Patents by Inventor Curtis C. Harris

Curtis C. Harris has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Expression protein-coding and noncoding genes as prognostic classifiers in early stage lung cancer
    Patent number: 10047401
    Abstract: The invention provides novel biomarkers (four genes BRCA1, HIF1A, DLC1, and XPO1 alone or in combination of miR-21) for early stage lung cancer.
    Type: Grant
    Filed: August 20, 2013
    Date of Patent: August 14, 2018
    Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services
    Inventors: Curtis C. Harris, Aaron Joseph Schetter, Hirokazu Okayama, Ichiro Akagi
  • Therapeutic applications of p53 isoforms in regenerative medicine, aging and cancer
    Patent number: 9944927
    Abstract: The present invention provides methods and compositions for modulating cell senescence and cell proliferation using isoforms of the p53 tumor suppressor protein. The methods and compositions of the invention find use in inhibiting cancer cell growth or in generating populations of cells for tissue regeneration through the modulation of cell senescence and proliferation.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: April 17, 2018
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, The University of Dundee, Masaryk Memorial Cancer Institute
    Inventors: Curtis C. Harris, Kaori Fujita, Izumi Horikawa, Borivoj Vojtesek, Jean-Christophe Bourdon, David P. Lane
  • Methods Of Inhibiting Tumorigenesis In Colon Adenocarcinoma And Compositions Therefor
    Publication number: 20170275625
    Abstract: Described herein are methods and compositions for the treatment of colon cancers.
    Type: Application
    Filed: April 11, 2017
    Publication date: September 28, 2017
    Applicants: The Ohio State University Research Foundation, The Government of the United States of America, as represented by the Secretary of the Department of
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
  • Methods of determining the prognosis of an adenocarcinoma
    Patent number: 9464324
    Abstract: Methods are disclosed for determining the prognosis of a subject with an adenocarcinoma in an organ, such as the lung. The methods can include quantitating expression of a plurality of cytokines of interest, such as IL-1a, IL-1b, IL-2, IL-8, IL-10, IL-12, IL-15, IFN-? and TNF-a in the adenocarcinoma and in non-cancerous tissue in the organ. Altered expression of IL-1a, IL-1b, IL-2, IL-8, IL-10, IL-12, IL-15, IFN-? and TNF-a in the adenocarcinoma as compared to a control and in non-cancerous tissue in the organ as compared to a control determines the prognosis for the subject. Methods for determining if a therapeutic agent is effective as an anti-cancer agent are also disclosed.
    Type: Grant
    Filed: July 16, 2007
    Date of Patent: October 11, 2016
    Assignee: The United States of America as represented by the Secretary, DHHS
    Inventors: Curtis C. Harris, Masahiro Seike, Xin Wei Wang
  • Methods of Inhibiting Tumorigenesis in Colon Adenocarcinoma and Compositions Therefor
    Publication number: 20160177305
    Abstract: Described herein are methods and compositions for the treatment of colon cancers.
    Type: Application
    Filed: March 1, 2016
    Publication date: June 23, 2016
    Applicants: The Ohio State University Research Foundation, The Government of the USA, as represented by the Secretary of the Department of Health and Human Se
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
  • EXPRESSION PROTEIN-CODING AND NONCODING GENES AS PROGNOSTIC CLASSIFIERS IN EARLY STAGE LUNG CANCER
    Publication number: 20150337385
    Abstract: The invention provides novel biomarkers (four genes BRCA1, HIF1A, DLC1, and XPO1 alone or in combination CODING GENE SELECTION of miR-21) for early stage lung cancer.
    Type: Application
    Filed: August 20, 2013
    Publication date: November 26, 2015
    Inventors: Curtis C. Harris, Aaron Joseph Schetter, Hirokazu Okayama, Ichiro Akagi
  • Therapeutic applications of P53 isoforms in regenerative medicine, aging and cancer
    Patent number: 9068165
    Abstract: The present invention provides methods and compositions for modulating cell senescence and cell proliferation using isoforms of the p53 tumor suppressor protein. The methods and compositions of the invention find use in inhibiting cancer cell growth or in generating populations of cells for tissue regeneration through the modulation of cell senescence and proliferation.
    Type: Grant
    Filed: July 26, 2013
    Date of Patent: June 30, 2015
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, The University of Dundee, Masaryk Memorial Cancer Institute
    Inventors: Curtis C. Harris, Kaori Fujita, Izumi Horikawa, Borivoj Vojtesek, Jean-Christophe Bourdon, David P. Lane
  • Tumor suppressor gene p47ING3
    Patent number: 8957015
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of novel human tumor suppressors, antibodies to such tumor suppressors, methods of detecting such nucleic acids and proteins, methods of screening for modulators of tumor suppressors, and methods of diagnosing and treating tumors with such nucleic acids and proteins.
    Type: Grant
    Filed: April 8, 2013
    Date of Patent: February 17, 2015
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Curtis C. Harris, Makoto Nagashima
  • TUMOR SUPPRESSOR GENE P47ING3
    Publication number: 20130302800
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of novel human tumor suppressors, antibodies to such tumor suppressors, methods of detecting such nucleic acids and proteins, methods of screening for modulators of tumor suppressors, and methods of diagnosing and treating tumors with such nucleic acids and proteins.
