method includes receiving input from a user selecting a sterilization cycle from a plurality of available sterilization cycles. The sterilizing cabinet identifies a biological indicator associated with the selected sterilization cycle. The sterilizing cabinet prompts the user via a touch screen display to place the medical device and the biological indicator into a sterilization chamber of a sterilizing cabinet. The sterilizing cabinet performs load conditioning on the medical device in the sterilization chamber. The sterilizing cabinet then performs the selected sterilization cycle on the medical device in the sterilization chamber after completing the act of load conditioning.Type: ApplicationFiled: May 7, 2020Publication date: October 22, 2020Inventors: Brian J. Thompson, Jacob S. Childs, Chunhui Xie, Marco A. Mangiaterra, Darius D. Eghbal, Margaret D. Shaffer, Jeremy M. Yarwood, Benjamin M. Fryer
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Publication number: 20200179549Abstract: A biological indicator analyzer includes a plurality of wells, a plurality of organism detector features, and a user input feature such as a touch screen. Each well is configured to receive a respective biological indicator. Each organism detector feature is configured to detect whether a biological indicator disposed in a corresponding well of the plurality of wells contains a living organism. The touch screen is configured to receive user input and provide information to the user indicating a status of biological indicator analysis. The biological indicator analyzer may be used to analyze a biological indicator that was positioned in a sterilization chamber of a sterilizing cabinet along with at least one medical device that is to be sterilized. The analysis may indicate whether the sterilization cycle in the sterilization chamber as successful.Type: ApplicationFiled: February 10, 2020Publication date: June 11, 2020Inventors: Brian J. Thompson, Jacob S. Childs, Chunhui Xie, Marco A. Mangiaterra, Darius D. Eghbal, Margaret D. Shaffer, Jeremy M. Yarwood, Benjamin M. Fryer, Howell B. Schwartz, Philippe Kanh Dang, Yaeer Lev, Venkata Danam
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Patent number: 10668180Abstract: A sterilizing cabinet performs a method of processing a medical device, such as a used medical device or an otherwise non-sterile medical device. The method includes receiving input from a user selecting a sterilization cycle from a plurality of available sterilization cycles. The sterilizing cabinet identifies a biological indicator associated with the selected sterilization cycle. The sterilizing cabinet prompts the user via a touch screen display to place the medical device and the biological indicator into a sterilization chamber of a sterilizing cabinet. The sterilizing cabinet performs load conditioning on the medical device in the sterilization chamber. The sterilizing cabinet then performs the selected sterilization cycle on the medical device in the sterilization chamber after completing the act of load conditioning.Type: GrantFiled: February 24, 2017Date of Patent: June 2, 2020Assignee: ASP GLOBAL MANUFACTURING GMBHInventors: Brian J. Thompson, Jacob S. Childs, Chunhui Xie, Marco A. Mangiaterra, Darius D. Eghbal, Margaret D. Shaffer, Jeremy M. Yarwood, Benjamin M. Fryer
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Patent number: 10561753Abstract: A biological indicator analyzer includes a plurality of wells, a plurality of organism detector features, and a user input feature such as a touch screen. Each well is configured to receive a respective biological indicator. Each organism detector feature is configured to detect whether a biological indicator disposed in a corresponding well of the plurality of wells contains a living organism. The touch screen is configured to receive user input and provide information to the user indicating a status of biological indicator analysis. The biological indicator analyzer may be used to analyze a biological indicator that was positioned in a sterilization chamber of a sterilizing cabinet along with at least one medical device that is to be sterilized. The analysis may indicate whether the sterilization cycle in the sterilization chamber as successful.Type: GrantFiled: February 24, 2017Date of Patent: February 18, 2020Assignee: ASP GLOBAL MANUFACTURING GMBHInventors: Brian J. Thompson, Jacob S. Childs, Chunhui Xie, Marco A. Mangiaterra, Darius D. Eghbal, Margaret D. Shaffer, Jeremy M. Yarwood, Benjamin M. Fryer, Howell B. Schwartz, Philippe Kanh Dang, Yaeer Lev, Venkata Danam
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Patent number: 10356949Abstract: A server heat dissipation system is provided, comprising a liquid cooling server cabinet comprising a cabinet body and multiple liquid cooling servers provided inside the cabinet body, wherein it is provided with a liquid cooling device to perform direct liquid cooling to the liquid cooling servers, and with an auxiliary heat dissipation device to perform auxiliary heat dissipation to the liquid cooling servers. The present invention provides high density cooling, high heat exchange efficiency, no local overheating, small space occupied, high reliability, low noise, and long life.Type: GrantFiled: May 5, 2015Date of Patent: July 16, 2019Assignee: GUANGDONG SHENLING ENVIRONMENTAL SYSTEMS CO., LTD.Inventors: Zhanhua Pan, Minhua Li, Hua Chen, Chunhui Xie, Ti Ouyang, Xuewei Zhang, Yuqun Qiu