Patents by Inventor Curtis W. Frank
Curtis W. Frank has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10752768Abstract: Orthopedic implants having a bone interface member and a water swellable IPN or semi-IPN with a stiffness, hydration, and/or composition gradient from one side to the other and physically attached to the bone interface member. The invention also includes an orthopedic implant system including an implant that may conform to a bone surface and a joint capsule. The invention also includes orthopedic implants with water swellable IPN or semi-IPNs including a hydrophobic thermoset or thermoplastic polymer first network and an ionic polymer second network, joint capsules, labral components, and bone interface members. The invention also includes a method of inserting an orthopedic implant having a metal portion and a flexible polymer portion into a joint, including inserting the implant in a joint in a first shape and changing the implant from a first shape to a second shape to conform to a shape of a bone.Type: GrantFiled: March 6, 2020Date of Patent: August 25, 2020Assignee: Hyalex Orthopaedics, Inc.Inventors: David Myung, Michael J. Jaasma, Lampros Kourtis, Curtis W. Frank
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Publication number: 20200239678Abstract: Orthopedic implants having a bone interface member and a water swellable IPN or semi-IPN with a stiffness, hydration, and/or composition gradient from one side to the other and physically attached to the bone interface member. The invention also includes an orthopedic implant system including an implant that may conform to a bone surface and a joint capsule. The invention also includes orthopedic implants with water swellable IPN or semi-IPNs including a hydrophobic thermoset or thermoplastic polymer first network and an ionic polymer second network, joint capsules, labral components, and bone interface members. The invention also includes a method of inserting an orthopedic implant having a metal portion and a flexible polymer portion into a joint, including inserting the implant in a joint in a first shape and changing the implant from a first shape to a second shape to conform to a shape of a bone.Type: ApplicationFiled: March 6, 2020Publication date: July 30, 2020Inventors: David MYUNG, Michael J. JAASMA, Lampros KOURTIS, Curtis W. FRANK
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Publication number: 20190015211Abstract: An arthroplasty device is provided having an interpenetrating polymer network (IPN) hydrogel that is strain-hardened by swelling and adapted to be held in place in a joint by conforming to a bone geometry. The strain-hardened IPN hydrogel is based on two different networks: (1) a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups, and (2) a non-silicone network of ionizable monomers. The second network was polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. Within the IPN, the degree of chemical cross-linking in the second network is less than in the first network. An aqueous salt solution (neutral pH) is used to ionize and swell the second network. The swelling of the second network is constrained by the first network resulting in an increase in effective physical cross-links within the IPN.Type: ApplicationFiled: May 16, 2018Publication date: January 17, 2019Applicant: The Board of Trustees of The Leland Stanford Junior UniversityInventors: David MYUNG, Lampros KOURTIS, Laura HARTMANN, Curtis W. FRANK, Stuart B. GOODMAN, Dennis R. CARTER
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Publication number: 20180191013Abstract: An ion exchange membrane is provided with a nanostructure material of random poly(ethylene glycol)-polyimide copolymers doped and annealed in an ionic liquid, the poly(ethylene glycol) having a molecular weight ranging from 1000 to 4000 and the poly(ethylene glycol) representing at least 40% of the volume of the ion exchange membrane. It is shown that the conductivity of these membranes was dramatically increased by the thermal annealing by 2-5 times. It was also shown that nanoscale structures were developed upon heating the membranes involving the increment of order, definition, and size of the poly(ethylene glycol)-ethylammonium nitrate [PEG+EAN] domains by the SAXS data analysis. This structural change improves the ion conduction in the membrane and result in the considerable enhancement of the conductivity.Type: ApplicationFiled: October 20, 2017Publication date: July 5, 2018Inventors: Curtis W. Frank, Euntaek Woo, Jie Lu, Michael F. Toney
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Patent number: 9750615Abstract: Prosthetic intervertebral discs and methods for using the same are described. The subject prosthetic discs include upper and lower endplates separated by a compressible core member. The prosthetic discs described herein include one-piece, two-piece, three-piece, and four-piece structures. The subject prosthetic discs exhibit stiffness in the vertical direction, torsional stiffness, bending stiffness in the sagittal plane, and bending stiffness in the front plane, where the degree of these features can be controlled independently by adjusting the components of the discs. The interface mechanism between the endplates and the core members of several embodiments of the described prosthetic discs enables a very easy surgical operation for implantation.Type: GrantFiled: January 1, 2008Date of Patent: September 5, 2017Assignee: SPINAL KINETICS, INC.Inventors: Daniel H. Kim, Thomas A. Afzal, Michael L. Reo, Uriel Hiram Chee, In Haeng Cho, Kunwoo Lee, Curtis W. Frank, Sung Kyu Ha
