Patents by Inventor Collin J. McKinney

Collin J. McKinney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190346422
    Abstract: The present invention is directed to a device that comprises a biomolecular processor and one or more nanotubes. Each biomolecular processor comprises a bioreactor chamber defined by a solid substrate, a plurality of spaced support structures within said bioreactor chamber and attached to the solid substrate, and one or more capture molecules immobilized to some or all of said plurality of spaced support structures, said one or more capture molecules suitable to bind to a portion of a target nucleic acid molecule in a sample. The device also comprises one or more nanotubes defined by the solid substrate and fluidically coupled to the bioreactor chamber. Each of the one or more nanotubes has a passage extending between an input end proximate to the bioreactor chamber and an output end distal to the bioreactor chamber, and comprises one or more nanopores within the passage with each nanopore having a reduced diameter relative to the passage.
    Type: Application
    Filed: July 17, 2019
    Publication date: November 14, 2019
    Inventors: Steven A. Soper, Francis Barany, Sunggook Park, Michael Murphy, Collin J. McKinney, John William Efcavitch, Mateusz Hupert
  • Publication number: 20190265714
    Abstract: Enhanced systems and methods for collision avoidance of a high value asset with reflective beacons around it using multi-sensor data fusion on a mobile industrial vehicle. The system has a sensing processing system with a LiDAR and camera sensors, and a multi-processor module responsive to the different sensors. The sensing processing system fuses the different sensor data to locate the reflective beacons. A model predictive controller on the vehicle determines possible control solutions where each defines a threshold allowable speed for the vehicle at discrete moments based upon an estimated path to a breaching point projected from the reflective beacons, and then identifies an optimal one of the control solutions based upon a performance cost function and associated with an optimal threshold allowable speed. The system has a vehicle actuator configured to respond and alter vehicle movement to avoid a collision when the vehicle exceeds the optimal threshold allowable speed.
    Type: Application
    Filed: February 26, 2019
    Publication date: August 29, 2019
    Inventors: John E. Ball, Reuben F. Burch, V, Lucas D. Cagle, Collin S. Davenport, James R. Gafford, Tyler J. Hannis, Andrew R. Hegman, Andrew M. LeClair, Yucheng Liu, Michael S. Mazzola, Howard G. McKinney, Tasmia Reza, Jian Shi, Pan Wei, Dennison W. Iacomini
  • Patent number: 10393726
    Abstract: The present invention is directed to a device that comprises a biomolecular processor and one or more nanotubes. Each biomolecular processor comprises a bioreactor chamber defined by a solid substrate, a plurality of spaced support structures within said bioreactor chamber and attached to the solid substrate, and one or more capture molecules immobilized to some or all of said plurality of spaced support structures, said one or more capture molecules suitable to bind to a portion of a target nucleic acid molecule in a sample. The device also comprises one or more nanotubes defined by the solid substrate and fluidically coupled to the bioreactor chamber.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: August 27, 2019
    Assignees: The University of North Carolina at Chapel Hill, Cornell University, Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Steven A. Soper, Francis Barany, Sunggook Park, Michael Murphy, Collin J. McKinney, John William Efcavitch, Mateusz Hupert
  • Publication number: 20180187257
    Abstract: The present invention relates to a device comprising a biomolecular processor. Each biomolecular processor has one or more bioreactor chambers defined by a solid substrate; a support structure within each bioreactor; a cleaving enzyme immobilized to the support structure and operatively positioned within the bioreactor chamber to cleave monomer or multimer units of a biopolymer molecule operatively engaged by the cleaving enzyme; and one or more time-of-flight channels formed in the solid substrate and fluidically coupled to said one or more bioreactor chambers. Each of the time-of-flight channels have two or more sensors including at least (i) a first sensor contacting the time-of-flight channel proximate to the input end of the channel and (ii) a second sensor contacting the time-of-flight channel proximate to the output end of channel. The present invention further relates to methods of sequencing and identifying biopolymer molecules using the device.