    Type: Application
    Filed: April 8, 2013
    Publication date: November 14, 2013
    Inventors: Curtis C. Harris, Makoto Nagashima
  • THERAPEUTIC APPLICATIONS OF P53 ISOFORMS IN REGENERATIVE MEDICINE, AGING AND CANCER
    Publication number: 20130302892
    Abstract: The present invention provides methods and compositions for modulating cell senescence and cell proliferation using isoforms of the p53 tumor suppressor protein. The methods and compositions of the invention find use in inhibiting cancer cell growth or in generating populations of cells for tissue regeneration through the modulation of cell senescence and proliferation.
    Type: Application
    Filed: July 26, 2013
    Publication date: November 14, 2013
    Applicants: The Government of the USA as represented by the Sec. of the Dept. of Health and Human Services, Masaryk Memorial Cancer Institute, The University of Dundee
    Inventors: Curtis C. Harris, Kaori Fujita, Izumi Horikawa, Barivoj Vojtesek, Jean-Christophe Bourdon, David P. Lane
  • Therapeutic applications of p53 isoforms in regenerative medicine, aging and cancer
    Patent number: 8575121
    Abstract: The present invention provides methods and compositions for modulating cell senescence and cell proliferation using isoforms of the p53 tumor suppressor protein. The methods and compositions of the invention find use in inhibiting cancer cell growth or in generating populations of cells for tissue regeneration through the modulation of cell senescence and proliferation.
    Type: Grant
    Filed: October 21, 2008
    Date of Patent: November 5, 2013
    Assignees: The United States of America as represented by the Secetary of the Department of Health and Human Services, The University of Dundee, Masaryk Memorial Cancer Institute
    Inventors: Curtis C. Harris, Kaori Fujita, Izumi Horikawa, Borivoj Vojtesek, Jean-Christophe Bourdon, David P. Lane
  • MANIPULATION OF STEM CELL FUNCTION BY P53 ISOFORMS
    Publication number: 20130267029
    Abstract: This invention provides methods and compositions for increasing the efficiency of obtaining pluripotent stem cells, the method comprising expressing a 133p53 in cells that are being re-programmed to obtain pluripotent cells. The invention also provides method of inhibiting the proliferation of cancer stem cells, the method comprising suppressing expression of 133p53 in the cells.
    Type: Application
    Filed: September 30, 2011
    Publication date: October 10, 2013
    Applicants: Fundacion Centro Nacional de Ivestigaciones Oncologicas, Carlos, The Government of the United States of America as Represented by the Secretary of The Dept. of Healt
    Inventors: Curtis C. Harris, Izumi Horikawa, Kaori Fujita, Abdul M. Mondal, Kye-Yoon Park, Sharon R. Pine, Manuel Serrano
  • Method of diagnosing poor survival prognosis colon cancer using miR-16b
    Patent number: 8518647
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: November 14, 2011
    Date of Patent: August 27, 2013
    Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology Transfer
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
  • POT1 alternative splicing variants
    Patent number: 8426379
    Abstract: The present invention provides methods and compositions for diagnosis and treatment of carcinomas with aberrant expression patterns of POT 1. The invention also provides methods of identifying compounds that may modulate the cellular expression of POT 1. The invention further provides methods for treating subjects suffering from or at risk of developing a colorectal carcinoma.
    Type: Grant
    Filed: February 15, 2011
    Date of Patent: April 23, 2013
    Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services
    Inventors: Qin Yang, Curtis C. Harris
  • Tumor suppressor gene, p47ING3
    Patent number: 8415097
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of novel human tumor suppressors, antibodies to such tumor suppressors, methods of detecting such nucleic acids and proteins, methods of screening for modulators of tumor suppressors, and methods of diagnosing and treating tumors with such nucleic acids and proteins.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: April 9, 2013
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Curtis C. Harris, Makoto Nagashima
  • MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer using miR-17-3P
    Patent number: 8377637
    Abstract: The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of lung cancer. The invention also provides methods of identifying anti-lung cancer agents.
    Type: Grant
    Filed: March 30, 2011
    Date of Patent: February 19, 2013
    Assignees: The Ohio State University Research Foundation, Department of Health and Human Services
    Inventors: Carlo M. Croce, Nozomu Yanaihara, Curtis C. Harris
  • TUMOR SUPPRESSOR GENE P33ING2
    Publication number: 20130034848
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of novel human tumor suppressors, antibodies to such tumor suppressors, methods of detecting such nucleic acids and proteins, methods of screening for modulators of tumor suppressors, and methods of diagnosing and treating tumors with such nucleic acids and proteins.
    Type: Application
    Filed: June 21, 2012
    Publication date: February 7, 2013
    Applicants: Health and Human Services
    Inventors: Curtis C. Harris, Makoto Nagashima
  • MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer using miR-21
    Patent number: 8361710
    Abstract: The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of lung cancer. The invention also provides methods of identifying anti-lung cancer agents.
    Type: Grant
    Filed: March 30, 2011
    Date of Patent: January 29, 2013
    Assignees: The Ohio State University Research Foundation, The United States of America as represented by the Department of Health and Human Services
    Inventors: Carlo M. Croce, Nozomu Yanaihara, Curtis C. Harris
  • Method of diagnosing poor survival prognosis colon cancer using let-7g
    Patent number: 8349568
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: November 14, 2011
    Date of Patent: January 8, 2013
    Assignees: The Ohio State University Research Foundation, The United States of America, as Represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology Transfer
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
  • Method of diagnosing poor survival prognosis colon cancer using miR-10a
    Patent number: 8343725
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: January 1, 2013
    Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology Transfer
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter