Patents by Inventor Dacie R. Bridge

Dacie R. Bridge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LIVE SALMONELLA TYPHI VECTORS ENGINEERED TO EXPRESS HETEROLOGOUS OUTER MEMBRANE PROTEIN ANTIGENS AND METHODS OF USE THEREOF
    Publication number: 20240156936
    Abstract: The present invention provides compositions and methods of inducing an immune response in a subject in need thereof, comprising administering to the subject an immunologically-effective amount of a live Salmonella typhi vector comprising a heterologous antigen from a pathogen, wherein the heterologous antigen comprises an outer membrane protein, an antigenic fragment thereof or a variant thereof, wherein the antigen is delivered to a mucosal tissue of the subject by an outer membrane vesicle.
    Type: Application
    Filed: September 5, 2023
    Publication date: May 16, 2024
    Inventors: James E. Galen, Thanh Pham, Dacie R. Bridge, Jin Yuan Wang, Wangxue Chen
  • Live vectors engineered to express heterologous outer membrane protein antigens and methods of use thereof
    Patent number: 11744884
    Abstract: The present invention provides compositions and methods of inducing an immune response in a subject in need thereof, comprising administering to the subject an immunologically-effective amount of a live Salmonella Typhi vector comprising a heterologous antigen from a pathogen, wherein the heterologous antigen comprises an outer membrane protein, an antigenic fragment thereof or a variant thereof, wherein the antigen is delivered to a mucosal tissue of the subject by an outer membrane vesicle.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: September 5, 2023
    Assignees: UNIVERSITY OF MARYLAND, BALTIMORE, NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: James E. Galen, Thanh Pham, Dacie R. Bridge, Jin Yuan Wang, Wangxue Chen
  • LIVE SALMONELLA TYPHI VECTORS ENGINEERED TO EXPRESS HETEROLOGOUS OUTER MEMBRANE PROTEIN ANTIGENS AND METHODS OF USE THEREOF
    Publication number: 20200179501
    Abstract: The present invention provides compositions and methods of inducing an immune response in a subject in need thereof, comprising administering to the subject an immunologically-effective amount of a live Salmonella Typhi vector comprising a heterologous antigen from a pathogen, wherein the heterologous antigen comprises an outer membrane protein, an antigenic fragment thereof or a variant thereof, wherein the antigen is delivered to a mucosal tissue of the subject by an outer membrane vesicle.
    Type: Application
    Filed: May 15, 2018
    Publication date: June 11, 2020
    Inventors: James E. Galen, Thanh Pham, Dacie R. Bridge, Jin Yuan Wang, Wangxue C. Chen