Patents by Inventor Clark K. Colton

Clark K. Colton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10179901
    Abstract: The invention provides methods and compositions relating to differentiated cell populations that derive from pluripotent stem cells. The methods relate to reducing the number of residual stem cells present in such populations. The compositions include differentiated cell populations that contain reduced number of stem cells or that contain no stem cells. Pluripotent stem cells may be reduced in number and/or function through exposure to low oxygen levels.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: January 15, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Clark K. Colton, Jeffrey R. Millman
  • Patent number: 9816070
    Abstract: Articles and methods for stem cell differentiation are generally described. In some embodiments, an article for stem cell differentiation may comprise an oxygen permeable substrate having at least a portion of a surface coated with a matrix. The matrix may allow the surface chemistry of the substrate to be altered, such that the cell-substrate surface interactions may be finely controlled without substantially affecting the oxygen permeability of the substrate. The surface chemistry may be altered to promote directed stem cell differentiation by, e.g., modification of the matrix surface with a specific density of biological molecules. In some embodiments, methods for stem cell differentiation may comprise directing the differentiation of stem cells on the articles, described herein, under suitable environmental conditions.
    Type: Grant
    Filed: June 13, 2014
    Date of Patent: November 14, 2017
    Assignee: Massachusetts Institute of Technology
    Inventors: Clark K. Colton, Karen K. Gleason, Anna M. Coclite, Amanda R. Dilenno
  • Publication number: 20170121677
    Abstract: The invention provides methods and compositions relating to differentiated cell populations that derive from pluripotent stem cells. The methods relate to reducing the number of residual stem cells present in such populations. The compositions include differentiated cell populations that contain reduced number of stem cells or that contain no stem cells. Pluripotent stem cells may be reduced in number and/or function through exposure to low oxygen levels.
    Type: Application
    Filed: June 10, 2016
    Publication date: May 4, 2017
    Applicant: Massachusetts Institute of Technology
    Inventors: Clark K. Colton, Jeffrey R. Millman
  • Patent number: 9447378
    Abstract: The invention provides inter alia methods for differentiating embryonic stem cells into insulin producing cells, as well as compositions comprising such cells, and therapeutic uses of such compositions.
    Type: Grant
    Filed: April 29, 2013
    Date of Patent: September 20, 2016
    Assignee: Massachusetts Institute of Technology
    Inventors: Clark K. Colton, Amanda Dilenno, Jeffrey R. Millman
  • Patent number: 9388381
    Abstract: The invention provides methods and compositions relating to differentiated cell populations that derive from pluripotent stem cells. The methods relate to reducing the number of residual stem cells present in such populations. The compositions include differentiated cell populations that contain reduced number of stem cells or that contain no stem cells. Pluripotent stem cells may be reduced in number and/or function through exposure to low oxygen levels.
    Type: Grant
    Filed: July 9, 2010
    Date of Patent: July 12, 2016
    Assignee: Massachusetts Institute of Technology
    Inventors: Clark K. Colton, Jeffrey R. Millman
  • Patent number: 9365972
    Abstract: A process for producing a water-absorbent high-porosity fibrous matrix from lignocellulosic raw materials, comprising wet mechanical processing of the raw material, drying, and then dry mechanical processing the fibers to provide a fibrous matrix is provided. The high-porosity fibrous matrix and absorbent articles prepared therefrom are also provided.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: June 14, 2016
    Assignee: Sustainable Health Enterprises (SHE)
    Inventors: Elizabeth Scharpf, Bernice Liying Huang, Hannah Hale, Joshua Velson, Sina Salehi Omran, Jeffrey Zhou, Rachel B. Licht, Clark K. Colton, William H. Dalzell
  • Publication number: 20150152597
    Abstract: A process for producing a water-absorbent high-porosity fibrous matrix from lignocellulosic raw materials, comprising wet mechanical processing of the raw material, drying, and then dry mechanical processing the fibers to provide a fibrous matrix is provided. The high-porosity fibrous matrix and absorbent articles prepared therefrom are also provided.
