Patents by Inventor Connie S. Kwok

Connie S. Kwok has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Coating compositions and coatings for medical devices containing PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid polymer
    Patent number: 8703293
    Abstract: Provided herein re a composition and a coating or a device (e.g., absorbable stent) that includes a PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid biocompatible polymer and the methods of use thereof.
    Type: Grant
    Filed: April 1, 2010
    Date of Patent: April 22, 2014
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Lothar W. Kleiner, Connie S. Kwok
  • Coatings for implantable medical devices comprising hydrophilic substances and methods for fabricating the same
    Patent number: 8658194
    Abstract: A segmented polyurethane and an amphiphilic random or block copolymer are disclosed. The segmented polyurethane and the amphiphilic random or block copolymer can be used for fabricating a coating for an implantable medical device such as a stent.
    Type: Grant
    Filed: October 21, 2010
    Date of Patent: February 25, 2014
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Thierry Glauser, Connie S. Kwok, Charles D. Claude, Eugene T. Michal, Yiwen Tang, Irina Astafieva, John Whatley, Stephen D. Pacetti, Ashok Shah
  • Coatings for implantable medical devices comprising hydrophilic substances and methods for fabricating the same
    Patent number: 8309112
    Abstract: A segmented polyurethane and an amphiphilic random or block copolymer are disclosed. The segmented polyurethane and the amphiphilic random or block copolymer can be used for fabricating a coating for an implantable medical device such as a stent.
    Type: Grant
    Filed: December 24, 2003
    Date of Patent: November 13, 2012
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Thierry Glauser, Connie S. Kwok, Charles D. Claude, Eugene T. Michal, Yiwen Tang, Irina Astafieva, John Whatley, Stephen D. Pacetti, Ashok Shah
  • Merhods of treatment with devices having a coating containing pegylated hyaluronic acid and a pegylated non-hyaluronic acid polymer
    Patent number: 8105391
    Abstract: Provided herein are a method, which comprises implanting in a patient an implantable device comprising a coating that includes a PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid biocompatible polymer and the methods of use thereof.
    Type: Grant
    Filed: April 1, 2010
    Date of Patent: January 31, 2012
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Lothar W. Kleiner, Connie S. Kwok
  • Methods of delivering a drug using a medical device with a coating comprising a self-assembled molecular structure
    Patent number: 7945319
    Abstract: A method for local delivery of a drug is provided. The method comprises acts of: (a) implanting a medical device including a drug-containing coating in a patient for the delivery of the drug, wherein the coating comprises a drug and a polymer; and (b) applying an electric current for an interval of time to the topcoat to cause the polymer to transform from a crystalline structure to an amorphous structure so as to increase the rate of release of the drug during the time interval, wherein after the electric current is terminated, the crystallinity of the polymer returns back to essentially the same degree of crystallinity or a more crystalline structure than that of when the polymer was exposed to the current.
    Type: Grant
    Filed: March 6, 2008
    Date of Patent: May 17, 2011
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Connie S. Kwok, Charles D. Claude
  • Method of delivering a drug using a medical device with a coating comprising a self-assembled molecular structure
    Patent number: 7941212
    Abstract: A method for local delivery of a drug is provided. The method comprises the acts of (a) implanting a medical device carrying a drug-containing coating in a patient for the sustained local delivery of the drug, wherein at least a portion of the coating is transformed from crystalline structure to amorphous structure; and (b) applying an electric current for an interval of time to the device for increasing the rate of release of the drug, wherein the coating is further transformed from crystalline structure to amorphous structure; and (c) terminating the current after an interval of time, wherein at least a portion of the amorphous structure in the coating is at least partially restored to crystalline structure.
    Type: Grant
    Filed: March 6, 2008
    Date of Patent: May 10, 2011
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Connie S. Kwok, Charles D. Claude
  • COATINGS FOR IMPLANTABLE MEDICAL DEVICES COMPRISING HYDROPHILIC SUBSTANCES AND METHODS FOR FABRICATING THE SAME
    Publication number: 20110033517
    Abstract: A segmented polyurethane and an amphiphilic random or block copolymer are disclosed. The segmented polyurethane and the amphiphilic random or block copolymer can be used for fabricating a coating for an implantable medical device such as a stent.
    Type: Application
    Filed: October 21, 2010
    Publication date: February 10, 2011
    Inventors: Thierry Glauser, Connie S. Kwok, Charles D. Claude, Eugene T. Michal, Yiwen Tang, Irina Astafieva, John Whatley, Stephen D. Pacetti, Ashok Shah
  • COATING CONTAINING PEGYLATED HYALURONIC ACID AND A PEGYLATED NON-HYALURONIC ACID POLYMER
    Publication number: 20100191325
    Abstract: Provided herein re a composition and a coating or a device (e.g., absorbable stent) that includes a PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid biocompatible polymer and the methods of use thereof.
    Type: Application
    Filed: April 1, 2010
    Publication date: July 29, 2010
    Inventors: Lothar W. Kleiner, Connie S. Kwok
  • COATING CONTAINING PEGYLATED HYALURONIC ACID AND A PEGYLATED NON-HYALURONIC ACID POLYMER
    Publication number: 20100189758
    Abstract: Provided herein are a method, which comprises implanting in a patient an implantable device comprising a coating that includes a PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid biocompatible polymer and the methods of use thereof.
