Patents by Inventor Claude Feniou

Claude Feniou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4818772
    Abstract: A compound with alpha 1-blocking activity having the formula: ##STR1## wherein R.sub.1 is --H, --CH.sub.3 or --COCH.sub.3 ; R.sub.2 is --H or CH.sub.3 ; and R.sub.3 is ##STR2## wherein .SIGMA. is --H or one or more substituents selected from the group consisting of halogen, --OH and --OCH.sub.3 ; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 9, 1982
    Date of Patent: April 4, 1989
    Assignee: Societe Cortial S.A.
    Inventors: Henri Pontagnier, Christian Courtiol, Marie-Helene Creuzet, Claude Feniou, Gisele Prat
  • Patent number: 4760139
    Abstract: The present invention relates to a novel method of preparing D-ribose.In this method, a 1,5-di-O-alkyl derivative of D-xylofuranose is prepared; the hydroxyl groups in positions 2 and 3 are each substituted by a group which is preferably mesyl (CH.sub.3 SO.sub.2) or methyldithiocarbonyl, CH.sub.3 SC(=S); the 2,3-unsaturated derivative is prepared; and D-ribose is finally obtained by cis-hydoxylation of the carbon-carbon double bond, followed by acid hydrolysis of the resulting 1,5-O-dialkyl derivative.
    Type: Grant
    Filed: September 22, 1986
    Date of Patent: July 26, 1988
    Assignee: Laboratoires Sarget
    Inventors: Claude Feniou, Micheline Grignon, Brigitte Lacourt, Henri Pontagnier, Bernadette Rezzonico
  • Patent number: 4758561
    Abstract: The present invention to pharmaceutical composition comprising an effective amount of products having the structural formula ##STR1## where R.sub.1 is a hydrogen atom or a lower alkyl group such as methyl or ethyl,R.sub.2 is a straight or branched cyclopropylmethyl, 2-furyl methyl, benzyl, phenyl or lower alkyl group from C.sub.1 to C.sub.4 such as methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tertiary butyl; the NR.sub.1 R.sub.2 group can also represent a nitrogenous heterocyclic compound N(CH.sub.2).sub.n in which n can be any value between 4 and 6.The products are useful in human and veterinary therapy because of their anti-inflammatory, diuretic, bronchodilating, anticholinergic, antispasmodic and antidepressant properties.
    Type: Grant
    Filed: July 22, 1985
    Date of Patent: July 19, 1988
    Assignee: Societe Cortial, S.A.
    Inventors: Guillaume Le Baut, Louis Sparfel, Marie-Helene Creuzet, Claude Feniou, Henri Pontagnier, Gisele Prat
  • Patent number: 4757067
    Abstract: The present invention to pharmaceutical composition comprising an effective amount of products having the structural formula ##STR1## where R.sub.1 is a hydrogen atom or a lower alkyl group such as methyl or ethyl,R.sub.2 is a straight or branched cyclopropylmethyl, 2-furyl methyl, benzyl, phenyl or lower alkyl group from C.sub.1 to C.sub.4 such as methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tertiary butyl; the NR.sub.1 R.sub.2 group can also represent a nitrogenous heterocyclic compound N(CH.sub.2).sub.n in which n can be any value between 4 and 6.The products are useful in human and veterinary therapy because of their anti-inflammatory, diuretic, bronchodilating, anticholinergic, antispasmodic and antidepressant properties.
    Type: Grant
    Filed: January 21, 1987
    Date of Patent: July 12, 1988
    Assignee: Societe Cortial, S.A.
    Inventors: Guillaume Le Baut, Louis Sparfel, Marie-Helene Creuzet, Claude Feniou, Henri Pontagnier, Gisele Prat
  • Patent number: 4721715
    Abstract: Compounds of the formula (I): ##STR1## wherein n is 0 or 1, R.sub.1 is H or a lower alkyl of 1 to 6 carbon atoms, R.sub.2 is an unsubstituted phenyl group or a phenyl group substituted by one or more of the same or different substituents selected from the group consisting of hydroxy, lower alkyl of 1 to 6 carbon atoms, lower alkoxy of 1 to 6 carbon atoms, chloro, fluoro, trifluoromethyl or a 2-, 3- or 4- pyridyl ring, in the form of a free base or a pharmaceutically acceptable acid addition salt thereof.The compounds of the present invention are useful in cardiovascular, antiallergy, psychotropic and hypolipidemic therapy.
    Type: Grant
    Filed: August 7, 1985
    Date of Patent: January 26, 1988
    Assignee: Societe Cortial, S.A.
