Patents by Inventor Craig M. Whitehouse

Craig M. Whitehouse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9748084
    Abstract: Certain embodiments described herein are directed to adapters for use in coupling a direct sample analysis device to an analytical instrument such as, for example, a mass spectrometer. In some examples, the adapter can include an internal coupler separated from an external coupler through an insulator.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: August 29, 2017
    Assignee: PerkinElmer Health Sciences, inc.
    Inventors: Paul L. St. Cyr, Michael L. DelVecchio, Craig M. Whitehouse
  • Patent number: 9302225
    Abstract: A method and apparatus to trap, release and/or separate sample components in solution passing through a channel with or without packing material present by passing ion current through the channel driven by an electric field. A portion of the ion current includes cation and/or anion species generated from second solution flows separated from the sample solution flow path by semipermeable membranes. Cation and/or anion species generated in the second solution flow regions are transferred into the sample solution flow path through ion selective semipermeable membranes. Ion current moving along the sample solution flow path is controlled by varying the composition of the second solutions and/or changing the voltage between membrane sections for a given sample solution composition. The sample composition may also be varied separately or in parallel to enhance trapping, release and/or separation efficiency and range.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: April 5, 2016
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Craig M. Whitehouse, Thomas P. White
  • Patent number: 9299553
    Abstract: A multiple function atmospheric pressure ion source interfaced to a mass spectrometer comprises multiple liquid inlet probes configured such that the sprays from two or more probes intersect in a mixing region. Gas phase sample ions or neutral species generated in the spray of one probe can react with reagent gas ions generated from one or more other probes by such ionization methods as Electrospray, photoionization, corona discharge and glow discharge ionization. Reagent ions may be optimally selected to promote such processes as Atmospheric Pressure Chemical Ionization of neutral sample molecules, or charge reduction or electron transfer dissociation of multiply charged sample ions. Selected neutral reagent species can also be introduced into the mixing region to promote charge reduction of multiply charged sample ions through ion-neutral reactions. Different operating modes can be performed alternately or simultaneously, and can be rapidly turned on and off under manual or software control.
    Type: Grant
    Filed: March 26, 2014
    Date of Patent: March 29, 2016
    Assignees: PerkinElmer Health Sciences, Inc., Chem-Space Associates, Inc.
    Inventors: Craig M. Whitehouse, Thomas P. White, Ross C. Willoughby, Edward William Sheehan
  • Publication number: 20160071712
    Abstract: Certain embodiments described herein are directed to adapters for use in coupling a direct sample analysis device to an analytical instrument such as, for example, a mass spectrometer. In some examples, the adapter can include an internal coupler separated from an external coupler through an insulator.
    Type: Application
    Filed: July 27, 2015
    Publication date: March 10, 2016
    Inventors: Paul L. St. Cyr, Michael L. DelVecchio, Craig M. Whitehouse
  • Patent number: 9240311
    Abstract: A Direct Sample Analysis (DSA) ion source system operating at essentially atmospheric pressure is configured to facilitate the ionization, or desorption and ionization, of sample species from a wide variety of gaseous, liquid, and/or solid samples, for chemical analysis by mass spectrometry or other gas phase ion detectors. The DSA system includes one or more means of ionizing samples and includes a sealed enclosure which provides protection from high voltages and hazardous vapors, and in which the local background gas environment may be monitored and well-controlled. The DSA system is configured to accommodate single or multiple samples at any one time, and provide external control of individual sample positioning, sample conditioning, sample heating, positional sensing, and temperature measurement.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: January 19, 2016
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Craig M. Whitehouse, Thomas Dresch
  • Patent number: 9117641
    Abstract: Certain embodiments described herein are directed to adapters for use in coupling a direct sample analysis device to an analytical instrument such as, for example, a mass spectrometer. In some examples, the adapter can include an internal coupler separated from an external coupler through an insulator.
    Type: Grant
    Filed: October 29, 2012
    Date of Patent: August 25, 2015
    Assignee: PERKINELMER HEALTH SCIENCES, INC.
    Inventors: Paul L. St. Cyr, Michael L. DelVecchio, Craig M. Whitehouse
  • Patent number: 8981290
    Abstract: Apparatus and methods are provided that enable the interaction of low energy electrons and positrons with sample ions to facilitate electron capture dissociation (EGO) and positron capture dissociation (PGO), respectively, within multipole ion guide structures.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: March 17, 2015
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Craig M. Whitehouse, David G. Welkie, Gholamreza Javahery, Lisa Cousins, Sergey Rakov
  • Publication number: 20140326871
    Abstract: A multiple function atmospheric pressure ion source interfaced to a mass spectrometer comprises multiple liquid inlet probes configured such that the sprays from two or more probes intersect in a mixing region Gas phase sample ions or neutral species generated in the spray of one probe can react with reagent gas ions generated from one or more other probes by such ionization methods as Electrospray, photoionization, corona discharge and glow discharge ionization. Reagent ions may be optimally selected to promote such processes as Atmospheric Pressure Chemical Ionization of neutral sample molecules, or charge reduction or electron transfer dissociation of multiply charged sample ions.
