Patents by Inventor Claudio Cherubini

Claudio Cherubini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210283714
    Abstract: According to the present invention, a system (1; 1?) for processing at least one substrate (2) containing a dried fluid sample (21) is provided, the system (1; 1?) comprising a support (12) configured to position the substrate (2), a laser device (3) for directing a laser beam (31) to the substrate (2), configured to cut at least one area of the substrate (2) containing the dried fluid sample (21) by means of the laser beam (31), a container holder (4; 4?) configured to hold and position a container (5) for receiving the cut area, the container holder (4; 4?) being arranged below the substrate (2), and an extraction subsystem (6) for extracting fume and/or dust generated when laser cutting the substrate (2), wherein the extraction subsystem (6) consists of at least two extraction components (61, 62) sandwiching the substrate (2) there between. Furthermore, a method for automated processing at least one substrate (2) containing a dried fluid (21) sample by means of such a system (1; 1?) is provided.
    Type: Application
    Filed: May 27, 2021
    Publication date: September 16, 2021
    Inventors: Claudio Cherubini, Andreas Drechsler, Reto Huesser, Emad Sarofim
  • Patent number: 11052484
    Abstract: According to the present invention, a system (1; 1?) for processing at least one substrate (2) containing a dried fluid sample (21) is provided, the system (1; 1?) comprising a support (12) configured to position the substrate (2), a laser device (3) for directing a laser beam (31) to the substrate (2), configured to cut at least one area of the substrate (2) containing the dried fluid sample (21) by means of the laser beam (31), a container holder (4; 4?) configured to hold and position a container (5) for receiving the cut area, the container holder (4; 4?) being arranged below the substrate (2), and an extraction subsystem (6) for extracting fume and/or dust generated when laser cutting the substrate (2), wherein the extraction subsystem (6) consists of at least two extraction components (61, 62) sandwiching the substrate (2) there between. Furthermore, a method for automated processing at least one substrate (2) containing a dried fluid (21) sample by means of such a system (1; 1?) is provided.
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: July 6, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Claudio Cherubini, Andreas Drechsler, Reto Huesser, Emad Sarofim
  • Publication number: 20210154684
    Abstract: A bucket insert for use in a centrifuge is disclosed. The bucket insert comprises an insert body, the insert body comprising a plurality of elongated receptacles for receiving elongated sample vessels. The bucket insert is configured for orienting the elongated sample vessels in a tilted orientation. In the tilted orientation, at least some of the elongated sample vessels are oriented in a non-parallel fashion.
    Type: Application
    Filed: November 20, 2020
    Publication date: May 27, 2021
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Claudio Cherubini, Andreas Drechsler
  • Patent number: 10809219
    Abstract: A sensor (100) for detecting a state of a fluid within a microfluidic plate (120) is disclosed. The sensor (100) comprises at least a first planar electrode (102) and a second planar electrode (104) arranged parallel to one another so as to form an electric capacitor (106). The first planar electrode (102) and the second planar electrode (104) are configured to generate an electric field (114) within the fluid, wherein the sensor (100) is configured to detect the state of the fluid by means of a capacitance of the electric capacitor (106). Further, a system (116) for controlling a preparation of a sample including a fluid is disclosed. Furthermore, a method for detecting a state of a fluid within a microfluidic plate (120) is disclosed.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: October 20, 2020
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Claudio Cherubini, Michal Dobrzynski, Paul Federer, Thomas Kern, Lukas Schneider
  • Publication number: 20200033240
    Abstract: A method and system for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion having a top opening for receiving the liquid comprising the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion having a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion having a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest.
    Type: Application
    Filed: August 16, 2019
    Publication date: January 30, 2020
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Claudio Cherubini, Martin Kopp, Nenad Milicevic, Daniel Mueller, Emad Sarofim, Goran Savatic
  • Publication number: 20190344260
    Abstract: The disclosure features methods, fluid delivery platforms, and apparatus for preparing a sample on a substrate that includes a substrate handler configured to move a substrate between a first position and a second position, and a platform positioned so that when the substrate is in the second position, the platform faces the substrate, where the platform includes a fluid delivery area having a second surface formed from a hydrophilic material for which a water contact angle is 40 degrees or less, and a first surface facing the substrate when the substrate is in the second position, formed from a hydrophobic material for which a water contact angle is 100 degrees or more.
    Type: Application
    Filed: December 29, 2017
    Publication date: November 14, 2019
    Inventors: Ertan Ergezen, Stephen Conroy, Rijk Edwin Oosterbroek, Claudio Cherubini
  • Patent number: 10436685
    Abstract: A method for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion having a top opening for receiving the liquid comprising the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion having a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion having a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: October 8, 2019
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Claudio Cherubini, Martin Kopp, Nenad Milicevic, Daniel Mueller, Emad Sarofim, Goran Savatic
  • Publication number: 20190239975
    Abstract: The present disclosure relates to a system for the thermally controlled processing of biological material in a liquid sample in a multiwell plate using magnetic particles. Also disclosed is a corresponding method for the thermally controlled processing of biological material in a liquid sample.
