Patents by Inventor Cristina E. Davis
Cristina E. Davis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11813050Abstract: A selective-sorting system for aerosol droplets in human breath includes a mouthpiece to receive a flow of human breath, and a flow path coupled to the mouthpiece. This flow path includes one or more bends that cause the flow of human breath to change direction, which causes aerosol droplets in the flow having different mass-sizes to change direction at different rates. Moreover, the flow path is shaped so that droplets that change direction at different rates are directed to different destinations. The system also includes a collection path, which is coupled to the flow path so that aerosol droplets meeting a specific mass-size criterion are directed into the collection path. A condenser tube is located in the collection path, wherein the condenser tube includes a cooling mechanism that cools the condenser tube to facilitate condensing aerosol droplets to sides of the condenser tube for subsequent collection.Type: GrantFiled: November 22, 2017Date of Patent: November 14, 2023Assignee: The Regents of the University of CaliforniaInventors: Cristina E. Davis, Konstantin O. Zamuruyev, Michael Schivo, Nicholas J. Kenyon, Jean-Pierre Delplanque, Alexander A. Aksenov
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Publication number: 20220387924Abstract: The disclosed embodiments relate to the design of a preconcentrator system for preconcentrating air samples. This preconcentrator system includes a plurality of preconcentrators that preconcentrate the air samples prior to chemical analysis, and a delivery structure comprising a manifold that selectively routes a sample airflow to the plurality of concentrators so that the plurality of preconcentrators receive a sample airflow concurrently or individually.Type: ApplicationFiled: August 10, 2022Publication date: December 8, 2022Applicant: The Regents of the University of CaliforniaInventors: Cristina E. Davis, Michael K. LeVasseur, Raquel Cumeras, Yuriy Zrodnikov, Mitchell M. McCartney, Alexander G. Fung, Daniel J. Peirano
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Patent number: 11491436Abstract: The disclosed embodiments relate to the design of a preconcentrator system for preconcentrating air samples. This preconcentrator system includes a plurality of preconcentrators that preconcentrate the air samples prior to chemical analysis, and a delivery structure comprising a manifold that selectively routes a sample airflow to the plurality of concentrators so that the plurality of preconcentrators receive a sample airflow concurrently or individually.Type: GrantFiled: January 25, 2021Date of Patent: November 8, 2022Assignee: The Regents of the University of CaliforniaInventors: Cristina E. Davis, Michael K. Levasseur, Raquel Cumeras, Yuriy Zrodnikov, Mitchell M. McCartney, Alexander G. Fung, Daniel J. Peirano
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Publication number: 20220298465Abstract: Disclosed is a method for monitoring cell density during cell expansion resulting from a cell culture process in a bioreactor comprising the steps of: a) cultivating cells in a bioreactor culture chamber according to a cell culture process having cell culture parameters; b) during said process, introducing cell culture fluid inputs and generating waste materials; c) determining the intensity of volatile organic compounds (VOCs) and their chemical species in the waste materials; and d) estimating the density or population of cells in the bioreactor based on said determination.Type: ApplicationFiled: June 9, 2020Publication date: September 22, 2022Inventors: Paul C. Goodwin, Paul Anthony Bowles, Rohin Iyer, Yarden Gratch, Mitch M. McCartney, Mei S. Yamaguchi, Cristina E. Davis
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Publication number: 20210316246Abstract: The disclosed embodiments relate to the design of a preconcentrator system for preconcentrating air samples. This preconcentrator system includes a plurality of preconcentrators that preconcentrate the air samples prior to chemical analysis, and a delivery structure comprising a manifold that selectively routes a sample airflow to the plurality of concentrators so that the plurality of preconcentrators receive a sample airflow concurrently or individually.Type: ApplicationFiled: January 25, 2021Publication date: October 14, 2021Applicant: The Regents of the University of CaliforniaInventors: Cristina E. Davis, Michael K. Levasseur, Raquel Cumeras, Yuriy Zrodnikov, Mitchell M. McCartney, Alexander G. Fung, Daniel J. Peirano