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Patent number: 9567432Abstract: Provided herein are graft co-polymers of lignin and poly(lactic acid) (lignin-g-PLA copolymer), thermoset and thermoplastic polymers including them, methods of preparing these polymers, and articles of manufacture including such polymers.Type: GrantFiled: August 23, 2013Date of Patent: February 14, 2017Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Johan Vilhelm Olsson, Yi-Lin Chung, Russell Jingxian Li, Robert Waymouth, Elizabeth Sattely, Sarah Billington, Curtis W. Frank
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Publication number: 20160346089Abstract: An arthroplasty device is provided having an interpenetrating polymer network (IPN) hydrogel that is strain-hardened by swelling and adapted to be held in place in a joint by conforming to a bone geometry. The strain-hardened IPN hydrogel is based on two different networks: (1) a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups, and (2) a non-silicone network of ionizable monomers. The second network was polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. Within the IPN, the degree of chemical cross-linking in the second network is less than in the first network. An aqueous salt solution (neutral pH) is used to ionize and swell the second network. The swelling of the second network is constrained by the first network resulting in an increase in effective physical cross-links within the IPN.Type: ApplicationFiled: July 8, 2016Publication date: December 1, 2016Inventors: David MYUNG, Lampros KOURTIS, Laura HARTMANN, Curtis W. FRANK, Stuart B. GOODMAN, Dennis R. CARTER
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Publication number: 20160248113Abstract: An anion transport membrane is provided, which is based on a linear polymer electrolyte with anion-exchange groups that mechanically reinforced by a covalently cross-linked network. The linear polymer electrolyte is partially or fully miscible with the second covalently cross-linked network. In another example, an anion transport membrane is provided, which is based on a linear quaternary ammonium polysulfone membrane backbone mechanically reinforced by a chemically-crosslinked network of poly(styrene-co-divinylbenzene), whereby the reinforcing network has covalent divinylbenzene cross-links.Type: ApplicationFiled: February 19, 2016Publication date: August 25, 2016Inventors: Steve S. He, Curtis W. Frank, Alaina Strickler
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Patent number: 9387082Abstract: An arthroplasty device is provided having an interpenetrating polymer network (IPN) hydrogel that is strain-hardened by swelling and adapted to be held in place in a joint by conforming to a bone geometry. The strain-hardened IPN hydrogel is based on two different networks: (1) a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups, and (2) a non-silicone network of ionizable monomers. The second network was polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. Within the IPN, the degree of chemical cross-linking in the second network is less than in the first network. An aqueous salt solution (neutral pH) is used to ionize and swell the second network. The swelling of the second network is constrained by the first network resulting in an increase in effective physical cross-links within the IPN.Type: GrantFiled: February 24, 2014Date of Patent: July 12, 2016Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States of America as Represented by the Department of Veterans AffairsInventors: David Myung, Lampros Kourtis, Laura Hartmann, Curtis W. Frank, Stuart B. Goodman, Dennis R. Carter
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Patent number: 9364337Abstract: Prosthetic intervertebral discs and methods for using the same are described. The subject prosthetic discs include upper and lower endplates separated by a compressible core member. The prosthetic discs described herein include one-piece, two-piece, three-piece, and four-piece structures. The subject prosthetic discs exhibit stiffness in the vertical direction, torsional stiffness, bending stiffness in the saggital plane, and bending stiffness in the front plane, where the degree of these features can be controlled independently by adjusting the components of the discs. The interface mechanism between the endplates and the core members of several embodiments of the described prosthetic discs enables a very easy surgical operation for implantation.Type: GrantFiled: March 7, 2012Date of Patent: June 14, 2016Assignee: SPINAL KINETICS, INC.Inventors: Daniel H. Kim, Thomas A. Afzal, Michael L. Reo, Uriel Hiram Chee, In Haeng Cho, Kunwoo Lee, Curtis W. Frank, Sung Kyu Ha
