Patents by Inventor Colin Houston MacPhee

Colin Houston MacPhee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lipoprotein Associated Phospholipase A2, Inhibitors Thereof and Use of the Same in Diagnosis and Therapy
    Publication number: 20120045774
    Abstract: The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
    Type: Application
    Filed: August 11, 2011
    Publication date: February 23, 2012
    Applicant: Smithkline Beecham Corporation
    Inventors: Colin Houston MacPhee, David Graham Tew
  • Lipoprotein associated phospholipase A, inhibitors thereof and use of the same in diagnosis and therapy
    Patent number: 8088886
    Abstract: The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
    Type: Grant
    Filed: April 2, 2003
    Date of Patent: January 3, 2012
    Assignee: Smith-Kline Beecham P.L.C.
    Inventors: Colin Houston MacPhee, David Graham Tew
  • Lipoprotein Associated Phospholipase A2, Inhibitors Thereof and Use of the Same in Diagnosis and Therapy
    Publication number: 20090136969
    Abstract: The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 28, 2009
    Inventors: Colin Houston MacPhee, David Graham Tew
  • Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy
    Patent number: 7314742
    Abstract: The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
    Type: Grant
    Filed: April 18, 2005
    Date of Patent: January 1, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Colin Houston MacPhee, David Graham Tew, Christopher Donald Southan, Deirdre Mary Bernadette Hickey, Israel Simon Gloger, Geoffrey Mark Prouse Lawrence, Simon Quentyn John Rice
  • Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy
    Patent number: 7045329
    Abstract: The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
    Type: Grant
    Filed: August 3, 2001
    Date of Patent: May 16, 2006
    Assignee: SmithKline Beecham plc
    Inventors: Colin Houston MacPhee, David Graham Tew, Christopher Donald Southan, Deirdre Mary Bernadette Hickey, Israel Simon Gloger, Geoffrey Mark Prouse Lawrence, Simon Quentyn John Rice
  • Novel method of treatment
    Publication number: 20040034067
    Abstract: A method for the treatment of a disease or condition associated with increased numbers of neutrophils and/or neutrophil over-activation in a mammal such as a human, which method comprises administering an effective, non-toxic and pharmaceutically acceptable amount of a PPAR&ggr; agonist, such as Compound (I), to a mammal in need thereof.
    Type: Application
    Filed: March 11, 2003
    Publication date: February 19, 2004
    Inventor: Colin Houston MacPhee
  • Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy
    Publication number: 20030186421
    Abstract: The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
    Type: Application
    Filed: April 2, 2003
    Publication date: October 2, 2003
    Inventors: Colin Houston MacPhee, David Graham Tew
  • Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy
    Publication number: 20020177209
    Abstract: The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
    Type: Application
    Filed: August 3, 2001
    Publication date: November 28, 2002
    Applicant: SmithKline Beecham plc
    Inventors: Colin Houston MacPhee, David Graham Tew, Christopher Donald Southan, Deirdre Mary Bernadette Hickey, Israel Simon Gloger, Geoffrey Mark Prouse Lawrence, Simon Quentyn John Rice
  • Phospholipase A2 inhibitors thereof and use of same in diagnosis and therapy
    Patent number: 6369045
    Abstract: The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule incoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
    Type: Grant
    Filed: October 8, 1996
    Date of Patent: April 9, 2002
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Colin Houston Macphee, David Graham Tew, Deirdre Mary Bernadette Hickey
  • Human p101 regulatory polypeptide
    Patent number: 6348341
    Abstract: SVP-1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SVP-1 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: February 19, 2002
    Assignee: SmithKline Beecham plc
    Inventors: Lisa Patel, Colin Houston MacPhee
  • Compounds
    Patent number: 6261819
    Abstract: p101 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing p101 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: July 17, 2001
    Assignee: SmithKline Beecham plc
    Inventors: Colin Houston MacPhee, Lisa Patel
  • P101 Polypeptides
    Patent number: 6258580
    Abstract: Human p101 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human p101 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: April 28, 2000
    Date of Patent: July 10, 2001
    Assignee: SmithKline Beecham plc
    Inventors: Colin Houston Macphee, Lisa Patel
  • Compounds
    Patent number: 6238886
    Abstract: SVP-1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SVP-1 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: February 16, 1999
    Date of Patent: May 29, 2001
    Assignee: SmithKline Beecham plc
    Inventors: Lisa Patel, Colin Houston MacPhee
  • Platelet factor-4 receptor assay
    Patent number: 6232084
    Abstract: The ligand PF-4 has been identifed as a ligand for the 7TM receptor HBMBU14, also known as TYMSTR, STRL-33 and BONZO.
    Type: Grant
    Filed: March 24, 1999
    Date of Patent: May 15, 2001
    Assignee: SmithKline Beecham plc
    Inventors: Colin Houston MacPhee, Kitty Moores, Theodorus Antonius Berkhout
  • Human p101 polynucleotides
    Patent number: 6200777
    Abstract: Human p101 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human p101 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: August 27, 1998
    Date of Patent: March 13, 2001
    Assignee: SmithKline Beecham plc
    Inventors: Colin Houston MacPhee, Lisa Patel
  • Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy
    Patent number: 6177257
    Abstract: The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
    Type: Grant
    Filed: April 20, 1999
    Date of Patent: January 23, 2001
    Assignee: SmithKline Beechman
    Inventors: Colin Houston Macphee, David Graham Tew, Christopher Donald Southan, Deirdre Mary Bernadette Hickey, Israel Simon Gloger, Geoffrey Mark Prouse Lawrence, Simon Quentyn John Rice
  • Compounds
    Patent number: 6174716
    Abstract: p101 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing p101 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: August 20, 1999
    Date of Patent: January 16, 2001
    Assignee: SmithKline Beecham plc
    Inventors: Colin Houston MacPhee, Lisa Patel
  • Lipoprotein associated phospholipase A.sub.2, inhibitors thereof and use of the same in diagnosis and therapy
    Patent number: 5981252
    Abstract: The enzyme Lp-PLA.sub.2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA.sub.2, the use of an inhibitor of the enzyme Lp-PLA.sub.2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
    Type: Grant
    Filed: February 24, 1995
    Date of Patent: November 9, 1999
    Assignee: SmithKline Beecham
    Inventors: Colin Houston MacPhee, David Graham Tew