    Type: Application
    Filed: March 26, 2014
    Publication date: November 6, 2014
    Applicants: Chem-Space Associates, Inc., PerkinElmer Health Sciences, Inc.
    Inventors: Craig M. Whitehouse, Thomas P. White, Ross C. Willoughby, Edward William Sheehan
  • Patent number: 8853624
    Abstract: An Atmospheric Pressure Chemical Ionization (APCI) source interfaced to a mass spectrometer is configured with a corona discharge needle positioned inside an APCI inlet probe assembly. Liquid sample flowing into the APCI inlet probe is nebulized and vaporized prior to passing through the corona discharge region all contained in the APCI inlet probe assembly. The APCI probe is configured to shield the electric field from the corona discharge region while allowing penetration of an external electric field to focus APCI generated ions into an orifice into vacuum for mass to charge analysis. Ions that exit the APCI probe are directed only by external electric fields and gas flow maximizing ion transmission into a mass to charge analyzer. Sample ions and gas phase reagent ions are generated in the APCI probe from liquid or gas inlet species or mixtures of both.
    Type: Grant
    Filed: August 5, 2013
    Date of Patent: October 7, 2014
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Craig M. Whitehouse, Victor Laiko
  • Patent number: 8847157
    Abstract: A Time-Of-Flight mass analyzer includes a multipole ion guide located in the ion flight path between the ion source and the flight tube of the Time-Of-Flight mass analyzer. The multipole ion guide can be positioned in the ion path between the ion source and the ion pulsing region of the TOF mass analyzer. The multipole ion guide electronics and the ion guide entrance and exit electrostatic lenses are configured to enable trapping or passing through of ions delivered from an atmospheric pressure ion source. The multipole ion guide can be used for ion transmission, trapping and fragmentation, and can reside in one vacuum pumping stage or can extend continuously into more than one vacuum pumping stage.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: September 30, 2014
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Craig M. Whitehouse, Thomas Dresch, Bruce A. Andrien, Jr.
  • Publication number: 20140209814
    Abstract: Apparatus and methods are provided that enable the interaction of low-energy electrons and positrons with sample ions to facilitate electron capture dissociation (ECD) and positron capture dissociation (PCD), respectively, within multipole ion guide structures. It has recently been discovered that fragmentation of protonated ions of many biomolecules via ECD often proceeds along fragmentation pathways not accessed by other dissociation methods, leading to molecular structure information not otherwise easily obtainable. However, such analyses have been limited to expensive Fourier transform ion cyclotron resonance (FTICR) mass spectrometers; the implementation of ECD within commonly-used multipole ion guide structures is problematic due to the disturbing effects of RF fields within such devices.
    Type: Application
    Filed: March 28, 2014
    Publication date: July 31, 2014
    Applicant: PerkinElmer Health Sciences, Inc.
    Inventors: Craig M. Whitehouse, David G. Welkie, Gholamreza Javahery, Lisa Cousins, Sergey Rakov
  • Patent number: 8723110
    Abstract: An apparatus for generating ions includes an Electrospray ionization source configured to provide a spray of charged droplets from a sample solution during operation of the apparatus; an atmospheric pressure chemical ionization (APCI) source including a corona discharge needle configured to produce a corona discharge that further ionizes the spray during operation of the apparatus; and a gas delivery system configured to deliver a gas flow to the corona discharge needle during operation of the apparatus, wherein the gas flow comprises a reagent ion gas which facilitates ionization of the spray by the corona discharge.
    Type: Grant
    Filed: August 26, 2011
    Date of Patent: May 13, 2014
    Assignees: PerkinElmer Health Sciences, Inc., Chem-Space Associates, Inc.
    Inventors: Craig M. Whitehouse, Thomas P. White, Ross C. Willoughby, Edward William Sheehan
  • Patent number: 8723107
    Abstract: Ions that are transported from an ion source to a mass spectrometer for mass analysis are often accompanied by background particles such as photons, neutral species, and cluster or aerosol ions which originate in the ion source. Background particles are also produced by scattering and neutralization of ions during collisions with background gas molecules in higher pressure regions with line-of-sight to the mass spectrometer detector. In either case, such background particles produce noise in mass spectra. Apparatus and methods are provided in which a multipole ion guide is configured to efficiently transport ions through multiple vacuum stages, while preventing background particles, produced both in the ion source and along the ion transport pathway, from reaching the detector, thereby improving signal-to-noise in mass spectra.
    Type: Grant
    Filed: July 1, 2013
    Date of Patent: May 13, 2014
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Craig M. Whitehouse, David G. Welkie
  • Publication number: 20140124661
    Abstract: A Time-Of-Flight mass analyzer includes a multipole ion guide located in the ion flight path between the ion source and the flight tube of the Time-Of-Flight mass analyzer. The multipole ion guide can be positioned in the ion path between the ion source and the ion pulsing region of the TOF mass analyzer. The multipole ion guide electronics and the ion guide entrance and exit electrostatic lenses are configured to enable trapping or passing through of ions delivered from an atmospheric pressure ion source. The multipole ion guide can be used for ion transmission, trapping and fragmentation, and can reside in one vacuum pumping stage or can extend continuously into more than one vacuum pumping stage.
