Patents by Inventor Colin J. H. Brenan
Colin J. H. Brenan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210187508Abstract: The present invention generally relates to microfluidic droplets and, in particular, to multiple emulsion microfluidic droplets. Provided are methods and a device of ordering, sorting and/or focusing particles, the method comprising leading the particles through a microfluidic channel comprising a channel height (H) in the range of (1.8) D to (1.2) D and a channel width (W) in the range of (1.33) D to 1 D, wherein D is the particle diameter.Type: ApplicationFiled: October 16, 2018Publication date: June 24, 2021Inventors: Steven Scherr, Colin J.H. Brenan, Michael J. Brenan, Marcel Reichen
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Patent number: 10974247Abstract: An interface is provided for storing microfluidic samples in a nanoliter sample chip. A fluid access structure provides a fluid access region to a selected subset of sample wells from an array of sample wells. A fluid introduction mechanism introduces a sample fluid to the fluid access region so that the sample wells in the selected subset are populated with the sample fluid without the unselected sample wells being populated with the sample fluid.Type: GrantFiled: August 31, 2018Date of Patent: April 13, 2021Assignee: Life Technologies CorporationInventors: Tanya S. Kanigan, Steve Smith, John Linton, Robert Hess, Karl Yoder, Colin J. H. Brenan
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Publication number: 20200338552Abstract: The present invention is directed to a fluidic interface for delivering a fluid into a microfluidic device, the interface comprising a chamber comprising a first accepting/delivering fluid opening and a second accepting/delivering fluid opening, each opening being positioned opposite to the other, wherein the diameter of the first accepting/delivering fluid opening is smaller than the internal diameter of the chamber and a tubing system connecting the first accepting/delivering fluid opening to a pressure source capable of generating positive or negative pressure. The interface is characterized in that the second accepting/delivering fluid opening is designed to mechanically limit its insertion into a receptacle of a microfluidic device to ensure a predetermined gap (H) between the second accepting/delivering fluid opening and a lower side of the receptacle of a microfluidic device.Type: ApplicationFiled: October 24, 2018Publication date: October 29, 2020Inventors: Steven Scherr, Colin J. H. Brenan, Michael J. Brenan, Marcel Reichen, Raphael Clement Li-Ming Doineau
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Publication number: 20190118173Abstract: An interface is provided for storing microfluidic samples in a nanoliter sample chip. A fluid access structure provides a fluid access region to a selected subset of sample wells from an array of sample wells. A fluid introduction mechanism introduces a sample fluid to the fluid access region so that the sample wells in the selected subset are populated with the sample fluid without the unselected sample wells being populated with the sample fluid.Type: ApplicationFiled: August 31, 2018Publication date: April 25, 2019Inventors: Tanya S. KANIGAN, Steve SMITH, John LINTON, Robert HESS, Karl YODER, Colin J. H. BRENAN
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Patent number: 10213761Abstract: A differentially coated device for conducting a plurality of nano-volume specified reactions, the device comprising a platen having at least one exterior surface modified to a specified physicochemical property, a plurality of nano-volume channels, each nano-volume channel having at least one interior surface in communication with the at least one exterior surface that is selectively coated with an optionally dissolvable coating agent physisorbed to at least one interior surface, wherein the optionally dissolvable coating agent comprises a coating agent and a first component for the plurality of specified reactions. Methods for preparing and using such devices are also provided, as well as a method of registering a location of a dispenser array in relation to a microfluidic array. A first one of the dispenser array and the microfluidic array is movable in relation to the frame, and the other of the first one of the dispenser array and the microfluidic array is fixed relative to the frame.Type: GrantFiled: June 9, 2014Date of Patent: February 26, 2019Assignee: Life Technologies CorporationInventors: Colin J. H. Brenan, Jamie Cho, Javier Garcia, Robert Hess, Tanya S. Kanigan, Arrin Katz, Namyong Kim, John Linton, Shailesh Srivastava, Karl Yoder
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Patent number: 10106843Abstract: One aspect of the invention provides container for thermal cycling a plurality of samples in a microfluidic array. The container includes a plurality of walls defining an interior volume and a conductive member for heating the interior volume. Another aspect of the invention provides container for thermal cycling a plurality of samples in a microfluidic array. The container includes a plurality of walls defining an interior volume and a plurality of conductive members for heating an interior volume. Another aspect of the invention provides a container for thermal cycling a plurality of samples in a microfluidic array. The container includes a plurality of walls defining an interior volume and a first conductive member located in the interior volume and adapted to contact a first end of the microfluidic array.Type: GrantFiled: November 6, 2015Date of Patent: October 23, 2018Assignee: Life Technologies CorporationInventors: Colin J. H. Brenan, Thomas B. Morrison, Tanya S. Kanigan