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Patent number: 10940428Abstract: The disclosed embodiments relate to the design of a preconcentrator system for preconcentrating air samples. This preconcentrator system includes a plurality of preconcentrators that preconcentrate the air samples prior to chemical analysis, and a delivery structure comprising a manifold that selectively routes a sample airflow to the plurality of concentrators so that the plurality of preconcentrators receive a sample airflow concurrently or individually.Type: GrantFiled: March 23, 2017Date of Patent: March 9, 2021Assignee: The Regents of the University of CaliforniaInventors: Cristina E. Davis, Michael K. Levasseur, Raquel Cumeras, Yuriy Zrodnikov, Mitchell M. McCartney, Alexander G. Fung, Daniel J. Peirano
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Publication number: 20200392448Abstract: Disclosed is a method for monitoring cell density during cell expansion resulting from a cell culture process in a bioreactor comprising the steps of: a) cultivating cells in a bioreactor culture chamber according to a cell culture process having cell culture parameters; b) during said process, introducing cell culture fluid inputs and generating waste materials; c) determining the amount of volatile organic compounds (VOCs) and their chemical species in the waste materials; and d) estimating the density or population of cells in the bioreactor based on said determination.Type: ApplicationFiled: June 14, 2019Publication date: December 17, 2020Inventors: Paul C. Goodwin, Paul A. Bowles, Yarden S. Gratch, Rohin K. Iyer, Cristina E. Davis, Mitchell M. McCartney, Mei S. Yamaguchi
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Publication number: 20200197855Abstract: The disclosed embodiments relate to the design of a preconcentrator system for preconcentrating air samples. This preconcentrator system includes a plurality of preconcentrators that preconcentrate the air samples prior to chemical analysis, and a delivery structure comprising a manifold that selectively routes a sample airflow to the plurality of concentrators so that the plurality of preconcentrators receive a sample airflow concurrently or individually.Type: ApplicationFiled: March 23, 2017Publication date: June 25, 2020Applicant: The Regents of the University of CaliforniaInventors: Cristina E. Davis, Michael K. Levasseur, Raquel Cumeras, Yuriy Zrodnikov, Mitchell M. McCartney, Alexander G. Fung, Daniel J. Peirano
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Publication number: 20190274584Abstract: A selective-sorting system for aerosol droplets in human breath includes a mouthpiece to receive a flow of human breath, and a flow path coupled to the mouthpiece. This flow path includes one or more bends that cause the flow of human breath to change direction, which causes aerosol droplets in the flow having different mass-sizes to change direction at different rates. Moreover, the flow path is shaped so that droplets that change direction at different rates are directed to different destinations. The system also includes a collection path, which is coupled to the flow path so that aerosol droplets meeting a specific mass-size criterion are directed into the collection path. A condenser tube is located in the collection path, wherein the condenser tube includes a cooling mechanism that cools the condenser tube to facilitate condensing aerosol droplets to sides of the condenser tube for subsequent collection.Type: ApplicationFiled: November 22, 2017Publication date: September 12, 2019Applicant: The Regents of the University of CaliforniaInventors: Cristina E. Davis, Konstantin O. Zamuruyev, Michael Schivo, Nicholas J. Kenyon, Jean-Pierre Delplanque, Alexander A. Aksenov
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Publication number: 20190234906Abstract: One embodiment of the present disclosure provides an ion mobility spectrometry (IMS) device for performing chemical analysis. The IMS device includes a first set of electrodes arranged linearly in a first direction and separated by a first set of gaps. The IMS device also includes a second set of electrodes positioned directly opposing the first set of electrodes to match the first set of electrodes on a one-to-one basis, wherein the second set of electrodes are separated by a second set of gaps. The IMS device includes a drift region between the first set of electrodes and the second set of electrodes, wherein charged particles enter at a first end of the drift region and traverse the drift region along the first direction. The IMS device additionally includes a detector positioned at a second end of the drift region and configured to receive charged particles exiting the drift region.Type: ApplicationFiled: April 12, 2019Publication date: August 1, 2019Applicant: SensIT Ventures, Inc.Inventors: Cristina E. Davis, Alexander A. Aksenov, Yuriy Zrodnikov