    Type: Application
    Filed: February 19, 2018
    Publication date: July 5, 2018
    Inventors: Steven A. SOPER, Francis BARANY, George GRILLS, Robin McCARLEY, Collin J. McKINNEY, Doral MOLDOVAN, Michael C. MURPHY, Dimitris NIKITOPOULOS, Sunggook PARK, Elizabeth J. PODLAHA-MURPHY
  • Publication number: 20180074039
    Abstract: The present invention is directed to a device that comprises a biomolecular processor and one or more nanotubes. Each biomolecular processor comprises a bioreactor chamber defined by a solid substrate, a plurality of spaced support structures within said bioreactor chamber and attached to the solid substrate, and one or more capture molecules immobilized to some or all of said plurality of spaced support structures, said one or more capture molecules suitable to bind to a portion of a target nucleic acid molecule in a sample. The device also comprises one or more nanotubes defined by the solid substrate and fluidically coupled to the bioreactor chamber.
    Type: Application
    Filed: March 23, 2016
    Publication date: March 15, 2018
    Inventors: Steven A. Soper, Francis Barany, Sunggook Park, Michael Murphy, Collin J. Mckinney, John William Efcavitch, Mateusz Hupert
  • Patent number: 9909173
    Abstract: The present invention relates to a device comprising a biomolecular processor. Each biomolecular processor has one or more bioreactor chambers defined by a solid substrate; a support structure within each bioreactor; a cleaving enzyme immobilized to the support structure and operatively positioned within the bioreactor chamber to cleave monomer or multimer units of a biopolymer molecule operatively engaged by the cleaving enzyme; and one or more time-of-flight channels formed in the solid substrate and fluidically coupled to said one or more bioreactor chambers. Each of the time-of-flight channels have two or more sensors including at least (i) a first sensor contacting the time-of-flight channel proximate to the input end of the channel and (ii) a second sensor contacting the time-of-flight channel proximate to the output end of channel. The present invention further relates to methods of sequencing and identifying biopolymer molecules using the device.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: March 6, 2018
    Assignees: Cornell University, University of North Carolina at Chapel Hill, Northeastern University, Board of Supervisors of Louisiana State University and Agriculture and Mechanical College
    Inventors: Steven A. Soper, Francis Barany, George Grills, Robin McCarley, Collin J. McKinney, Dorel Moldovan, Michael C. Murphy, Dimitris Nikitopoulos, Sunggook Park, Elizabeth J. Podlaha-Murphy
  • Publication number: 20150361489
    Abstract: The present invention relates to a device comprising a biomolecular processor. Each biomolecular processor has one or more bioreactor chambers defined by a solid substrate; a support structure within each bioreactor; a cleaving enzyme immobilized to the support structure and operatively positioned within the bioreactor chamber to cleave monomer or multimer units of a biopolymer molecule operatively engaged by the cleaving enzyme; and one or more time-of-flight channels formed in the solid substrate and fluidically coupled to said one or more bioreactor chambers. Each of the time-of-flight channels have two or more sensors including at least (i) a first sensor contacting the time-of-flight channel proximate to the input end of the channel and (ii) a second sensor contacting the time-of-flight channel proximate to the output end of channel. The present invention further relates to methods of sequencing and identifying biopolymer molecules using the device.
    Type: Application
    Filed: February 10, 2014
    Publication date: December 17, 2015
    Inventors: Steven A. SOPER, Francis BARANY, George GRILLS, Robin McCARLEY, Collin J. McKINNEY, Dorel MOLDOVAN, Michael C. MURPHY, Dimitris NIKITOPOULOS, Sunggook PARK, Elizabeth J. PODLAHA-MURPHY
  • Patent number: 4570152
    Abstract: A method and apparatus are described for monitoring the condition of a rotating pneumatic tire on a moving vehicle. A plurality of magnetic studs are embedded into the body of a pneumatic tire at the selected points about the periphery thereof. A magnetic field sensor is mounted upon a non-rotating portion of the vehicle adjacent to the tire and is utilized to detect the magnetic field pulsations generated by the rotating plurality of magnetic studs. As the temperature of the tire increases, toward imminent failure, or tread separation, the heat generated will decrease the magnetic field associated with the magnetic studs. When the temperature increases to a selected point and the magnetic field decreases accordingly, a display device is utilized to generate a visual and/or audible indication of imminent tire failure.
    Type: Grant
    Filed: April 23, 1984
    Date of Patent: February 11, 1986
    Assignee: Hyperion Corporation
    Inventors: Jack D. Melton, Collin J. McKinney, James A. Reimund