    Type: Application
    Filed: December 5, 2014
    Publication date: June 4, 2015
    Inventors: Elizabeth SCHARPF, Liying HUANG, Hannah BRICE, Joshua VELSON, Sina Salehi OMRAN, Jeffrey ZHOU, Rachel B. LICHT, Clark K. COLTON, William H. DALZELL
  • Patent number: 9029147
    Abstract: The invention provides methods for differentiating pluripotent stem cells such as ES cells with improved progenitor and differentiated cell yield using low oxygen conditions and optionally in the absence of exogenously added differentiation factors.
    Type: Grant
    Filed: June 13, 2008
    Date of Patent: May 12, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Clark K. Colton, Daryl E. Powers, Jeffrey R. Millman
  • Patent number: 8936697
    Abstract: A process for producing a water-absorbent high-porosity fibrous matrix from lignocellulosic raw materials, comprising wet mechanical processing of the raw material, drying, and then dry mechanical processing the fibers to provide a fibrous matrix is provided. The high-porosity fibrous matrix and absorbent articles prepared therefrom are also provided.
    Type: Grant
    Filed: January 5, 2011
    Date of Patent: January 20, 2015
    Assignee: Sustainable Health Enterprises
    Inventors: Elizabeth Scharpf, Liying Huang, Hannah Brice, Joshua Velson, Sina Salehi Omran, Jeffrey Zhou, Rachel B. Licht, Clark K. Colton, William H. Dalzell
  • Publication number: 20140370598
    Abstract: Articles and methods for stem cell differentiation are generally described. In some embodiments, an article for stem cell differentiation may comprise an oxygen permeable substrate having at least a portion of a surface coated with a matrix. The matrix may allow the surface chemistry of the substrate to be altered, such that the cell-substrate surface interactions may be finely controlled without substantially affecting the oxygen permeability of the substrate. The surface chemistry may be altered to promote directed stem cell differentiation by, e.g., modification of the matrix surface with a specific density of biological molecules. In some embodiments, methods for stem cell differentiation may comprise directing the differentiation of stem cells on the articles, described herein, under suitable environmental conditions.
    Type: Application
    Filed: June 13, 2014
    Publication date: December 18, 2014
    Applicant: Massachusetts Institute of Technology
    Inventors: Clark K. Colton, Karen K. Gleason, Anna M. Coclite, Amanda R. Diienno
  • Patent number: 8801768
    Abstract: Aneurysms are treated by filling at least one double-walled filling structure with a filling medium within the aneurysm, such as filling structures having a membrane that allows water molecules to permeate across the membrane in response to a water potential differential across the membrane. The transport of fluid across the membrane allows the bag to expand or shrink to accommodate changes in the size or shape of the aneurysm, thereby maintaining a seal between the filling structure against the vessel wall and maintaining apposition of the filling structure against the inside surface of the aneurysm. Transport of water molecules into or out of the filling structure is controlled by adjusting for the osmolarity of the filling fluid medium. The filling structures may be delivered over balloon deployment mechanisms in order to shape occlude the aneurysm and open a tubular lumen for flow of blood through the filling structure.
    Type: Grant
    Filed: January 23, 2012
    Date of Patent: August 12, 2014
    Assignee: Endologix, Inc.
    Inventors: Anupama Karwa, Raj P. Ganpath, Clark K. Colton, K. T. Venkateswara Rao
  • Publication number: 20130287743
    Abstract: The invention provides inter alia methods for differentiating embryonic stem cells into insulin producing cells, as well as compositions comprising such cells, and therapeutic uses of such compositions.
    Type: Application
    Filed: April 29, 2013
    Publication date: October 31, 2013
    Applicant: Massachusetts Institute of Technology
    Inventors: Clark K. Colton, Amanda Dilenno, Jeffrey R. Millman
  • Publication number: 20130216480
    Abstract: The present invention relates to amphiphilic polymers, and micelles and compositions comprising the same, and their use in a variety of biological settings, including imaging, targeting drugs, or a combination thereof for diagnostic and therapeutic purposes.
    Type: Application
    Filed: September 11, 2012
    Publication date: August 22, 2013
    Applicant: Massachusetts Institute of Technology
    Inventors: Clark K. Colton, Arthur Watterson, Rajesh Kumar, Virinder S. Parmar, Robert Fisher, Jayant Kumar
  • Patent number: 8349991
    Abstract: The present invention relates to amphiphilic polymers, and micelles and compositions comprising the same, and their use in a variety of biological settings, including imaging, targeting drugs, or a combination thereof for diagnostic and therapeutic purposes.