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Publication number: 20190137476Abstract: The disclosed embodiments relate to a technique for detecting Huanglongbing (HLB) infection in a citrus plant. This technique involves first gathering one or more samples of volatile organic compounds (VOCs) emanating from the citrus plant. Next, a system measures VOCs in the gathered samples to determine a VOC profile for the citrus plant, wherein the VOC profile comprises measured values for a set of VOCs that comprise disease-specific biomarkers for HLB infection. Finally, the system determines an HLB infection status for the citrus plant by analyzing the VOC profile.Type: ApplicationFiled: March 23, 2017Publication date: May 9, 2019Applicant: The Regents of the University of CaliforniaInventors: Cristina E. Davis, Abhaya M. Dandekar, Alexander A. Aksenov, Alberto Pasamontes Funez, Daniel J. Peirano, Mitchell M. McCartney, Oliver Fiehn, Susan E. Ebeler, Yuriy Zrodnikov
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Patent number: 10261048Abstract: One embodiment of the present disclosure provides an ion mobility spectrometry (IMS) device for performing chemical analysis. The IMS device includes a first set of electrodes arranged linearly in a first direction and separated by a first set of gaps. The IMS device includes a second set of electrodes positioned directly opposing the first set of electrodes to match the first set of electrodes on a one-to-one basis, wherein the second set of electrodes are separated by a second set of gaps. The IMS device includes a drift region between the first set of electrodes and the second set of electrodes, wherein charged particles enter at a first end of the drift region and traverse the drift region along the first direction. The IMS device additionally includes a detector positioned at a second end of the drift region and configured to receive charged particles exiting the drift region.Type: GrantFiled: August 30, 2013Date of Patent: April 16, 2019Assignee: SENSIT VENTURES, INC.Inventors: Cristina E. Davis, Alexander A. Aksenov, Yuriy Zrodnikov
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Patent number: 9824870Abstract: A system that integrates several technologies into a single, portable medical diagnostic apparatus for analyzing a sample body fluid (liquid and/or gas): (1) a mechanism to capture airborne microdroplets and to separate the body fluid into a first fluid component (primarily gas) and a second fluid component (primarily liquid); (2) a volatilizer to convert a portion of the second fluid component into a third fluid component that is primarily a gas; (3) a functionalized nanostructure (NS) array configured to receive, identify, and estimate concentration of at least one constituent in the first and/or third fluid components; (4) a miniaturized differential mobility spectrometer (DMS) module; and (5) a biomarker sensor, to detect volatile and non-volatile molecules in a sample fluid, which may contain one or more components of blood, breath, perspiration, saliva, and urine.Type: GrantFiled: April 29, 2015Date of Patent: November 21, 2017Assignee: The United States of America as Represented by the Administrator of NASAInventors: Tore Straume, David J. Loftus, Jing Li, Cristina E. Davis, Anup K. Singh, Matthew A. Coleman
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Publication number: 20170245495Abstract: The present disclosure relates to compositions containing a mixture of e.g. one or more or two or more compounds released by a citrus plant in quantities that are altered during infection with Huanglongbing disease, where the composition is an attractant for psyllids. Furthermore, compositions contain one or more active compounds which constitute a synthetic chemical blend for attracting psyllids. Active compounds in the compositions may include, for example, one or more compounds selected from linalool, tridecane, 4-OH-4-Me-2-pentanone, hexacosane, 1-tetradecene, tricosane, geranial, tetradecanal, phenylacetaldehyde, methyl salicylate, cumacrene, (E)-beta-ocimene, hexadecanol, and geranyl acetone.Type: ApplicationFiled: October 27, 2015Publication date: August 31, 2017Inventors: Cristina E. DAVIS, Alexander AKSENOV, Lukasz STELINSKI, Xavier MARTINI
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Publication number: 20150323500Abstract: One embodiment of the present disclosure provides an ion mobility spectrometry (IMS) device for performing chemical analysis. The IMS device includes a first set of electrodes arranged linearly in a first direction and separated by a first set of gaps. The IMS device includes a second set of electrodes positioned directly opposing the first set of electrodes to match the first set of electrodes on a one-to-one basis, wherein the second set of electrodes are separated by a second set of gaps. The IMS device includes a drift region between the first set of electrodes and the second set of electrodes, wherein charged particles enter at a first end of the drift region and traverse the drift region along the first direction. The IMS device additionally includes a detector positioned at a second end of the drift region and configured to receive charged particles exiting the drift region.Type: ApplicationFiled: August 30, 2013Publication date: November 12, 2015Applicant: The Regents of the University of CaliforniaInventors: Cristina E. Davis, Alexander A. Aksenov, Yuriy Zrodnikov