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Patent number: 9364336Abstract: A prosthetic intervertebral disc and methods for using the same are provided. The subject prosthetic discs are characterized by including top and bottom endplates separated by a fibrous compressible element that includes an annular region and a nuclear region. The two plates are held together at least one fiber wound around at least one region of the top endplate and at least one region of the bottom endplate. The subject discs may be employed with separate vertebral body fixation elements, or they may include integrated vertebral body fixation elements. Also provided are kits and systems that include the subject prosthetic discs.Type: GrantFiled: September 27, 2006Date of Patent: June 14, 2016Assignee: SPINAL KINETICS INC.Inventors: Daniel H. Kim, Kunwoo Lee, Curtis W. Frank, Sung Kyu Ha
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Patent number: 9233345Abstract: An anion transport membrane is provided enabling efficient anion exchange across the membrane, which could be used in applications like fuel cells, water electrolyzers, or water filtration systems. The structural membrane morphology is based on a hydrophobic polysulfone membrane backbone and co-grafted thereon hydrophilic poly(ethylene glycol) grafts and anion conducting quaternary ammonium species. This structure defines a bi-continuous morphology with locally phase-separated hydrophobic-hydrophilic domains, and a co-localization of the anion conducting quaternary ammonium species with respect to the hydrophilic poly(ethylene glycol) grafts enabling efficient and continuous ion transport channels for facilitating anion transport.Type: GrantFiled: February 12, 2014Date of Patent: January 12, 2016Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Steve S. He, Curtis W. Frank
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Publication number: 20150284654Abstract: A composition of matter comprising a hydrophobic or hydrophilic (or both) interpenetrating polymer network containing a non-ionic/ionic polymer and a hydrophobic thermoset or thermoplastic polymer, articles made from such composition and methods of preparing such articles. The invention also includes a process for preparing a hydrophobic/hydrophilic IPN or semi-IPN from a hydrophobic thermoset or thermoplastic polymer including the steps of placing an non-ionizable/ionizable monomer solution in contact with a hydrophobic thermoset or thermoplastic polymer; diffusing the monomer solution into the hydrophobic thermoset or thermoplastic polymer; and polymerizing the monomers to form a penetrating polymer inside the hydrophobic thermoset or thermoplastic polymer, thereby forming the IPN or semi-IPN.Type: ApplicationFiled: November 7, 2014Publication date: October 8, 2015Inventors: David MYUNG, Michael J. JAASMA, Lampros KOURTIS, Daniel CHANG, Curtis W. FRANK
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Patent number: 8998989Abstract: Prosthetic intervertebral discs and methods for using the same are described. The subject prosthetic discs include upper and lower endplates separated by a compressible core member. The prosthetic discs described herein include one-piece, two-piece, three-piece, and four-piece structures. The subject prosthetic discs exhibit stiffness in the vertical direction, torsional stiffness, bending stiffness in the sagittal plane, and bending stiffness in the front plane, where the degree of these features can be controlled independently by adjusting the components of the discs. The interface mechanism between the endplates and the core members of several embodiments of the described prosthetic discs enables a very easy surgical operation for implantation.Type: GrantFiled: July 31, 2012Date of Patent: April 7, 2015Assignee: Spinal Kinetics Inc.Inventors: Daniel H. Kim, Thomas A. Afzal, Michael L. Reo, Uriel Hiram Chee, In Haeng Cho, Kunwoo Lee, Curtis W. Frank, Sun-Kyu Ha
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Publication number: 20140357559Abstract: A strain-hardened interpenetrating polymer network (IPN) hydrogel is provided. The interpenetrating polymer network hydrogel is based on two different networks. The first network is a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups. The second network is a non-silicone network of ionizable monomers. The second network has been polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. An aqueous salt solution having a neutral pH is used to ionize and swell the second network in the interpenetrating polymer network. The swelling of the second network is constrained by the first network, and this constraining effect results in an increase in effective physical cross-links within the interpenetrating polymer network, and, in turn, an increase its elastic modulus.Type: ApplicationFiled: August 19, 2014Publication date: December 4, 2014Inventors: David Myung, Laura Hartmann, Jaan Noolandi, Christopher N. Ta, Curtis W. Frank