    Type: Application
    Filed: April 1, 2010
    Publication date: July 29, 2010
    Inventors: Lothar W. Kleiner, Connie S. Kwok
  • Coating containing PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid polymer
    Patent number: 7713637
    Abstract: Provided herein are a coating or a device (e.g., absorbable stent) that includes a PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid biocompatible polymer and the methods of use thereof.
    Type: Grant
    Filed: March 3, 2006
    Date of Patent: May 11, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Lothar W. Kleiner, Connie S. Kwok
  • Coatings Comprising Self-Assembled Molecular Structures
    Publication number: 20090197850
    Abstract: A coating for an implantable medical device is disclosed, the coating including a self-assembled molecular structure. The coating can be used for altering the release rate of a therapeutic substance from the implantable device.
    Type: Application
    Filed: April 7, 2009
    Publication date: August 6, 2009
    Applicant: Advanced Cardiovascular Systems, Inc.
    Inventors: Connie S. Kwok, Charles D. Claude
  • Coatings comprising self-assembled molecular structures
    Patent number: 7536221
    Abstract: A coating for an implantable medical device is disclosed, the coating including a self-assembled molecular structure. The coating can be used for altering the release rate of a therapeutic substance from the implantable device.
    Type: Grant
    Filed: March 6, 2008
    Date of Patent: May 19, 2009
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Connie S. Kwok, Charles D. Claude
  • Plasma-generated coating apparatus for medical devices and a method of coating deposition
    Patent number: 7441513
    Abstract: An apparatus for plasma polymerize coating of medical devices, such as stents, is disclosed. A method for forming plasma-polymerized coating for implantable medical devices is also disclosed.
    Type: Grant
    Filed: September 26, 2003
    Date of Patent: October 28, 2008
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Shamim M. Malik, Charles D. Claude, Connie S. Kwok, Michael Seegmiller
  • COATINGS COMPRISING SELF-ASSEMBLED MOLECULAR STRUCTURES AND A METHOD OF DELIVERING A DRUG USING THE SAME
    Publication number: 20080154232
    Abstract: A method for local delivery of a drug is provided. The method comprises the acts of (a) implanting a medical device carrying a drug-containing coating in a patient for the sustained local delivery of the drug, wherein at least a portion of the coating is transformed from crystalline structure to amorphous structure; and (b) applying an electric current for an interval of time to the device for increasing the rate of release of the drug, wherein the coating is further transformed from crystalline structure to amorphous structure; and (c) terminating the current after an interval of time, wherein at least a portion of the amorphous structure in the coating is at least partially restored to crystalline structure.
    Type: Application
    Filed: March 6, 2008
    Publication date: June 26, 2008
    Inventors: CONNIE S. KWOK, Charles D. Claude
  • COATINGS COMPRISING SELF-ASSEMBLED MOLECULAR STRUCTURES AND A METHOD OF DELIVERING A DRUG USING THE SAME
    Publication number: 20080154231
    Abstract: A method for local delivery of a drug is provided. The method comprises acts of: (a) implanting a medical device including a drug-containing coating in a patient for the delivery of the drug, wherein the coating comprises a drug and a polymer; and (b) applying an electric current for an interval of time to the topcoat to cause the polymer to transform from a crystalline structure to an amorphous structure so as to increase the rate of release of the drug during the time interval, wherein after the electric current is terminated, the crystallinity of the polymer returns back to essentially the same degree of crystallinity or a more crystalline structure than that of when the polymer was exposed to the current.
    Type: Application
    Filed: March 6, 2008
    Publication date: June 26, 2008
    Inventors: CONNIE S. KWOK, Charles D. Claude
  • COATINGS COMPRISING SELF-ASSEMBLED MOLECULAR STRUCTURES AND A METHOD OF DELIVERING A DRUG USING THE SAME
    Publication number: 20080153793
    Abstract: A coating for an implantable medical device is disclosed, the coating including a self-assembled molecular structure. The coating can be used for altering the release rate of a therapeutic substance from the implantable device.
    Type: Application
    Filed: March 6, 2008
    Publication date: June 26, 2008
    Inventors: CONNIE S. KWOK, Charles D. Claude
  • Coatings comprising self-assembled molecular structures and a method of delivering a drug using the same
    Patent number: 7363074
    Abstract: A coating for an implantable medical device is disclosed, the coating including a self-assembled molecular structure. The coating can be used for altering the release rate of a therapeutic substance from the implantable device.
    Type: Grant
    Filed: August 20, 2002
    Date of Patent: April 22, 2008
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Connie S. Kwok, Charles D. Claude
  • Coating containing PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid polymer
    Publication number: 20070207181
    Abstract: Provided herein are a coating or a device (e.g., absorbable stent) that includes a PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid biocompatible polymer and the methods of use thereof.
    Type: Application
    Filed: March 3, 2006
    Publication date: September 6, 2007
    Inventors: Lothar W. Kleiner, Connie S. Kwok