Patents by Inventor Cynthia A. Maryanoff

Cynthia A. Maryanoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8164055
    Abstract: Holding devices for securely holding medical devices, such as stents, are utilized in performing molecular imaging of the medical devices.
    Type: Grant
    Filed: May 1, 2009
    Date of Patent: April 24, 2012
    Inventors: Lori Alquier, Cynthia A. Maryanoff, Gail Reed, Gyorgy Vas
  • Publication number: 20090294695
    Abstract: Holding devices for securely holding medical devices, such as stents, are utilized in performing molecular imaging of the medical devices.
    Type: Application
    Filed: May 1, 2009
    Publication date: December 3, 2009
    Inventors: Lori Alquier, Cynthia A. Maryanoff, Gail Reed, Gyorgy Vas
  • Patent number: 7622145
    Abstract: Processes for coating implantable medical devices that improve the stability of therapeutic agents contained within the coating.
    Type: Grant
    Filed: July 26, 2005
    Date of Patent: November 24, 2009
    Assignee: Cordis Corporation
    Inventors: Eugena A. Akerman, Dirk Cleeren, Gerard Llanos, Cynthia A. Maryanoff, Georgios Papandreou, William Rion, Karel Six, Thomas L. Todd
  • Patent number: 7560459
    Abstract: The present invention is directed to novel compounds of the formula (I) wherein X, R1, R2, R3, R4, R5 and R6 are as described in the specification, processes for the preparation of and pharmaceutical compositions comprising said derivatives. The compounds of the present invention are useful for the treatment of epilepsy. The invention is further directed to a process for the preparation of compounds of formula (XX), wherein X, R3, R4, R5 and R6 are as described in the specification.
    Type: Grant
    Filed: November 2, 2005
    Date of Patent: July 14, 2009
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Ahmed Abdel-Magid, Cynthia Maryanoff, Steven Mehrman, Allen B. Reitz, Bruce Maryanoff
  • Publication number: 20090049064
    Abstract: A software application, which allows the addition, modification and deletion of database fields dynamically, may be utilized without having to modify the database structure, application code, or user interface elements. Essentially, additional attributes may be added, subtracted or changed by users without the assistance of a database administrator. In addition to being more efficient, the application also dynamically conforms to the needs of the users and the requirements of the project for which the data is being captured. As additional project needs are defined, the structure of the database can grow and contract dynamically in real time.
    Type: Application
    Filed: August 5, 2008
    Publication date: February 19, 2009
    Inventors: Lori Alquier, Cynthia A. Maryanoff, Vladimir Veselov
  • Publication number: 20080228428
    Abstract: A method and system for the non-destructive analysis of medical devices uses a confocal Raman microscope and other non-destructive analytical tools to assess the spatial distribution of components of an object such as the distribution of an active pharmaceutical ingredient (API) within a polymer matrix. In a preferred embodiment, confocal Raman spectroscopy was used to differentiate each component found in the sirolimus-eluting coronary stent. The unique spectral features identified for each component were then used to develop three separate calibration curves to describe the solid phase distribution found on drug-polymer coated stents. The calibration curves were obtained by analyzing confocal Raman spectral depth profiles from a set of 16 unique formulations of drug-polymer coatings sprayed onto stents and planar substrates.
    Type: Application
    Filed: July 19, 2007
    Publication date: September 18, 2008
    Inventors: Karin Maria Balss, Gerard Llanos, Cynthia Maryanoff, George Papandreou, Vladimir Veselov
  • Publication number: 20080227982
    Abstract: An improved process for coating implantable medical devices utilizes a number of techniques for improving the stability of therapeutic agents contained within the coating. The stability of the therapeutic agents may be improved by creating substantially solvent-free, amorphous forms of the therapeutic agents.
    Type: Application
    Filed: May 27, 2008
    Publication date: September 18, 2008
    Inventors: Cynthia A. Maryanoff, Karel Six, Roger Vandecruys
  • Patent number: 7393952
    Abstract: An improved process for coating implantable medical devices utilizes a number of techniques for improving the stability of therapeutic agents contained within the coating. The stability of the therapeutic agents may be improved by creating substantially solvent-free, amorphous forms of the therapeutic agents.
    Type: Grant
    Filed: August 24, 2005
    Date of Patent: July 1, 2008
    Assignee: Cordis Corporation
    Inventors: Cynthia A. Maryanoff, Karel Six, Roger Vandecruys
  • Patent number: 7247745
    Abstract: A process for making a compound of formula I wherein the substituents are as described in the specification comprising reacting a ketone of formula II with succinic anhydride and an alkoxide base to form a compound of formula III which is reacted with a compound of formula IV to form a compound of V and reacting with an alcohol to form the corresponding ester of formula VI and reacting the ester with N-methylhydroxylamine.
    Type: Grant
    Filed: August 30, 2005
    Date of Patent: July 24, 2007
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Ahmed F. Abdel-Magid, Bruce D. Harris, Cynthia A. Maryanoff
  • Patent number: 7196209
    Abstract: The present invention is directed to a continuous process for the preparation of fructopyranose sulfamate derivatives of the general formula (I) wherein R1, R3, R4, R5, R6 and X are as herein defined. The present invention is further directed to a continuous process for the preparation of Topiramate.