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Patent number: 8883915Abstract: A composition of matter comprising a hydrophobic or hydrophilic (or both) interpenetrating polymer network containing a non-ionic/ionic polymer and a hydrophobic thermoset or thermoplastic polymer, articles made from such composition and methods of preparing such articles. The invention also includes a process for preparing a hydrophobic/hydrophilic IPN or semi-IPN from a hydrophobic thermoset or thermoplastic polymer including the steps of placing an non-ionizable/ionizable monomer solution in contact with a hydrophobic thermoset or thermoplastic polymer; diffusing the monomer solution into the hydrophobic thermoset or thermoplastic polymer; and polymerizing the monomers to form a penetrating polymer inside the hydrophobic thermoset or thermoplastic polymer, thereby forming the IPN or semi-IPN.Type: GrantFiled: August 26, 2011Date of Patent: November 11, 2014Assignee: Biomimedica, Inc.Inventors: David Myung, Michael J. Jaasma, Lampros Kourtis, Daniel Chang, Curtis W. Frank
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Patent number: 8852614Abstract: Compositions and methods are provided for the manufacture and use of hydrogels with increased permeability to macromolecules with minimum loss of matrix mechanical strength and prepolymer viscosity for patternability. The hydrogels of the invention are formed from a prepolymer, which is polymerized in the presence of hydrophobic nanoparticles. In some embodiments of the invention cells are present during polymerization, and are encapsulated by the hydrogel. A high interfacial energy between the hydrophobic substrate and the aqueous polymerizing solution disrupts the hydrogel network structure, leading to network defects that increase permeability without loss of patternability.Type: GrantFiled: March 11, 2011Date of Patent: October 7, 2014Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Curtis W. Frank, Won Jae Lee, Nam-Joon Cho, Jeffrey S. Glenn
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Patent number: 8821583Abstract: A strain-hardened interpenetrating polymer network (IPN) hydrogel is provided. The interpenetrating polymer network hydrogel is based on two different networks. The first network is a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups. The second network is a non-silicone network of ionizable monomers. The second network has been polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. An aqueous salt solution having a neutral pH is used to ionize and swell the second network in the interpenetrating polymer network. The swelling of the second network is constrained by the first network, and this constraining effect results in an increase in effective physical cross-links within the interpenetrating polymer network, and, in turn, an increase its elastic modulus.Type: GrantFiled: February 15, 2008Date of Patent: September 2, 2014Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: David Myung, Laura Hartmann, Jean Noolandi, Christopher N. Ta, Curtis W. Frank
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Patent number: 8808381Abstract: Prosthetic intervertebral discs and methods for using the same are described. The subject prosthetic discs include upper and lower endplates separated by a compressible core member. The prosthetic discs described herein include one-piece, two-piece, three-piece, and four-piece structures. The subject prosthetic discs exhibit stiffness in the vertical direction, torsional stiffness, bending stiffness in the saggital plane, and bending stiffness in the front plane, where the degree of these features can be controlled independently by adjusting the components of the discs. The interface mechanism between the endplates and the core members of several embodiments of the described prosthetic discs enables a very easy surgical operation for implantation.Type: GrantFiled: May 12, 2010Date of Patent: August 19, 2014Assignee: Spinal Kinetics Inc.Inventors: Daniel H. Kim, Thomas A. Afzal, Michael L. Reo, Uriel Hiram Chee, In Haeng Cho, Kunwoo Lee, Curtis W. Frank, Sung Kyu Ha
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Publication number: 20140227627Abstract: An anion transport membrane is provided enabling efficient anion exchange across the membrane, which could be used in applications like fuel cells, water electrolyzers, or water filtration systems. The structural membrane morphology is based on a hydrophobic polysulfone membrane backbone and co-grafted thereon hydrophilic poly(ethylene glycol) grafts and anion conducting quaternary ammonium species. This structure defines a bi-continuous morphology with locally phase-separated hydrophobic-hydrophilic domains, and a co-localization of the anion conducting quaternary ammonium species with respect to the hydrophilic poly(ethylene glycol) grafts enabling efficient and continuous ion transport channels for facilitating anion transport.Type: ApplicationFiled: February 12, 2014Publication date: August 14, 2014Inventors: Steve S. He, Curtis W. Frank