    Type: Grant
    Filed: April 17, 2006
    Date of Patent: January 8, 2013
    Assignees: Massachusetts Institute of Technology, University of Massachusetts Lowell
    Inventors: Clark K. Colton, Arthur Watterson, Rajesh Kumar, Virinder S. Parmar, Robert Fisher, Jayant Kumar
  • Publication number: 20120219532
    Abstract: The invention provides methods and compositions relating to differentiated cell populations that derive from pluripotent stem cells. The methods relate to reducing the number of residual stem cells present in such populations. The compositions include differentiated cell populations that contain reduced number of stem cells or that contain no stem cells. Pluripotent stem cells may be reduced in number and/or function through exposure to low oxygen levels.
    Type: Application
    Filed: July 9, 2010
    Publication date: August 30, 2012
    Applicant: Massachusetts Institute of Technology
    Inventors: Clark K. Colton, Jeffrey R. Millman
  • Publication number: 20120203264
    Abstract: Aneurysms are treated by filling at least one double-walled filling structure with a filling medium within the aneurysm, such as filling structures having a membrane that allows water molecules to permeate across the membrane in response to a water potential differential across the membrane. The transport of fluid across the membrane allows the bag to expand or shrink to accommodate changes in the size or shape of the aneurysm, thereby maintaining a seal between the filling structure against the vessel wall and maintaining apposition of the filling structure against the inside surface of the aneurysm. Transport of water molecules into or out of the filling structure is controlled by adjusting for the osmolarity of the filling fluid medium. The filling structures may be delivered over balloon deployment mechanisms in order to shape occlude the aneurysm and open a tubular lumen for flow of blood through the filling structure.
    Type: Application
    Filed: January 23, 2012
    Publication date: August 9, 2012
    Applicant: Endologix, Inc.
    Inventors: Anupama Karwa, Raj P. Ganpath, Clark K. Colton, K.T. Venkateswara Rao
  • Patent number: 7984642
    Abstract: Devices, systems and methods for measuring and detecting properties of a variety of particles or cells in suspension. Properties, such as, for example, velocity of particles, concentration and/or size may be measured according to the methods of the invention. Acoustic energy may be introduced to a focal zone and narrow band interrogating signals may be used. The acoustic energy may cause movement or streaming of the fluid or suspension. The acoustic streaming may allow a Doppler effect measurement without any other source of velocity.
    Type: Grant
    Filed: June 9, 2009
    Date of Patent: July 26, 2011
    Assignee: Massachusetts Institute of Technology
    Inventors: Steven A. Africk, Clark K. Colton
  • Publication number: 20110045077
    Abstract: This invention is directed, inter alia, to encapsulated cell products, compositions comprising the same and uses thereof to treat diabetes, and related complications, increase islet cell masses, improve a metabolic profile in a subject, and other related conditions. Processes to produce the encapsulated islet cell product are described.
    Type: Application
    Filed: November 13, 2007
    Publication date: February 24, 2011
    Inventors: Gordon Weir, Clark K. Colton, Esther O'Sullivan, Amy Lewis
  • Publication number: 20100261277
    Abstract: The invention provides methods for differentiating pluripotent stem cells such as ES cells with improved progenitor and differentiated cell yield using low oxygen conditions and optionally in the absence of exogenously added differentiation factors.
    Type: Application
    Filed: June 13, 2008
    Publication date: October 14, 2010
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Clark K. Colton, Daryl Powers, Jeffrey R. Millman
  • Publication number: 20100031735
    Abstract: Devices, systems and methods for measuring and detecting properties of a variety of particles or cells in suspension. Properties, such as, for example, velocity of particles, concentration and/or size may be measured according to the methods of the invention. Acoustic energy may be introduced to a focal zone and narrow band interrogating signals may be used. The acoustic energy may cause movement or streaming of the fluid or suspension. The acoustic streaming may allow a Doppler effect measurement without any other source of velocity.
    Type: Application
    Filed: June 9, 2009
    Publication date: February 11, 2010
    Inventors: Steve A. AFRICK, Clark K. Colton