    Type: Grant
    Filed: October 23, 2003
    Date of Patent: March 27, 2007
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Thomas W. Adkins, Charles F. Cicco, Penina Feibush, Donald A. Koch, Cynthia Maryanoff, Walter E. Stalzer
  • Patent number: 7098188
    Abstract: The invention relates to novel pharmaceutically acceptable salts of anticonvulsant derivatives, processes for preparation of and pharmaceutical compositions containing said salts, useful in the treatment of epilepsy.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: August 29, 2006
    Assignee: Ortho-McNeil Pharmaceutical., Inc.
    Inventors: Ahmed Abdel-Magid, Cynthia Maryanoff
  • Publication number: 20060128739
    Abstract: An improved process for coating implantable medical devices utilizes a number of techniques for improving the stability of therapeutic agents contained within the coating. The stability of the therapeutic agents may be improved by creating substantially solvent-free, amorphous forms of the therapeutic agents.
    Type: Application
    Filed: August 24, 2005
    Publication date: June 15, 2006
    Inventors: Cynthia Maryanoff, Karel Six, Roger Vandecruys
  • Patent number: 7060725
    Abstract: The present invention is directed to novel compounds of the formula (I) wherein X, R1, R2, R3, R4, R5 and R6 are as described in the specification, processes for the preparation of and pharmaceutical compositions comprising said derivatives. The compounds of the present invention are useful for the treatment of epilepsy. The invention is further directed to a process for the preparation of compounds of formula (XX), wherein X, R3, R4, R5 and R6 are as described in the specification.
    Type: Grant
    Filed: May 8, 2003
    Date of Patent: June 13, 2006
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Ahmed Abdel-Magid, Cynthia Maryanoff, Steven Mehrman, Kirk Sorgi, Frank Villani, Cheryl Kordik, Allen B. Reitz, Bruce Maryanoff
  • Publication number: 20060105966
    Abstract: The invention relates to novel pharmaceutically acceptable salts of anticonvulsant derivatives, processes for preparation of and pharmaceutical compositions containing said salts, useful in the treatment of epilepsy.
    Type: Application
    Filed: January 9, 2006
    Publication date: May 18, 2006
    Inventors: Ahmed Abdel-Magid, Cynthia Maryanoff
  • Patent number: 7041650
    Abstract: The invention relates to novel pharmaceutically acceptable salts of anticonvulsant derivatives, processes for preparation of and pharmaceutical compositions containing said salts, useful in the treatment of epilepsy.
    Type: Grant
    Filed: January 3, 2003
    Date of Patent: May 9, 2006
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Ahmed Abdel-Magid, Cynthia Maryanoff
  • Publication number: 20060094744
    Abstract: The present invention provides a pharmaceutical dosage form comprising stable amorphous rapamycin like compounds and a pharmaceutically acceptable excipient and methods of making the pharmaceutical dosage form.
    Type: Application
    Filed: September 28, 2005
    Publication date: May 4, 2006
    Inventors: Cynthia Maryanoff, Karl Pieter Six, Roger Petrus Vandecruys
  • Publication number: 20060058373
    Abstract: The present invention is directed to novel compounds of the formula (I) wherein X, R1, R2, R3, R4, R5 and R6 are as described in the specification, processes for the preparation of and pharmaceutical compositions comprising said derivatives. The compounds of the present invention are useful for the treatment of epilepsy. The invention is further directed to a process for the preparation of compounds of formula (XX), wherein X, R3, R4, R5 and R6 are as described in the specification.
    Type: Application
    Filed: November 2, 2005
    Publication date: March 16, 2006
    Inventors: Ahmed Abdel-Magid, Cynthia Maryanoff, Steven Mehrman, Allen Reitz, Bruce Maryanoff
  • Publication number: 20060024426
    Abstract: Processes for coating implantable medical devices that improve the stability of therapeutic agents contained within the coating.
    Type: Application
    Filed: July 26, 2005
    Publication date: February 2, 2006
    Inventors: Eugena Akerman, Dirk Cleeren, Gerard Llanos, Cynthia Maryanoff, Georgios Papandreou, William Rion, Karel Six, Thomas Todd
  • Publication number: 20060014929
    Abstract: The invention realtes to improved liquid phase processes for the preparation of the 21 residue protein component, (Lys-Leu4)4-Lys, of the pulmonary surfactant KL-4. These process are amenable to large scale synthesis and one process employs a method of saponifying an ester which reduces the inherent racemization of the ?-carbon.
    Type: Application
    Filed: May 29, 2002
    Publication date: January 19, 2006
    Inventors: Ahmed Abdel-Magid, Urs Eggmann, Cynthia Maryanoff, Adrian Thaler, Frank Villani
  • Publication number: 20060004208
    Abstract: A process for making a compound of formula I wherein the substituents are as described in the specification comprising reacting a ketone of formula II with succinic anhydride and an alkoxide base to form a compound of formula III which is reacted with a compound of formula IV to form a compound of V and reacting with an alcohol to form the corresponding ester of formula VI and reacting the ester with N-methylhydroxylamine.
    Type: Application
    Filed: August 30, 2005
    Publication date: January 5, 2006
    Inventors: Ahmed Abdel-Magid, Bruce Harris, Cynthia Maryanoff