    Type: Application
    Filed: January 25, 2019
    Publication date: August 8, 2019
    Inventors: Roland Bernet, Claudio Cherubini, Pius Hermann, Emad Sarofim
  • Publication number: 20180333806
    Abstract: According to the present invention, a system (1; 1?) for processing at least one substrate (2) containing a dried fluid sample (21) is provided, the system (1; 1?) comprising a support (12) configured to position the substrate (2), a laser device (3) for directing a laser beam (31) to the substrate (2), configured to cut at least one area of the substrate (2) containing the dried fluid sample (21) by means of the laser beam (31), a container holder (4; 4?) configured to hold and position a container (5) for receiving the cut area, the container holder (4; 4?) being arranged below the substrate (2), and an extraction subsystem (6) for extracting fume and/or dust generated when laser cutting the substrate (2), wherein the extraction subsystem (6) consists of at least two extraction components (61, 62) sandwiching the substrate (2) there between. Furthermore, a method for automated processing at least one substrate (2) containing a dried fluid (21) sample by means of such a system (1; 1?) is provided.
    Type: Application
    Filed: May 17, 2018
    Publication date: November 22, 2018
    Inventors: Claudio Cherubini, Andreas Drechsler, Reto Huesser, Emad Sarofim
  • Patent number: 9957111
    Abstract: A conveyor device for conveying test tube holders in a laboratory distribution system is presented. The conveyor device is a screw conveyor device comprising a helical track having a helix axis and a drive shaft having an axis of rotation parallel or coaxial to the helix axis, which drive shaft is adapted to be driven to rotate about the axis of rotation for causing a movement of one test tube holder or a plurality of test tube holders contacting the helical track between an entry region and an exit region. The entry region and the exit region are spaced in a direction of the helix axis. A laboratory distribution system for conveying test tube holders and a laboratory automation system comprising a laboratory distribution system are also presented.
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: May 1, 2018
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Claudio Cherubini, Andreas Drechsler, Reto Huesser, Nenad Milicevic, Gottlieb Schacher
  • Patent number: 9956559
    Abstract: An instrument and a method for the automated thermal treatment of liquid samples are disclosed. An inter-distance between a temperature-controlled receptacle for loading with a plurality of vessels for containing the samples and end portions of optical fibers can be varied, wherein the receptacle is configured to form a thermal communication with the loaded vessels and wherein the optical fibers have first and second end portions. The first end portion and the second end portion of each optical fiber is fixed with respect to each other for transmitting light, wherein the variation of the in-ter-distance allows the vessels to be loaded to or unloaded from the receptacle and to enable detection of light from the samples contained in the one or more receptacle-loaded vessels.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: May 1, 2018
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Claudio Cherubini, Roger Iten, Emad Sarofim, Kurt Schildknecht
  • Publication number: 20180095046
    Abstract: A sensor (100) for detecting a state of a fluid within a microfluidic plate (120) is disclosed. The sensor (100) comprises at least a first planar electrode (102) and a second planar electrode (104) arranged parallel to one another so as to form an electric capacitor (106). The first planar electrode (102) and the second planar electrode (104) are configured to generate an electric field (114) within the fluid, wherein the sensor (100) is configured to detect the state of the fluid by means of a capacitance of the electric capacitor (106). Further, a system (116) for controlling a preparation of a sample including a fluid is disclosed. Furthermore, a method for detecting a state of a fluid within a microfluidic plate (120) is disclosed.
    Type: Application
    Filed: September 27, 2017
    Publication date: April 5, 2018
    Applicant: Roche Molecular System, Inc.
    Inventors: Claudio Cherubini, Michal Dobrzynski, Paul Federer, Thomas Kern, Lukas Schneider
  • Publication number: 20180010990
    Abstract: A method for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion comprising a top opening for receiving the liquid comprising the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion comprising a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion comprising a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest.
    Type: Application
    Filed: January 27, 2017
    Publication date: January 11, 2018
    Inventors: Claudio Cherubini, Martin Kopp, Nenad Milicevic, Daniel Mueller, Emad Sarofim, Goran Savatic
  • Patent number: 9638612
    Abstract: A method of individually releasing from an entity one or more members of a sub-group of biological units included in a heterogeneous group of biological units is provided. The method includes binding the group of biological units including the sub-group of biological units to the entity via a linker. Following binding, the location of the one or more members on the entity is determined. Once the location is determined, a localized physical pulse is applied to the one or more members. The localized physical pulse individually releases the one or more members from the entity by dissociating the linker.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: May 2, 2017
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Judith Brand-Meier, Claudio Cherubini, Andreas Drechsler, Nicole Gwerder, Martin Kopp, Edwin Oosterbroek, Emad Sarofim
  • Publication number: 20170101272
    Abstract: A conveyor device for conveying test tube holders in a laboratory distribution system is presented. The conveyor device is a screw conveyor device comprising a helical track having a helix axis and a drive shaft having an axis of rotation parallel or coaxial to the helix axis, which drive shaft is adapted to be driven to rotate about the axis of rotation for causing a movement of one test tube holder or a plurality of test tube holders contacting the helical track between an entry region and an exit region. The entry region and the exit region are spaced in a direction of the helix axis. A laboratory distribution system for conveying test tube holders and a laboratory automation system comprising a laboratory distribution system are also presented.
