Patents by Inventor D. Lansing Taylor

D. Lansing Taylor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180204085
    Abstract: Graph-theoretic segmentation methods for segmenting histological structures in H&E stained images of tissues. The method relies on characterizing local spatial statistics in the images. Also, a method for quantifying intratumor spatial heterogeneity that can work with single biomarker, multiplexed, or hyperplexed immunofluorescence (IF) data. The method is holistic in its approach, using both the expression and spatial information of an entire tumor tissue section and/or spot in a TMA to characterize spatial associations. The method generates a two-dimensional heterogeneity map to explicitly elucidate spatial associations of both major and minor sub-populations.
    Type: Application
    Filed: June 10, 2016
    Publication date: July 19, 2018
    Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: S. Chakra CHENNUBHOTLA, D. Lansing TAYLOR
  • Publication number: 20170292117
    Abstract: Microfluidic devices for modeling three-dimensional tissue structures and methods for making and using the same are described herein.
    Type: Application
    Filed: September 30, 2015
    Publication date: October 12, 2017
    Inventors: D. Lansing TAYLOR, Albert GOUGH, Larry VERNETTI
  • Publication number: 20140212892
    Abstract: The invention provides an improved method for identifying and interpreting tissue specimens and/or cells derived from tissue specimens. A panel of cell-based reagents provides a number of readouts of cellular states or biomarkers that together define a profile of a diversity of cellular states or biomarkers in a tissue specimen representing the ‘systems” nature of biology. This cellular profile is interpreted using informatics tools, to identify similarities between specimens, in vivo medical conditions, and suggest options for treating medical conditions.
    Type: Application
    Filed: October 30, 2013
    Publication date: July 31, 2014
    Applicant: Cernostics, Inc.
    Inventors: Albert H. Gough, Kenneth A. Giuliano, D. Lansing Taylor
  • Patent number: 8597899
    Abstract: The invention provides an improved method for identifying and interpreting tissue specimens and/or cells derived from tissue specimens. A panel of cell-based reagents provides a number of readouts of cellular states or biomarkers that together define a profile of a diversity of cellular states or biomarkers in a tissue specimen representing the ‘systems” nature of biology. This cellular profile is interpreted using informatics tools, to identify similarities between specimens, in vivo medical conditions, and suggest options for treating medical conditions.
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: December 3, 2013
    Assignee: Cernostics, Inc.
    Inventors: Albert H. Gough, Kenneth A. Giuliano, D. Lansing Taylor
  • Publication number: 20130190198
    Abstract: The invention provides an improved method for identifying and interpreting tissue specimens and/or cells derived from tissue specimens. A panel of cell-based reagents provides a number of readouts of cellular states or biomarkers that together define a profile of a diversity of cellular states or biomarkers in a tissue specimen representing the ‘systems” nature of biology. This cellular profile is interpreted using informatics tools, to identify similarities between specimens, in vivo medical conditions, and suggest options for treating medical conditions.
    Type: Application
    Filed: August 24, 2012
    Publication date: July 25, 2013
    Applicant: Cernostics, Inc.
    Inventors: Albert H. Gough, Kenneth A. Giuliano, D. Lansing Taylor
  • Patent number: 8114615
    Abstract: The invention provides an improved method for identifying and interpreting tissue specimens and/or cells derived from tissue specimens. A panel of cell-based reagents provides a number of readouts of cellular states or biomarkers that together define a profile of a diversity of cellular states or biomarkers in a tissue specimen representing the “systems” nature of biology. This cellular profile is interpreted using informatics tools, to identify similarities between specimens, in vivo medical conditions, and suggest options for treating medical conditions.
    Type: Grant
    Filed: May 17, 2007
    Date of Patent: February 14, 2012
    Assignee: Cernostics, Inc.
    Inventors: Albert H. Gough, Kenneth A. Giuliano, D. Lansing Taylor
  • Patent number: 7853409
    Abstract: The invention relates to an optical system for determining the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for specific biological activity. The invention involves providing cells containing fluorescent reporter molecules in an array of locations and scanning numerous cells in each location with a fluorescent microscope, converting the optical information into digital data, and utilizing the digital data to determine the distribution, environment or activity of the fluorescently labeled reporter molecules in the cells. The array of locations may be an industry standard 96 well or 384 well microtiter plate or a microplate which is a microplate having a cells in a micropatterned array of locations. The invention includes apparatus and computerized method for processing, displaying and storing the data.
    Type: Grant
    Filed: June 4, 2007
    Date of Patent: December 14, 2010
    Assignee: Cellomics, Inc.