    Inventors: Marie-Helene Creuzet, Claude Feniou, Francoise Guichard, Henri Pontagnier, Gisele Prat
  • Patent number: 4698343
    Abstract: A compound of the formula ##STR1## wherein R.sub.1 is C.sub.3 -C.sub.6 branched alkyl group, e.g., an isopropyl group or a tert-butyl group, R.sub.2 is a C.sub.1 -C.sub.6 alkoxy group, e.g., a methoxy, an ethoxy or a propoxy group, and X is a CHOH group or a (CH.sub.2).sub.n --group where n=0, 1 or 2 and a process for making this compound are disclosed.This compound is useful in human and veterinary therapeutics.
    Type: Grant
    Filed: September 19, 1985
    Date of Patent: October 6, 1987
    Assignee: Societe Cortial, S.A.
    Inventors: Marie-Helene Creuzet, Claude Feniou, Francoise Guichard, Henri Pontagnier, Gisele Prat
  • Patent number: 4668681
    Abstract: This invention relates to 2-(4-phenylpiperazinylethyl)anilines, to methods for preparing them and to their uses in medical therapy.These compounds have the following general formula ##STR1## wherein R.sub.1 represents one or more substituents selected from the group consisting of H, CH.sub.3, CF.sub.3, F, Cl, and OCH.sub.3 ; R.sub.2 and R.sub.3, which may be the same or different, and are selected from the group consisting of H and (C.sub.1 -C.sub.4) alkoxy, or R.sub.2 and R.sub.3 taken together can form a chain selected from the group consisting of --O-- (CH.sub.2).sub.n --O--, wherein n=1 or 2 and --O--CH.sub.2 --O--CH.sub.2 with the proviso that R.sub.1 is not meta CF.sub.3 when R.sub.2 =R.sub.3 =H, and pharmaceutically non-toxic salts thereof. The compounds of this invention are useful in the treatment of allergic and anaphylatic conditions and motion sickness.
    Type: Grant
    Filed: March 21, 1986
    Date of Patent: May 26, 1987
    Assignee: Societe Cortial, S.A.
    Inventors: Henri Pontagnier, Marie-H/e/ l/e/ ne Creuzet, Claude Feniou, Francoise Guichard, Gis/e/ le Prat
  • Patent number: 4638082
    Abstract: A novel method of producing the p-chlorophenol ester of p-chlorophenoxyisobutyric acid, which is a product useful in the treatment of hyperlipemias, is disclosed.
    Type: Grant
    Filed: February 25, 1986
    Date of Patent: January 20, 1987
    Assignee: Societe Corial, S.A.
    Inventors: Claude Feniou, Patrick Descas
  • Patent number: 4605768
    Abstract: A compound having the formula: ##STR1## wherein n is an integer between 6 and 11, inclusive; or the pharmaceutically-acceptable salts thereof.The compounds of the present invention and compositions containing the same are useful as antimicrobial agents in the disinfection of healthy or injured skin or mucous or serous membranes.
    Type: Grant
    Filed: December 21, 1984
    Date of Patent: August 12, 1986
    Assignee: Societe Cortial
    Inventors: Chantal Boyer, Jean C. Colleter, Marie-Helene Creuzet, Claude Feniou, Michel Laguerre, Henri Pontagnier, Gisele Prat
  • Patent number: 4600788
    Abstract: This invention relates to new products of the general formula ##STR1## where R.sub.1 =H, OH, OCOCH.sub.3, OSO.sub.2 CH.sub.3, branched or unbranched alkyl containing 1 to 5 carbon atoms. R.sub.2 =NHCOR.sub.3, NHCOCH.sub.2 X, NHSO.sub.2 CH.sub.3, N(SO.sub.2 CH.sub.3).sub.2, SO.sub.2 N(CH.sub.3).sub.2, SO.sub.2 NHCH.sub.3, SO.sub.2 NCH.sub.3 CH.sub.2 CH.sub.2 OH, SO.sub.2 NH.sub.2 wherein R.sub.3 is a lower alkyl containing 1 to 4 carbon atoms; and X is NR.sub.4 R.sub.5 or ##STR2## wherein R.sub.4 and R.sub.5 are both independently lower alkyls containing 1 to 4 carbon atoms and ##STR3## is piperidine, pyrrolidine or morpholine. These products can be in the form of pharmaceutically acceptable derivatives such as esters, amides, salts. When R.sub.2 contains an amino function, the product can be in the form of an acid salt.These products are prepared from their methyl esters either by reaction between ##STR4## and paramethoxycarbonylbenzoic acid chloride or by means of derivative I such as R.sub.2 is NH.sub.2.
