Abstract: Object of the present invention are new aza-tanshinone derivatives, a method for their preparation and their use in therapy, particularly, but not limited to, as anti-tumor agents and anti-inflammatories. The invention comprises also the pharmaceutical compositions containing them.

Abstract: Correlation information between captured characteristics and chemical shift values of captured NMR spin systems is provided by a model appliance for a fluid class. An NMR spectrum of a sample of the fluid class is recorded. Peaks in the recorded NMR spectrum which belong to defined reference NMR spin systems are identified, and experimental chemical shift values of the peaks from the recorded NMR spectrum are determined. A chemical shift value of at least one of the captured NMR spin systems not belonging to the reference NMR spin systems is predicted by applying the model appliance onto the experimental chemical shift values of the reference NMR spin systems. Peaks in an NMR spectrum of a sample of a fluid class are attributed more quickly and reliably to NMR spins systems of compounds contained in the sample.

Abstract: Object of the present invention are new aza-tanshinone derivatives, a method for their preparation and their use in therapy, particularly, but not limited to, as anti-tumor agents and anti-inflammatories. The invention comprises also the pharmaceutical compositions containing them.

Abstract: Correlation information between captured characteristics and chemical shift values of captured NMR spin systems is provided by a model appliance for a fluid class. An NMR spectrum of a sample of the fluid class is recorded. Peaks in the recorded NMR spectrum which belong to defined reference NMR spin systems are identified, and experimental chemical shift values of the peaks from the recorded NMR spectrum are determined. A chemical shift value of at least one of the captured NMR spin systems not belonging to the reference NMR spin systems is predicted by applying the model appliance onto the experimental chemical shift values of the reference NMR spin systems. Peaks in an NMR spectrum of a sample of a fluid class are attributed more quickly and reliably to NMR spins systems of compounds contained in the sample.

Abstract: The invention provides prodrugs activated by RNA-dependent DNA-polymerases, and methods for treating hematological tumors, blood, and blood derivatives from patients affected by retroviral infections by administering the prodrugs. The invention also provides methods for the preparation of pharmaceutical compositions containing the prodrugs.

Abstract: Described herein are derivatives of arylsulfonamido-substituted hydroxamic acid of formula (I) having good solubility in water and inhibitory activity of matrix metalloproteinases, useful for the preparation of pharmaceutical compositions for the treatment of diseases associated to a pathologic activity and/or an over-expression of metalloproteinases, and of cosmetic preparations having anti-ageing properties in particular for hair and skin.

Abstract: Described herein are derivatives of arylsulfonamido-substituted hydroxamic acid of formula (I) having good solubility in water and inhibitory activity of matrix metalloproteinases, useful for the preparation of pharmaceutical compositions for the treatment of diseases associated to a pathologic activity and/or an over-expression of metalloproteinases, and of cosmetic preparations having anti-ageing properties in particular for hair and skin.

Abstract: The use of matrix metalloproteinases, mutated and not mutated, for the preparation of pharmaceutical compositions useful in the treatment of pathologies associated with an accumulation of matrix bio-polymers and/or an excess of TIMPs (Tissue Inhihitors MetalloProteinases) is described; mutated matrix metalloproteinases, in which at least an aminoacid residue in a definite position in the protein, has been mutated into a hydrophilic and/or charged aminoacidic residue, obtaining an increased stability toward autoproteolysis are also described.

Abstract: Herein described are prodrugs activated by RNA-dependent DNA-polymerases, such as telomerase and retroviral reverse transcriptases, their use for the treatment of haematological tumours and of blood and blood derivatives from patients affected by retroviral infections, and their use for the preparation of pharmaceutical compositions, to be used for the treatment of solid tumours, of precancerous states and of diseases caused by infection with retroviruses.

Abstract: Described herein are derivatives of arylsulfonamido-substituted hydroxamic acid of formula (I) having good solubility in water and inhibitory activity of matrix metalloproteinases, useful for the preparation of pharmaceutical compositions for the treatment of diseases associated to a pathologic activity and/or an over-expression of metalloproteinases, and of cosmetic preparations having anti-ageing properties in particular for hair and skin.