Patents by Inventor Craig A. Parish

Craig A. Parish has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AZIDE INSULIN ANALOGUES
    Publication number: 20230365646
    Abstract: The present invention relates to insulin analogues and processes of making such insulin analogues by direct conversion of a free amine to an azide via diazo-transfer with an azotransfer agent.
    Type: Application
    Filed: July 31, 2023
    Publication date: November 16, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Sobhana Babu Boga, Ahmet Kekec, Songnian Lin, Craig A. Parish, Weijuan Tang, Lin Yan
  • Substituted RIG-I agonists: compositions and methods thereof
    Patent number: 11542505
    Abstract: This invention provides compositions, compounds, and uses thereof, wherein said compounds comprise a single strand oligonucleotide that may form a short oligonucleotide hairpin or stem loop molecule with self complementary base pairing of less than 12 base pairs that bind to RIG-I and activate the RIG-I pathway.
    Type: Grant
    Filed: April 15, 2019
    Date of Patent: January 3, 2023
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Craig A. Parish, Hongwu Wang, Wonsuk Chang, Quang T. Truong, Tony Siu, Anne Mai Wassermann
  • Tyrosine-specific functionalized insulin and insulin analogs
    Patent number: 11530250
    Abstract: The present invention relates to tyrosine-specific functionalized insulin analogs and processes of making such tyrosine-specific functionalized insulin analogs using R-3H-1,2,4-triazoline-3,5-(4H)diones (PTAD).
    Type: Grant
    Filed: March 18, 2019
    Date of Patent: December 20, 2022
    Assignee: MERCK SHARP & DOHME LLC
    Inventors: Ahmet Kekec, Nancy Jo Kevin, Bing Li, Songnian Lin, Craig A. Parish, Weijuan Tang
  • AZIDE INSULIN ANALOGUES
    Publication number: 20210163568
    Abstract: The present invention relates to insulin analogues and processes of making such insulin analogues by direct conversion of a free amine to an azide via diazo-transfer with an azotransfer agent.
    Type: Application
    Filed: April 8, 2019
    Publication date: June 3, 2021
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Sobhana Babu Boga, Ahmet Kekec, Songnian Lin, Craig A. Parish, Weijuan Tang, Lin Yan
  • TYROSINE-SPECIFIC FUNCTIONALIZED INSULIN AND INSULIN ANALOGS
    Publication number: 20210002345
    Abstract: The present invention relates to tyrosine-specific functionalized insulin analogs and processes of making such tyrosine-specific functionalized insulin analogs using R-3H-1,2,4-triazoline-3,5-(4H)diones (PTAD).
    Type: Application
    Filed: March 18, 2019
    Publication date: January 7, 2021
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Ahmet Kekec, Nancy Jo Kevin, Bing Li, Songnian Lin, Craig A. Parish, Weijuan Tang
  • Tetragalnac containing conjugates and methods for delivery of oligonucleotides
    Patent number: 10214742
    Abstract: Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; and optionally, 4) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: February 26, 2019
    Assignee: Sima Therapeutics, Inc.
    Inventors: David Tellers, Steven Colletti, Vadim Dudkin, Norihiro Ikemoto, Hongbiao Liao, Craig Parish, Tao Pei, Anthony Shaw, Quang Truong, Lijun Wang, Yu Yuan, Man Zhu
  • NOVEL TETRAGALNAC CONTAINING CONJUGATES AND METHODS FOR DELIVERY OF OLIGONUCLEOTIDES
    Publication number: 20170233731
    Abstract: Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; and optionally, 4) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.
    Type: Application
    Filed: November 29, 2016
    Publication date: August 17, 2017
    Inventors: David TELLERS, Steven COLLETTI, Vadim DUDKIN, Norihiro IKEMOTO, Hongbiao LIAO, Craig PARISH, Tao PEI, Anthony SHAW, Quang TRUONG, Lijun WANG, Yu YUAN, Man ZHU
  • Tetragalnac containing conjugates and methods for delivery of oligonucleotides
    Patent number: 9540639
    Abstract: Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; and optionally, 4) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: January 10, 2017
    Assignee: Sirna Therapeutics, Inc.
    Inventors: David Tellers, Steven Colletti, Vadim Dudkin, Norihiro Ikemoto, Hongbiao Liao, Craig Parish, Tao Pei, Anthony Shaw, Quang Truong, Lijun Wang, Yu Yuan, Man Zhu
  • NOVEL TETRAGALNAC CONTAINING CONJUGATES AND METHODS FOR DELIVERY OF OLIGONUCLEOTIDES
    Publication number: 20150203843
    Abstract: Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; and optionally, 4) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.
    Type: Application
    Filed: May 1, 2013
    Publication date: July 23, 2015
    Inventors: David Tellers, Steven Colletti, Vadim Dudkin, Norihiro Ikemoto, Hongbiao Liao, Craig Parish, Tao Pei, Anthony Shaw, Quang Truong, Lijun Wang, Yu Yuan, Man Zhu
  • Poly(amide) polymers for the delivery of oligonucleotides
    Patent number: 8987377
    Abstract: The present invention provides poly(amide) polymers, polyconjugates, compositions and methods for the delivery of oligonucleotides for therapeutic purposes.
    Type: Grant
    Filed: November 16, 2011
    Date of Patent: March 24, 2015
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Stephanie E. Barrett, Marina Busuek, Steven L. Colletti, Robert M. Garbaccio, Erin N. Guidry, Robert A. Kowtoniuk, Jing Liao, Craig A. Parish, Rubina G. Parmar, Tao Pei, Kevin M. Schlosser, David M. Tellers, Sandra C. Tobias, Quang T. Truong, Jacob H. Waldman, Weimin Wang, J. Michael Williams
  • POLY(AMIDE) POLYMERS FOR THE DELIVERY OF OLIGONUCLEOTIDES
    Publication number: 20130253135
    Abstract: The present invention provides poly(amide) polymers, polyconjugates, compositions and methods for the delivery of oligonucleotides for therapeutic purposes.
    Type: Application
    Filed: November 16, 2011
    Publication date: September 26, 2013
    Inventors: Stephanie E. Barrett, Marina Busuek, Steven L. Colletti, Robert M. Garbaccio, Erin N. Guidry, Robert A. Kowtoniuk, Jing Liao, Craig A. Parish, Rubina G. Parmar, Tao Pei, Kevin M. Schlosser, David M. Tellers, Sandra C. Tobias, Quang T. Truong, Jacob H. Waldman, Weimin Wang, J. Michael Williams
  • Antifungal Agents
    Publication number: 20100279861
    Abstract: Novel isoxazolidinone compounds useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of phytopathogenic fungi in crops are described. Two novel strains of fungi, ATCC No. PAT-7894 and ATCC No. PAT-7895, are disclosed for the preparation of the described isoxazolidinone compounds.
    Type: Application
    Filed: August 12, 2008
    Publication date: November 4, 2010
    Inventors: Gerald F Bills, Javier Collado, Craig A. Parish, Fernando Pelaez, Gonzalo Platas, Terry Roemer