    Type: Grant
    Filed: March 22, 1984
    Date of Patent: July 15, 1986
    Assignee: Societe Cortial, S.A.
    Inventors: Marie-Helene Creuzet, Claude Feniou, Francoise Guichard, Gisele Prat, Jacqueline Mosser, Henri Pontagnier
  • Patent number: 4591600
    Abstract: This invention relates to quercetin or fisetin derivatives substituted on the oxygen in the 3 position by groups such as lower alkyl, cycloalkyl, methanesulfonyl or paratoluenesulfonyl.The derivatives substituted by methanesulfonyl or paratoluenesulfonyl are obtained from a 3-O-glycoside whose phenol OH groups are blocked in the form of benzoate, and from which the OH in the 3 position is released by the action of concentrated HCl; this OH is esterified by mesityl chloride or paratoluenesulfonic acid chloride, and the benzoate groups are eliminated by soda treatment. The O derivatives substituted by alkyl or cycloakyl are prepared from a suitably substituted acetonitrile or metadiphenol; the resulting derivative reacts with 3,4-dibenzyloxybenzoic acid and the resulting flavone is debenzylated by hydrogenolysis.The derivatives, object of this invention, are useful in preventive or curative therapy of ocular and nervous complications from diabetes and are also useful as hypolipidemic or hypoglycemic agents.
    Type: Grant
    Filed: March 29, 1984
    Date of Patent: May 27, 1986
    Assignee: Societe Cortial, S.A.
    Inventors: Marie-Helene Creuzet, Claude Feniou, Francoise Guichard, Gisele Prat, Jacqueline Mosser, Henri Pontagnier
  • Patent number: 4590193
    Abstract: This invention relates to 3-(2-(4-phenylpiperazinylethyl)anilino)-isobenzofuranones, their method of preparation and their use in the treatment of conditions such as hypertension, and allergies.These compounds are characterized by the formula: ##STR1## in which R.sub.1 may be one or more substituents located at the ortho, meta, or para positions selected from the group of H, CH.sub.3, CF.sub.3, F, Cl and OCH.sub.3 ; R.sub.2 and R.sub.3 are the same or different and are H or OCH.sub.3. These compounds are in the form of free bases or their pharmaceutically safe salts. They can be obtained by a reaction between a 2-(phenylpiperazinylethyl) aniline and an aromatic aldehyde having an acid function at the ortho position of the carboxaldehyde function.These derivatives are useful for the treatment of hypertension and allergic conditions.
    Type: Grant
    Filed: July 27, 1983
    Date of Patent: May 20, 1986
    Assignee: Societe Cortial, S.A.
    Inventors: Marie-Helene Creuzet, Claude Feniou, Francoise Guichard, Gisele Prat, Henri Pontagnier
  • Patent number: 4499090
    Abstract: This invention relates to new N-(5-aminomethyl-2-oxazoline-2-yl)-N'-phenylureas, the method for producing them and their application in therapy, particularly in treating convulsions, rhythm troubles, ulcerous disorders or inflammatory or edematous conditions.The products of this invention have the general formula: ##STR1## wherein R.sub.1 and R.sub.2 independently represent an alkyl radical of C.sub.1 to C.sub.4, or a carbocyclic alkyl radical having 3 or less rings, or a carbocyclic radical having 3 or less rings; R.sub.1 and R.sub.2 can form, with the nitrogen atom to which they are attached, a 4 to 7 member heterocycle containing 1 or 2 nitrogen atoms and 1 or 0 oxygen atoms, said heterocycle can be substituted by R with R being an alkyl radical of C.sub.1 to C.sub.4, allyl, benzyl, pyridyl, phenyl substituted or not by one or more substituents such as halogen, trihalomethyl, alkyl of C.sub.1 to C.sub.4, hydroxy, or alkoxy having a C.sub.1 to C.sub.4 alkyl radical.
    Type: Grant
    Filed: October 5, 1983
    Date of Patent: February 12, 1985
    Assignee: Societe Cortial, S.A.
    Inventors: Marie-Helene Creuzet, Claude Feniou, Christian Jarry, Gisele Prat, Henri Pontagnier
  • Patent number: 4497812
    Abstract: This invention relates to new 2-amino-5-aminomethyl-2-oxazolines, the method of preparing them, and their pharmacological properties making possible their application in cardiovascular, psychotropic, antiinflammatory antiallergic, antihistamine, antiH.sub.2 therapy.These new products have the general formula: ##STR1## wherein R.sub.1 and R.sub.2 independently represent an alkyl radical of C.sub.1 to C.sub.4, or a carbocyclic alkyl radical having less than 4 rings, or a carbocyclic radical having less than 4 rings; R.sub.1 and R.sub.2 can form, with the nitrogen atom to which they are attached, a 4 to 7 member heterocycle containing 1 or 2 nitrogen atoms, and either 1 or 0 oxygen atoms. This heterocycle can be substituted by R with R being a lower alkyl, allyl, benzyl, pyridyl, phenyl substituted or not by one or more substituents such as halogen, trifluoromethyl, methyl, methoxy, hydroxy.