    Inventors: R. Terry Dunlay, D. Lansing Taylor
  • Publication number: 20100009352
    Abstract: The invention described herein provides for methods of profiling cellular models of disease. Cellular systems biology is the investigation of the integrated and interacting networks of genes, proteins, and metabolites that are responsible for normal and abnormal cell functions. Methods and reagents for the profiling a disease state, the treatment of a disease state and assaying of treatments of a disease state are provided.
    Type: Application
    Filed: May 24, 2007
    Publication date: January 14, 2010
    Inventors: Albert H. Gough, Patricia Johnston, Kenneth A. Giuliano, D. Lansing Taylor
  • Publication number: 20090298703
    Abstract: The invention provides an improved method for identifying and interpreting tissue specimens and/or cells derived from tissue specimens. A panel of cell-based reagents provides a number of readouts of cellular states or biomarkers that together define a profile of a diversity of cellular states or biomarkers in a tissue specimen representing the “systems” nature of biology. This cellular profile is interpreted using informatics tools, to identify similarities between specimens, in vivo medical conditions, and suggest options for treating medical conditions.
    Type: Application
    Filed: May 17, 2007
    Publication date: December 3, 2009
    Inventors: Albert H. Gough, Kenneth A. Giullano, D. Lansing Taylor
  • Patent number: 7565247
    Abstract: The invention relates to an optical system for determining the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for specific biological activity. The invention involves providing cells containing fluorescent reporter molecules in an array of locations and scanning numerous cells in each location with a fluorescent microscope, converting the optical information into digital data, and utilizing the digital data to determine the distribution, environment or activity of the fluorescently labeled reporter molecules in the cells. The array of locations may be an industry standard 96 well or 384 well microtiter plate or a microplate which is a microplate having a cells in a micropaterned array of locations. The invention includes apparatus and computerized method for processing, displaying and storing the data.
    Type: Grant
    Filed: November 22, 2000
    Date of Patent: July 21, 2009
    Assignee: Cellomics, Inc.
    Inventors: R. Terry Dunlay, D. Lansing Taylor
  • Publication number: 20090170091
    Abstract: The inventive method employs a “systems biology” approach to predicting biological responses resulting from exposure to the test substance. In one embodiment, the invention provides an automated method for predicting the biological systems effects of a test substance. In another embodiment, the invention provides a method for constructing a knowledgebase (or database) of response profiles for reference substances with known biological systems effects. In another embodiment, the invention provides a set of protocols and software tools used to carry out the profiling. Another embodiment of the invention is a panel of reagents and protocols required for generating response profiles, either to create an knowledgebase, or to use with an existing knowledgebase and informatics software to profile substance physiological effects. Another embodiment of the invention is a database of physiological profiles.
    Type: Application
    Filed: January 17, 2007
    Publication date: July 2, 2009
    Inventors: Kenneth Giuliano, Albert H. Gough, Patricia A. Johnston, D. Lansing Taylor
  • Publication number: 20090131270
    Abstract: The invention provides a method of detecting the effect of an agent of interest on the interaction between two or more polypeptides introduced into a cell. The invention also provides a method for quantifying the interaction between at least two molecules of interest, which are introduced into a cell. A method for quantifying the effects of an agent of interest or the interaction between two molecules of interest on cellular constituents or functions in the same cells is also provided. The above inventive methods can be automatically quantified by a device, such as a HCS device, and utilized in the construction of a database.
    Type: Application
    Filed: August 2, 2005
    Publication date: May 21, 2009
    Applicant: Cellumen, Inc.a Corporation
    Inventors: D. Lansing Taylor, Kenneth A. Giuliano
  • Patent number: 7235373
    Abstract: The invention relates to an optical system for determining the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for specific biological activity. The invention involves providing cells containing fluorescent reporter molecules in an array of locations and scanning numerous cells in each location with a fluorescent microscope, converting the optical information into digital data, and utilizing the digital data to determine the distribution, environment or activity of the fluorescently labeled reporter molecules in the cells. The array of locations may be an industry standard 96 well or 384 well microtiter plate or a microplate which is a microplate having a cells in a micropaterned array of locations. The invention includes apparatus and computerized method for processing, displaying and storing the data.
    Type: Grant
    Filed: April 11, 2003
    Date of Patent: June 26, 2007
    Assignee: Cellomics, Inc.
    Inventors: R. Terry Dunlay, D. Lansing Taylor
  • Patent number: 7117098
    Abstract: The present invention provides systems, methods, and screens for an optical system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for those that specifically affect particular biological functions. The invention involves providing cells containing fluorescent reporter molecules in an array of locations and scanning numerous cells in each location with a high magnification fluorescence optical system, converting the optical information into digital data, and utilizing the digital data to determine the distribution, environment or activity of the fluorescently labeled reporter molecules in the cells. The array of locations may be an industry standard 96 well or 384 well microtiter plate or a microplate which is a microplate having a cells in a micropaterned array of locations.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: October 3, 2006
    Assignee: Cellomics, Inc.
