Patents by Inventor Cynthia C. Bamdad

Cynthia C. Bamdad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7615340
    Abstract: Porous members can be positioned so as to partially or fully span channels in microfluidic systems. The porous members can be assembled and/or disassembled in situ. The porous members can be made such that pores are separated by connections including but a single molecule at one location, allowing for a high level of open area in a very small pore size member. The porous member can be made up of colloid particles interconnected with molecular species. These can be used to detect analytes qualitatively and/or quantitatively, or to selectively bind and/or release agents on command for a variety of purposes including first blocking, then opening a channel, concentrating analyte over time followed by release of analyte and detection downstream, etc. Porous members can define valves in multiple-channel systems and, with controlled binding and release of agents at the porous members, these valves can be opened and closed and fluid flow controlled in a multi-channel system.
    Type: Grant
    Filed: October 3, 2001
    Date of Patent: November 10, 2009
    Assignee: Minerva Biotechnologies Corporation
    Inventor: Cynthia C. Bamdad
  • Patent number: 7585682
    Abstract: The invention involves methods, assays, and components for the detection and analysis of binding between biological or chemical species, and can specifically be used for drug discovery. In an example where drug discovery is carried out, different candidate drugs can be attached to different articles such as magnetic beads. The beads can be exposed to colloid particles carrying signaling entities, or other signaling entities, immobilized with respect to protein targets of the drug candidates. After incubation, all beads are drawn to separate surface locations magnetically. Beads are released from surface locations where it is determined that signaling entities do not exist, and are removed from the assay. Beads held at other surface locations then are released, re-distributed, and re-attracted to surface locations. This is repeated with appropriate wash steps, until individual drug candidates can be isolated and identified.
    Type: Grant
    Filed: October 3, 2001
    Date of Patent: September 8, 2009
    Assignee: Minerva Biotechologies Corporation
    Inventor: Cynthia C. Bamdad
  • Publication number: 20090092603
    Abstract: A method of determining likelihood of acquiring drug resistance of a tumor or cancerous cells, cancer metastasis, cancer recurrence, or decreased life expectancy, comprising measuring the level of MUC1 or MUC1-associated factor expressed in the cancerous cells or tumor.
    Type: Application
    Filed: September 25, 2008
    Publication date: April 9, 2009
    Inventor: Cynthia C. BAMDAD
  • Publication number: 20090075926
    Abstract: The present application discloses a method of isolating or selecting stem cells from a mixed population containing stem cells, which includes the population of cells with a ligand specific for a truncated MUC1 receptor, wherein the presence of the truncated MUC1 receptor on the cells indicates that they are stem cells.
    Type: Application
    Filed: December 6, 2007
    Publication date: March 19, 2009
    Inventor: Cynthia C. Bamdad
  • Publication number: 20090069367
    Abstract: A method for treating or preventing cancer in a subject comprising administering a treatment effective amount of a chemotype 4 compound.
    Type: Application
    Filed: September 25, 2008
    Publication date: March 12, 2009
    Inventor: Cynthia C. BAMDAD
  • Publication number: 20080254548
    Abstract: The invention relates to the use of particles comprising binding ligands and electron transfer moieties (ETMs). Upon binding of a target analyte, a particle and a reporter composition are associated and transported to an electrode surface. The ETMs are then detected, allowing the presence or absence of the target analyte to be determined.
    Type: Application
    Filed: October 31, 2007
    Publication date: October 16, 2008
    Applicant: Clinical Micro Sensors, Inc.
    Inventors: Cynthia C. Bamdad, Robert C. Mucic
  • Publication number: 20080248592
    Abstract: The invention relates to the use of particles comprising binding ligands and electron transfer moieties (ETMs). Upon binding of a target analyte, a particle and a reporter composition are associated and transported to an electrode surface. The ETMs are then detected, allowing the presence or absence of the target analyte to be determined.
    Type: Application
    Filed: October 31, 2007
    Publication date: October 9, 2008
    Applicant: Clinical Micro Sensors, Inc.
    Inventors: Cynthia C. Bamdad, Robert C. Mucic
  • Publication number: 20080064680
    Abstract: The present application discloses methods of detecting and treating cancer which express MUC1 aberrantly.
