Patents by Inventor Cornelius Jungheinrich

Cornelius Jungheinrich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8916518
    Abstract: The invention relates to a method for coupling proteins to a starch-derived modified polysaccharide. The binding interaction between the modified polysaccharide and the protein is based on a covalent bond which is the result of a coupling reaction between the terminal aldehyde group or a functional group of the modified polysaccharide molecule resulting from the chemical reaction of this aldehyde group and a functional group of the protein which reacts with the aldehyde group or with the resulting functional group of the polysaccharide molecule. The bond directly resulting from the coupling reaction can be optionally modified by a further reaction to the aforementioned covalent bond. The invention further relates to pharmaceutical compositions that comprise conjugates formed in this coupling process and to the use of conjugates and compositions for the prophylaxis or therapy of the human or animal body.
    Type: Grant
    Filed: May 28, 2009
    Date of Patent: December 23, 2014
    Assignee: Fresenius Kabi Deutschland GmbH
    Inventors: Jurgen Hemberger, Michele Orlando, Klaus Sommermeyer, Wolfram Eichner, Sven Frie, Katharina Lutterbeck, Cornelius Jungheinrich, Roland Scharpf
  • Publication number: 20140073602
    Abstract: The present invention relates to nitric oxide delivering hydroxyalkyl starch derivatives, methods of preparing the same, and specific uses of these hydroxyalkyl starch derivatives.
    Type: Application
    Filed: July 11, 2011
    Publication date: March 13, 2014
    Applicant: FRESENIUS KABI DEUTSCHLAND GMBH
    Inventors: Martin Schimmel, Dominik Heckmann, Cornelius Jungheinrich
  • Publication number: 20130184237
    Abstract: The present invention relates to nitric oxide delivering hydroxyalkyl starch derivatives, methods of preparing the same, and specific uses of these hydroxyalkyl starch derivatives.
    Type: Application
    Filed: July 11, 2011
    Publication date: July 18, 2013
    Applicant: FRESENIUS KABI DEUTSCHLAND GMBH
    Inventors: Martin Schimmel, Dominik Heckmann, Cornelius Jungheinrich
  • Patent number: 8466277
    Abstract: The invention relates to a method for coupling low-molecular weight substances to a starch-derived modified polysaccharide. The binding interaction between the modified polysaccharide and the low-molecular weight substance is based on a covalent bond which is the result of a coupling reaction between the terminal aldehyde group or a functional group of the modified polysaccharide molecule resulting from the chemical reaction of this aldehyde group and a functional group of the low-molecular weight substance which reacts with this aldehyde group or with the resulting functional group of the polysaccharide molecule. The bond directly resulting from the coupling reaction can be optionally modified by a further reaction to the aforementioned covalent bond. The invention further relates to pharmaceutical compositions that comprise conjugates formed in this coupling process and to the use of said conjugates and compositions for the prophylaxis or therapy of the human or animal body.
    Type: Grant
    Filed: February 28, 2003
    Date of Patent: June 18, 2013
    Assignee: Fresenius Kabi Deutschland GmbH
    Inventors: Michele Orlando, Jurgen Hemberger, Klaus Sommermeyer, Wolfram Eichner, Sven Frie, Katharina Lutterbeck, Cornelius Jungheinrich, Roland Scharpf
  • Publication number: 20120259107
    Abstract: The invention relates to a method for coupling low-molecular substances to a starch-derived modified polysaccharide. The binding interaction between the modified polysaccharide and the low-molecular substance is based on a covalent bond which is the result of a coupling reaction between the terminal aldehyde group or a functional group of the modified polysaccharide molecule resulting from the chemical reaction of this aldehyde group and a functional group of the low-molecular substance which reacts with this aldehyde group or with the resulting functional group of the polysaccharide molecule. The bond directly resulting from the coupling reaction can be optionally modified by a further reaction to the aforementioned covalent bond. The invention further relates to pharmaceutical compositions that comprise conjugates formed in this coupling process and to the use of said conjugates and compositions for the prophylaxis or therapy of the human or animal body.