    Inventors: R. Terry Dunlay, D. Lansing Taylor, Albert H. Gough, Kenneth A. Giuliano
  • Patent number: 7060445
    Abstract: The invention relates to an optical system for determining the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for specific biological activity. The invention involves providing cells containing fluorescent reporter molecules in an array of locations and scanning numerous cells in each location with a fluorescent microscope, converting the optical information into digital data, and utilizing the digital data to determine the distribution, environment or activity of the fluorescently labeled reporter molecules in the cells. The array of locations may be an industry standard 96 well or 384 well microtiter plate or a microplate which is a microplate having a cells in a micropaterned array of locations. The invention includes apparatus and computerized method for processing, displaying and storing the data.
    Type: Grant
    Filed: November 22, 2000
    Date of Patent: June 13, 2006
    Assignee: Cellomics, Inc.
    Inventors: R. Terry Dunlay, D. Lansing Taylor
  • Patent number: 6902883
    Abstract: The invention relates to an optical system for determining the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for specific biological activity. The invention involves providing cells containing fluorescent reporter molecules in an array of locations and scanning numerous cells in each location with a fluorescent microscope, converting the optical information into digital data, and utilizing the digital data to determine the distribution, environment or activity of the fluorescently labeled reporter molecules in the cells. The array of locations may be an industry standard 96 well or 384 well microtiter plate or a microplate which is a microplate having a cells in a micropaterned array of locations. The invention includes apparatus and computerized method for processing, displaying and storing the data.
    Type: Grant
    Filed: May 6, 2003
    Date of Patent: June 7, 2005
    Inventors: R. Terry Dunlay, D. Lansing Taylor
  • Patent number: 6727071
    Abstract: The present invention provides systems, methods, and screens for an optical system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for those that specifically affect particular biological functions. The invention involves providing cells containing fluorescent reporter molecules in an array of locations and scanning numerous cells in each location with a high magnification fluorescence optical system, converting the optical information into digital data, and utilizing the digital data to determine the distribution, environment or activity of the fluorescently labeled reporter molecules in the cells. The array of locations may be an industry standard 96 well or 384 well microtiter plate or a microplate which is microplate having cells in a micropaterned array of locations.
    Type: Grant
    Filed: December 8, 1999
    Date of Patent: April 27, 2004
    Assignee: Cellomics, Inc.
    Inventors: R. Terry Dunlay, D. Lansing Taylor, Albert H. Gough, Kenneth A. Giuliano
  • Publication number: 20040063162
    Abstract: The present invention provides systems, methods, and screens for an optical system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for those that specifically affect particular biological functions. The invention involves providing cells containing fluorescent reporter molecules in an array of locations and scanning numerous cells in each location with a high magnification fluorescence optical system, converting the optical information into digital data, and utilizing the digital data to determine the distribution, environment or activity of the fluorescently labeled reporter molecules in the cells. The array of locations may be an industry standard 96 well or 384 well microtiter plate or a microplate which is a microplate having a cells in a micropaterned array of locations.
    Type: Application
    Filed: October 15, 2003
    Publication date: April 1, 2004
    Applicant: Cellomics, Inc.
    Inventors: R. Terry Dunlay, D. Lansing Taylor, Albert H. Gough, Kenneth A. Giuliano
  • Publication number: 20040009539
    Abstract: The invention relates to an optical system for determining the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for specific biological activity. The invention involves providing cells containing fluorescent reporter molecules in an array of locations and scanning numerous cells in each location with a fluorescent microscope, converting the optical information into digital data, and utilizing the digital data to determine the distribution, environment or activity of the fluorescently labeled reporter molecules in the cells. The array of locations may be an industry standard 96 well or 384 well microtiter plate or a microplate which is a microplate having a cells in a micropaterned array of locations. The invention includes apparatus and computerized method for processing, displaying and storing the data.
    Type: Application
    Filed: April 11, 2003
    Publication date: January 15, 2004
    Inventors: R. Terry Dunlay, D. Lansing Taylor
  • Patent number: 6671624
    Abstract: The present invention provides systems, methods, and screens for an optical system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for those that specifically affect particular biological functions. The invention involves providing cells containing fluorescent reporter molecules in an array of locations and scanning numerous cells in each location with a high magnification fluorescence optical system, converting the optical information into digital data, and utilizing the digital data to determine the distribution, environment or activity of the fluorescently labeled reporter molecules in the cells. The array of locations may be an industry standard 96 well or 384 well microtiter plate or a microplate which is a microplate having a cells in a micropaterned array of locations.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: December 30, 2003
    Assignee: Cellomics, Inc.
    Inventors: R. Terry Dunlay, D. Lansing Taylor, Albert H. Gough, Kenneth A. Giuliano