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Publication number: 20170028376Abstract: A method and an array filling system for loading a plurality of disparate sample containers, the sample containers comprising an integral structure. Each receptacle is characterized by a hydrophilic surface,, and the receptacles are separated by a hydrophobic surface. The system has a liquid transfer device capable of holding liquid and adapted for motion to cause sequential communication of liquid held in the liquid transfer device with successive receptacles of the array by dragging the liquid across the hydrophobic surface.Type: ApplicationFiled: December 23, 2014Publication date: February 2, 2017Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Ian Hunter, Colin J.H. Brenan, Tanya S. Kanigan
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Publication number: 20160160265Abstract: One aspect of the invention provides container for thermal cycling a plurality of samples in a microfluidic array. The container includes a plurality of walls defining an interior volume and a conductive member for heating the interior volume. Another aspect of the invention provides container for thermal cycling a plurality of samples in a microfluidic array. The container includes a plurality of walls defining an interior volume and a plurality of conductive members for heating an interior volume. Another aspect of the invention provides a container for thermal cycling a plurality of samples in a microfluidic array. The container includes a plurality of walls defining an interior volume and a first conductive member located in the interior volume and adapted to contact a first end of the microfluidic array.Type: ApplicationFiled: November 6, 2015Publication date: June 9, 2016Inventors: Colin J.H. BRENAN, Thomas B. MORRISON, Tanya S. KANIGAN
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Patent number: 9180459Abstract: One aspect of the invention provides container for thermal cycling a plurality of samples in a microfluidic array. The container includes a plurality of walls defining an interior volume and a conductive member for heating the interior volume. Another aspect of the invention provides container for thermal cycling a plurality of samples in a microfluidic array. The container includes a plurality of walls defining an interior volume and a plurality of conductive members for heating an interior volume. Another aspect of the invention provides a container for thermal cycling a plurality of samples in a microfluidic array. The container includes a plurality of walls defining an interior volume and a first conductive member located in the interior volume and adapted to contact a first end of the microfluidic array.Type: GrantFiled: March 6, 2009Date of Patent: November 10, 2015Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Colin J. H. Brenan, Thomas B. Morrison, Tanya S. Kanigan
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Publication number: 20150298089Abstract: A method and an array filling system for loading a plurality of disparate sample containers, the sample containers comprising an integral structure. Each receptacle is characterized by a hydrophilic surface,, and the receptacles are separated by a hydrophobic surface. The system has a liquid transfer device capable of holding liquid and adapted for motion to cause sequential communication of liquid held in the liquid transfer device with successive receptacles of the array by dragging the liquid across the hydrophobic surface.Type: ApplicationFiled: December 23, 2014Publication date: October 22, 2015Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Ian Hunter, Colin J.H. Brenan, Tanya S. Kanigan
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Publication number: 20150126412Abstract: A method and an array filling system for loading a plurality of disparate sample containers, the sample containers comprising an integral structure. Each receptacle is characterized by a hydrophilic surface, and the receptacles are separated by a hydrophobic surface. The system has a liquid transfer device capable of holding liquid and adapted for motion to cause sequential communication of liquid held in the liquid transfer device with successive receptacles of the array by dragging the liquid across the hydrophobic surface.Type: ApplicationFiled: June 10, 2014Publication date: May 7, 2015Inventors: Ian Hunter, Colin J.H. Brenan
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Publication number: 20150011436Abstract: A differentially coated device for conducting a plurality of nano-volume specified reactions, the device comprising a platen having at least one exterior surface modified to a specified physicochemical property, a plurality of nano-volume channels, each nano-volume channel having at least one interior surface in communication with the at least one exterior surface that is selectively coated with an optionally dissolvable coating agent physisorbed to at least one interior surface, wherein the optionally dissolvable coating agent comprises a coating agent and a first component for the plurality of specified reactions. Methods for preparing and using such devices are also provided, as well as a method of registering a location of a dispenser array in relation to a microfluidic array. A first one of the dispenser array and the microfluidic array is movable in relation to the frame, and the other of the first one of the dispenser array and the microfluidic array is fixed relative to the frame.Type: ApplicationFiled: June 9, 2014Publication date: January 8, 2015Inventors: Colin J. H. Brenan, Jamie Cho, Javier Garcia, Robert Hess, Tanya S. Kanigan, Arrin Katz, Namyong Kim, John Linton, Shailesh Srivastava, Karl Yoder
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Patent number: 8740958Abstract: A platform Smart Scalpel system using rapid real-time feedback for effecting laser treatment. The platform system includes an imaging system for rapid real-time detection of tissue characteristics, a processing system for processing the detected characteristics, and a treatment system for effecting treatment in accordance with results of the processing. The platform system provides for preprogramming and real-time inputting conditions and parameters for diagnosis using the imaging system and/or treatment using the treatment system.Type: GrantFiled: June 27, 2011Date of Patent: June 3, 2014Assignees: Massachusetts Institute of Technology, General Hospital CorporationInventors: Richard Rox Anderson, Ian W. Hunter, Colin J. H. Brenan, Keng Hui Lim, Elizabeth Sebem