    Type: Application
    Filed: June 12, 2012
    Publication date: October 11, 2012
    Inventors: Michele Orlando, Jurgen Hemberger, Klaus Sommermeyer, Wolfram Eichner, Sven Frie, Katharina Lutterbeck, Cornelius Jungheinrich, Roland Scharpf
  • Patent number: 7816516
    Abstract: The invention relates to compounds, comprising a conjugate of hydroxyalkyl starch (HAS) and an active agent, whereby the hydroxyalkyl starch is either directly covalently bonded to the active agent, or by means of a linker. The invention further relates to methods for the production of a covalent HAS-active agent conjugate, whereby HAS and an active agent are reacted in a reaction medium, characterised in that the reaction medium is water or a mixture of water and an organic solvent, comprising at least 10 wt. % water.
    Type: Grant
    Filed: March 15, 2002
    Date of Patent: October 19, 2010
    Assignee: Fresenius Kabi Deutschland GmbH
    Inventors: Klaus Sommermeyer, Wolfram Eichner, Sven Frie, Cornelius Jungheinrich, Roland Scharpf, Katharina Lutterbeck, Jurgen Hemberger, Michele Orlando
  • Publication number: 20090233847
    Abstract: The invention relates to a method for coupling proteins to a starch-derived modified polysaccharide. The binding interaction between the modified polysaccharide and the protein is based on a covalent bond which is the result of a coupling reaction between the terminal aldehyde group or a functional group of the modified polysaccharide molecule resulting from the chemical reaction of this aldehyde group and a functional group of the protein which reacts with the aldehyde group or with the resulting functional group of the polysaccharide molecule. The bond directly resulting from the coupling reaction can be optionally modified by a further reaction to the aforementioned covalent bond. The invention further relates to pharmaceutical compositions that comprise conjugates formed in this coupling process and to the use of conjugates and compositions for the prophylaxis or therapy of the human or animal body.
    Type: Application
    Filed: May 28, 2009
    Publication date: September 17, 2009
    Inventors: Jurgen Hemberger, Michele Orlando, Klaus Sommermeyer, Wolfram Eichner, Sven Frie, Katharina Lutterbeck, Cornelius Jungheinrich, Roland Scharpf
  • Patent number: 7541328
    Abstract: The invention relates to a method for coupling proteins to a starch-derived modified polysaccharide. The binding interaction between the modified polysaccharide and the protein is based on a covalent bond which is the result of a coupling reaction between the terminal aldehyde group or a functional group of the modified polysaccharide molecule resulting from the chemical reaction of this aldehyde group and a functional group of the protein which reacts with the aldehyde group or with the resulting functional group of the polysaccharide molecule. The bond directly resulting from the coupling reaction can be optionally modified by a further reaction to the aforementioned covalent bond. The invention further relates to pharmaceutical compositions that comprise conjugates formed in this coupling process and to the use of conjugates and compositions for the prophylaxis or therapy of the human or animal body.
    Type: Grant
    Filed: February 28, 2003
    Date of Patent: June 2, 2009
    Assignee: Fresenius Kabi Deutschland GmbH
    Inventors: Jurgen Hemberger, Michele Orlando, Klaus Sommermeyer, Wolfram Eichner, Sven Frie, Katharina Lutterbeck, Cornelius Jungheinrich, Roland Scharpf
  • Publication number: 20060188472
    Abstract: The invention relates to compounds comprising a conjugate of hydroxyalkyl starch (HAS) and an active agent, whereby the hydroxyalkyl starch is either directly covalently bonded to the active agent, or by means of a linker. The invention further relates to methods for the production of a covalent HAS-active agent conjugate, whereby HAS and an active agent are reacted in a reaction medium, characterised in that the reaction medium is water or a mixture of water and an organic solvent, comprising at least 10 wt. % water.
    Type: Application
    Filed: February 10, 2006
    Publication date: August 24, 2006
    Inventors: Klaus Sommermeyer, Wolfram Eichner, Sven Frie, Cornelius Jungheinrich, Roland Scharpf, Katharina Lutterbeck
  • Publication number: 20050063943
    Abstract: The invention relates to compounds, comprising a conjugate of hydroxyalkyl starch (HAS) and an active agent, whereby the hydroxyalkyl starch is either directly covalently bonded to the active agent, or by means of a linker. The invention further relates to methods for the production of a covalent HAS-active agent conjugate, whereby HAS and an active agent are reacted in a reaction medium, characterised in that the reaction medium is water or a mixture of water and an organic solvent, comprising at least 10 wt. % water.
    Type: Application
    Filed: March 15, 2002
    Publication date: March 24, 2005
    Inventors: Klaus Sommermeyer, Wolfram Eichner, Sven Frie, Cornelius Jungheinrich, Roland Scharpf, Katharina Lutterbeck