    Type: Application
    Filed: September 14, 2005
    Publication date: March 13, 2008
    Inventor: Cynthia C. Bamdad
  • Patent number: 6809196
    Abstract: An article suitable for use as a biosensor includes a molecule of a formula X—R—Ch adhered to a surface of the article as part of a self-assembled monolayer. X is a functionality that adheres to the surface, R is a spacer moiety, and Ch is a chelating agent. A metal ion can be coordinated by the chelating agent, and a polyamino acid-tagged biological binding partner of a target biological molecule coordinated to the metal ion. A method of the invention involves bringing the article into contact with a medium containing or suspected of containing the target biological molecule and allowing the biological molecule to biologically bind to the binding partner. The article is useful particularly as a surface plasmon resonance chip.
    Type: Grant
    Filed: July 25, 2001
    Date of Patent: October 26, 2004
    Assignee: President and Fellows of Harvard College
    Inventors: Cynthia C. Bamdad, George B. Sigal, Jack L. Strominger, George M. Whitesides
  • Publication number: 20030130293
    Abstract: This invention generally relates to compositions and methods for cancer treatment and, in particular, to compositions able to interact (e.g., bind to) with MUC1 growth factor receptor or its ligands, and methods for treating the same. The invention also relates to assays or use of such compositions for the treatment of patients susceptible to or exhibiting symptoms characteristic of cancer or tumorigenesis. Other compositions of the present invention useful for the treatment or prevention of cancer or tumorigenesis include homologs, analogs, derivatives, enantiomers or functional equivalents. The present compositions can also be packaged in kits in some cases.
    Type: Application
    Filed: September 5, 2002
    Publication date: July 10, 2003
    Inventor: Cynthia C. Bamdad
  • Publication number: 20030119834
    Abstract: The present invention generally relates to compositions useful in the treatment or prevention of cancer, in some cases by limiting or preventing angiogenesis. Other compositions useful for the treatment or prevention of cancer or angiogenesis include homologs, analogs, derivatives, enantiomers or functionally equivalent compositions of the present invention. The present compositions can be packaged in kits. The present invention also relates to the use of compositions useful for the treatment of patients susceptible to or exhibiting symptoms characteristic of cancer, for example, patients with solid tumors.
    Type: Application
    Filed: September 5, 2002
    Publication date: June 26, 2003
    Inventor: Cynthia C. Bamdad
  • Patent number: 6541617
    Abstract: The invention relates to the use of particles comprising binding ligands and electron transfer moieties (ETMs). Upon binding of a target analyte, a particle and a reporter composition are associated and transported to an electrode surface. The ETMs are then detected, allowing the presence or absence of the target analyte to be determined.
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: April 1, 2003
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Cynthia C. Bamdad, Robert C. Mucic
  • Publication number: 20030059955
    Abstract: The present invention provides methods, assays, kits, and components for the detection and analysis of binding between various biological or chemical species, as well as techniques for facilitating the attachment of various biological or chemical species to a particle. In some cases, particles having the ability to emit electromagnetic radiation within a narrow wavelength band, for example, semiconductor nanocrystals, are attached to a substrate or a structure, such as a molecule, a particle, a fluid sample, a cell, or a tissue. The attachment may be a direct attachment or an indirect attachment, for example, an attachment comprising an affinity tag/recognition entity interaction. The particles may then be further used to assay biological or chemical entities, or combined with other detection techniques.
    Type: Application
    Filed: August 30, 2002
    Publication date: March 27, 2003
    Inventor: Cynthia C. Bamdad
  • Publication number: 20030060487
    Abstract: In some aspects, the invention relates to treatments for peptide aggregation associated with disease states such as neurodegenerative disease, particularly physiology associated with Alzheimer's Disease, and non-neurodegenerative disease aggregation. Other aspects of the invention provide a variety of novel assays for screening candidate drugs. Yet other aspects of the present invention provide a series of compositions useful for treatment of peptide aggregation associated with disease states such as neurodegenerative disease, as determined from these assays. These compositions can be packaged in kits. Other aspects of the invention relate to the use of these compositions for the treatment and/or prevention of patients susceptible to or exhibiting symptoms characteristic of fibril formation or aberrant protein aggregation.
