Patents by Inventor Colin Steel

Colin Steel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9063158
    Abstract: An HPLC module utilizes a combination of compound-dedicated hardware providing line clearance between differing radiosynthesis and includes multiple compound-dedicated HPLC inject valves, each inject valve directing a fluid to a serially-connected HPLC column and UV flowcell so as to prevent cross-contamination between differing radiopharmaceutical syntheses. The module provides a disposable fluid path from each UV flowcell allowing for radioactive detection, fraction collection, formulation and final product dispensing. In this manner, a level of GMP compliance is achieved that is suitable for meeting the requirements of an MHRA approved site-license.
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: June 23, 2015
    Assignee: GE Healthcare Limited
    Inventors: Colin Steel, Farah Shah, Sajinder Luthra
  • Patent number: 8664617
    Abstract: A multi-stream optical interrogation flow cell (60) for a radiopharmaceutical includes a multiple flow cell body (10a-f) defining a first elongate fluid flowpath (A1-6;B1-6) therethrough for individually conducting a radiopharmaceutical therethrough in fluid isolation from other of the flow cell bodies. Each flow cell body further defines a first and second aligned UV transparent optical guides (36,38) and a first interrogation passageway (26a-f) extending between the first and second optical guides such that a portion of the elongate first fluid flowpath intersects the interrogation passageway such that the radiopharmaceutical flows in between the first and second optical guides. The first and second interrogation passageways of all of the flow cell bodies are optically aligned so that a single interrogation beam is able to extend through each of the interrogation passageways.
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: March 4, 2014
    Assignees: GE Healthcare UK Limited, General Electric Company
    Inventors: Robin Fortt, Colin Steel, Victor D. Samper, Marko Baller
  • Publication number: 20130334443
    Abstract: Components and systems for a PET radiopharmacy include a transport shield for a radioisotope cartridge, a cassette for dispensing from a transport shield, a cassette synthesis platform for a cassette, and a synthesizer shield.
    Type: Application
    Filed: December 22, 2011
    Publication date: December 19, 2013
    Applicant: GE HEALTHCARE LIMITED
    Inventors: Colin Steel, Sajinder Kaur Luthra, Robin Fortt, Farah Shah
  • Publication number: 20120207650
    Abstract: A multi-stream optical interrogation flow cell (60) for a radiopharmaceutical includes a multiple flow cell body (10a-f) defining a first elongate fluid flowpath (A1-6;B1-6) therethrough for individually conducting a radiopharmaceutical therethrough in fluid isolation from other of the flow cell bodies. Each flow cell body further defines a first and second aligned UV transparent optical guides (36,38) and a first interrogation passageway (26a-f) extending between the first and second optical guides such that a portion of the elongate first fluid flowpath intersects the interrogation passageway such that the radiopharmaceutical flows in between the first and second optical guides. The first and second interrogation passageways of all of the flow cell bodies are optically aligned so that a single interrogation beam is able to extend through each of the interrogation passageways.
    Type: Application
    Filed: October 8, 2010
    Publication date: August 16, 2012
    Inventors: Robin Fortt, Colin Steel, Victor D. Samper, Marko Baller
  • Publication number: 20120193555
    Abstract: An HPLC module utilizes a combination of compound-dedicated hardware providing line clearance between differing radiosynthesis and includes multiple compound-dedicated HPLC inject valves, each inject valve directing a fluid to a serially-connected HPLC column and UV flowcell so as to prevent cross-contamination between differing radiopharmaceutical syntheses. The module provides a disposable fluid path from each UV flowcell allowing for radioactive detection, fraction collection, formulation and final product dispensing. In this manner, a level of GMP compliance is achieved that is suitable for meeting the requirements of an MHRA approved site-license.
    Type: Application
    Filed: October 8, 2010
    Publication date: August 2, 2012
    Inventors: Colin Steel, Farah Shah, Sajinder Luthra
  • Publication number: 20120184722
    Abstract: Disposable components for a separation and purification system include a flow cell, an end cap for a chromatography column, and a chromatography column useful for medium-pressure liquid chromatography (MPLC).
    Type: Application
    Filed: October 8, 2010
    Publication date: July 19, 2012
    Inventors: Victor Samper, Marko Baller, Emiliano De Marco, Xavier Franci, Philippe DuMont, Sali Kuci, Colin Steel, Robin Fortt
  • Publication number: 20110094619
    Abstract: The present invention provides a dispenser cassette (110) which provides at least one product dispense vial (122) to be filled. The cassette provides a filtrate conduit (128) extending between the dispense vial and a filter unit (116) so that flowpath (120) of the filtrate conduit and the dispense vial is provided and maintained as an environmentally-controlled, or GMP-compliant, volume. The resulting product dispensed into the dispense vial is thus dispensed in a GMP-compliant environment.
    Type: Application
    Filed: February 9, 2009
    Publication date: April 28, 2011
    Inventors: Colin Steel, Roger Pettitt, Paul Crosby, Svein-Erik Lindgaard
  • Publication number: 20090311157
    Abstract: A microscale solution for conducting [18F]fluoride phase transfer and subsequent radiosynthesis of 2-[18F]FDG that eliminates the azeotropic drying process. [18F]fluoride phase transfer is performed using an inexpensive disposable microchip. Additionally, each subsequent each step may be performed on the same single microchip.
    Type: Application
    Filed: December 20, 2007
    Publication date: December 17, 2009
    Inventors: Colin Steel, Robin Fortt, Elaine Liow, Stefan Riese
  • Publication number: 20090274603
    Abstract: The present invention provides a method and an apparatus for extracting an isotope from a gas. More specifically, the present invention depicts a system that has been devised which provides [18F] fluoride from a cyclotron target in non-aqueous media.
    Type: Application
    Filed: December 5, 2007
    Publication date: November 5, 2009
    Inventors: Colin Steel, Sajinder Luthra, Frank Brady