Patents by Inventor Clarence Stanley Rooney

Clarence Stanley Rooney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrrolo[2,1-b] [3]benzazepines useful for producing a skeletal muscle relaxing or tranquilizing effect
    Patent number: 4112112
    Abstract: 11-Aminopropylidene-Pyrrolo[2,1-b] [3]benzazepines are disclosed to have pharmaceutical utility as skeletal muscle relaxants and tranquilizers. They are prepared by a Grignard reaction on pyrrolo[2,1-b] [3]benzazapin-11-ones followed by dehydration, or by a Wittig reaction on the same ketones.
    Type: Grant
    Filed: June 6, 1977
    Date of Patent: September 5, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Clarence Stanley Rooney, Joshua Rokach, Joseph George Atkinson
  • Amino acids and esters thereof useful as antihypertensive agents
    Patent number: 4065572
    Abstract: A compound of the formula ##STR1## possesses antihypertensive activity. Also provided are methods for the preparation of the compounds as well as pharmaceutical formulations and methods for their use as antihypertensive agents.
    Type: Grant
    Filed: February 13, 1976
    Date of Patent: December 27, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Joseph George Atkinson, Clarence Stanley Rooney, Yves Girard, Edward L. Engelhardt
  • 1,8-Naphthyridine compounds
    Patent number: 4031103
    Abstract: There is described 2-amino-5,7-disubstituted-naphthyridine and 5,7-disubstituted-naphthyridin-2(1H)-one derivatives with bronchodilating and hypotensive properties prepared by the reaction of 2,6-diaminopyridine with an appropriate .beta.-diketone providing the 2-amino products. The 2-oxo analogs are prepared from the 2-amino products by treatment with nitrous acid.
    Type: Grant
    Filed: December 9, 1975
    Date of Patent: June 21, 1977
    Assignee: Merck Sharp & Dohme (I.A.) Corporation
    Inventors: Hayden Windsor Richard Williams, Clarence Stanley Rooney
  • Pyrazolo [1,5-a] [1,3,5] triazines
    Patent number: 3995039
    Abstract: Novel pyrazolo [1,5-a] [1,3,5] triazines are provided which are active agents to inhibit bronchial constriction with very low chronotropic effects. The novel compounds are prepared by the reaction of an appropiately substituted 1-amidino-5-amino pyrazole with an appropriately substituted trialkyl orthoester. Suitable compositions for utilizing this bronchodilating activity by administration to humans are also disclosed.
    Type: Grant
    Filed: May 27, 1975
    Date of Patent: November 30, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Clarence Stanley Rooney, Haydn Windsor Richard Williams
  • 1,8-Naphthyridine compounds
    Patent number: 3993656
    Abstract: There is described 1,8-naphthyridin-2(1H)-one compounds with bronchodilating and hypotensive properties prepared by reaction of 2,6-diaminopyridine with an appropriate .beta.-diketone providing a 2-aminonaphthyridine compound which upon treatment with nitrous acid is converted to the 2-oxo product. Alternatively, an appropriate .beta.-diketone can be reacted with an alkyl alkoxycarbonylacetimidate, the alkyl 2-aminonicotinate thus formed converted to the hydrazide, which upon treatment with a sulfonyl halide forms the N-sulfonyl hydrazide derivative. This intermediate is reacted with an alkali metal carbonate to provide the 2-aminonicotinaldehyde which upon reaction with an ester of a substituted aliphatic carboxylic acid provides the desired product. In some cases the aminonicotinaldehyde is generated in situ in the presence of the ester thereby giving the desired product in one step from the N-sulfonyl hydrazide derivative.
    Type: Grant
    Filed: February 20, 1975
    Date of Patent: November 23, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Clarence Stanley Rooney, Haydn Windsor Richard Williams, Burton Kendall Wasson
  • 1,8-Naphthyridine compounds
    Patent number: 3962262
    Abstract: There is described 2-amino-5,7-disubstituted-naphthyridine and 5,7-disubstituted-naphthyridin-2(1H)-one derivatives with bronchodilating and hypotensive properties prepared by the reaction of 2,6-diaminopyridine with an appropriate .beta.-diketone providing the 2-amino products. The 2-oxo analogs are prepared from the 2-amino products by treatment with nitrous acid.
    Type: Grant
    Filed: June 7, 1974
    Date of Patent: June 8, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Haydn Windsor Richard Williams, Clarence Stanley Rooney