    Type: Application
    Filed: April 12, 2001
    Publication date: March 27, 2003
    Inventors: R. Shoshana Bamdad, Cynthia C. Bamdad
  • Publication number: 20030036199
    Abstract: The invention provides a series of compositions, methods, kits, articles and species associated primarily with the diagnosis and/or treatment of cell proliferation, specifically cancer. Cell proliferation associated with aberrant expression of MUC1 is particularly focused upon. Mechanisms associated with MUC1 cell proliferation are discussed.
    Type: Application
    Filed: November 27, 2001
    Publication date: February 20, 2003
    Inventors: Cynthia C. Bamdad, R. Shoshana Bamdad
  • Publication number: 20020164611
    Abstract: Methods, assays, and components are described in which biological samples can be rapidly and sensitively analyzed for the presence of species associated with neurodegenerative disease. Techniques and components are provided for diagnosis of disease, as well as for screening of candidate drugs for treatment of neurodegenerative disease. The techniques are simple, extremely sensitive, and utilize readily-available components. Binding species, capable of binding a neurodegenerative disease aggregate-forming or aggregate-forming species, are fastened to surfaces of electrodes and surfaces of particles, or provided free in solution, to bind aggregate-forming species and/or be involved in aggregation.
    Type: Application
    Filed: November 15, 2001
    Publication date: November 7, 2002
    Inventors: R. Shoshana Bamdad, Cynthia C. Bamdad
  • Patent number: 6472148
    Abstract: An article suitable for use as a biosensor includes a molecule of a formula X—R—Ch adhered to a surface of the article as part of a self-assembled monolayer. X is a functionality that adheres to the surface, R is a spacer moiety, and Ch is a chelating agent. A metal ion can be coordinated by the chelating agent, and a polyamino acid-tagged biological binding partner of a target biological molecule coordinated to the metal ion. A method of the invention involves bringing the article into contact with a medium containing or suspected of containing the target biological molecule and allowing the biological molecule to biologically bind to the binding partner. The article is useful particularly as a surface plasmon resonance chip.
    Type: Grant
    Filed: January 21, 1997
    Date of Patent: October 29, 2002
    Assignee: President and Fellows of Harvard College
    Inventors: Cynthia C. Bamdad, George B. Sigal, Jack L. Strominger, George M. Whitesides
  • Publication number: 20020156112
    Abstract: A treatment for cancer is provided. The treatment may include administering a therapeutic amount of L-histidine, D-cycloserine, quisqualic acid or suramin or analogs thereof.
    Type: Application
    Filed: November 15, 2001
    Publication date: October 24, 2002
    Inventors: R. Shoshana Bamdad, Cynthia C. Bamdad
  • Publication number: 20020098526
    Abstract: Porous members can be positioned so as to partially or fully span channels in microfluidic systems. The porous members can be assembled and/or disassembled in situ. The porous members can be made such that pores are separated by connections including but a single molecule at one location, allowing for a high level of open area in a very small pore size member. The porous member can be made up of colloid particles interconnected with molecular species. These can be used to detect analytes qualitatively and/or quantitatively, or to selectively bind and/or release agents on command for a variety of purposes including first blocking, then opening a channel, concentrating analyte over time followed by release of analyte and detection downstream, etc. Porous members can define valves in multiple-channel systems and, with controlled binding and release of agents at the porous members, these valves can be opened and closed and fluid flow controlled in a multi-channel system.
    Type: Application
    Filed: October 3, 2001
    Publication date: July 25, 2002
    Inventor: Cynthia C. Bamdad
  • Publication number: 20020086443
    Abstract: The invention involves methods, assays, and components for the detection and analysis of binding between biological or chemical species, and can specifically be used for drug discovery. In an example where drug discovery is carried out, different candidate drugs can be attached to different articles such as magnetic beads. The beads can be exposed to colloid particles carrying signaling entities, or other signaling entities, immobilized with respect to protein targets of the drug candidates. After incubation, all beads are drawn to separate surface locations magnetically. Beads are released from surface locations where it is determined that signaling entities do not exist, and are removed from the assay. Beads held at other surface locations then are released, re-distributed, and re-attracted to surface locations. This is repeated with appropriate wash steps, until individual drug candidates can be isolated and identified.
    Type: Application
    Filed: October 3, 2001
    Publication date: July 4, 2002
    Inventor: Cynthia C. Bamdad