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Publication number: 20150164373Abstract: A personal lung function monitoring device capable of exhaled breath analysis is described. The personal lung function monitoring device includes a physical measuring device and a microcontroller. This physical measuring device further includes a flow chamber configured to receive a flow of exhaled breath from a patient/user, and a set of sensors integrated with the flow chamber. The set of sensors can be used to measure a set of properties of the exhaled breath, which can include one or more common lung function parameters and/or one or more biomarkers of the exhaled breath. The microcontroller is coupled to the physical measuring device and configured to receive analog sensor signals from the set of sensors and transmit the digitized sensor signals to a mobile device. In one embodiment, the personal lung function monitoring device combines peak expiratory flow, spirometry, and exhaled breath biomarker measurements into a single device.Type: ApplicationFiled: June 11, 2013Publication date: June 18, 2015Inventors: Cristina E. Davis, Jean-Pierre Delplanque, Nicholas J. Kenyon, Alice M. Kwan
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Patent number: 7968842Abstract: The invention provides an interface assembly for delivering an ionized analyte from an ionization apparatus into an ion mobility spectrometer. This allows analysis of biological and non-biological samples, even non-volatile solids, via differential mobility spectrometry, without fragmentation of molecules. The invention also provides portable sample analysis systems that operate at ambient pressure. Systems of the invention may be used for high molecular weight species detection, for example, drinking water contaminants, pathogenic biological agents, bio-organic substances, non-biological material, peptides, proteins, oligonucleotides, polymers, bacteria, and hydrocarbons.Type: GrantFiled: May 16, 2008Date of Patent: June 28, 2011Assignee: The Charles Stark Draper Laboratory, Inc.Inventors: Angela M. Zapata, Ernest S. Kim, Priya Agrawal, Melissa D. Krebs, Cristina E. Davis
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Patent number: 7576319Abstract: Disclosed herein are systems, methods and apparatus, for detection and identification of chemical warfare agents (CWAs) using a differential mobility spectrometer.Type: GrantFiled: February 1, 2008Date of Patent: August 18, 2009Assignees: Sionex Corporation, The Charles Stark Draper Laboratory, Inc.Inventors: Raanan A. Miller, Erkinjon G. Nazarov, Angela Zapata, Cristina E. Davis, Gary A. Eiceman, Anthony D. Bashall
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Publication number: 20090078865Abstract: The invention provides an interface assembly for delivering an ionized analyte from an ionization apparatus into an ion mobility spectrometer. This allows analysis of biological and non-biological samples, even non-volatile solids, via differential mobility spectrometry, without fragmentation of molecules. The invention also provides portable sample analysis systems that operate at ambient pressure. Systems of the invention may be used for high molecular weight species detection, for example, drinking water contaminants, pathogenic biological agents, bio-organic substances, non-biological material, peptides, proteins, oligonucleotides, polymers, bacteria, and hydrocarbons.Type: ApplicationFiled: May 16, 2008Publication date: March 26, 2009Applicant: Charles Stark Draper Laboratory, Inc.Inventors: Angela M. Zapata, Ernest S. Kim, Priya Agrawal, Melissa D. Krebs, Cristina E. Davis
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Patent number: 7388195Abstract: The invention provides an interface assembly for delivering an ionized analyte from an ionization apparatus into an ion mobility spectrometer. This allows analysis of biological and non-biological samples, even non-volatile solids, via differential mobility spectrometry, without fragmentation of molecules. The invention also provides portable sample analysis systems that operate at ambient pressure. Systems of the invention may be used for high molecular weight species detection, for example, drinking water contaminants, pathogenic biological agents, bio-organic substances, non-biological material, peptides, proteins, oligonucleotides, polymers, bacteria, and hydrocarbons.Type: GrantFiled: September 30, 2005Date of Patent: June 17, 2008Assignee: Charles Stark Draper Laboratory, Inc.Inventors: Angela M. Zapata, Ernest S. Kim, Priya Agrawal, Melissa D. Krebs, Cristina E. Davis