    Type: Application
    Filed: September 27, 2013
    Publication date: May 8, 2014
    Applicant: PerkinElmer Health Sciences, Inc.
    Inventors: Craig M. Whitehouse, Thomas Dresch, Bruce A. Andrien, Jr.
  • Patent number: 8686356
    Abstract: Apparatus and methods are provided that enable the interaction of low energy electrons and positrons with sample ions to facilitate electron capture dissociation (EGO) and positron capture dissociation (PGO), respectively, within multipole ion guide structures. The apparatus and methods described herein allow EGO (and PCO) to be performed within multipole ion guides, either alone, or in combination with conventional ion fragmentation methods.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: April 1, 2014
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Craig M. Whitehouse, David G. Welkie, Gholamreza Javahery, Lisa Cousins, Sergey Rakov
  • Publication number: 20140048700
    Abstract: A method and apparatus to trap, release and/or separate sample components in solution passing through a channel with or without packing material present by passing ion current through the channel driven by an electric field. A portion of the ion current includes cation and/or anion species generated from second solution flows separated from the sample solution flow path by semipermeable membranes. Cation and/or anion species generated in the second solution flow regions are transferred into the sample solution flow path through ion selective semipermeable membranes. Ion current moving along the sample solution flow path is controlled by varying the composition of the second solutions and/or changing the voltage between membrane sections for a given sample solution composition. The sample composition may also be varied separately or in parallel to enhance trapping, release and/or separation efficiency and range.
    Type: Application
    Filed: July 15, 2013
    Publication date: February 20, 2014
    Inventors: Craig M. Whitehouse, Thomas P. White
  • Publication number: 20140008530
    Abstract: Ions that are transported from an ion source to a mass spectrometer for mass analysis are often accompanied by background particles such as photons, neutral species, and cluster or aerosol ions which originate in the ion source. Background particles are also produced by scattering and neutralization of ions during collisions with background gas molecules in higher pressure regions with line-of-sight to the mass spectrometer detector. In either case, such background particles produce noise in mass spectra. Apparatus and methods are provided in which a multipole ion guide is configured to efficiently transport ions through multiple vacuum stages, while preventing background particles, produced both in the ion source and along the ion transport pathway, from reaching the detector, thereby improving signal-to-noise in mass spectra.
    Type: Application
    Filed: July 1, 2013
    Publication date: January 9, 2014
    Inventors: Craig M. Whitehouse, David G. Welkie
  • Publication number: 20130341503
    Abstract: An Atmospheric Pressure Chemical Ionization (APCI) source interfaced to a mass spectrometer is configured with a corona discharge needle positioned inside an APCI inlet probe assembly. Liquid sample flowing into the APCI inlet probe is nebulized and vaporized prior to passing through the corona discharge region all contained in the APCI inlet probe assembly. The APCI probe is configured to shield the electric field from the corona discharge region while allowing penetration of an external electric field to focus APCI generated ions into an orifice into vacuum for mass to charge analysis. Ions that exit the APCI probe are directed only by external electric fields and gas flow maximizing ion transmission into a mass to charge analyzer. Sample ions and gas phase reagent ions are generated in the APCI probe from liquid or gas inlet species or mixtures of both.
    Type: Application
    Filed: August 5, 2013
    Publication date: December 26, 2013
    Applicant: PerkinElmer Health Sciences, Inc.
    Inventors: Craig M. Whitehouse, Victor Laiko
  • Patent number: 8610056
    Abstract: An apparatus includes an atmospheric pressure ion source; a first vacuum stage and a second vacuum stage separated from the first vacuum stage by a vacuum partition; a first ion guide positioned within a first vacuum stage and arranged to receive ions from the atmospheric pressure ion source; a second ion guide positioned within a second vacuum stage downstream of the first vacuum stage from the atmospheric pressure ion source, the second ion guide being a multipole ion guide arranged to receive ions from the first ion guide; and a time-of-flight mass analyzer that includes an orthogonal pulsing region arranged to receive ions from the second ion guide.
    Type: Grant
    Filed: June 20, 2011
    Date of Patent: December 17, 2013
    Assignee: PerkinElmer Health Sciences Inc.
    Inventors: Craig M. Whitehouse, Thomas Dresch, Bruce Andrien, Jr.
  • Patent number: RE44887
    Abstract: The invention provides a method and apparatus for trapping, releasing and/or separating sample components in solution passing through a channel with or without packing material present by passing ion current through the channel driven by an electric field. A portion of the ion current comprises cation and/or anion species generated from second solution flows separated from the sample solution flow path by semipermeable membranes. Cation and/or Anion ion species generated in the second solution flow regions are transferred into the sample solution flow path through ion selective semipermeable membranes. Ion current moving along the sample solution flow path is controlled by varying the composition of the second solutions and/or changing the voltage between membrane sections for a given sample solution composition. The sample composition may also be varied separately or in parallel to enhance trapping, release and/or separation efficiency and range.
    Type: Grant
    Filed: March 23, 2011
    Date of Patent: May 13, 2014
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Craig M. Whitehouse, Thomas P. White