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Patent number: 8685340Abstract: A liquid dispenser for a microfluidic assay system is described. The dispenser includes at least one transfer pin for transferring a microfluidic sample of liquid to a target receptacle. A pin tip at one end of the transfer pin is structured to cooperate with an opening in the target receptacle. The tip uses capillary action to transfer the sample from the pin to the receptacle.Type: GrantFiled: April 17, 2008Date of Patent: April 1, 2014Assignee: Life Technologies CorporationInventors: Leila Hasan, John Linton, Colin J. H. Brenan
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Patent number: 8277753Abstract: A liquid dispenser for a microfluidic assay system is described. The dispenser includes at least one transfer pin for transferring a microfluidic sample of liquid to a target receptacle. A pin tip at one end of the transfer pin is structured to cooperate with an opening in the target receptacle. The tip uses a high voltage potential to transfer the sample from the pin to the receptacle.Type: GrantFiled: August 23, 2002Date of Patent: October 2, 2012Assignee: Life Technologies CorporationInventors: Leila Hasan, John Linton, Colin J. H. Brenan
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Publication number: 20110319300Abstract: A method and an array filling system for loading a plurality of disparate sample containers, the sample containers comprising an integral structure. Each receptacle is characterized by a hydrophilic surface, and the receptacles are separated by a hydrophobic surface. The system has a liquid transfer device capable of holding liquid and adapted for motion to cause sequential communication of liquid held in the liquid transfer device with successive receptacles of the array by dragging the liquid across the hydrophobic surface.Type: ApplicationFiled: September 9, 2011Publication date: December 29, 2011Applicant: Massachusetts Institute of TechnologyInventors: Ian Hunter, Colin J.H. Brenan, Tanya S. Kanigan
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Publication number: 20110319877Abstract: A platform Smart Scalpel system using rapid real-time feedback for effecting laser treatment. The platform system includes an imaging system for rapid real-time detection of tissue characteristics, a processing system for processing the detected characteristics, and a treatment system for effecting treatment in accordance with results of the processing. The platform system provides for preprogramming and real-time inputting conditions and parameters for diagnosis using the imaging system and/or treatment using the treatment system.Type: ApplicationFiled: June 27, 2011Publication date: December 29, 2011Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE GENERAL HOSPITAL CORPORATIONInventors: R. Rox Anderson, Ian W. Hunter, Colin J. H. Brenan, Keng Hui Lim, Elizabeth Sebem
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Patent number: 8029745Abstract: Systems for filling sample array by droplet dragging are provided. One aspect of the invention provides an array filling system for filling a platen having a platen surface and an array of receptacles, the receptacles having an internal surface and the receptacles separated by the platen surface, the system comprising: a liquid transfer device capable of holding liquid; and a controller configured to position the liquid transfer device in proximity to the platen surface and to move the liquid transfer device across the surface and over the receptacles to be filled so as to cause sequential communication of liquid in the liquid transfer device with the interior surface of each receptacle.Type: GrantFiled: May 19, 2009Date of Patent: October 4, 2011Assignee: Massachusetts Institute of TechnologyInventors: Ian Hunter, Colin J. H. Brenan, Tanya S. Kanigan
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Patent number: 7967016Abstract: A platform Smart Scalpel system using rapid real-time feedback for effecting laser treatment. The platform system includes an imaging system for rapid real-time detection of tissue characteristics, a processing system for processing the detected characteristics, and a treatment system for effecting treatment in accordance with results of the processing. The platform system provides for preprogramming and real-time inputting conditions and parameters for diagnosis using the imaging system and/or treatment using the treatment system.Type: GrantFiled: October 19, 2006Date of Patent: June 28, 2011Assignees: The General Hospital Corporation, Massachusetts Institute of TechnologyInventors: R. Rox Anderson, Ian W. Hunter, Colin J. H. Brenan, Keng Hui Lim, Elizabeth Sebern
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Publication number: 20110152108Abstract: One aspect of the invention provides container for thermal cycling a plurality of samples in a microfluidic array. The container includes a plurality of walls defining an interior volume and a conductive member for heating the interior volume. Another aspect of the invention provides container for thermal cycling a plurality of samples in a microfluidic array. The container includes a plurality of walls defining an interior volume and a plurality of conductive members for heating an interior volume. Another aspect of the invention provides a container for thermal cycling a plurality of samples in a microfluidic array. The container includes a plurality of walls defining an interior volume and a first conductive member located in the interior volume and adapted to contact a first end of the microfluidic array.Type: ApplicationFiled: March 6, 2009Publication date: June 23, 2011Inventors: Colin J.H. Brenan, Thomas B. Morrison, Tanya S. Kanigan