Patents by Inventor Craig Tuerk

Craig Tuerk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid ligands to HIV-RT and HIV-1 rev
    Patent number: 5496938
    Abstract: Methods for the identification and production of improved nucleic acid ligands are based on the SELEX process. Nucleic acid ligands to HIV-RT and HIV-1 Rev are identified according to the methods described herein.
    Type: Grant
    Filed: October 21, 1992
    Date of Patent: March 5, 1996
    Assignee: NeXstar Pharmaceuticals, Inc.
    Inventors: Larry Gold, Craig Tuerk
  • Nucleic acid ligands
    Patent number: 5475096
    Abstract: A new class of nucleic acid compounds, referred to as nucleic acid ligands, have been shown to exist that have a specific binding affinity for three dimensional molecular targets. In a preferred embodiment the nucleic acid ligands are identified by the method of the invention referred to as the Systematic Evolution of Ligands by EXponential enrichment (SELEX), wherein a candidate mixture of nucleic acids are iteratively enriched in high affinity nucleic acids and amplified for further partitioning.
    Type: Grant
    Filed: June 10, 1991
    Date of Patent: December 12, 1995
    Assignee: University Research Corporation
    Inventors: Larry Gold, Craig Tuerk
  • Methods for identifying nucleic acid ligands
    Patent number: 5270163
    Abstract: The SELEX (Systematic Evolution of Ligands by EXponential Enrichment) method is disclosed for the identification of nucleic acid ligands. A candidate mixture of single stranded nucleic acids having regions of randomized sequence is contacted with a target compound and those nucleic acids having an increased affinity to the target are partitioned from the remainder of the candidate mixture. The partitioned nucleic acids are amplified to yield a ligand enriched mixture.
    Type: Grant
    Filed: August 17, 1992
    Date of Patent: December 14, 1993
    Assignee: University Research Corporation
    Inventors: Larry Gold, Craig Tuerk