    Type: Application
    Filed: September 26, 2016
    Publication date: April 13, 2017
    Inventors: Claudio Cherubini, Andreas Drechsler, Reto Huesser, Nenad Milicevic, Gottlieb Schacher
  • Publication number: 20170100715
    Abstract: An instrument and a method for the automated thermal treatment of liquid samples are disclosed. An inter-distance between a temperature-controlled receptacle for loading with a plurality of vessels for containing the samples and end portions of optical fibers can be varied, wherein the receptacle is configured to form a thermal communication with the loaded vessels and wherein the optical fibers have first and second end portions. The first end portion and the second end portion of each optical fiber is fixed with respect to each other for transmitting light, wherein the variation of the in-ter-distance allows the vessels to be loaded to or unloaded from the receptacle and to enable detection of light from the samples contained in the one or more receptacle-loaded vessels.
    Type: Application
    Filed: December 20, 2016
    Publication date: April 13, 2017
    Inventors: Claudio Cherubini, Roger Iten, Emad Sarofim, Kurt Schildknecht
  • Patent number: 9557269
    Abstract: An instrument and a method for the automated thermal treatment of liquid samples are disclosed. An inter-distance between a temperature-controlled receptacle for loading with a plurality of vessels for containing the samples and end portions of optical fibers can be varied, wherein the receptacle is configured to form a thermal communication with the loaded vessels and wherein the optical fibers have first and second end portions. The first end portion and the second end portion of each optical fiber is fixed with respect to each other for transmitting light, wherein the variation of the inter-distance allows the vessels to be loaded to or unloaded from the receptacle and to enable detection of light from the samples contained in the one or more receptacle-loaded vessels.
    Type: Grant
    Filed: April 2, 2014
    Date of Patent: January 31, 2017
    Inventors: Claudio Cherubini, Roger Iten, Emad Sarofim, Kurt Schildknecht
  • Publication number: 20140329249
    Abstract: A method of individually releasing from an entity one or more members of a sub-group of biological units included in a heterogeneous group of biological units is provided. The method includes binding the group of biological units including the sub-group of biological units to the entity via a linker. Following binding, the location of the one or more members on the entity is determined. Once the location is determined, a localized physical pulse is applied to the one or more members. The localized physical pulse individually releases the one or more members from the entity by dissociating the linker.
    Type: Application
    Filed: April 25, 2014
    Publication date: November 6, 2014
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Judith Brand-Meier, Claudio Cherubini, Andreas Drechsler, Nicole Gwerder, Martin Kopp, Edwin Oosterbroek, Emad Sarofim
  • Patent number: 8808647
    Abstract: Systems, methods and multi-well plates comprising an array of wells for thermal treatment of chemical or biological samples are disclosed. Each of the wells comprises a bottom opening, an upper opening, inner side walls extending from the bottom opening to the upper opening, a protrusion extending from the inner side walls into the well with a first cross-sectional area and located at a height from the bottom opening which is smaller than the height from the upper opening. A sample chamber with a second cross-sectional area is formed between the bottom opening and the protrusion. An upper chamber with a third cross-sectional area is formed between the protrusion and the upper opening, and in which the first cross-sectional area is smaller than the third cross-sectional area and smaller than or equal to the second cross-sectional area.
    Type: Grant
    Filed: September 10, 2009
    Date of Patent: August 19, 2014
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Claudio Cherubini, Nicole Gwerder, Martin Kopp, Edwin Oosterbroek, Emad Sarofim
  • Publication number: 20140220669
    Abstract: An instrument and a method for the automated thermal treatment of liquid samples are disclosed. An inter-distance between a temperature-controlled receptacle for loading with a plurality of vessels for containing the samples and end portions of optical fibers can be varied, wherein the receptacle is configured to form a thermal communication with the loaded vessels and wherein the optical fibers have first and second end portions. The first end portion and the second end portion of each optical fiber is fixed with respect to each other for transmitting light, wherein the variation of the inter-distance allows the vessels to be loaded to or unloaded from the receptacle and to enable detection of light from the samples contained in the one or more receptacle-loaded vessels.
    Type: Application
    Filed: April 2, 2014
    Publication date: August 7, 2014
    Inventors: Claudio Cherubini, Roger Iten, Emad Sarofim, Kurt Schildknecht