    Type: Grant
    Filed: October 5, 1983
    Date of Patent: February 5, 1985
    Assignee: Societe Cortial, S.A.
    Inventors: Marie-Helene Creuzet, Claude Feniou, Christian Jarry, Gisele Prat, Henri Pontagnier
  • Patent number: 4333930
    Abstract: Compounds, exhibiting central nervous system activity, of the formula ##STR1## wherein R.sub.1 is phenyl which is unsubstituted or substituted by at least one member selected from the group consisting of halogen, CF.sub.3, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy and COOH, orR.sub.1 is ##STR2## or R.sub.1 is a heterocycle selected from the group consisting of ##STR3## R.sub.2 R.sub.3 R.sub.4 and R.sub.5, which may be identical or different, are H or CH.sub.3 ;R.sub.6 and R.sub.7, which may be identical or different, are C.sub.1 -C.sub.6 alkyl, which may be straight-chained or branched, orR.sub.7 can be H when R.sub.6 is a branched-chain alkyl, orR.sub.6 and R.sub.7 can form, with the nitrogen to which they are bonded, a heterocycle selected from the group consisting of ##STR4## R.sub.8 R.sub.9 R.sub.10 and R.sub.11, which may be identical or different, are H, halogen, CF.sub.3, hydroxy or C.sub.1 -C.sub.4 alkoxy, or two contiguous members of R.sub.8 R.sub.9, R.sub.10 and R.sub.
    Type: Grant
    Filed: February 23, 1981
    Date of Patent: June 8, 1982
    Assignee: Laboratoires Sarget
    Inventors: Marie-Helene Creuzet, Claude Feniou, Francoise Guichard, Gisele Prat
  • Patent number: 4333938
    Abstract: New compounds of the general formula: ##STR1## wherein R.sub.1 is an unsaturated heterocyclic radical selected from the group consisting of: ##STR2## wherein R.sub.2 is H or one substituent selected from the group consisting of CH.sub.3, halogen, and nitro, are useful as anti-inflammatories and in the oral treatment of diabetes.
    Type: Grant
    Filed: June 25, 1980
    Date of Patent: June 8, 1982
    Assignee: Laboratoires Sarget
    Inventors: Marie-Helene Creuzet, Claude Feniou, Gisele Prat, Henri Pontagnier
  • Patent number: 4211772
    Abstract: Acetals and ketals of benzopyran glycosides, prepared by condensing a benzopyran glycoside with a carbonyl compound using a chloroformate ester as condensing agent, show enhanced activity in treating capillary fragility and related pathologies, as well as effectiveness in modifying the evolution of diabetic cataracts.
    Type: Grant
    Filed: June 1, 1978
    Date of Patent: July 8, 1980
    Assignee: Laboratoires Sarget
    Inventors: Francois Fauran, Claude Feniou, Jacqueline Mosser, Annie Thibault, Claude Andre, Gisele Prat
  • Patent number: 4179519
    Abstract: A method for reducing serum lipid levels in humans and animals is provided which comprises administering a hypolipidemically effective amount of p-chlorophenyl 2-(p-chlorophenoxy)-2-methylpropionate. A hypolipidemic composition is provided which comprises p-chlorophenyl 2-(p-chlorophenoxy)-2-methylpropionate, as principal active ingredient, in combination with a pharmaceutically acceptable carrier. Total serum lipids and serum cholesterol levels are significantly reduced.
    Type: Grant
    Filed: March 8, 1978
    Date of Patent: December 18, 1979
    Assignee: Laboratoires Sarget
    Inventors: Francois Fauran, Claude Feniou, Jacqueline Mosser, Gisele Prat
  • Patent number: 4122202
    Abstract: 3-Amino 3H-isobenzofuranones substituted on the nitrogen atom with benzodioxol-1,3, benzodioxane-1,4 or benzodioxane-1,3 rings are described which possess analgesic and anti-edematous properties.
    Type: Grant
    Filed: July 8, 1976
    Date of Patent: October 24, 1978
    Assignee: Societe Cortial
    Inventors: Francois Fauran, Claude Feniou, Annie Thibault, Gisele Prat